Cell Division

News Cell Division

• Clarifying the effect of stem cell therapy on cancer

  Injection of human stem cells into mice with tumors slowed down tumor growth, finds research published in BioMed Central's open access journal Stem Cell Research & Therapy. Human mesenchymal stem cells (MSC), isolated from bone marrow, caused changes in blood vessels supplying the tumor, and it is t more

• New genetic link found between normal fetal growth and cancer

  Two researchers at the National Institutes of Health discovered a new genetic link between the rapid growth of healthy fetuses and the uncontrolled cell division in cancer. The findings shed light on normal development and on the genetic underpinnings of common cancers. The work, conducted using mou more

• Protein maintains order in the nucleus
  

  Two metres of DNA are packed into the cell nucleus, presumably based on a strictly defined arrangement. Researchers working with biologist Patrick Heun from the Max Planck Institute of Immunobiology and Epigenetics in Freiburg have now succeeded in explaining a phenomenon, which was first observed 4 more

White papers Cell Division

• Rapid High-Throughput Methylation Analysis Using the LightCycler® 480 System
  

  The LightCycler® 480 Instrument is a versatile platform for molecular studies. We assessed the performance of the instrument combined with the LightCycler® 480 High Resolution Melting Master mix for DNA methylation analysis using the methylation-sensitive high resolution melting (MS-HRM) methodology. This proved to be a robust platform for performing MS-HRM experiments, allowing rapid and high-throughput studies of DNA methylation. more

• HelpCorner - Gene Silencing
  

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• Successful Isolation of a Proliferating Cell Population with Stem Cell-like Properties from Rat Pancreas
  

  Exocrine glands have been shown to be potential sources of pluri-/multipotent adult stem cells that are highly versatile as demonstrated for pancreas, testis, salivary glands, and sweat glands. Primary cultures of these adult stem cells have the capacity for extended self-renewal and are able to differentiate in vitro into cell types of the three embryonic germ layers. The Fraunhofer EMB established a standardized isolation procedure that was successfully applied to the isolation of proliferating cells from different animal tissues and human biopsies. With this technique, tissue specimens are ­generally dissociated in a two-step protocol using collagenase. The gland-derived cell populations adhere to the culture dish and start to proliferate. During in vitro propagation, these glandular stem cells exhibit a population doubling of at least 30, depending on the organ and the species more

Publications Cell Division

• Essential and non‐essential interactions in interactome networks: The Escherichia coli division proteins FtsQ‐FtsN interaction

  Summary The Escherichia coli division protein FtsQ, that plays a central role in the septosome assembly, interacts with several protein partners of the division machinery. Its interaction with FtsB and FtsL allows the formation of the tetrameric complex connecting the early cytoplasmic cell divi more

• Multiple genetic pathways regulate replicative senescence in telomerase‐deficient yeast

  Summary Most human tissues express low levels of telomerase and undergo telomere shortening and eventual senescence; the resulting limitation on tissue renewal can lead to a wide range of age‐dependent pathophysiologies. Increasing evidence indicates that the decline in cell division capacity in more

• Multiple tubulins: evolutionary aspects and biological implications

  Abstract Plant tubulin is a dimeric protein that chiefly contributes to the formation of microtubules, major intracellular structures involved in the control of fundamental processes such as cell division, polarity of growth, cell wall deposition, intracellular trafficking and communications. Be more

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