Kinases

Companies Kinases

Biomol GmbH, Germany

Biomol GmbH offers antibodies, enzymes, bioactive lipids, microarrays and reagents for biomedical research. Our focus is on cellular regulation and signal transduction. Together with our partners, we also provide a variety of specialized kits for drug discovery. more

dichrom GmbH, Germany

dichrom - formerly SeQuant GmbH – is concentrating on the distribution and support of high quality products for liquid chromatography synthesis and isolation. The personal and individual customer support is of substantial importance for dichrom. Here a competent and comprehensive product and applica more

News Kinases

• Skin-deep communication: Messenger substance and signaling molecule influence the development of the skin’s immune cells

  A signalling molecule known as Axl has been discovered on immune cells of the epidermis. This recently published finding provides new insight into the development of important skin immune cells known as Langerhans cells. These cells fight off invading microorganisms and play a crucial role in our he more

• Anchoring proteins influence glucose metabolism and insulin release
  

  Scientists from the United States and Sweden have discovered a new control point that could be important as a drug target for the treatment of diabetes and other metabolic diseases. A-kinase anchoring proteins or AKAPs are known to influence the spatial distribution of kinases within the cell, cruci more

• MEK Inhibitors: A New Weapon in the Fight Against Melanoma

  Cancer cell signaling has long been an attractive target for oncology drug development. Increased activation of cell survival signaling cascades promotes tumor cell growth and makes cancer cells difficult to kill. Inhibiting proteins that are involved in these survival pathways is one strategy to se more

White papers Kinases

• Label-Free and Dynamic Monitoring of Cell-Based Assays
  

  The xCELLigence system from Roche Applied Science, originally invented by the US company ACEA Biosciences, allows for label-free and dynamic monitoring of cell-based assays. The xCELLigence system utilizes impedance readout to non-invasively quantify cellular status in real-time [1]. The cells are seeded in 96-well microtiter E-Plates with integrated microelectronic sensor arrays at the bottom of each well. more

• Dynamics of Kinases Involved in Cell Growth Using the xCELLigence System
  

  Studies investigating endogenous cellular regulatory mechanisms have substantially pushed the application of high-throughput screens. RNA interference has developed into an extremely powerful tool for mediating the loss-of-function of specific mRNA molecules and preventing their translation into proteins. Numerous studies have helped to uncover novel gene functions in many biological processes, but most have used single endpoint analysis as readout for the respective phenotypes to characterize the outcome of a cascade of regulatory mechanisms. The xCELLigence System offers a new way to analyze the effect of gene knock downs on living cells, as the system provides continuous, quantitative information about the electrical impedance at the bottom surface of microtiter plates. Thus, any change in cell number, cell morphology or cell attachment can be detected in real-time. more

Publications Kinases

• Molecular insights from dysregulation of the thiazide‐sensitive WNK/SPAK/NCC pathway in the kidney: Gordon syndrome and Thiazide‐Induced Hyponatraemia

  Abstract Human blood‐pressure is dependent on balancing dietary salt intake with its excretion by the kidney. Mendelian‐syndromes of altered blood pressure demonstrate the importance of the distal nephron in this process and of the thiazide‐sensitive pathway in particular. Gordon‐Syndrome(GS more

• 4‐Hydroxyderricin and xanthoangelol from Ashitaba (Angelica keiskei) suppress differentiation of preadiopocytes to adipocytes via AMPK and MAPK pathways

  Scope Adipocytes differentiation is deeply involved in the onset of obesity. 4‐Hydroxyderricin (4HD) and xanthoangelol (XAG) are the chalcones that are derived from Ashitaba (Angelica keiskei). In this study, we demonstrated the inhibitory effects of these chalcones on adipocytes differentiation more

• Rhesus Monkey Rhadinovirus Uses Eph Family Receptors for Entry into B Cells and Endothelial Cells but Not Fibroblasts

  by Alexander S. Hahn, Ronald C. Desrosiers Cellular Ephrin receptor tyrosine kinases (Ephrin receptors, Ephs) were found to interact efficiently with the gH/gL glycoprotein complex of the rhesus monkey rhadinovirus (RRV). Since EphA2 was recently identified as a receptor for the Kaposi's sarcoma more

Market studies Kinases

• Comparative Analysis of Late Stage Pipeline Molecules in Major Indications - Oncology Pipeline Leads with Most Promising Molecules in Late Stage Development

  GBI Research, a leading business intelligence provider, has released its latest research “Comparative Analysis of Late Stage Pipeline Molecules in Major Indications - Oncology Pipeline Leads with Most Promising Molecules in Late Stage Development”, which provides insights into the unmet needs target more

• Carna Biosciences, Inc. (4572) - Financial and Strategic SWOT Analysis Review

  Carna Biosciences, Inc. (Carna Biosciences) is a biotechnology company, principally engaged in the discovery and development of new drug candidates for the treatment of patients with cancer and anti-inflammatory diseases using QuickScout, an innovative kinase drug discovery platform. The company's p more

• Pipeline Insight: Small Molecule Targeted Cancer Therapies - New targets set to drive growth

  Introduction Small molecule targeted therapies represent a highly lucrative class of anticancer therapies with 12 drugs currently approved for various tumor types. This promise of high commercial rewards has driven considerable pipeline activity for small molecule targeted therapies within cancer. more

Websites Kinases