Cardiovascular Disease

News Cardiovascular Disease

• Body fat hardens arteries after middle age

  In young people, blood vessels appear to be able to compensate for the effects of obesity. But after middle age, this adaptability is lost, and arteries become progressively stiffer as body fat rises – potentially increasing the risk of dying from cardiovascular disease. The researchers suggest that more

• High leukemia treatment costs may be harming patients

  The increasing cost of treatments for chronic myeloid leukemia (CML) in the United States has reached unsustainably high levels and may be leaving many patients under- or untreated because they cannot afford care, according to a Blood Forum article supported by nearly 120 CML experts from more than more

• Uncleaned cells mean weak muscles
  

  The protein complex mTORC1 promotes muscle growth. However, should this complex remain constantly active, it impairs the ability of the cells to self-clean, causing myopathy. Scientists working with Markus Rüegg, Professor at the Biozentrum, University of Basel. Similarly to parts in a machine, indi more

White papers Cardiovascular Disease

• Orphan Drugs – An Alternative to the declining Blockbuster Model?
  

  Up until the new millennium, the pharmaceutical industry grew stronger by 11%. However, the blockbuster model is increasingly at risk and the declining growth rates in the industry require a search for new strategies. In this context, orphan drugs are becoming increasingly important more

• High-Throughput Cardiac Gene Expression Analysis Using the Universal ProbeLibrary and the Novel LightCycler® 1536 Real-Time PCR System
  

  Although congenital heart malformations are the most common birth defects in humans, the underlying patho­mechanisms remain widely unknown. Through linkage analyzes and candidate-gene approaches, several gene mutations causing congenital heart defects (e.g., CITED2, GATA4, NKX2-5) have been identified. However, most heart malformations display variable expressivity and pene­trance, which indicates a multifactorial and multigenic basis. This suggests that the regulatory context of transcription factors plays an important role in the manifestation of the defects. In order to better understand the molecular pathways in cardiogenesis and disease we studied the global genetic network that is deregulated in malformed hearts more

• ORAC Assay Performed on the POLARstar Omega and PHERAstar FS microplate reader
  

  In all oxygen consuming cells, metabolism and oxidative stress generate several intermediates and byproducts that are collectively known as reactive oxygen species (ROS). ROS are necessary intermediates in the human body, but they are also involved in the aging process and in the development of many degenerative diseases, including cancer, heart disease, Alzheimer's and Parkinson's. Herein we describe the determination of the antioxidant capacity of different fruit juices using the ORAC assay; a standardized method that uses Trolox®, a water-soluble analogue of vitamin E, as a standard substance more

Publications Cardiovascular Disease

• Inhibition of galectin-3 reduces atherosclerosis in apolipoprotein E-deficient mice

  Atherosclerosis is a major risk factor for cardiovascular disease (CVD) and stroke. Galectin-3 is a carbohydrate-binding lectin implicated in the pathophysiology of CVD and is highly expressed within atherosclerotic lesions in mice and humans. The object of this present study was to use genetic del more

• Mutations in NEK8 link multiple organ dysplasia with altered Hippo signalling and increased c-MYC expression

  Mutations affecting the integrity and function of cilia have been identified in various genes over the last decade accounting for a group of diseases called ciliopathies. Ciliopathies display a broad spectrum of phenotypes ranging from mild manifestations to lethal combinations of multiple severe s more

• White‐Coat Hypertension

  Summary Aim A number of studies have examined if WCHT is associated with increased cardiovascular risk but with definitions of WCHT that were not sufficiently robust, and results have been inconsistent. This review aims to standardise the evidence by only including studies which used a definit more

Market studies Cardiovascular Disease

• Drug-eluting Stent Market in Europe 2011-2015

  TechNavio’s analysts forecast the Drug-eluting Stent market in Europe to grow at a CAGR of 4.3 percent over the period 2011–2015. One of the key factors contributing to this market growth is the high prevalence of cardiovascular diseases in the region. The Drug-eluting Stent market in Europe has als more

• Global Implantable Cardioverter Defibrillators Market 2011-2015

  TechNavio’s analysts forecast the Global Implantable Cardioverter Defibrillator (ICD) market to reach US$6.22 billion by 2015. One of the key factors contributing to this market growth is the rising incidence of Cardiovascular diseases. The Global ICD market has also been witnessing the development more

• Hypertension – Pipeline Review, H1 2012

  Introduction Global Markets Direct’s, 'Hypertension - Pipeline Review, H1 2012', provides an overview of the Hypertension therapeutic pipeline. This report provides information on the therapeutic development for Hypertension, complete with latest updates, and special features on late-stage and dis more

Websites Cardiovascular Disease