Cytotoxicity

Companies Cytotoxicity

CCS Cell Culture Service GmbH, Germany

CCS generates stably transfected cell lines for cell based drug screening and produces recombinant proteins from mammalian and insect cells. more

BSL Bioservice Scientific Laboratories GmbH, Germany

BSL BIOSERVICE Scientific Laboratories GmbH is a GLP-accredited Contract Research Organisation, offering a broad spectrum of safety testing. more

Labor Dr.Merk & Kollegen GmbH, Germany

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Products Cytotoxicity

A flexible Single Tube Luminometer of Highest Sensitivity

The new developed Sirius L Tube Luminometer allows high quality luminescence measurements with state-of-the-art technique more

News Cytotoxicity

• Probiodrug Collaborators Explain Interplay of Key Suspects in Alzheimer’s Disease

  Probiodrug AG announced its scientists and academics collaborators published seminal findings on the role of pyroglu Aβ in AD pathology in Nature. The new findings add to the growing body of evidence that pyroglu Aβ plays a crucial role in the initiation of AD. In addition, the research results furt more

• Is lunar dust harmful to humans?

  Exposure to lunar dust during the Apollo missions resulted in reports of ocular, respiratory and dermal irritation, suggesting that lunar dust is a potential risk to human health. Because it is highly reactive and fine, extraterrestrial dust can quickly become wide-spread in human habitats. To best more

• ACEA Biosciences, Inc. Announces New Patent

  ACEA Biosciences, Inc. reported the issuance of a new U. S. Patent for chemical compound screening, with important applications in the development of new pharmaceutical products. Testing and profiling of these candidate compounds by means of ACEA's real-time, label-free microelectronic technology pr more

White papers Cytotoxicity

• HelpCorner - Transfection
  

  Transfection is the delivery of DNA, RNA, proteins, and macromelecules into eukaryotic cells. The goals for transfection include the study of gene function and regulation as well as protein expression and function. It is also used for gene silencing and protein production. According to the application, the information can be either transiently (transient transfection) or permanently expressed (stable transfection). Based on the strategies, the transfection methods can be divided into three groups: more

• Functional Analysis of Side Effects of Transfection Reagents in the Context of Bax-induced Apoptosis
  

  FuGENE® HD Transfection Reagent is well-suited for studying the impact of apoptosis-inducing proteins such as bax. Transfection with FuGENE® HD Transfection Reagent produced only minimal cytotoxic side effects while maintaining a high transfection efficiency. In contrast, cytotoxicity, and off-target effects of the other commercially available transfection reagents tested made it impossible to distinguish the impact of the bax protein from the impact of the transfection reagent itself more

• Efficient Transfection of VeroE6 Cells with DNA and RNA for Luciferase Reporter Assays Using FuGENE® HD Transfection Reagent
  

  The interferon (IFN) system of mammalian cells is the first line of defense against viral infections. Following infection, danger signals such as double-stranded RNA or single-stranded RNA with an unmodified 5´ triphosphate end (e.g., VSV-RNA) are recognized by membrane-bound Toll-like receptors and/or cytoplasmic receptors (MDA5, RIG-I). This initiates a signal cascade which leads to the production of type I interferons. By autocrine and paracrine stimulation via the IFN-a/b receptor the expression of antiviral proteins is induced in the infected cell as well as in the surrounding cells. more

Publications Cytotoxicity

• Hyaluronan nanocapsules as a new vehicle for intracellular drug delivery

  Publication date: Available online 15 May 2013 Source:European Journal of Pharmaceutical Sciences Author(s): Felipe A. Oyarzun-Ampuero , Gustavo R. Rivera-Rodríguez , Maria J. Alonso , Dolores Torres Here we report the development of new drug nanocarriers -named hyaluronan nanocapsules- fo more

• 4‐Hydroxyderricin and xanthoangelol from Ashitaba (Angelica keiskei) suppress differentiation of preadiopocytes to adipocytes via AMPK and MAPK pathways

  Scope Adipocytes differentiation is deeply involved in the onset of obesity. 4‐Hydroxyderricin (4HD) and xanthoangelol (XAG) are the chalcones that are derived from Ashitaba (Angelica keiskei). In this study, we demonstrated the inhibitory effects of these chalcones on adipocytes differentiation more

• Adipocytes Cause Leukemia Cell Resistance to L-Asparaginase via Release of Glutamine

  Obesity is a significant risk factor for cancer. A link between obesity and a childhood cancer has been identified: obese children diagnosed with high-risk acute lymphoblastic leukemia (ALL) had a 50% greater risk of relapse than their lean counterparts. l-asparaginase (ASNase) is a first-line thera more

Websites Cytotoxicity