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Look up urine in Wiktionary, the free dictionary.
Urine is an aqueous solution of waste electrolytes and metabolites excreted by mammals, birds, reptiles, fish and amphibians. Although urine is excreted as a paste by most birds, it is commonly excreted a fluid varying in colour from clear, when dilute, to a dark amber, when concentrated. Urine is produced by the kidneys, and plays a vital role in maintaining homeostasis by removing excess water, electrolytes such as sodium, chloride, potassium, and calcium ions, urea and other metabolites from the blood. The production of urine is called diuresis.
The main constituent of urine is water. All vertebrates must carefully maintain the volume of fluid in their extra-cellular space in order to prevent fluid overload or dehydration. Some water is inevitably lost during solute excretion, and represents an unavoidable fluid loss. However, the majority of water excreted in the urine is lost to prevent fluid overload. Different animals have different renal physiologies depending on their need to retain water. Fish, for example, produce very large amounts of very dilute urine, whereas desert-dwelling animals such as the meerkat have evolved very effective renal systems, allowing them to conserve water by producing small amounts of extremely concentrated urine. Human kidneys are not that effective - even the most concentrated human urine is relatively dilute. The excretion of water is called aquaresis.
Along with volume regulation, one of urine's most important functions is regulation of the osmolality of an animal's internal space. There are narrow limits on the concentration of ions, in the blood and extra-cellular fluid, which are compatible with life. Although some are lost, most animals gain a large surplus of ions in their diets and must excrete them. Most humans, for example, ingest massively more sodium and chloride ions than they need in the form of salt - it is excretion of these surplus ions which makes urine taste salty.
Urine production and excretion is a vertabrate's primary method for removal of nitrogen. This is a waste product, produced in the form of ammonia by the liver. Excess nitrogen is found in the diet, and released into the blood during the deamination of amino acids in protein metabolism. In fish, where water conservation is not an issue, ammonia is excreted in dilute urine. However, at higher concentrations it is toxic, and so in mammals' urine, this mainly is in the form of urea, produced from ammonia in the liver. Birds generally excrete uric acid as a paste, to further conserve water.
The kidneys play a vital role in regulating body pH, preventing acidosis or alkalosis by excreting excess hydrogen ions or bicarbonate ions as required. When it leaves the body, urine is usually around pH 6, though it may be as low as 4.5 or as high as 8.2. As urea—the compound which accounts for 75–90% of the nitrogen in urine—begins to decay, hydroxide ions form, raising the pH as high as 9–9.3.
The decay of urea into carbon dioxide is catalyzed by urease:
Animals ingest a wide variety of compounds daily. Not least are humans, who consume an incredible array of natural and artificial chemicals in the form of food, drink and pharmaceutical products. With the exception of vitamins, minerals and other micro-nutrients such as essential fatty acids, none of these are needed or desirable within the body. All are either metabolised by the liver, excreted in bile or filtered from the blood by the kidneys, and excreted in urine.
Dissolved heavy metals
Studies of urine in organic cattle farms in Sweden in 1999 and 2002 yielded the following concentrations of heavy metals (all in μg/kg wet weight):
Glucose is constantly lost from the blood into the filtrate at the kidneys - however, active reuptake in the proximal tubule usually prevents any being excreted. This is desirable, as glucose is a valuable source of energy, not a waste product. However, in hyperglycaemia - most commonly arising from diabetes mellitus in humans - the tubular limit on glucose reabsorbtion may be breached, in which case some glucose with be lost in the urine.
Urine excreted by healthy kidneys is sterile. When it leaves the body, however, the urine can pick up bacteria from the surrounding skin, which would contaminate it. It is not advisable to use urine to clean open wounds.
Testing urine for its constituents is a cost-effective and non-invasive means of assessing the internal situation of an animal. It is commonly used to test for pregnancy, by measuring levels of hormones excreted. Urinalysis can also be used to test for the metabolites of illegal drugs, if substance abuse is suspected. It is also an invaluable first-line investigation in clinical medicine, where pH, glucose, protein, white blood cell, bacteria and blood content can all be tested to aid in making a diagnosis.
Urine has been and is used extensively as fertilizer. It's high nitrogen content allows increased amino acid synthesis by plants.
Taking advantage of the scents of male animals' urine, some companies sell animal urine, usually coyote or fox, to cities and other organizations to repel those animals by essentially "marking their territory". The scents of carnivore urine (bobcat, mountain lion, and wolf, in addition to coyote and fox) are also sold to the public in pelletized form to repel garden browsing by herbivores such as squirrels and rabbits, as well as deterring domestic or feral cats from marking territory, or catching birds, in gardens. When the pellets are sprinkled on a target area, the intruding animal will instinctively recognize the territorial urinary scent of its predators and avoid the area.
In historical times, urine was collected and used in the manufacture of gunpowder. Stale urine was filtered through a barrel full of straw and allowed to continue to sour for a year or more. After this period of time, water was used to wash the resulting chemical salts from the straw. This slurry was filtered through wood ashes and allowed to dry in the sun. Saltpeter crystals were then collected and added to sulfur and charcoal to create black powder.
Urine has often been used as a mordant to help prepare textiles, especially wool, for dyeing. Urine was used for dyes such as indigo where the urea in the urine reacted with the insoluble dye to form a soluble solution.
Hormone Replacement Therapy
Steroid hormones extracted from the urine of pregnant mares are used in a drug sold under the trade name Premarin. The drug, manufactured and sold by Wyeth Pharmaceuticals, is an estrogen replacement therapy used in the treatment of menopause symptoms.
Contrary to popular belief, urine should not be applied to jellyfish stings. The urine could actually cause the release of more of the poisonous venom from the sting. 
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Urine". A list of authors is available in Wikipedia.|