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High-performance thin-layer chromatography

Merck's high-performance silica gel plates are faster and more sensitive than conventional silica gel plates, making them ideally suited to advanced chromatographical separations more

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• Mammograms reveal response to common cancer drug
  

  Researchers at Karolinska Institutet have developed a method for assessing the effect of tamoxifen, a common drug to prevent the relapse of breast cancer. The key lies in monitoring changes in the proportion of dense tissue, which appears white on a mammogram, during treatment. Women who show a pron more

• Margaret Gourlay wins Top 10 Clinical Research Achievement Award from Clinical Research Forum
  

  For leading a study that was the first to define appropriate bone density screening intervals for older women, Margaret Gourlay, MD, MPH, of the University of North Carolina School of Medicine has been honored with a Top 10 Clinical Research Achievement Award from the Clinical Research Forum. The wi more

• BioInvent announces approval to start Phase II trial for its novel cardiovascular drug BI-204

  BioInvent International AB announced IND clearance from the U.S. Food & Drug Administration (FDA) to initiate a Phase II study for BI-204. BI-204 is a human monoclonal antibody that specifically targets oxidized forms of a low-density lipoprotein (LDL) which has been linked to increased inflammatory more

White papers Density

• Characterizing Biotherapeutics with HPLC
  

  As demonstrated here, there are a broad range of HPLC applications used in development, production, validation and release of protein therapeutics for human use. Some of the applications mentioned above are mandatory when submitting a new biopharmaceutical to approval at the regulatory agencies. The introduction of the first so-called biosimilars in Europe further increased the demand for highly efficient analysis methods. The continuous development of new stationary phases for the common modes of biochromatography, such as size exclusion, ion exchange and hydrophilic interaction chromatography support biochemists in increasing lab productivity and establishing high-throughput HPLC analysis not only for small molecules but also for large biopolymers more

• alamarBlue® Assay for Assessment of Cell Proliferation using the FLUOstar OPTIMA
  

  The alamarBlue® cell proliferation assay is based on a reducing environment that indicates metabolic active cells. Active cells are able to convert resazurin into the resorufin. Resazurin is blue and non-fluorescent whereas resorufin is red and highly fluorescent; therefore a fluorescent and a colorimetric detection are possible. This application notes focuses on the quantification of cell proliferation in a Human Osteoblast cell culture by measuring alamarBlue® fluorescence on the FLUOstar OPTIMA microplate reader more

• Outstanding Microarray Experimental Results Using FuGENE® HD Transfection Reagent
  

  Transfection is a method for delivering nucleic acids, either DNA or RNA, into animal cells in vitro. In applications such as protein production, the main purpose is to produce protein; consequently any effects on endogenous gene expression are generally irrelevant, unless the changes relate directly to loss of the cell's ability to produce protein, i.e., cell death. In contrast, in applications where the biochemical pathways are of interest, changes within the cell can alter the interpretation of the data. Unintended up- or down-regulation of genes within transfected cells is termed an off-target effect. This may be caused by the reagent itself, the vector, or the process of transfection. Such effects, if not carefully evaluated, may lead to misinterpretation of the transfection results and to misleading conclusions. Critically important in transfection experiments is the selection of the appropriate control. more

Publications Density

• Deciphering the 8q24.21 association for glioma

  We have previously identified tagSNPs at 8q24.21 influencing glioma risk. We have sought to fine-map the location of the functional basis of this association using data from four genome-wide association studies, comprising a total of 4147 glioma cases and 7435 controls. To improve marker density ac more

• Escherichia coli rimM and yjeQ null strains accumulate immature 30S subunits of similar structure and protein complement [ARTICLES]

  Assembly of the Escherichia coli 30S ribosomal subunits proceeds through multiple parallel pathways. The protein factors RimM, YjeQ, RbfA, and Era work in conjunction to assist at the late stages of the maturation process of the small subunit. However, it is unclear how the functional interplay bet more

• Digital microfabrication of user‐defined 3D microstructures in cell‐laden hydrogels

  Abstract Complex 3D interfacial arrangements of cells are found in several in vivo biosystems such as blood vasculature, renal glomeruli, and intestinal villi. Current tissue engineering techniques fail to develop suitable 3D microenvironments to evaluate the concurrent effects of complex topog more

Market studies Density

• Healthcare, Regulatory and Reimbursement Landscape - Taiwan

  Introduction GlobalData, the industry analysis specialist, has released its latest report, “Healthcare, Regulatory and Reimbursement Landscape - Taiwan”. It is an essential source of information and analysis on Taiwan’s healthcare, regulatory and reimbursement landscape. It identifies the key tren more

• Endpoints - Clinical Trials in Cardiovascular Disorders - Optimal Use of Surrogate Endpoints and Clinical Biomarkers are Key Determinants of Success

  GBI Research, the leading business intelligence provider, has released its latest research “Endpoints - Clinical Trials in Cardiovascular Disorders - Optimal Use of Surrogate Endpoints and Clinical Biomarkers are Key Determinants of Success” which provides an insight into the different endpoints tha more

• Emerging Market for Clinical Trials in Argentina - Major Cost Advantages over the US in Conducting Clinical Trials Will Encourage Drug Development

  GBI Research has released its latest report, “Emerging Market for Clinical Trials in Argentina - Major Cost Advantages over the US in Conducting Clinical Trials Will Encourage Drug Development” that provides key data, information and analysis of the major trends and issues affecting the clinical tri more

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