Gene Silencing

Companies Gene Silencing

SIRION BIOTECH GmbH, Germany

SIRION BIOTECH is a technology leader in the field of functional gene analysis and cell models for basic research, drug and compound development. The company serves leading European and Japanese Drug and Biotech companies as a provider of latest technologies for them to advance identification of nov more

Integrated DNA Technologies, BVBA, Belgium

Integrated DNA Technologies (IDT) is advancing biotechnology research as a leading supplier of custom oligonucleotides and gene synthesis services as well as a developer of innovative new biotechnologies. more

Products Gene Silencing

Unique RNAi tools for powerful gene silencing in vitro and in vivo

Our pre-designed, customized or validated RNAi tools and services are dedicated to help life scientist achieve highly efficient gene silencing more

News Gene Silencing

• Gene Silencing biotechnology developed at BGU to advance Vietnamese Aquaculture

  Prof. Amir Sagi from Ben-Gurion University of the Negev (BGU) participated in a ceremony marking the realization of an agreement between the Israeli Tiran Group and Green Advances, a Vietnamese company, to advance aquaculture in Vietnam using BGU biotechnology to change the sex of prawns and yield f more

• PBL awarded two US patents on RNAi

  Plant Bioscience Limited (PBL) announced that the United States Patent and Trademark Office (USPTO) has issued out US Patent No. 8,258,285 with fundamental claims directed to compositions to effect gene silencing and US Patent No. 8,263,569 with fundamental claims directed to methods of inducing gen more

• Finnish researchers discover genes inhibiting the spread of prostate cancer

  The research team of Professor Johanna Ivaska (University of Turku and VTT Technical Research Centre of Finland) screened dozens of prostate cancers using gene silencing and discovered mechanisms of that inhibit the spread of cancer cells.Published in the Journal of Cell Science, the study shows tha more

White papers Gene Silencing

• Real-Time PCR Quality Control for Gene Expression
  

  Quantitative real-time PCR (qPCR) has become the de facto standard for nucleic acid quantification. This achievement is due in large part to its sensitivity, specificity, accuracy, large dynamic range of linear quantification, and its speed. The qPCR technology has matured to a ready-to-use commonly available method in most molecular biology laboratories. Nevertheless, the reliability of the final quantification result depends heavily on all elements in the workflow, such as the quality of the input template (integrity and absence of inhibitors), the PCR assay (specificity, efficiency, limit of detection), and normalization strategy (validated reference genes). more

• HelpCorner - Transfection
  

  Transfection is the delivery of DNA, RNA, proteins, and macromelecules into eukaryotic cells. The goals for transfection include the study of gene function and regulation as well as protein expression and function. It is also used for gene silencing and protein production. According to the application, the information can be either transiently (transient transfection) or permanently expressed (stable transfection). Based on the strategies, the transfection methods can be divided into three groups: more

• Rapid High-Throughput Methylation Analysis Using the LightCycler® 480 System
  

  The LightCycler® 480 Instrument is a versatile platform for molecular studies. We assessed the performance of the instrument combined with the LightCycler® 480 High Resolution Melting Master mix for DNA methylation analysis using the methylation-sensitive high resolution melting (MS-HRM) methodology. This proved to be a robust platform for performing MS-HRM experiments, allowing rapid and high-throughput studies of DNA methylation. more

Publications Gene Silencing

• CD40 Gene Silencing Reduces the Progression of Experimental Lupus Nephritis Modulating Local Milieu and Systemic Mechanisms

  by Èlia Ripoll, Ana Merino, Montse Goma, Josep M. Aran, Nuria Bolaños, Laura de Ramon, Immaculada Herrero-Fresneda, Oriol Bestard, Josep M. Cruzado, Josep M. Grinyó, Juan Torras Lupus nephritis (LN) is an autoimmune disorder in which co-stimulatory signals have been involved. Here we tested a cho more

• Genome-wide RNAi Screen Reveals a New Role of a WNT/CTNNB1 Signaling Pathway as Negative Regulator of Virus-induced Innate Immune Responses

  by Martin Baril, Salwa Es-Saad, Laurent Chatel-Chaix, Karin Fink, Tram Pham, Valérie-Ann Raymond, Karine Audette, Anne-Sophie Guenier, Jean Duchaine, Marc Servant, Marc Bilodeau, Éric Cohen, Nathalie Grandvaux, Daniel Lamarre To identify new regulators of antiviral innate immunity, we completed t more

• Comparison of the Efficiency of Complexes Based on S413-PV Cell-Penetrating Peptides in Plasmid DNA and siRNA Delivery

  The successful application of gene therapy approaches is highly dependent on the efficient delivery of nucleic acids into target cells. In the present study, new peptide-based nonviral systems were developed to enhance plasmid DNA and siRNA delivery, aiming at generating appropriate gene delivery an more

Market studies Gene Silencing

• Genesis Research and Development Corporation Limited (GEN) - Financial and Strategic SWOT Analysis Review

  Genesis Research and Development Corporation Ltd. (Genesis) is a publicly held NewZealand-based biotechnology company. The company is principally engaged in the development of therapeutics for the treatment of cancer and diseases of the immune system. It is completely focused on the development of t more

• Genesis Research and Development Corporation Ltd. (GEN) - Financial and Strategic SWOT Analysis Review

  Genesis Research and Development Corporation Ltd. (Genesis) is a publicly held NewZealand-based biotechnology company. The company is principally engaged in the development of therapeutics for the treatment of cancer and diseases of the immune system. It is completely focused on the development of t more

Websites Gene Silencing