Gene Regulation

Companies Gene Regulation

Biomol GmbH, Germany

Biomol GmbH offers antibodies, enzymes, bioactive lipids, microarrays and reagents for biomedical research. Our focus is on cellular regulation and signal transduction. Together with our partners, we also provide a variety of specialized kits for drug discovery. more

News Gene Regulation

• Tactics of new Middle East virus suggest treating by altering lung cells' response to infection
  

  A new virus that causes severe breathing distress and kidney failure elicits a distinctive airway cell response to allow it to multiply. Scientists studying the Human Coronavirus-Erasmus Medical Center, which first appeared April 2012 in the Middle East, have discovered helpful details about its str more

• Learning the alphabet of gene control

  Scientists at Karolinska Institutet in Sweden have made a large step towards the understanding of how human genes are regulated. In a new study they identified the DNA sequences that bind to over four hundred proteins that control expression of genes. This knowledge is required to understand how dif more

• “Junk DNA“ May Give Rise to Evolutionary Innovation
  

  The vast majority of the human genome consists of DNA without any apparent function, so-called “junk DNA”. A study conducted by the scientists Dr. Laurence Ettwiller and Michael Eichenlaub at Heidelberg University's Centre for Organismal Studies now highlights this “dark matter” of the genome as a r more

White papers Gene Regulation

• miRNA Extraction and Profiling on FFPE Samples
  

  RNA silencing is a mechanism of gene regulation whereby small double-stranded RNAs (dsRNAs) of 21-18 nucleotides in length cause mRNA degradation, mRNA translation, or chromatin modification. In the past years, more than 500 novel genes have been identified in animals and plants encoding small transcripts that can form small dsRNA hairpin structures. From these hairpin precursors, small 22-nt RNAs - so called microRNAs (miRNA) - are excised by dsRNA-specific endonucleases. The miRNAs are then integrated in ribonucleoprotein particles (RNPs). Most miRNAs in animals act by binding to partially complementary regions of the 3' untranslated region of their target mRNA, thereby blocking translation. more

• A High-Throughput Experimental Tool for Studying Gene Pathways
  

  The post-genome era has lead to great advances in high-throughput genomics studies. Genomic approaches such as microarray expression analyses and Chromatin Immuno-Precipitation on Chip (ChIP-chip) transcription factor binding assays have yielded new discoveries and insights into genetic pathways. These technologies provide valuable observational data but do not identify the functional connections within networks or explain the mechanism of gene regulation. Reporter gene based experiments like functional promoter assays provide an important additional layer of data for understanding mechanisms of regulation in genetic networks. Efficient and reproducible transfection methods are a prerequisite for all of these assays involving transfections. more

• Optimized Production of Lentivirus Using FuGENE® HD Transfection Reagent
  

  Lentiviral vectors are ideally suited vehicles for a broad range of research applications. Depending on pseudotype, lentiviruses infect a wide range of cell types, non-discriminately transducing both dividing and non-dividing cells. As opposed to other popular vector delivery systems, lentivirus stably and rapidly integrates genetic payload into the host genome allowing for long-term studies in vivo. Current lentiviral vector systems can accommodate upwards of ten kilobases of foreign DNA [1], although promoter and enhancer elements reduce the practical size of gene open-reading frames to perhaps five or six kilo­bases, which is sufficient to accommodate most genes commonly studied in the mammalian genome. more

Publications Gene Regulation

• Exaptation of Transposable Elements into Novel Cis-Regulatory Elements: Is the Evidence Always Strong?

  Transposable elements (TEs) are mobile genetic sequences that can jump around the genome from one location to another, behaving as genomic parasites. TEs have been particularly effective in colonizing mammalian genomes, and such heavy TE load is expected to have conditioned genome evolution. Indeed more

• RNA‐Seq facilitates a new perspective on signal transduction and gene regulation in important plant pathogens

  Summary RNA‐Seq is opening new doors for the functional understanding of microorganisms. Advances in RNA‐Seq technology are allowing investigators to focus their studies on specific functional questions. An interesting example is presented by An et al. (2013) in this issue of Molecular Microbiol more

• Regulation of Noise in Gene Expression

  The biochemical processes leading to the synthesis of new proteins are random, as they typically involve a small number of diffusing molecules. They lead to fluctuations in the number of proteins in a single cell as a function of time and to cell-to-cell variability of protein abundances. These in t more

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