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CYP2E1



cytochrome P450, family 2, subfamily E, polypeptide 1
Identifiers
Symbol CYP2E1
Alt. Symbols CYP2E
Entrez 1571
HUGO 2631
OMIM 124040
RefSeq NM_000773
UniProt P05181
Other data
Locus Chr. 10 q24.3-qter

Cytochrome P450 2E1 (abbreviated CYP2E1, EC 1.14.14.1), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body. While it is involved only in the oxidative metabolism of a small range of substrates (mostly small polar molecules), there are many important drug interactions mediated by CYP2E1.

Contents

CYP2E1 Ligands

Selected inducers, inhibitors and substrates of CYP2E1[1]
Substrates Inhibitors Inducers
Often mentioned: [2]

Other:

Strong: [3]
  • diethyldithiocarbamate (in cancer)

unspecified:

Regulation of CYP2E1

Within one day of birth, the rat hepatic CYP2E1 gene is activated transcriptionally. CYP2E1 expression is easily inducible. It seems that there exist two stages of induction, a posttranslational mechanism for increased protein stability at low levels of ethanol, and an additional transciptional induction at high levels of ethanol[4]

See also

References

  1. ^ Where classes of agents are listed, there may be exceptions within the class
  2. ^ Mentioned both in the reference named FASS and were previously mentioned in Wikipedia. Further contributions may follow other systems
  3. ^ Swedish environmental classification of pharmaceuticals Facts for prescribers (Fakta för förskrivare)
  4. ^ Charles S. Lieber. 1999. Microsomal Ethanol-Oxidizing System (MEOS) The First 30 Years (1968-1998)-A Review. Alcoholism: Clinical and Experimental Research 23(6):991-1007
v • d • e
Oxidoreductases: dioxygenases, including steroid hydroxylases (EC 1.14)
1.14.11 - 2-oxoglutarateProlyl hydroxylase - Lysyl hydroxylase
1.14.13 - NADH or NADPHFlavin-containing monooxygenase - Nitric oxide synthase - Cholesterol 7 alpha-hydroxylase - Methane monooxygenase - 3A4 -51A1
1.14.14 - reduced flavin or flavoprotein19A1 - 2D6 - 2E1
1.14.15 - reduced iron-sulfur protein11B1 - 11B2 - 11A1
1.14.16 - reduced pteridinePhenylalanine hydroxylase - Tyrosine hydroxylase - Tryptophan hydroxylase
1.14.17 - reduced ascorbateDopamine beta hydroxylase
1.14.18-19 - otherTyrosinase - Stearoyl-CoA desaturase-1
1.14.99 - miscellaneousCyclooxygenase - Heme oxygenase (HMOX1) - Squalene monooxygenase - 17A1 - 21A2
v • d • e
Cytochromes, oxygenases: cytochrome P450 (EC 1.14)
CYP1A1, A2, B1
CYP2A6, A7, A13, B6, C8, C9, C18, C19, D6, E1, F1, J2, R1, S1, U1, W1
CYP3A4, A5, A7, A43
CYP4A11, A22, B1, F2, F3, F8, F11, F12, F22, V2, X1, Z1
CYP5-20CYP5 (A1) - CYP7 (A1, B1) - CYP8 (A1, B1) - CYP11 (A1, B1, B2) - CYP17 (A1) - CYP19 (A1) - CYP20 (A1)
CYP21-51CYP21 (A2) - CYP24 (A1) - CYP26 (A1, B1, C1) - CYP27 (A1, B1, C1) - CYP39 (A1) - CYP46 (A1) - CYP51 (A1)
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "CYP2E1". A list of authors is available in Wikipedia.
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