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• Study pinpoints, prevents stress-induced drug relapse in rats

  All too often, stress turns addiction recovery into relapse, but years of basic brain research have provided scientists with insight that might allow them develop a medicine to help. A new study in the journal Neuron pinpoints the neural basis for stress-related relapse in rat models to an unprecede more

• Neupro approved in Japan for Parkinson’s disease and Restless Legs Syndrome

  The Japanese Ministry of Health, Labour and Welfare (MHLW) has approved Neupro® (rotigotine transdermal patch) for the treatment of Parkinson’s disease (PD) and for the symptomatic treatment of moderate-to-severe idiopathic Restless Legs Syndrome (RLS) in adults. In 2002 Otsuka Pharmaceutical acquir more

• Targeting drugs with hydrogels

  Researchers in Japan have developed a technique which allows them to control and target drug delivery to specific sites of the body at specific times, thus reducing side effects and improving treatment dramatically. The results were published in Science and Technology of Advanced Materials.Better co more

Publications Dopamine

• Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited {alpha}-synuclein accumulation and age-dependent sensorimotor deficits

  Mutations in ATP13A2 (PARK9), encoding a lysosomal P-type ATPase, are associated with both Kufor–Rakeb syndrome (KRS) and neuronal ceroid lipofuscinosis (NCL). KRS has recently been classified as a rare genetic form of Parkinson's disease (PD), whereas NCL is a lysosomal storage disorder. Although more

• Design, Synthesis and Evaluation of Indolebutylamines as a Novel Class of Selective Dopamine D3 Receptor Ligands

  A series of indolebutylamine (IBA) derivatives were designed, synthesized and evaluated as a novel class of selective ligands for the dopamine 3 receptor (D3R). The most potent compound 11q binds to D3R with a Ki value of 124 nM and displays excellent selectivity over the dopamine 1 receptor (D1R) more

• TFEB-mediated autophagy rescues midbrain dopamine neurons from {alpha}-synuclein toxicity [Neuroscience]

  The aggregation of α-synuclein plays a major role in Parkinson disease (PD) pathogenesis. Recent evidence suggests that defects in the autophagy-mediated clearance of α-synuclein contribute to the progressive loss of nigral dopamine neurons. Using an in vivo model of α-synuclein toxicity, we show th more

Market studies Dopamine

• Product Profiles: Autism Spectrum Disorders -Underserved market eagerly anticipates pipeline trial data

  Introduction Over the past 6 years, three major events have impacted the autism spectrum disorders market. In 2006, Risperdal became the first drug to receive approval from the US FDA for the symptomatic treatment of irritability in children and adolescents with ASDs. Later, in 2009, the FDA approv more

• Vanda Pharmaceuticals Inc. (VNDA) - Financial and Strategic SWOT Analysis Review

  Vanda Pharmaceuticals Inc. (Vanda), is a biopharmaceutical company, engaged in developing and commercializing clinical-stage drug candidates targeting central nervous system disorders. Recently, the company and its development partner Novartis Pharmaceuticals Corporation have launched Fanapt (iloper more

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