High-Throughput Screening (HTS)

Companies High-Throughput Screening

GATC Biotech AG, Germany

GATC Biotech is a leading provider of sequencing services and innovative bioinformatics solutions for industry and academia worldwide. The company offers sequencing services using ABI 3730XLTM, 454’s GS FLXTM and Illumina/Solexa’s Genome Analyzer. GATC’s sequencing service portfolio is complemented more

Porvair Sciences Ltd., United Kingdom

Porvair Sciences Ltd has specialised in the manufacture of microplates since 1992. Via our global distributor network, we serve Life Sciences, Biotechnology, R&D and Molecular Biology with microplate solutions for all applications, from sample preparation to high throughput screening more

BioTek Instruments GmbH, Germany

BioTek is a leading developer and supplier of high-value microplate instrumentation and software solutions. Our instrumentation is used to accelerate the drug discovery process, to advance discoveries in genomics and proteomics, and to aid in the advancement of life science research. As part of the more

Products High-Throughput Screening

High-Throughput Technology for Label-Free Protein Analysis

The system provides real-time, label-free analysis of biomolecular interactions with unprecedented ease of use and cost-efficiency more

Purospher® STAR HPLC and UHPLC columns

Purospher® STAR RP-18 endcapped UHPLC columns are ideal for ultra-fast applications where resolution, sensitivity and sample throughput are crucial more

Measure compound solubility or microbial growth in a microplate reader

NEPHELOstar Plus: Measure light scattering in a microplate - the only laser based microplate nephelometer more

Videos High-Throughput Screening

Speed and sensitivity for your high-throughput screening

Looking for the best microplate reader available? Then look no further than the PHERAstar FS from BMG LABTECH, the Microplate Reader Company. Based upon the successful PHERAstar, the PHERAstar FS incorporates features not found on other microplate readers, including: Two dedicated lasers for AlphaS more

News High-Throughput Screening

• Novel anti-malarial drug target identified
  

  An international team of scientists, led by researchers from the Department of Pediatrics at the University of California, San Diego School of Medicine, have identified the first reported inhibitors of a key enzyme involved in survival of the parasite responsible for malaria. Their findings, which m more

• Cancer Therapeutics reveals proof of concept for second development drug

  Cancer Therapeutics announced the validation and performance of a new targeted drug, CTx-294886, in combination with Avastin™ (bevacizumab – Genentech/Roche) in a preclinical model of breast cancer. At the same time the Company announced that it has developed a new High Throughput Screening (HTS) pl more

• Proteros and University of Cincinnati, Drug Discovery Center establish collaboration to offer high-throughput screening services

  Proteros Biostructures GmbH announced that it has entered into an agreement with University of Cincinnati, Drug Discovery Center (UC DDC), under which Proteros will provide biotech and pharmaceutical companies with access to UC DDC’s ultra-high-throughput and high-content screening platform coupled more

White papers High-Throughput Screening

• Dynamics of Kinases Involved in Cell Growth Using the xCELLigence System
  

  Studies investigating endogenous cellular regulatory mechanisms have substantially pushed the application of high-throughput screens. RNA interference has developed into an extremely powerful tool for mediating the loss-of-function of specific mRNA molecules and preventing their translation into proteins. Numerous studies have helped to uncover novel gene functions in many biological processes, but most have used single endpoint analysis as readout for the respective phenotypes to characterize the outcome of a cascade of regulatory mechanisms. The xCELLigence System offers a new way to analyze the effect of gene knock downs on living cells, as the system provides continuous, quantitative information about the electrical impedance at the bottom surface of microtiter plates. Thus, any change in cell number, cell morphology or cell attachment can be detected in real-time. more

• Promotion of Aggregation as a Means of Assessing the Stability of Antibody Molecules
  

  The efficiency of antibody molecules is dependent on their stability. We introduce an assay setup where stability of antibodies is measured. Shaking stress is initiated by the FLUOstar Omega microplate reader and aggregation propensity of antibody candidates is measured in 96-well format more

• Cytokine Quantification in Drug Development
  

  Immuno-PCR (IPCR) and ElectroChemiLuminescence (ECL) are technologies for improved performance of immunoassays. The specific advantages of the different technologies, using enzymatic or electrical signal amplification, allow for tailored assay design and address several specific challenges, such as maximum sensitivity up to 1 fg/ml target cytokine, simultaneous detection of multiple antigens, and high robustness against biological matrices more

Publications High-Throughput Screening

• Digital microfabrication of user‐defined 3D microstructures in cell‐laden hydrogels

  Abstract Complex 3D interfacial arrangements of cells are found in several in vivo biosystems such as blood vasculature, renal glomeruli, and intestinal villi. Current tissue engineering techniques fail to develop suitable 3D microenvironments to evaluate the concurrent effects of complex topog more

• Diversity selection of compounds based on ‘Protein Affinity Fingerprints’ improves sampling of bioactive chemical space

  Diversity selection is a frequently applied strategy for assembling high‐throughput screening libraries, making the assumption that a diverse compound set increases chances of finding bioactive molecules. Based on previous work on experimental “Affinity Fingerprints”, in this study a novel diversi more

• Viscosity of high concentration protein formulations of monoclonal antibodies of the IgG1 and IgG4 subclass - prediction of viscosity through protein-protein interaction measur ...

  Publication date: Available online 26 April 2013Source:European Journal of Pharmaceutical Sciences Author(s): Martin S. Neergaard , Devendra S. Kalonia , Henrik Parshad , Anders D. Nielsen , Eva H. Møller , Marco van de Weert The purpose of this work was to explore the relation between pro more

Market studies High-Throughput Screening

• Global Flow Cytometry Market

  Flow cytometry is a laboratory analytical technique that can rapidly measure multiple parameters of individual cells or particles as they pass through a beam of light, typically a laser. The global flow cytometry market remains one of the fastest-growing segments of life sciences and clinical diagno more

• Biomagnetics Diagnostics Corporation - Strategic SWOT Analysis Review

  Biomagnetics Diagnostics Corporation (Biomagnetics Diagnostics) is a medical devices company that is principally engaged in providing advanced medical device and biotechnology industries. The company provides diagnostics system and test kit testing technology for HIV, Hepatitis, H-Pylori, HPV, Tuber more

• Carna Biosciences, Inc. (4572) - Financial and Strategic SWOT Analysis Review

  Carna Biosciences, Inc. (Carna Biosciences) is a biotechnology company, principally engaged in the discovery and development of new drug candidates for the treatment of patients with cancer and anti-inflammatory diseases using QuickScout, an innovative kinase drug discovery platform. The company's p more

Websites High-Throughput Screening