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The new EZ-Stream vacuum filtration pump is specifically designed for microbiology analysis

The new EZ-Stream™ vacuum pump offers altogether direct transfer of filtered liquid, a compact design and high performances more

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• Novartis unveils long-term strategy to grow in a dynamically changing healthcare environment

  Novartis presented a strategic overview of the company's diversified healthcare portfolio which creates the potential for future sustainable growth. The company's focused healthcare portfolio across key growth segments in healthcare provides Novartis a leading position in the respective market segme more

• Antibacterial agent could cause pregnancy problems

  A chemical found in everything from antibacterial soaps and lotions to socks and toothpaste may disrupt an enzyme that plays an important role in pregnancy, University of Florida researchers say. Thought to be harmless, triclosan gives many soaps and lotions their antibacterial oomph and is found in more

• UF scientists find clues to aid injury recovery in aged livers, improve transplant success in seniors

  University of Florida scientists have identified a key cellular process involved in age-related damage to the liver — and ways to reverse that damage by manipulating genes or administering certain drugs. The findings could ultimately help shorten the national liver transplant waiting list by allowin more

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• Characterizing Biotherapeutics with HPLC
  

  As demonstrated here, there are a broad range of HPLC applications used in development, production, validation and release of protein therapeutics for human use. Some of the applications mentioned above are mandatory when submitting a new biopharmaceutical to approval at the regulatory agencies. The introduction of the first so-called biosimilars in Europe further increased the demand for highly efficient analysis methods. The continuous development of new stationary phases for the common modes of biochromatography, such as size exclusion, ion exchange and hydrophilic interaction chromatography support biochemists in increasing lab productivity and establishing high-throughput HPLC analysis not only for small molecules but also for large biopolymers more

• Agrisera Western Blot recommendations, troubleshooting and protocol
  

  Each antibody-antigen interaction has unique characteristics. A protocol giving good results for one antibody-antigen pair might found to be unsatisfactory for a second antibody even on the same sample. The interaction of antisera with protein epitopes in Western blot dependens upon a number of factors, all contributing to the final signal/noise ratio. Knowledge and control of those factors allows for modifications and optimization of the procedure. Polyclonal antibodies (serum or IgY-fractions from egg yolk) usually contain a number of different antibodies interacting independently with different epitopes on the target used for immunization. This number is limited for peptide-antigens but if recombinant or native proteins have been used for immunization the signal obtained has to be regarded as cumulative (=caused by several different types of antibodies present in the serum/IgY used) more

• Increased productivity for downstream processing of biotherapeutics
  

  Polymer-based chromatographic resins featuring high mechanical and chemical stability and high protein binding capacities can help to increase the throughput and robustness of biopharmaceutical manufacturing processes. Advances in genetic engineering and cell culture technology have raised upstream productivity in the production of recombinant proteins. Increased titres of up to 10 g/l stress the need for highly efficient and robust downstream processes (DSP). Most industrial bioprocess development groups apply generic DSP platforms that are designed to purify various candidates of the same class of proteins applying the same process design. Besides various filtration and virus inactivation steps, they usually involve two or three chromatographic unit operations with orthogonal separation modes. The use of high capacity chromatographic resins can help to overcome the DSP bottleneck by increasing process throughput and robustness more

Publications flow

• Influence of flow rate and scaffold pore size on cell behavior during mechanical stimulation in a flow perfusion bioreactor

  Abstract Mechanically stimulating cell‐seeded scaffolds by flow‐perfusion is one approach utilized for developing clinically applicable bone graft substitutes. A key challenge is determining the magnitude of stimuli to apply that enhances cell differentiation but minimizes cell detachment from th more

• Correlation between crossed cerebellar diaschisis and clinical neurological scales

  Szilágyi G, Vas Á, Kerényi L, Nagy Z, Csiba L, Gulyás B. Correlation between crossed cerebellar diaschisis and clinical neurological scales. 
Acta Neurol Scand: 2012: 125: 373–381. 
© 2011 John Wiley & Sons A/S. Background –  A common consequence of unilateral stroke is crossed cerebellar diasc more

• Retraction: Vascular Endothelial Growth Factor in Cerebral Ischemia. Y. Ma, Y. Qu, and Z. Fei

  Abstract Retraction: The following article from Journal of Neuroscience Research, ‘Vascular Endothelial Growth Factor in Cerebral Ischemia,’ by Yihui Ma, Yan Qu, and Zhou Fei, published online on April 5, 2011 in Wiley Online Library (onlinelibrary.wiley.com), has been retracted by agreement betw more

Market studies flow

• Type 2 Diabetes - Global Drug Forecasts and Treatment Analysis to 2020

  Introduction GlobalData, the industry analysis specialist, has released its new report, “Type 2 Diabetes - Global Drug Forecasts and Treatment Analysis to 2020”. The report is an essential source of information and analysis on the global type 2 diabetes therapeutics market. The report provides comp more

• FDA Approves Erivedge (Vismodegib) for Metastatic or Locally Advanced Basal Cell Carcinoma

  Introduction GlobalData, the industry analysis specialist, has released its new report, “FDA Approves Erivedge (Vismodegib) for Metastatic or Locally Advanced Basal Cell Carcinoma”. The report is an essential source of information on the approval of Erivedge by the US FDA. The report also provides more

• Ovarian Cancer Therapeutics - Global Drug Forecasts and Treatment Analysis 2020

  Introduction GlobalData, the industry analysis specialist, has released its new report, “Ovarian Cancer Therapeutics - Global Drug Forecasts and Treatment Analysis 2020”. The report is an essential source of information and analysis on the global ovarian cancer therapeutics market. The report provi more

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