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Cryoprecipitate, formally "Cryoprecipitated AHF" and commonly called "cryo" is a frozen blood product prepared from plasma. Each 15 mL unit typically contains 100 IU of factor VIII, and 250 mg of fibrinogen. It also contains von Willebrand factor (vWF), factor XIII, and fibronectin. It is often transfused as a four to six unit pool instead of as a single product. The AHF stands for antihemophyllic factor, which is an anachronism since Cryo is no longer the therapy of choice for these patients. Many uses of the product have replaced by factor concentrates, but it is still routinely stocked by many hospital blood banks.
US standards require manufacturers to test at least four units each month, and the products must have an average of 150 mg or more of fibrinogen and 80 IU of factor VIII. Individual products may actually have less than these amounts as long as the average remains above these minimums. Typical values for a unit are substantially higher, and aside from infants it is rare to transfuse just one unit.
Like FFP, compatibility testing is not indicated, but it is given as ABO compatible. Compatibility is reversed for plasma products: AB is the universal donor type and O is the universal recipient.
Indications for giving cryoprecipitate include:
The product is manufactured by slowly thawing a unit of FFP at temperatures just above freezing, typically in a water bath or a refrigerator. The product is then centrifuged to remove the majority of the plasma and the precipitate is resuspended in the remaining plasma or in sterile saline. The product may then be pooled and frozen or frozen as individual units.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Cryoprecipitate". A list of authors is available in Wikipedia.|