Luminescence

Companies Luminescence

BMG LABTECH GmbH, Germany

BMG LABTECH offers high-end plate reader solutions for drug discovery and HTS. The plate readers provides best sensitivity, best flexibility and reliability. The integration of these microplate readers into robotic systems is easy; especially for the robot integration in high throughput screening (H more

Products Luminescence

Zero Crosstalk Luminescence Assay Plate

Constructed in ultra-pure grade polystyrene, the opaque white Krystal 2000 plate maximises reflectivity enabling even weakly emitting luminescence assays more

A flexible Single Tube Luminometer of Highest Sensitivity

The new developed Sirius L Tube Luminometer allows high quality luminescence measurements with state-of-the-art technique more

The top class multi-mode reader for assay development

No compromise – Tecan’s Infinite® M 1000 PRO is the top class multi-mode reader for assay development - speed, high flexibility, outstanding results more

News Luminescence

• Symbiotic bacteria program daily rhythms in squid using light and chemicals

  Glowing bacteria inside squids use light and chemical signals to control circadian-like rhythms in the animals, according to a study to be published in mBio®. The Hawaiian bobtail squid, Euprymna scolopes, houses a colony of Vibrio fischeri bacteria in its light organ, using the bacteria at night as more

• New Screening Strategy for Epigenetic Targets: European ScreeningPort Forms Strategic Alliance with Hypha

  Hypha Discovery Ltd and European ScreeningPort GmbH (ESP) announced a collaboration to evaluate Hypha’s MycoDiverseTM natural products library in ESP’s in-house epigenetic target assay panel. Currently, ESP provides access to Hypha’s MycoDiverseTM screening library to customers as part of its academ more

• New tagging technique enhances view of living cells

  Scientists hoping to understand how cells work may get a boost from a new technique to tag and image proteins within living mammalian cells. The new technique, developed by a research team led by University of Illinois at Chicago assistant professor of chemistry Lawrence Miller, provides the cleare more

White papers Luminescence

• A High-Throughput Experimental Tool for Studying Gene Pathways
  

  The post-genome era has lead to great advances in high-throughput genomics studies. Genomic approaches such as microarray expression analyses and Chromatin Immuno-Precipitation on Chip (ChIP-chip) transcription factor binding assays have yielded new discoveries and insights into genetic pathways. These technologies provide valuable observational data but do not identify the functional connections within networks or explain the mechanism of gene regulation. Reporter gene based experiments like functional promoter assays provide an important additional layer of data for understanding mechanisms of regulation in genetic networks. Efficient and reproducible transfection methods are a prerequisite for all of these assays involving transfections. more

• Homogeneous IgG AlphaLISA® assay performed on BMG LABTECH's PHERAstar Plus
  

  Immunoglobulins or antibodies are proteins that are involved in the immune response. That makes them interesting drug targets. This application note shows the detection of the immunoglobulin IgG using an AlphaLISA® assay performed on BMG LABTECH's PHERAstar Plus. The AlphaLISA® technology utilizes oxygen to start a cascade of chemical reactions resulting in a luminescence signal at 615 nm. Sensitivity and Z´values obtained in different plate formats are presented. more

• Predictor(TM) hERG Fluorescence Polarization Assay Kit performed on the PHERAstar/PHERAstar Plus
  

  The potential for cardiotoxic side-effects continues to challenge the development of small molecule based therapies. These intolerable side-effects are often precipitated by drug-induced long QT syndrome (LQT), which is often linked to blocking the human ether-a-go-go related gene (hERG) potassium channel. Although patch-clamp electrophysiology remains the gold standard for determining the interaction of compounds with the function of the hERG channel, radioligand displacement assays have proven to be a cost-effective initial alternative assay for hERG channel liability at early stages of compound development. more

Publications Luminescence

• Microinjecting Holo-Aequorin into Dechorionated and Intact Zebrafish Embryos

  The injection of holo-aequorin into embryos at the one-cell stage, along with the use of a simple photomultiplier tube or luminescence imaging system, allows transient localized elevations of free cytosolic Ca2+ to be recorded and observed during the first 24 h of zebrafish development. The techniq more

• Reporter Enzyme Inhibitor Study To Aid Assembly of Orthogonal Reporter Gene Assays

  Reporter gene assays (RGAs) are commonly used to measure biological pathway modulation by small molecules. Understanding how such compounds interact with the reporter enzyme is critical to accurately interpret RGA results. To improve our understanding of reporter enzymes and to develop optimal RGA s more

• The Dynamics Simulation and Quantum Calculation Investigation about Luminescence Mechanism of Coelenteramide

  Abstract The dynamics simulation and quantum chemical calculation are employed to investigate spectrum properties of deprotonation process of coelenteramide and two final states neutral state and phenolate anion. According to the calculation results, theoretical evidence supporting the luminesce more

Market studies Luminescence

• Atto Corporation - Strategic SWOT Analysis Review

  Atto Corporation (Atto) is a medical device manufacturing company principally engaged in developing, manufacturing and marketing of biological macromolecules and analytical products in the biochemistry, molecular biology and biotechnology fields. The company develops Electrophoresis systems, Chromat more

Websites Luminescence