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• Water is an active element in proteins
  

  Biophysicists in Bochum have discovered a diode for protons: just like the electronic component determines the direction of flow of electric current, the “proton diode” ensures that protons can only pass through a cell membrane in one direction. Water molecules play an important role here as active more

• Ronin recruits protein 'allies' to sustain embryonic stem cell growth

  Ronin, crucial to the self-renewal of embryonic stem cells, and a co-regulator called Hcf-1, binds to a small strand of DNA called a hyperconserved enhancer element to control a gene "program" that stimulates growth of the stem cells and may even play a role in cancer, said a group of researchers le more

• UF discovery could lead to better genetic screening for diabetes

  University of Florida researchers have identified a protein that affects how much insulin the body produces in people with a hereditary form of diabetes. Called maturity onset diabetes of the young, or MODY, the disease can be difficult to detect and is sometimes misdiagnosed as the more common type more

White papers Binding Site

• RealTime ready RT-qPCR Assay Development and Qualification
  

  On the RealTime ready Configurator, we offer function tested human, mouse, and rat qPCR assays for gene expression quantification based on the unique Universal ProbeLibrary technology (UPL). The Universal ProbeLibrary is a set of short hydrolysis probes (8–9-mers) containing modified bases in order to stabilize the binding and thus ensure high flexibility together with good amplicon specificity more

• Genome Sequencer 20 System: Breakthrough in a New Applications Age of Sequencing
  

  The Genome Sequencer 20 System is an ultra-high-throughput automated DNA sequencing system capable of carrying out and monitoring sequencing reactions in a massively parallel fashion. Since the Genome Sequencer 20 System provides a complete solution for ultra-high-throughput DNA sequencing, an individual researcher can for the first time prepare samples and sequencing reactions, generate sequence reads, and assemble genome sequence data within days. more

• RealTime ready qPCR Assay Design and Configuration Portal Content
  

  The gene and transcript annotational content of the RealTime ready Configurator offers a combined view of three of the main gene annotation authorities. The positional information of the lab-tested RealTime ready assays regarding transcript or exon coverage is presented in a graphical overview and tabular format. Additional content provides a convenient and browsable entry point for target gene selection for cataloged as well as new assays that are developed on demand more

Publications Binding Site

• Tumor-associated Neu5Ac-Tn and Neu5Gc-Tn antigens bind to C-type lectin CLEC10A (CD301, MGL)

  In human tumors, glycoproteins often exhibit abnormal glycosylation patterns, e.g. certain Lewis structures, TF antigen, Tn antigen and/or their sialylated forms, creating additional binding sites for glycoreceptors. In the present study, we have analyzed the carbohydrate specificity of the C-type more

• Organization of the extracellular portion of the macrophage galactose receptor: A trimeric cluster of simple binding sites for N-acetylgalactosamine

  The properties of the human macrophage galactose receptor have been investigated. Specificity for N-acetylgalactosamine (GalNAc) residues with exposed 3- and 4-hydroxyl groups explains virtually all of the results obtained from a recently expanded array of synthetic glycans and is consistent with a more

• Structural basis of preferential binding of fucose-containing saccharide by the Caenorhabditis elegans galectin LEC-6

  Galectins are a group of lectins that can bind carbohydrate chains containing β-galactoside units. LEC-6, a member of galectins of Caenorhabditis elegans, binds fucose-containing saccharides. We solved the crystal structure of LEC-6 in complex with galactose-β1,4-fucose (Galβ1-4Fuc) at 1.5 Å resolu more

Market studies Binding Site

• IVAX Diagnostics, Inc. (IVD) - Financial and Strategic SWOT Analysis Review

  IVAX Diagnostics, Inc. (IVAX), is a medical device company engaged in develops, manufactures and markets diagnostic test kits, or assays, and automated systems, which are used to assist in the detection of disease markers principally in the fields of autoimmune and infectious diseases. It is a holdi more

• Theravance, Inc. (THRX) - Financial and Strategic SWOT Analysis Review

  Theravance, Inc. (Theravance) is engaged in the discovery, development and commercialization of new medicines. Its drug discovery efforts are based on its expertise in multivalency. Multivalency involves the instantaneous attachment of a single molecule to multiple binding sites on biological target more

• Lead Generation Strategies and Technologies in Drug Development - Emerging Techniques Such as Antisense Technology Will Allow Innovators to Minimize Costs

  GBI Research has released its latest report, “Lead Generation Strategies and Technologies in Drug Development - Emerging Techniques Such as Antisense Technology Will Allow Innovators to Minimize Costs” that provides key data, information and analysis of the major trends and developments in the drug more

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