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It is used in diseases featuring high LDL, such as the rare homozygous familial hypercholesterolemia, when the heterozygous form does not respond to medical treatment, or when the treatment has led to dangerous side-effects (such as rhabdomyolysis).
The procedure takes 2-4 hours and must be repeated every several weeks to keep the LDL levels from accumulation and causing cardiovascular disease.
It is an expensive procedure, limiting its use to severe cases of hyperlipidemia.
LDL apheresis works by leading venous blood through a collumn coated with antibodies to apolipoprotein B (the main protein of LDL particles), dextran sulphate or polyacrylate, or by precipitating LDL with heparin at low pH. In all cases (apart from polyacrylate absorption), plasma is separated from cells by a cell separator.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "LDL_apheresis". A list of authors is available in Wikipedia.|