G-Proteins

Companies G-Proteins

Biomol GmbH, Germany

Biomol GmbH offers antibodies, enzymes, bioactive lipids, microarrays and reagents for biomedical research. Our focus is on cellular regulation and signal transduction. Together with our partners, we also provide a variety of specialized kits for drug discovery. more

News G-Proteins

• Heptares granted patents covering stabilised receptor technology in Europe and Japan

  Heptares Therapeutics announced that the first of a series of patent applications  covering its methods for generating G-protein coupled receptors (GPCR) with increased conformational stability (StaR® technology) has resulted in patents being granted in Europe (EP2121919) and Japan (JP4842400). This more

• Heptares generates new insight into caffeine's molecular pharmacology to drive design of next-generation CNS therapeutics

  The journal Structure has published data from researchers at Heptares Therapeutics elucidating the molecular pharmacology of caffeine and its interaction with G-protein coupled receptors (GPCRs). Caffeine is known to inhibit adenosine receptors, a subfamily of GPCRs widely expressed in the brain, ca more

• Adrenaline receptor ‘frozen in action’ by VIB researchers

  Adrenaline, the hormone that prepares our body to fight or flight, acts on a hyperdynamic receptor. This molecule switches so fast between several positions, that it was impossible to image it. Until now. Scientists, including Jan Steyaert of VIB and the Vrije Universiteit Brussel in Belgium, and co more

White papers G-Proteins

• HelpCorner - xCELLigence System
  

  Automated monitoring and data collection contribute to significant time savings when using the xCELLigence System, with only a few minutes of extra setup time. For example, in a 96-well plate, 32 different conditions can be tested in triplicate; the wells need to be seeded with cells, monitored, and sampled. For both manual and xCELLigence System experiments, it takes approximately 1 hour to prepare the 32 conditions (including dilution series and mixing of components). Plating of the cells is more straightforward on the E-Plate, because a manual experiment involves manipulation of a number of vessels (e.g., 96 T25 flasks) to obtain relevant data for cell counting. more

• Real-time and Dynamic Monitoring of Virus-mediated Cytopathogenicity
  

  To understand overall infectivity, virus progression and disease onset it is important to perform a detailed examination of cytopathic effects. Depending on the type of viruses and cells, different cytopathic effects might be observed dependent on the timepoint of infection (e.g., during the growth or stationary phase) and the amount of virus used. One of the most common methods for measuring lysogenic/lytic activity of viruses is the plaque test [1]. In this assay culture plates with confluent cells that are sensitive towards the specific virus type/strain are used. Lytic activity of a virus is detected by macroscopic analysis of plaques in a confluent cell layer after staining (e.g., with crystal violet). This technique is an end-point assay and it is well-suited to determine viral titers; however, it provides no information about the onset of cytopathic effects and kinetics of the viral replication. Moreover, infection with a number of viruses (e.g., attenuated mutants) leads to the formation of small and more

• Label-Free and Dynamic Monitoring of Cell-Based Assays
  

  The xCELLigence system from Roche Applied Science, originally invented by the US company ACEA Biosciences, allows for label-free and dynamic monitoring of cell-based assays. The xCELLigence system utilizes impedance readout to non-invasively quantify cellular status in real-time [1]. The cells are seeded in 96-well microtiter E-Plates with integrated microelectronic sensor arrays at the bottom of each well. more

Publications G-Proteins

• Pasteurella Multocida Toxin Prevents Osteoblast Differentiation by Transactivation of the MAP-Kinase Cascade via the Gαq/11 - p63RhoGEF - RhoA Axis

  by Peter Siegert, Gudula Schmidt, Panagiotis Papatheodorou, Thomas Wieland, Klaus Aktories, Joachim H. C. Orth The 146-kDa Pasteurella multocida toxin (PMT) is the main virulence factor to induce P. multocida-associated progressive atrophic rhinitis in various animals. PMT leads to a destruction more

• Network predicting drug’s anatomical therapeutic chemical code

  Motivation: Discovering drug’s Anatomical Therapeutic Chemical (ATC) classification rules at molecular level is of vital importance to understand a vast majority of drugs action. However, few studies attempt to annotate drug’s potential ATC-codes by computational approaches. Results: Here, we int more

• Regulator of G protein signaling is a crucial modulator of antidepressant drug action in depression and neuropathic pain models [Neuroscience]

  Regulator of G protein signaling 4 (Rgs4) is a signal transduction protein that controls the function of monoamine, opiate, muscarinic, and other G protein-coupled receptors via interactions with Gα subunits. Rgs4 is expressed in several brain regions involved in mood, movement, cognition, and addic more

Market studies G-Proteins

• Medical & Biological Laboratories Co., Ltd. - Strategic SWOT Analysis Review

  Medical & Biological Laboratories Co., Ltd.(MBL) is engaged in the research, development and manufacture of clinical reagents and basic research reagents. It products are marketed to hospitals, research institutions and clinical testing centers. Its subsidiaries include MBL International (MBLI) and more

• Medical & Biological Laboratories Co., Ltd. (4557) - Strategic SWOT Analysis Review

  Medical & Biological Laboratories Co., Ltd.(MBL) is engaged in the research, development and manufacture of clinical reagents and basic research reagents. It products are marketed to hospitals, research institutions and clinical testing centers. Its subsidiaries include MBL International (MBLI) and more

Websites G-Proteins