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Methysergide (UML-491) is a prescription drug used for prophylaxis of migraine headaches and is sold under the brand names Sansert and Deseril in 2mg dosages. Methysergide was approved by the FDA in 1962. Its molecular structure is closely related to that of LSD. It is a 5-HT (serotonin) antagonist. It is a receptor antagonist for the 5-HT receptor 2C.
Methysergide is one of the most effective medications for the prevention of migraine, but not for the treatment of an acute attack. It has a known side effect, retroperitoneal fibrosis, which is severe, although uncommon. Novartis withdrew it from the U.S. market after taking over Sandoz, but currently lists it as a product.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Methysergide". A list of authors is available in Wikipedia.|