Clusters

News Clusters

• Cornell: Alternative alpha-synuclein aggregates

  Proteins perform almost every function our bodies require for life. But, they also can misbehave in myriad ways. By retracing the history of each abnormal reaction, biochemists aim to determine the events that lead to disease and to intervene in the process. Collaborative research between Cornell a more

• Bismuth for Bone Cement: Water-soluble cluster is key to the formation of a hybrid material

  Organic–inorganic hybrid materials, uniting the advantages of their organic and inorganic parts, are used for a wide variety of applications. However, making a homogeneous composite material is only possible if a solvent can be found in which both components are soluble. Materials containing the met more

• A new Concept in Microscopy: Self-reconstructing Laser Beams

  It’s a familiar situation for all car drivers. In the autumn, when the roads are foggy, visibility drops below 50 metres. The light of the car’s headlights are scattered by the drops of fog, meaning we can’t see objects further away because the light can’t reach them. This everyday example illustrat more

White papers Clusters

• Expression Analysis of ABC Transporters in Lung Cancer Cell Lines Using a RealTime ready qPCR Focus Panel
  

  The novel small molecule inhibitors are often substrates of ABC transporters which influence the pharmacokinetic parameters of the drug candidates and cause drug resistance of tumor cells. Therefore expression profiling of ABC transporter genes in cell lines used for drug screening is highly important for anti-cancer drug discovery projects. Our purpose was to create a basic expression profile of ABC transporters in our mainly used lung cancer cell lines using the RealTime ready ABC Transporter Panel.The RealTime ready ABC-Transporter Panel comprises the 42 most important human ABC transporters in duplicate. The panel includes five controls for RNA quality and seven reference gene assays. The assays are supplied in a LightCycler® Instrument 480 Multiwell Plate 96 and contain target specific primers and a FAM-labeled Universal ProbLibrary hydrolysis probe that contains LNA more

• Structural and Chemical 3D Imaging with AFM and Raman.
  

  In the Life Sciences and Bio-medical Research, the characterization of chemical compounds within cells or tissues is one of the most important and difficult tasks for researchers to perform. The development of pharmaceuticals such as drug delivery coatings or capsules also requires as much information as possible about their chemical and structural compositions. For the fields of nanotechnology and materials science, a thorough knowledge of the samples' surface morphology on a sub-micron scale is essential more

• Ultrafast De Novo Sequencing of Corynebacterium urealyticum Using the Genome Sequencer 20 System
  

  A microbial genome sequence provides a wealth of data and specific information that cannot be obtained by other experimental approaches. A genome sequence can be regarded as the starting point for detailed bioinformatics analysis, metabolic reconstruction and systematic functional examination of all identified genes. In particular, genome sequencing has revealed important information on genes and deduced proteins of human pathogens, including putative virulence factors and potential new drug targets. more

Publications Clusters

• Organization of the extracellular portion of the macrophage galactose receptor: A trimeric cluster of simple binding sites for N-acetylgalactosamine

  The properties of the human macrophage galactose receptor have been investigated. Specificity for N-acetylgalactosamine (GalNAc) residues with exposed 3- and 4-hydroxyl groups explains virtually all of the results obtained from a recently expanded array of synthetic glycans and is consistent with a more

• Identification of a Novel Antimicrobial Peptide from Human Hepatitis B Virus Core Protein Arginine-Rich Domain (ARD)

  by Heng-Li Chen, Pei-Yi Su, Ya-Shu Chang, Szu-Yao Wu, You-Di Liao, Hui-Ming Yu, Tsai-Ling Lauderdale, Kaichih Chang, Chiaho Shih The rise of multidrug-resistant (MDR) pathogens causes an increasing challenge to public health. Antimicrobial peptides are considered a possible solution to this probl more

• An In Silico Identification of Human Promoters: A Soft Computing Based Approach

  Abstract: Promoter region of a gene sequence of Eukaryotes is very important as it helps us to understand the mechanism of transcription regulation. The identification of this region is a complex problem as the signature for identification turns out to be fuzzy. Several in silico methods ar more

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