Informatics

News Informatics

• Computer-designed molecules point to new therapy for cystic fibrosis

  By developing software that uses 3-D models of proteins involved in cystic fibrosis, a team of scientists at Duke University has identified several new molecules that may ease the symptoms of the disease.  Computer algorithms created by the team predict how well a given molecular structure will bloc more

• Agilent Technologies Awards Two Integrated-Biology Research Grants

  Agilent Technologies Inc. announced the winners of the 2011 eMerging Insights grant program: Dr. Michael J. MacCoss of the University of Washington and Dr. Peter J. Park of Harvard University. Each will be awarded $75,000 toward their ongoing research on open source data-integration tools.The first more

• Imaging Biomarkers

  Large pharma has been seeking new biomarkers for years – all part of their drug discovery process, but often only as an afterthought in the development process. That’s changed over recent years, but by-and-large the bulk of biomarker work remains in the hands of small -to -medium-sized companies who more

White papers Informatics

• Outsourcing R&D Innovation takes on New Meaning
  

  Innovative drugs are the lifeblood of pharmaceutical companies, but the cost of developing them is rising to unsustainable levels. Pharma executives are already saying that as the economy falters, they foresee bleak prospects and mergers unless their companies get more innovative drugs into their pipelines. The clock is ticking on the race to increase productivity, as key patents worth a projected $30 billion in revenue will expire between 2010 and 2013, opening the floodgates to competition from generics, according to Barbara Ryan, an analyst at Deutsche Bank. This imperative is propelling increased outsourcing of R&D operations as companies trim overcapacity. more

Publications Informatics

• The Secure Medical Research Workspace: An IT Infrastructure to Enable Secure Research on Clinical Data

  Abstract Clinical data have tremendous value for translational research, but only if security and privacy concerns can be addressed satisfactorily. A collaboration of clinical and informatics teams, including RENCI, NC TraCS, UNC's School of Information and Library Science, Information Technolog more

• Ab Initio Modeling and Experimental Assessment of Janus Kinase 2 (JAK2) Kinase-Pseudokinase Complex Structure

  by Xiaobo Wan, Yue Ma, Christopher L. McClendon, Lily Jun-shen Huang, Niu Huang The Janus Kinase 2 (JAK2) plays essential roles in transmitting signals from multiple cytokine receptors, and constitutive activation of JAK2 results in hematopoietic disorders and oncogenesis. JAK2 kinase act more

• Discovery and characterization of artifactual mutations in deep coverage targeted capture sequencing data due to oxidative DNA damage during sample preparation

  As researchers begin probing deep coverage sequencing data for increasingly rare mutations and subclonal events, the fidelity of next generation sequencing (NGS) laboratory methods will become increasingly critical. Although error rates for sequencing and polymerase chain reaction (PCR) are well do more

Market studies Informatics

• Kuwait Pharmaceuticals and Healthcare Report Q4 2012

  BMI View: In BMI's Pharmaceuticals Risk/Reward Ratings (RRR) table for Q412, Kuwait remains in second position, trailing the United Arab Emirates (UAE). Its risks profile is stronger than its rewards, which are squeezed by the small market size and political instability that may stall the reform of more

• Canon Acquires Delft - To Expand into Medical Imaging Informatics and PACS Market - Deal Analysis from GlobalData

  Introduction GlobalData’s report, “Canon Acquires Delft - To Expand into Medical Imaging Informatics and PACS Market” provides key information and analysis on Canon’s acquisition of the Netherlands-based company. The report provides information on deal rationale that includes analysis of Canon’s ex more

• Qatar Pharmaceuticals and Healthcare Report Q4 2012

  BMI View: The future growth of Qatar’s pharmaceutical market will remain constrained by small population numbers, although we expect that the planned overhaul of Qatar’s public health strategy in the 2011-2016 period to increase per-capita spending on healthcare in general. While some downward press more

Websites Informatics