Cystic Fibrosis

News Cystic Fibrosis

• Squaraine rotaxane shuttle as a ratiometric deep-red optical chloride sensor

  Chloride ions are central to many biological processes and measuring the concentration of chloride ions in biological fluids can help diagnose a number of diseases, including cystic fibrosis. Scientists from the US have synthesised a squaraine rotaxane which can detect chloride ions via colorimetric more

• Exome sequencing of health condition extremes can reveal susceptibility genes

  Comparing the DNA from patients at the best and worst extremes of a health condition can reveal genes for resistance and susceptibly. This approach discovered rare variations in the DCTN4 gene among cystic fibrosis patients most prone to early, chronic airway infections.The DCTN4 gene codes for dyna more

• BGU Kahn Center research group unravels genetic mutations for intestinal obstruction
  

  Intestinal obstructions have many causes, some of which are genetic. In extreme cases, such as in some instances of cystic fibrosis (CF), intestinal blockages are found even at birth. Ben-Gurion University of the Negev and Soroka University Medical Center Prof. Ohad Birk’s research group has discove more

White papers Cystic Fibrosis

• Orphan Drugs – An Alternative to the declining Blockbuster Model?
  

  Up until the new millennium, the pharmaceutical industry grew stronger by 11%. However, the blockbuster model is increasingly at risk and the declining growth rates in the industry require a search for new strategies. In this context, orphan drugs are becoming increasingly important more

• Enzyme Kinetic Measurements for a Combinatorial Library of Inhibitors of Pseudomonas Elastase
  

  Pseudomonas elastase (LasB) is a key drug target in various chronic and intractable infections. A library of 160 potential, in-house synthesised, elastase inhibitors were screened using a fluorescence assay with the internally quenched substrate Abz-Ala-Gly-Leu-Ala-Nba. Enzymatic kinetic measurements were done on a FLUOstar OPTIMA and Km and Vmax values were calculated for each inhibitor using the MARS Data Analysis software more

Publications Cystic Fibrosis

• Skin pretreatment with microneedles prior to pilocarpine iontophoresis increases sweat production

  Summary Collection of sweat via pilocarpine iontophoresis is commonly used to diagnose cystic fibrosis (CF), with thousands of tests performed each day. The main source of resistance to the passage of pilocarpine ions to the sweat glands is the electrical resistance of the stratum corneum. It wa more

• Evolutionary remodeling of global regulatory networks during long-term bacterial adaptation to human hosts [Evolution]

  The genetic basis of bacterial adaptation to a natural environment has been investigated in a highly successful Pseudomonas aeruginosa lineage (DK2) that evolved within the airways of patients with cystic fibrosis (CF) for more than 35 y. During evolution in the CF airways, the DK2 lineage underwent more

• Pneumonia pathogen detection and microbial interactions in polymicrobial episodes

  Recent reports show that microbial communities associated with respiratory infections, such as pneumonia and cystic fibrosis, are more complex than expected. Most of these communities are polymicrobial and might comprise microorganisms originating from several diverse biological and ecological sourc more

Market studies Cystic Fibrosis

• Endpoints - Clinical Trials in Respiratory Diseases - Pulmonary Function Tests, Biomarkers and Quality of Life Questionnaires All Play Prominent Roles

  GBI Research in its report “Endpoints - Clinical Trials in Respiratory Diseases - Pulmonary Function Tests, Biomarkers and Quality of Life Questionnaires All Play Prominent Roles” presents the use of endpoints or outcomes measures in respiratory disease’s clinical trials. In this report, endpoint us more

• Cystic Fibrosis – Pipeline Review, H1 2012

  Introduction Global Markets Direct’s, 'Cystic Fibrosis - Pipeline Review, H1 2012', provides an overview of the Cystic Fibrosis therapeutic pipeline. This report provides information on the therapeutic development for Cystic Fibrosis, complete with latest updates, and special features on late-stag more

• Orphan Disease Therapeutics in Genetic Disorders to 2018 - Emerging Agents in Cystic Fibrosis Offer Strong Opportunities for Investment and Licensing Activity

  GBI Research, the leading business intelligence provider, has released its latest research, “Orphan Disease Therapeutics in Genetic Disorders to 2018 - Emerging Agents in Cystic Fibrosis Offer Strong Opportunities for Investment and Licensing Activity”, which provides insights into the global orphan more

Websites Cystic Fibrosis