Systematic (IUPAC) name
Formula C 9 H 11 F N 2 O 5
Mol. mass 246.193 g/mol
Half life ?
Floxuridine is an oncology drug that belongs to the class known as antimetabolites. The drug is most often used in the treatment of colorectal cancer.
Floxuridine, an analog of 5-fluorouracil, is a fluorinated
Meachanism of action
Floxuridine works because it is broken down by the body into its active form, which is the same as a metabolite of 5-Fluorouracil.
Floxuridine first gained FDA approval in December 1970 under the brand name FUDR. The drug was initially marketed by Roche, which also did a lot of the initial work on 5-fluorouracil. The
National Cancer Institute was an early developer of the drug. Roche sold its FUDR product line in 2001 to Faulding, which became Mayne Pharma.
In the US the drug is supplied by Mayne Pharma as well as APP and Bedford.
Chemotherapeutic agents/Antineoplastic agents (L01) Alkylating and alkylating-like agents Nitrogen mustards: ( Chlorambucil, Chlormethine, Cyclophosphamide, Ifosfamide, Melphalan). Nitrosoureas:(Carmustine, Fotemustine, Lomustine, Streptozocin). Platinum (alkylating-like): ( Carboplatin, Cisplatin, Oxaliplatin, BBR3464). Busulfan, Dacarbazine, Procarbazine, Temozolomide, ThioTEPA, Uramustine Antimetabolites Folic acid: ( Aminopterin, Methotrexate, Pemetrexed, Raltitrexed). Purine:(Cladribine, Clofarabine, Fludarabine, Mercaptopurine, Pentostatin, Thioguanine). ( Pyrimidine: Capecitabine, Cytarabine, Fluorouracil, Floxuridine, Gemcitabine) Spindle poison/ mitotic inhibitor Taxane: ( Docetaxel, Paclitaxel). Vinca: (Vinblastine, Vincristine, Vindesine, Vinorelbine). Cytotoxic/antitumor antibiotics (Daunorubicin, Anthracycline family: Doxorubicin, Epirubicin, Idarubicin, Mitoxantrone, Valrubicin) - ( streptomyces Actinomycin, Bleomycin, Mitomycin, Plicamycin) - Hydroxyurea Topoisomerase inhibitors Camptotheca: ( Camptothecin, Topotecan, Irinotecan), ( Podophyllum: Etoposide, Teniposide) CI monoclonal antibodies ( Receptor tyrosine kinase Cetuximab, Panitumumab, Trastuzumab) - CD20 ( Rituximab, Tositumomab) - other ( Alemtuzumab, Bevacizumab, Gemtuzumab) Photosensitizers Aminolevulinic acid, Methyl aminolevulinate, Porfimer sodium, Verteporfin Tyrosine kinase inhibitors Dasatinib, Erlotinib, Gefitinib, Imatinib, Lapatinib, Nilotinib, Sorafenib, Sunitinib Other (Alitretinoin, retinoids Tretinoin) - Altretamine, Amsacrine, Anagrelide, Arsenic trioxide, Asparaginase (Pegaspargase), Bexarotene, Bortezomib, Denileukin diftitox, Estramustine, Ixabepilone, Masoprocol, Mitotane