Lead Discovery

News Lead Discovery

• Lead Discovery Center participates in new pan-European drug discovery platform

  The European Lead Factory, a novel platform for innovative drug discovery, was launched early February by an international consortium of 30 partners including the Lead Discovery Center GmbH (LDC). LDC is an expert in the discovery and generation of small molecule lead series by translating basic res more

• Proteros and SUPERGEN enter into an integrated lead discovery agreement

  Proteros Biostructures GmbH announced that it has entered into an agreement with SuperGen Inc., under which Proteros will collaborate on the discovery of small molecule lead compounds against a specific target of interest. Under the agreement, Proteros will deploy its integrated lead discovery platf more

• Proteros enters into a research agreement for structure based lead generation

  Proteros biostructures GmbH (Proteros) announced that it has entered into an agreement with Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (J&JPRD), under which Proteros will perform research to discover small molecule lead compounds against a specific target for delivery to J&JPRD. more

Publications Lead Discovery

• aCSM: noise-free graph-based signatures to large-scale receptor-based ligand prediction

  Motivation: Receptor-ligand interactions are a central phenomenon in most biological systems. They are characterized by molecular recognition, a complex process mainly driven by physicochemical and structural properties of both receptor and ligand. Understanding and predicting these interactions ar more

• Fragment Informatics and Computational Fragment‐Based Drug Design: An Overview and Update

  Abstract Fragment‐based drug design (FBDD) is a promising approach for the discovery and optimization of lead compounds. Despite its successes, FBDD also faces some internal limitations and challenges. FBDD requires a high quality of target protein and good solubility of fragments. Biophysical te more

• Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery

  Knowledge and investigation of therapeutic targets (responsible for drug efficacy) and the targeted drugs facilitate target and drug discovery and validation. Therapeutic Target Database (TTD, http://bidd.nus.edu.sg/group/ttd/ttd.asp) has been developed to provide comprehensive information about ef more

Market studies Lead Discovery

• Shanghai Fudan-zhangjiang Bio-Pharmaceutical Co.,Ltd. (8231) - Financial and Strategic SWOT Analysis Review

  Shanghai Fudan-zhangjiang Bio-Pharmaceutical Co., Ltd. (FDZJ) is a publically held company engaged in the research, development, manufacturing and commercialization of innovative therapeutics. The company focuses on development of therapeutics like genetic engineering drugs, photodynamic drugs, diag more

Websites Lead Discovery