Bone Marrow

Products Bone Marrow

ELISA kits for the measurment of SDF-1/CXCL12

SDF-1α (CXCL12) is a CXC chemokine. The small basic protein (ca. 8 kDa) has no glycosylation site in its sequence. The homology properties of SDF-1α are unique among the chemokines more

News Bone Marrow

• Stem cells fill gaps in bones

  For many patients the removal of several centimetres of bone from the lower leg following a serious injury or a tumour extraction is only the beginning of a long-lasting ordeal. Autologous stem cells have been found to accelerate and boost the healing process. Surgeons at the RUB clinic Bergmannshei more

• Moffitt Cancer Center researchers study use of dasatinib for patients with high-risk MDS

  Researchers at Moffitt Cancer Center have completed a phase II clinical trial to determine the safety and efficacy of dasatinib for patients with higher-risk myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia, or acute myeloid leukemia resulting from MDS and have failed treatment with more

• White blood cells found to play key role in controlling red blood cell levels

  Researchers at Albert Einstein College of Medicine of Yeshiva University and the Icahn School of Medicine at Mount Sinai have found that macrophages – white blood cells that play a key role in the immune response – also help to both produce and eliminate the body's red blood cells (RBCs). The findin more

White papers Bone Marrow

• Acquired Copy Number Alterations in Adult Acute Myeloid Leukemia Genomes
  

  To complement cytogenetic studies and to identify genes altered in AML genomes, Walter and co-workers performed a genome-wide copy number analysis with paired normal and tumor DNA obtained from 86 adult subjects with de novo AML using 1.85 million feature SNP arrays. A total of 201 somatic CNAs were found in the 86 AML genomes (mean, 2.34 CNAs per genome), with FAB-System M6 and M7 genomes containing the most changes (10-29 CNAs per genome). According to the authors' conclusions, the use of an unbiased high-resolution genomic screen identified many genes not previously implicated in AML that may be relevant for pathogenesis, along with many known oncogenes and tumor suppressor genes. Despite the ability of next-generation sequencing platforms to accurately identify amplifications, deletions, and translocations, a multiplatform approach (traditional cytogenetics, FISH, SNP array, array CGH, and targeted gene resequencing) will continue to be the most practical approach to studying AML genomes at most institut more

• Evidence for a Cysteine Proteinase Involved in BSE Infection and/or Progression
  

  According to the "protein-only" hypothesis, the prion protein seemed to be - for more than a decade - the infectious agent of transmissible spongiform encephalopathies (TSEs) in different species. TSEs are neurodegenerative diseases reported e.g., for humans (Creutzfeld-Jakob disease, CJD), cattle (bovine spongiform encephalo­pathy, BSE), and sheep (scrapie). In contrast to the "protein-only" hypothesis, some researchers published data showing that retrovirus-like RNA transcripts, a viral structure, and viral particles might be involved in disease infection/progression of CJD. In addition, there is no final proof for the "protein-only" hypothesis and the infectivity of the prion protein. more

• Analysis of Prostate Tumour Cell Invasion Using BD FluoroBlokTMand FLUOstar OPTIMA
  

  The FLUOstar OPTIMA is used for reading the BD Biosciences FluoroBlok(TM) tumour cell invasion system. In this application note we show that the results are comparable to the traditional invasion assays. The introduced method is fast, saving time and labour. The FLUOstar OPTIMA is able to take multiple readings over time at a user defined temperature more

Publications Bone Marrow

• A novel bidirectional continuous perfusion bioreactor for the culture of large‐sized bone tissue‐engineered constructs

  Abstract This works reports the development and preliminary assessment of a new bioreactor for culturing large‐sized three‐dimensional constructs in bone tissue engineering. The bidirectional continuous perfusion bioreactor (BCPB) promotes mechanical stimulation of cells through the creation of more

• Orbital wall repair in canines with beta‐tricalcium phosphate and induced bone marrow stromal cells

  Abstract Bone tissue engineering is a new approach for the repair of orbital defects. The aim of the present study was to evaluate prefabricated beta‐tricalcium phosphate (β‐TCP) combined with autologous bone marrow stromal cells (BMSCs) to repair orbital wall defect in canine models. Defects me more

• Comparative analysis of reference gene stability in human mesenchymal stromal cells during osteogenic differentiation

  Mesenchymal stromal cells (MSCs) are one of the most frequently used cell sources for tissue engineering strategies. Cultivation of osteogenic MSCs is a prerequisite for cell‐based concepts that aim at bone regeneration. Quantitative real time reverse transcription polymerase chain reaction (qRT‐P more

Market studies Bone Marrow

• Bone Marrow Transplantation – Pipeline Review, H2 2012

  Introduction Global Markets Direct’s, 'Bone Marrow Transplantation - Pipeline Review, H2 2012', provides an overview of the Bone Marrow Transplantation therapeutic pipeline. This report provides information on the therapeutic development for Bone Marrow Transplantation, complete with latest update more

• Oman Pharmaceuticals and Healthcare Report Q3 2011

  BMI View: Regionally speaking, Oman represents a moderately attractive market. While its positives include well-developed healthcare and an improved intellectual property (IP) environment, Oman is a small market, limited by a modest population of under 3mn. Nevertheless, the traditionally dominant p more

• Global Cord Blood Banking Market: Focus on China

  Umbilical cord carries rich nutrient blood and gases to the fetus through arteries and veins it encloses. Blood contained in the umbilical cord is rich in stem cells. In the adult body, there are few active sites of blood cell production. Throughout an individual’s life, they are responsible for pro more

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