Creutzfeldt-Jakob Disease

News Creutzfeldt-Jakob Disease

• Multitarget Drugs against Prion Diseases

  The central nervous systems of humans and cattle alike are attacked by prions (abnormal insoluble amyloidogenic proteins) when they suffer from Creutzfeldt–Jakob disease (CJD) or bovine spongiform encephalopathy (BSE). This causes a steady deterioration of neurological function and ultimately leads more

• BSE pathogens can be transmitted by air

  Airborne prions are also infectious and can induce mad cow disease or Creutzfeldt-Jakob disorder. This is the surprising conclusion of researchers at the University of Zurich, the University Hospital Zurich and the University of Tübingen. They recommend precautionary measures for scientific labs, sl more

• Scientists develop new method to identify glycosylated proteins
  

  Various processes in our body are controlled by subsequent changes of proteins. Therefore, the identification of such modifications is essential for the further exploration of our organism. Now, scientists of the Max Planck Institute of Biochemistry in Martinsried, Germany, have made a crucial contr more

Publications Creutzfeldt-Jakob Disease

• Unique drug screening approach for prion diseases identifies tacrolimus and astemizole as antiprion agents [Neuroscience]

  Prion diseases such as Creutzfeldt–Jakob disease (CJD) are incurable and rapidly fatal neurodegenerative diseases. Because prion protein (PrP) is necessary for prion replication but dispensable for the host, we developed the PrP–FRET-enabled high throughput assay (PrP–FEHTA) to screen for compounds more

• Thermodynamic analysis of structural transitions during GNNQQNY aggregation

  Abstract Amyloid protein aggregation characterizes many neurodegenerative disorders, including Alzheimer's, Parkinson's, and Creutzfeldt‐Jakob disease. Evidence suggests that amyloid aggregates may share similar aggregation pathways, implying simulation of full‐length amyloid proteins is not nec more

• Substitutions at residue 211 in the prion protein drive a switch between CJD and GSS syndrome, a new mechanism governing inherited neurodegenerative disorders

  Human prion diseases are a heterogeneous group of fatal neurodegenerative disorders, characterized by the deposition of the partially protease-resistant prion protein (PrPres), astrocytosis, neuronal loss and spongiform change in the brain. Among inherited forms that represent 15% of patients, diff more

Websites Creutzfeldt-Jakob Disease