Electron Microscopy

Products Electron Microscopy

Tabletop Microscope from Hitachi offers improved performance and a smaller footprint

The TM3000 offers significantly improved performance, including magnification up to 30,000x and better resolution, in a unit that occupies 20% less space more

Powerful All-In-One Electron Microscope with Integrated Element Analysis

The Phenom pro X with integrated EDX analysis, intuitive handling, and ultrafast sample loading is currently the most powerful desktop SEM on the market more

News Electron Microscopy

• Virtual nanoscopy: Like 'Google Earth' for cell biologists

  Just as users of Google Earth can zoom in from space to a view of their own backyard, researchers can now navigate biological tissues from a whole embryo down to its subcellular structures thanks to recent advances in electron microscopy and image processing, as described in The Journal of Cell Biol more

• Locating muscle proteins
  

  Muscle contraction and many other movement processes are controlled by the interplay between myosin and actin filaments. Two further proteins, tropomyosin and troponin, regulate how myosin binds to actin. While theoretical models have in fact described exactly how these muscle proteins interact, thi more

• Research breakthrough for drugs via the skin

  A research team at Karolinska Institutet in Sweden has succeeded in describing the structure and function of the outermost layer of the skin – the stratum corneum – at a molecular level. This opens the way not only for the large-scale delivery of drugs via the skin, but also for a deeper understandi more

White papers Electron Microscopy

• Structural and Chemical 3D Imaging with AFM and Raman.
  

  In the Life Sciences and Bio-medical Research, the characterization of chemical compounds within cells or tissues is one of the most important and difficult tasks for researchers to perform. The development of pharmaceuticals such as drug delivery coatings or capsules also requires as much information as possible about their chemical and structural compositions. For the fields of nanotechnology and materials science, a thorough knowledge of the samples' surface morphology on a sub-micron scale is essential more

• Identification of a New Arenavirus Using High-Throughput Sequencing
  

  Culture, PCR, serologic, and oligonucleotide microarray analyses for a wide range of infectious agents were negative in samples from three individuals who had received organ transplants from a single donor and died of a febrile illness 4-6 weeks after transplantation. Palacios et al. used high-troughput sequencing with the Genome Sequencer FLX system to identify microbial sequences from RNA samples taken from the liver and kidney transplants in two recipients. They found 14 sequences representing an Old World arenavirus related to lymphocytic choriomeningitis viruses. more

Publications Electron Microscopy

• Tissue-specific effects of saposin A and saposin B on glycosphingolipid degradation in mutant mice

  Individual saposin A (A–/–) and saposin B (B–/–)-deficient mice show unique phenotypes caused by insufficient degradation of myelin-related glycosphingolipids (GSLs): galactosylceramide and galactosylsphingosine and sulfatide, respectively. To gain insight into the interrelated functions of saposin more

• Multilamellar Structures and Filament Bundles Are Found on the Cell Surface during Bunyavirus Egress

  by Laura Sanz-Sánchez, Cristina Risco Inside cells, viruses build specialized compartments for replication and morphogenesis. We observed that virus release associates with specific structures found on the surface of mammalian cells. Cultured adherent cells were infected with a bunyavirus and pro more

• CD73 expression on extracellular vesicles derived from CD4+CD25+ Foxp3+ T cells contributes to their regulatory function

  CD4+CD25+Foxp3+ T regulatory (Treg) cells maintain immunological tolerance. In this study the possibility that Treg cells control immune responses via the production of secreted membrane vesicles, such as exosomes, was investigated. Exosomes are released by many cell types, including T cells, and more

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