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• DNA motor programmed to navigate a network of tracks
  

  Expanding on previous work with engines traveling on straight tracks, a team of researchers at Kyoto University and the University of Oxford have successfully used DNA building blocks to construct a motor capable of navigating a programmable network of tracks with multiple switches. The findings, pu more

• Genome-wide study reveals 3 new susceptibility loci for adult asthma in Japanese population

  Researchers at the RIKEN Center for Genomic Medicine (CGM), together with colleagues at Kyoto University, Tsukuba University, Harvard University, and other medical institutions have identified three new loci associated with susceptibility to adult asthma in the Japanese population. The findings appe more

• Ovarian cancer clue: Methylation-mediated suppression of a key pathway is found

  Ovarian cancer is the leading cause of death among gynecological cancers. To better understand the disease and improve therapies, researchers are investigating how deregulation of genes across the genome could be contributing to malignancy. In a study published in Genome Research, scientists have more

White papers Kyoto University

• Efficient Transfection of VeroE6 Cells with DNA and RNA for Luciferase Reporter Assays Using FuGENE® HD Transfection Reagent
  

  The interferon (IFN) system of mammalian cells is the first line of defense against viral infections. Following infection, danger signals such as double-stranded RNA or single-stranded RNA with an unmodified 5´ triphosphate end (e.g., VSV-RNA) are recognized by membrane-bound Toll-like receptors and/or cytoplasmic receptors (MDA5, RIG-I). This initiates a signal cascade which leads to the production of type I interferons. By autocrine and paracrine stimulation via the IFN-a/b receptor the expression of antiviral proteins is induced in the infected cell as well as in the surrounding cells. more

• Superior Transfection of Human Embryonic Stem Cells with FuGENE® HD Transfection Reagent
  

  Gene manipulation techniques are potentially powerful tools in many applications for human embryonic stem (ES) cell research. Controlling expression levels of specific genes may improve the efficiency of differentiation induction. Cell types of interest may be collected using marker genes and antibiotic resistance genes. Tracking of ES cells derived after engraftment could be facilitated by tracer genes. It may also be possible to selectively destroy transplanted cells. more

Publications Kyoto University

• Distribution of Streptococcus troglodytae and Streptococcus dentirousetti in chimpanzee oral cavities

  Abstract Aim of this study was to analyze the distribution and the phenotypic properties of the indigenous streptococci in the chimpanzee (Pan troglodytes) oral cavities. Eleven chimpanzees (from 9 to 44, average ± SD, 26.9 ± 12.6 years old) in the primate research institutes, Kyoto University, more

• In response

  In response Content Type Journal Article Category Reply to the Letter Pages 1-1 DOI 10.1007/s00280-012-1928-5 Authors Masashi Kanai, Department of Clinical Oncology and Pharmacogenomics, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507 Ja more

• Profile of Shinya Yamanaka [Profiles]

  More than a decade ago, Shinya Yamanaka gazed through a microscope at human embryos growing in a laboratory dish at a fertility clinic in Osaka, Japan. The pulsating blobs struck a primitive chord in the young researcher. “Watching the embryos, I felt that if there was a way to find cures for human more

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