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• Bayer: YAZ approved in Japan for the treatment of dysmenorrhea

  Bayer Schering Pharma AG, Germany, and Bayer Yakuhin, Ltd., Japan, announced that the Japanese regulatory authorities have granted approval for YAZ® (3 mg drospirenone/20 mcg ethinyl estradiol) for the treatment of dysmenorrhea. YAZ is available in the US, Europe, Latin America and the region Asia more

• MSU researchers discover potential genetic factor in eating disorders

  For the first time, scientists have discovered a possible biological culprit in the development of eating disorders during puberty: a type of estrogen called estradiol. The groundbreaking pilot study led by Michigan State University found that influence of one's genes on eating disorder symptoms was more

• Coffee break: Compound brewing new research in colon, breast cancer

  A compound in coffee has been found to be estrogenic in studies by Texas AgriLife Research scientists. Though the studies have not been conducted to determine recommended consumption amounts, scientists say the compound, called trigonelline or "trig," may be a factor in estrogen-dependent breast can more

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• Real-Time Analysis of LNCaP Cell Growth in Different Media
  

  Our results suggest that the influence of androgen receptor-stimulating or -blocking substances strongly depends upon the composition of the growth medium. The use of hormone-depleted FBS in combination with phenol red-free medium is strongly recommended for monitoring stimulator effects, whereas inhibitory effects may be more readily analyzed in medium containing normal FBS. Because the mutated androgen receptor in LNCaP can also be stimulated by estrogens, progestogens, and several antiandrogens, we suggest that the stimulatory effect of normal FBS compared with hormone-reduced FBS may be explained by differences in estradiol levels (192 pg/ml in normal FBS compared with <12 pg/ml in hormone-reduced FBS) rather than by differences in progesterone levels (0.29 ng/ml in normal FBS compared with 0.13 ng/ml in hormone-reduced FBS) or testosterone levels (0.08 ng/ml in normal FBS compared with 0.03 ng/ml in hormone-reduced FBS). Our results show that the optimal time point for monitoring inhibitory and stimulat more

Publications estradiol

• Aromatase knockout mice show normal steroid‐induced activation of GnRH neurones and LH surges with a reduced population of kisspeptin neurones in the rostral hypothalamus

  Abstract We recently reported that female aromatase knockout (ArKO) mice show deficits in sexual behaviour and a decreased population of kisspeptin‐immunoreactive neurones in the rostral periventricular area of the third ventricle (RP3V), resurrecting the question of whether oestradiol actively c more

• Estrogen improved metabolic syndrome through down-regulation of VEGF and HIF-1α to inhibit hypoxia of periaortic and intra-abdominal fat in ovariectomized female rats

  Metabolic syndrome (MBS), a cluster of metabolic abnormalities and visceral fat accumulation, increases cardiovascular risks in postmenopausal women. In addition to visceral fat, perivascular adipose tissue has been recently found to play an important role in vascular pathophysiology. Hence, the pre more

• Biochemical analysis of cystic fluid in the diagnosis of fetal intra‐abdominal masses

  ABSTRACT Objective The aim of the study was to evaluate a biochemical analysis of fluid sampled in utero from fetal abdominal cystic masses. Methods A retrospective study of 42 intra‐abdominal cystic masses [ovarian cysts (n = 22), cloaca (n = 8), urodigestive fistulae (n = 4), and urogen more

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