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SDF-1α (CXCL12) is a CXC chemokine. The small basic protein (ca. 8 kDa) has no glycosylation site in its sequence. The homology properties of SDF-1α are unique among the chemokines more
All stem cells — regardless of their source — share the remarkable capability to replenish themselves by undergoing self-renewal. Yet, so far, efforts to grow and expand scarce hematopoietic (or blood-forming) stem cells in culture for therapeutic applications have been met with limited success.Now, more
Like a switch stuck in the on position, the bone marrow can churn out blood cells that bloat internal organs and clog blood vessels, leading to life-threatening disease. Now University of Florida scientists have discovered a potential new drug that can throw the switch on the runaway blood cell-prod more
A prototype drug already shown to hold promise for treating autoimmune disorders like lupus, arthritis and psoriasis halts established graft-versus-host disease (GVHD) in mouse models of bone marrow transplantation, research at the University of Michigan and the University of Florida shows. The res more
To complement cytogenetic studies and to identify genes altered in AML genomes, Walter and co-workers performed a genome-wide copy number analysis with paired normal and tumor DNA obtained from 86 adult subjects with de novo AML using 1.85 million feature SNP arrays. A total of 201 somatic CNAs were found in the 86 AML genomes (mean, 2.34 CNAs per genome), with FAB-System M6 and M7 genomes containing the most changes (10-29 CNAs per genome). According to the authors' conclusions, the use of an unbiased high-resolution genomic screen identified many genes not previously implicated in AML that may be relevant for pathogenesis, along with many known oncogenes and tumor suppressor genes. Despite the ability of next-generation sequencing platforms to accurately identify amplifications, deletions, and translocations, a multiplatform approach (traditional cytogenetics, FISH, SNP array, array CGH, and targeted gene resequencing) will continue to be the most practical approach to studying AML genomes at most institut more
The FLUOstar OPTIMA is used for reading the BD Biosciences FluoroBlok(TM) tumour cell invasion system. In this application note we show that the results are comparable to the traditional invasion assays. The introduced method is fast, saving time and labour. The FLUOstar OPTIMA is able to take multiple readings over time at a user defined temperature more
According to the "protein-only" hypothesis, the prion protein seemed to be - for more than a decade - the infectious agent of transmissible spongiform encephalopathies (TSEs) in different species. TSEs are neurodegenerative diseases reported e.g., for humans (Creutzfeld-Jakob disease, CJD), cattle (bovine spongiform encephalopathy, BSE), and sheep (scrapie). In contrast to the "protein-only" hypothesis, some researchers published data showing that retrovirus-like RNA transcripts, a viral structure, and viral particles might be involved in disease infection/progression of CJD. In addition, there is no final proof for the "protein-only" hypothesis and the infectivity of the prion protein. more
Abstract Strontium (Sr) has been successfully used for the treatment of osteoporotic bone, increasing new bone formation while reducing bone resorption by stimulating proliferation and differentiation of osteoblastic cells and inhibiting osteoclast function. In this study, Sr‐incorporated Ti oxid more
Abstract Poly[(R)‐3‐hydroxybutyrate‐co‐(R)‐3‐hydroxyvalerate] (PHBV) is a nature‐derived polyester with potential application in tissue engineering scaffolds. However, PHBV is associated with disadvantages including high brittleness, slow degradation, high hydrophobicity, and unsatisfactory bioco more
Abstract Aim Bone marrow endothelial progenitor cells (BMEPCs) are believed to be a promising cell source for regenerative medicine; however, their electrophysiology properties have not been fully clarified, which is important to the clinical application of BMEPCs. The current study was designe more
BMI View: Regionally speaking, Oman represents a moderately attractive market. While its positives include well-developed healthcare and an improved intellectual property (IP) environment, Oman is a small market, limited by a modest population of under 3mn. Nevertheless, the traditionally dominant p more
Umbilical cord carries rich nutrient blood and gases to the fetus through arteries and veins it encloses. Blood contained in the umbilical cord is rich in stem cells. In the adult body, there are few active sites of blood cell production. Throughout an individual’s life, they are responsible for pro more
Mycenax Biotech Inc. (4726) - Financial and Strategic SWOT Analysis Review Summary Mycenax Biotech Inc. (Mycenax) is a biopharmaceutical company engaged in developing and manufacturing biopharmaceutical products derived from mammalian and microbial cells. Mycenax has three pipeline products, namel more
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Bone marrow illustration of cells in bone marrow. Bone marrow (or medulla ossea) is the soft tissue found in the hollow interior of bone s. In adults, marrow in large bones produces new blood cell s. Marrow types There are two types of bone ... more
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