Industrial Scales

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• Microchip patented which separates and extracts tumor cells in the blood

  Ikerlan-IK4 and Mondragón Unibertsitatea are taking part in a project initiated by the Spanish National Research Council, CSIC, and which has developed a microchip capable of separating and extracting tumour cells in the blood stream by means of ultrasonic waves. The Foundation General Hospital of t more

• Surface hygiene test wins the Chemical Industry Innovation Award

  Surface hygiene is a major food safety and healthcare challenge across the world. Orion Diagnostica Oy and VTT Technical Research Centre of Finland have developed a chemical test card for surface hygiene monitoring. A wide range of applications is envisioned for the innovation. The innovation, uniq more

• Microbes produce fuels directly from biomass
  

  A collaboration led by researchers with the U.S. Department of Energy's Joint BioEnergy Institute (JBEI) has developed a microbe that can produce an advanced biofuel directly from biomass. Deploying the tools of synthetic biology, the JBEI researchers engineered a strain of Escherichia coli bacteria more

White papers Industrial Scales

• From Sephadex to GE Healthcare
  

  The success of chromatography as a technique for separating biomolecules is inevitably linked to the introduction of the gel filtration medium Sephadex(TM) by Pharmacia AB in 1959 more

Publications Industrial Scales

• Biosynthesis of (R)‐epichlorohydrin at high substrate concentration by kinetic resolution of racemic epichlorohydrin with a recombinant epoxide hydrolase

  The substrate concentration and yield were shown to be very low in the production of (R)‐epichlorohydrin by hydrolysis of racemic epichlorohydrin using epoxide hydrolases in previous studies. In this work, we synthesized an epoxide hydrolase gene from Agrobacterium radiobacter and expressed it in more

• Resilient immortals, characterizing and utilizing Bax/Bak deficient Chinese hamster ovary (CHO) cells for high titer antibody production

  Cell death due to apoptosis is frequently observed in large‐scale manufacturing of therapeutic proteins, and can reduce product accumulation in bioreactors. Several different strategies that involve overexpression of antiapoptotic or downregulation of proapoptotic proteins have been designed in at more

• Consistent development of bioprocesses from microliter cultures to the industrial scale

  Bioprocess development today is slow and expensive compared to chemical process development. A drastic paradigm shift is necessary and possible by the consistent application of engineering strategies that are typically used in the process development phase already in the early product development. more

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