Endocrinology

Products Endocrinology

Setting New Standards in Steroid Hormone Analysis

SteroIDQ® Kit allows for the simultaneous analysis of a panel of 16 steroid hormones using tandem mass spectrometry from a single blood sample more

News Endocrinology

• Actavis plans to enter into Biosimilars

  Actavis Group announced that it plans to enter into the field of biosimilars. Dr. Claudio Albrecht CEO of Actavis commented on the upcoming due diligence on Biopartners in Switzerland: “By entering into Biosimilars the generic companies gain access to a portfolio that requires a new approach to dev more

• Mayo researchers develop new laboratory cell lines to study treatment for ATC

  To their deep dismay, researchers at Mayo Clinic discovered several years ago that laboratory samples of anaplastic thyroid cancer (ATC) they were using to help them find new treatments for this lethal disease were probably some other kind of cancer. It quickly became evident that the situation in t more

• Ben-Gurion University of the Negev professor awarded the 2010 Elkeles Prize for Cancer Research

  Ben-Gurion University of the Negev (BGU) Professor Ron N. Apte has been awarded the 2010 Samuel and Paula Elkeles Prize for Outstanding Scientist in the Field of Medicine. Professor Apte is chairman of the Shraga Segal Department of Microbiology and Immunology and vice dean of the Basic Sciences di more

White papers Endocrinology

• Real-Time Analysis of LNCaP Cell Growth in Different Media
  

  Our results suggest that the influence of androgen receptor-stimulating or -blocking substances strongly depends upon the composition of the growth medium. The use of hormone-depleted FBS in combination with phenol red-free medium is strongly recommended for monitoring stimulator effects, whereas inhibitory effects may be more readily analyzed in medium containing normal FBS. Because the mutated androgen receptor in LNCaP can also be stimulated by estrogens, progestogens, and several antiandrogens, we suggest that the stimulatory effect of normal FBS compared with hormone-reduced FBS may be explained by differences in estradiol levels (192 pg/ml in normal FBS compared with <12 pg/ml in hormone-reduced FBS) rather than by differences in progesterone levels (0.29 ng/ml in normal FBS compared with 0.13 ng/ml in hormone-reduced FBS) or testosterone levels (0.08 ng/ml in normal FBS compared with 0.03 ng/ml in hormone-reduced FBS). Our results show that the optimal time point for monitoring inhibitory and stimulat more

• To Probe or Not to Probe
  

  In our efforts to measure the expression levels of the thyroid hormone receptor ß2 in small areas of mouse brain, we encountered primer-dimer prob­lems when using SYBR Green I assays. With the Universal ProbeLibrary and the LightCycler® 2.0 Instrument we were able to solve the primer-dimer problem, increase PCR efficiency, and continue our investigations. more

• Cytokine Quantification in Drug Development
  

  Immuno-PCR (IPCR) and ElectroChemiLuminescence (ECL) are technologies for improved performance of immunoassays. The specific advantages of the different technologies, using enzymatic or electrical signal amplification, allow for tailored assay design and address several specific challenges, such as maximum sensitivity up to 1 fg/ml target cytokine, simultaneous detection of multiple antigens, and high robustness against biological matrices more

Publications Endocrinology

• Quantitative Analytical Method for Determining the Levels of Gastric Inhibitory Polypeptides GIP1–42 and GIP3–42 in Human Plasma Using LC–MS/MS/MS

  Gastric inhibitory polypeptide (GIP), an incretin, is an important subject in endocrinology. Some LC–MS assays have been proposed; however, their sensitivities are insufficient for the study of endogenous human incretin. Here, we describe a nanoflow LC hybrid triple quadrupole/linear ion trap MS ass more

• Heterochronic Parabiosis: Historical Perspective and Methodological Considerations for Studies of Aging and Longevity

  Abstract Pairing two animals in parabiosis to test for systemic or circulatory factors from one animal affecting the other animal has been used in scientific studies for at least 150 years. These studies have led to advances in fields as diverse as endocrinology, immunology, and oncology. A vari more

• Elwood V. Jensen (1920-2012): Father of the nuclear receptors [Retrospectives]

  With the passing of Dr. Elwood Jensen, the field of Molecular Endocrinology recently lost another of its major pioneers. Jensen is popularly credited with the discovery of the mammalian estrogen receptor, and the promulgation of this important molecule as a key player in female endocrine function an more

Market studies Endocrinology

• Immunochemistry Analyzers and Test Kits - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2018

  Introduction GlobalData’s new report, “Immunochemistry Analyzers and Test Kits - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2018” provides key data, information and analysis on the global immunochemistry market. The report provides market landscape, competitive landsca more

• Immuno Chemistry Market Outlook in BRICS (Brazil, Russia, India, China, South Africa) to 2017

  Introduction GlobalData’s new report, “Immuno Chemistry Market Outlook in BRICS (Brazil, Russia, India, China, South Africa) to 2017” provides key market data on the Immuno Chemistry market in the BRICS countries. The report provides value ($m) data for each segment and sub-segment within nine mark more

• Endocrinology Market to 2018 - Advanced Injection Devices for Growth Hormone and Somatostatin will Improve Ease of Use for Patients

  GBI Research, the leading business intelligence provider, has released its latest research “Endocrinology Market to 2018-Advanced Injection Devices for Growth Hormone and Somatostatin will Improve Ease of Use for Patients”, which provides insights into the endocrine disease therapeutics market until more

Websites Endocrinology