Immunoglobulins

Products Immunoglobulins

Increase throughput and robustness of your antibody purification

TOYOPEARL AF-rProtein A affinity resin is well-suited for capturing of antibodies out of high titre feedstocks more

Videos Immunoglobulins

Increase throughput and robustness of your antibody purification

TOYOPEARL AF-rProtein A-650F combines a high binding capacity at short residence time and fast mass transfer kinetics with alkaline stability. Protein A based affinity chromatography is the industry standard for the capture of monoclonal antibodies (MAbs) in downstream processing. Rising fermentatio more

News Immunoglobulins

• Symphogen and Swedish Orphan Biovitrum receive U.S. orphan drug designation for Rozrolimupab in ITP

  Symphogen and Swedish Orphan Biovitrum announced that the United States Food and Drug Administration (FDA) has granted orphan drug designation to rozrolimupab (Sym001) for the treatment of primary Immune Thrombocytopenia (ITP). ITP is an autoimmune bleeding disorder characterized by abnormally low p more

• Micromet Initiates Phase 2 Trial of Blinatumomab in Adult Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia

  Micromet, Inc. announced the initiation of a phase 2 trial of the Company’s lead product candidate blinatumomab (MT103) in adult patients with relapsed or refractory B-precursor acute lymphoblastic leukemia (ALL). Blinatumomab is the first of a new class of agents called BiTE® antibodies, designed t more

• Scientists identify genetic cause of previously undefined primary immune deficiency disease

  Researchers at the National Institutes of Health have identified a genetic mutation that accounts for a perplexing condition found in people with an inherited immunodeficiency. The disorder, called combined immunodeficiency, is characterized by a constellation of severe health problems, including pe more

White papers Immunoglobulins

• Interference and HAMA problems
  

  Immunoassays are bioanalytical methods based on antibodies. These include ELISA, EIA, RIA, Western blotting, protein arrays, lateral flow assays (immuno-chromatography), immunohistochemistry or immuno-PCR. Antibodies detect the substances (analytes) in immunoassays. This detection is always highly specific and only the analytes are detected and bound. This is the theory! Practically any antibody not only binds its analyte. It also binds several other substances, but with very different affinities. more

• Homogeneous IgG AlphaLISA® assay performed on BMG LABTECH's PHERAstar Plus
  

  Immunoglobulins or antibodies are proteins that are involved in the immune response. That makes them interesting drug targets. This application note shows the detection of the immunoglobulin IgG using an AlphaLISA® assay performed on BMG LABTECH's PHERAstar Plus. The AlphaLISA® technology utilizes oxygen to start a cascade of chemical reactions resulting in a luminescence signal at 615 nm. Sensitivity and Z´values obtained in different plate formats are presented. more

Publications Immunoglobulins

• Network-guided sparse regression modeling for detection of gene-by-gene interactions

  Motivation: Genetic variants identified by genome-wide association studies to date explain only a small fraction of total heritability. Gene-by-gene interaction is one important potential source of unexplained total heritability. We propose a novel approach to detect such interactions that uses pen more

• A Polymorphism Affecting MYB Binding within the Promoter of the PDCD4 Gene is Associated with Severe Asthma in Children

  ABSTRACT A previous Genome‐Wide Association Study in asthma revealed putative associations that merit further investigation. In this study, the genome‐wide significant associations of Single Nucleotide Polymorphisms (SNPs) at the 5% False Discovery Rate were examined in independent groups of sev more

• scFv-Based “Grababody” as a General Strategy to Improve Recruitment of Immune Effector Cells to Antibody-Targeted Tumors

  Recruitment of immune cells to tumor cells targeted by a therapeutic antibody can heighten the antitumor efficacy of the antibody. For example, p185her2/neu-targeting antibodies not only downregulate the p185her2/neu kinase (ERBB2) but also trigger complement-dependent cytotoxicity (CDC) and antibod more

Market studies Immunoglobulins

• Regulatory Intelligence on Biologics Recalls – Immunoglobulins and Vaccines are Involved in More Recalls than Other Drug Classes

  GBI Research’s report, “Regulatory Intelligence on Biologics Recalls – Immunoglobulins and Vaccines are Involved in More Recalls than Other Drug Classes”, provides in-depth analysis of biologics recalls issued or reported with the US Food and Drug Administration (FDA) and its constituent agencies. T more

• Kamada Ltd. (KMDA) - Financial and Strategic SWOT Analysis Review

  Kamada Ltd. (Kamada) is a publicly traded, biopharmaceutical company that is engaged in development, production and marketing of specialty, life-saving therapeutics. The product portfolio of the company, include respiratory products, immunoglobulins products, critical care products, coagulation fact more

Websites Immunoglobulins