Cirrhosis

News Cirrhosis

• Largest ever study of liver function finds multiple genetic links to liver injury

  Researchers have identified a large number of areas in the human genetic code that are involved in regulating the way in which the liver functions, in a new study of over 61,000 people, published in Nature Genetics.The work is an international collaboration led by Imperial College London and it iden more

• NovImmune Initiates a Proof-of-Concept Study in Primary Biliary Cirrhosis (PBC)

  NovImmune announced that a Proof-of–Concept (PoC) study with NI-0801, a fully human monoclonal antibody neutralizing the CXCL10/Interferon-gamma-inducible protein-10 (IP-10) chemokine, was initiated in patients with PBC. This is a chronic inflammatory, debilitating condition of the bile ducts that l more

• Combining therapies appears safe, may benefit patients with advanced liver cancer, UF scientists say

  Few treatments exist for patients with advanced primary liver cancer, but University of Florida researchers have found a new way to broaden the range of options and potentially improve health outcomes by combining two treatments.In the first study of its kind, the researchers combined sorafenib, the more

White papers Cirrhosis

• Molecular diagnostic test applied to ascitic fluid
  

  Spontaneous bacterial peritonitis (SBP) is a common and life-threatening complication of patients with ascites and cirrhosis of the liver. The mortality accounts for up to 30-50% and such patients die within several hours after infection. An early diagnosis and subsequent antibiotic therapy are prerequisites for the survival of the patients. The clinical standard for a diagnosis of SBP is the increased number of polymorphic neutrophilic cells in the ascites (> 250/l), independent of the results obtained with ascites cultures. An increased cell count is not detectable in all patients. Positive ascites cultures are typically found in 40-90% of all SBP cases. more

Publications Cirrhosis

• Genetic variation in the PNPLA3 gene and hepatocellular carcinoma in USA: Risk and prognosis prediction

  Abstract Nonalcoholic fatty liver disease (NAFLD) is an emerging epidemic with high prevalence in Western countries. Genome‐wide association studies had reported that a variation in the patatin‐like phospholipase domain containing 3 (PNPLA3) gene is associated with high susceptibility to NAFLD. more

• Full genome ultra‐deep pyrosequencing associates G‐to‐A hypermutation of the hepatitis B virus genome with the natural progression of hepatitis B

  Summary Human APOBEC3 (A3) cytosine deaminases are antiviral restriction factors capable of editing the genome the hepatitis B virus (HBV). Despite the importance of the human A3 protein family for the innate immune response little is known about the clinical relevance for hepatitis B. The aim more

• Viruses, Vol. 5, Pages 1292-1324: Hepatitis C Virus, Cholesterol and Lipoproteins — Impact for the Viral Life Cycle and Pathogenesis of Liver Disease

  Hepatitis C virus (HCV) is a leading cause of chronic liver disease, including chronic hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. Hepatitis C infection associates with lipid and lipoprotein metabolism disorders such as hepatic steatosis, hypobetalipoproteinemia, and hypocholestero more

Market studies Cirrhosis

• Primary Biliary Cirrhosis – Pipeline Review, H1 2012

  Introduction Global Markets Direct’s, 'Primary Biliary Cirrhosis - Pipeline Review, H1 2012', provides an overview of the Primary Biliary Cirrhosis therapeutic pipeline. This report provides information on the therapeutic development for Primary Biliary Cirrhosis, complete with latest updates, and more

• Cirrhosis – Pipeline Review, H2 2012

  Introduction Global Markets Direct’s, 'Cirrhosis - Pipeline Review, H2 2012', provides an overview of the indication’s therapeutic pipeline. This report provides information on the therapeutic development for Cirrhosis, complete with latest updates, and special features on late-stage and discontin more

• Biliary Cirrhosis Global Clinical Trials Review, H2, 2012

  Introduction GlobalData's clinical trial report, “Biliary Cirrhosis Global Clinical Trials Review, H2, 2012" provides data on the Biliary Cirrhosis clinical trial scenario. This report provides elemental information and data relating to the clinical trials on Biliary Cirrhosis. It includes an over more

Websites Cirrhosis