Cancer

Companies Cancer

Biomol GmbH, Germany

Biomol GmbH offers antibodies, enzymes, bioactive lipids, microarrays and reagents for biomedical research. Our focus is on cellular regulation and signal transduction. Together with our partners, we also provide a variety of specialized kits for drug discovery. more

Products Cancer

ELISA kits for the measurment of SDF-1/CXCL12

SDF-1α (CXCL12) is a CXC chemokine. The small basic protein (ca. 8 kDa) has no glycosylation site in its sequence. The homology properties of SDF-1α are unique among the chemokines more

News Cancer

• Clarifying the effect of stem cell therapy on cancer

  Injection of human stem cells into mice with tumors slowed down tumor growth, finds research published in BioMed Central's open access journal Stem Cell Research & Therapy. Human mesenchymal stem cells (MSC), isolated from bone marrow, caused changes in blood vessels supplying the tumor, and it is t more

• Cancer drug prevents build-up of toxic brain protein

  Researchers at Georgetown University Medical Center have used tiny doses of a leukemia drug to halt accumulation of toxic proteins linked to Parkinson's disease in the brains of mice. This finding provides the basis to plan a clinical trial in humans to study the effects. They say their study, publi more

• Exercise-related changes in estrogen metabolism may lower breast cancer risk

  Changes in estrogen breakdown, or metabolism, may be one of the mechanisms by which aerobic exercise lowers a woman's breast cancer risk, according to data published in Cancer Epidemiology, Biomarkers & Prevention. "Observational studies suggest physical activity lowers breast cancer risk, but there more

White papers Cancer

• Mutation Scanning Using High Resolution Melting or dHPLC: a Performance Comparison Study
  

  High Resolution Melting (HRM) is a novel and promising screening technique used for mutation analysis and detection. Its application prevents the need to sequence all the exons of a gene when looking for novel mutations. The method is therefore time- and cost-effective for the analysis of large genes comprising many exons. In the research project described here, we compared HRM on the LightCycler® 480 System with denaturing high-performance liquid chromatography (dHPLC), a more conventional method for mutation scanning. A WAVE 4500 HT System has been used for many years in our accredited human genetic laboratory for screening human samples by dHPLC, to identify unknown mutations that can then be characterized in detail by sequence analysis more

• Aphidicolin-Mediated Replication Stress Induces Submicroscopic Tumor-Like Deletions in FHIT/FRA3B
  

  Common fragile sites (CFSs) are loci that are particularly susceptible to forming gaps and breaks on metaphase chromosomes after partial inhibition of DNA synthesis, for example induced by aphidicolin (APH). FRA3B, a fragile site lying within the FHIT tumor suppressor gene, is a site of frequent heterozygous and homozygous deletions in cancer cells and precancerous lesions. Most FHIT and other CFS-associated gene rearrangements in tumors are deletions of hundreds of kilobases often resulting in the inactivation of associated genes. However, there has been no direct evidence showing that CFS instability or replication stress can induce submicroscopic deletions like the ones found in cancer cells. Durkin et al. produced FHIT/FRA3B deletions similar to those in tumor cells by inducing replication stress in human-mouse chromosome 3 somatic hybrid cells with APH. more

• Expression Analysis of ABC Transporters in Lung Cancer Cell Lines Using a RealTime ready qPCR Focus Panel
  

  The novel small molecule inhibitors are often substrates of ABC transporters which influence the pharmacokinetic parameters of the drug candidates and cause drug resistance of tumor cells. Therefore expression profiling of ABC transporter genes in cell lines used for drug screening is highly important for anti-cancer drug discovery projects. Our purpose was to create a basic expression profile of ABC transporters in our mainly used lung cancer cell lines using the RealTime ready ABC Transporter Panel.The RealTime ready ABC-Transporter Panel comprises the 42 most important human ABC transporters in duplicate. The panel includes five controls for RNA quality and seven reference gene assays. The assays are supplied in a LightCycler® Instrument 480 Multiwell Plate 96 and contain target specific primers and a FAM-labeled Universal ProbLibrary hydrolysis probe that contains LNA more

Publications Cancer

• The epigenetic potentials of dietary polyphenols in prostate cancer management

  Le cancer de la prostate est une maladie grandement affectée par le style de vie, particulièrement la diète, et il est plus fréquent aux États-Unis et dans les pays européens comparativement à l'Asie de sud et de l'est. Parmi les nombreuses causes et facteurs de risques connus, la nutrition joue un more

• A non-enzymatic function of Golgi glycosyltransferases: Mediation of Golgi fragmentation by interaction with non-muscle myosin IIA

  The Golgi apparatus undergoes morphological changes under stress or malignant transformation, but the precise mechanisms are not known. We recently showed that non-muscle myosin IIA (NMIIA) binds to the cytoplasmic tail of Core 2 N-acetylglucosaminyltransferase mucus-type (C2GnT-M) and transports i more

• Occurrence of free deaminoneuraminic acid (KDN)-containing complex-type N-glycans in human prostate cancers

  We previously reported on the accumulation of a substantial amount of free N-acetylneuraminic acid (Neu5Ac)-containing complex-type N-glycans in human pancreatic cancer cells (Yabu M, Korekane H, Takahashi H, Ohigashi H, Ishikawa O, Miyamoto Y. 2013. Accumulation of free Neu5Ac-containing complex-t more

Market studies Cancer

• Anal Cancer Therapeutics - Pipeline Assessment and Market Forecasts to 2019

  Introduction GlobalData, the industry analysis specialist, has released its new report, “Anal Cancer Therapeutics - Pipeline Assessment and Market Forecasts to 2019”. The report is an essential source of information and analysis on the global Anal Cancer Therapeutics market. The report identifies t more

• Non-Small Cell Lung Cancer – Pipeline Review, H1 2012

  Introduction Global Markets Direct’s, 'Non-Small Cell Lung Cancer - Pipeline Review, H1 2012', provides an overview of the Non-Small Cell Lung Cancer therapeutic pipeline. This report provides information on the therapeutic development for Non-Small Cell Lung Cancer, complete with latest updates, more

• BIOQUAL, Inc. - Strategic SWOT Analysis Review

  BIOQUAL, Inc. (Bioqual) is a public traded, research, development and consulting company and is engaged in providing quality research, development and consulting services to Government and commercial contract clients. The company is accredited by the association for the assessment and accreditation more

Websites Cancer