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Topic bone marrow

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ELISA kits for the measurment of SDF-1/CXCL12

SDF-1α (CXCL12) is a CXC chemokine. The small basic protein (ca. 8 kDa) has no glycosylation site in its sequence. The homology properties of SDF-1α are unique among the chemokines more

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  • Acquired Copy Number Alterations in Adult Acute Myeloid Leukemia Genomes

    To complement cytogenetic studies and to identify genes altered in AML genomes, Walter and co-workers performed a genome-wide copy number analysis with paired normal and tumor DNA obtained from 86 adult subjects with de novo AML using 1.85 million feature SNP arrays. A total of 201 somatic CNAs were found in the 86 AML genomes (mean, 2.34 CNAs per genome), with FAB-System M6 and M7 genomes containing the most changes (10-29 CNAs per genome). According to the authors' conclusions, the use of an unbiased high-resolution genomic screen identified many genes not previously implicated in AML that may be relevant for pathogenesis, along with many known oncogenes and tumor suppressor genes. Despite the ability of next-generation sequencing platforms to accurately identify amplifications, deletions, and translocations, a multiplatform approach (traditional cytogenetics, FISH, SNP array, array CGH, and targeted gene resequencing) will continue to be the most practical approach to studying AML genomes at most institut more

  • Analysis of Prostate Tumour Cell Invasion Using BD FluoroBlokTMand FLUOstar OPTIMA

    The FLUOstar OPTIMA is used for reading the BD Biosciences FluoroBlok(TM) tumour cell invasion system. In this application note we show that the results are comparable to the traditional invasion assays. The introduced method is fast, saving time and labour. The FLUOstar OPTIMA is able to take multiple readings over time at a user defined temperature more

  • Evidence for a Cysteine Proteinase Involved in BSE Infection and/or Progression

    According to the "protein-only" hypothesis, the prion protein seemed to be - for more than a decade - the infectious agent of transmissible spongiform encephalopathies (TSEs) in different species. TSEs are neurodegenerative diseases reported e.g., for humans (Creutzfeld-Jakob disease, CJD), cattle (bovine spongiform encephalo­pathy, BSE), and sheep (scrapie). In contrast to the "protein-only" hypothesis, some researchers published data showing that retrovirus-like RNA transcripts, a viral structure, and viral particles might be involved in disease infection/progression of CJD. In addition, there is no final proof for the "protein-only" hypothesis and the infectivity of the prion protein. more

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Market studies bone marrow

  • Oman Pharmaceuticals and Healthcare Report Q3 2011

    BMI View: Regionally speaking, Oman represents a moderately attractive market. While its positives include well-developed healthcare and an improved intellectual property (IP) environment, Oman is a small market, limited by a modest population of under 3mn. Nevertheless, the traditionally dominant p more

  • Global Cord Blood Banking Market: Focus on China

    Umbilical cord carries rich nutrient blood and gases to the fetus through arteries and veins it encloses. Blood contained in the umbilical cord is rich in stem cells. In the adult body, there are few active sites of blood cell production. Throughout an individual’s life, they are responsible for pro more

  • Mycenax Biotech Inc. (4726) - Financial and Strategic SWOT Analysis Review

    Mycenax Biotech Inc. (4726) - Financial and Strategic SWOT Analysis Review Summary Mycenax Biotech Inc. (Mycenax) is a biopharmaceutical company engaged in developing and manufacturing biopharmaceutical products derived from mammalian and microbial cells. Mycenax has three pipeline products, namel more

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Definition

Bone marrow

Bone marrow illustration of cells in bone marrow. Bone marrow (or medulla ossea) is the soft tissue found in the hollow interior of bone s. In adults, marrow in large bones produces new blood cell s. Marrow types There are two types of bone ... more

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