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News Bases

• Allumera shows significant improvements in appearance of skin compared to light

  Photocure announced positive preliminary results from its consumer trial on Allumera™, demonstrating that the product can improve the appearance of skin. The RevitAll ™ study was designed to determine the ability of Allumera™ cream to improve the appearance of skin compared to illumination by light more

• Manufacturing Safety Raises Concern

  Last week Pharmaceutical heads met as a result of a drugs recall after a pill mix up of breast cancer pills. The drug, Fresenius Kabi’s Anastrozole, was made by the German company’s subsidiary in India. The ingredient mix up led to the voluntary recall of 7,192 bottles, each containing 30 tablets. more

• Pharmaceutical Question Time

  With access, cost and quality concerns plaguing pharmaceutical delivery systems both in the US as well as globally, the Next Generation Pharmaceutical Drug Discovery committee has been formed to confront, assess and deliver new strategies to secure the future of the industry. Meeting in Miami, Flori more

White papers Bases

• Ultrafast De Novo Sequencing of Corynebacterium urealyticum Using the Genome Sequencer 20 System
  

  A microbial genome sequence provides a wealth of data and specific information that cannot be obtained by other experimental approaches. A genome sequence can be regarded as the starting point for detailed bioinformatics analysis, metabolic reconstruction and systematic functional examination of all identified genes. In particular, genome sequencing has revealed important information on genes and deduced proteins of human pathogens, including putative virulence factors and potential new drug targets. more

• Genome Sequencer 20 System: Breakthrough in a New Applications Age of Sequencing
  

  The Genome Sequencer 20 System is an ultra-high-throughput automated DNA sequencing system capable of carrying out and monitoring sequencing reactions in a massively parallel fashion. Since the Genome Sequencer 20 System provides a complete solution for ultra-high-throughput DNA sequencing, an individual researcher can for the first time prepare samples and sequencing reactions, generate sequence reads, and assemble genome sequence data within days. more

• Major Histocompatibility Complex Genotyping with Massively Parallel Pyrosequencing
  

  Macaques provide essential preclinical models for infectious disease, vaccine, biodefense, and transplantation research. Unfortunately, they also have the most complex MHC genetics of any primate species described to date, and existing methods for MHC typing are simply inadequate. As shown here, massively parallel pyrosequencing using the Genome Sequencer FLX System can provide comprehensive and cost-effective MHC class-I genotyping, thus potentially revolutionizing the use of macaques to guide immunological studies more

Publications Bases

• The Specificity and Flexibility of L1 Reverse Transcription Priming at Imperfect T-Tracts

  by Clément Monot, Monika Kuciak, Sébastien Viollet, Ashfaq Ali Mir, Caroline Gabus, Jean-Luc Darlix, Gaël Cristofari L1 retrotransposons have a prominent role in reshaping mammalian genomes. To replicate, the L1 ribonucleoprotein particle (RNP) first uses its endonuclease (EN) to nick the genomic more

• Gene prediction using FIR filter

  Gene prediction using FIR filterRenu Sharma; Ajay Kaushik; Neeraj SharmaInternational Journal of Biomedical Engineering and Technology, Vol. 11, No. 1 (2013) pp. 33 - 45Gene identification is a critical and challenging problem in bioinformatics. The task of gene prediction is to find sub-sequences more

• Artemis is required to improve the accuracy of repair of double-strand breaks with 5′-blocked termini generated from non-DSB-clustered lesions

  Clustered DNA lesions are defined as ≥2 damage events within 20bp. Oxidised bases, abasic (AP) sites, single-strand breaks and double-strand breaks (DSBs) exist in radiation-induced clusters, and these lesions are more difficult to repair and can be more mutagenic than single lesions. Understanding more

Market studies Bases

• Type 2 Diabetes - Global Drug Forecasts and Treatment Analysis to 2020

  Introduction GlobalData, the industry analysis specialist, has released its new report, “Type 2 Diabetes - Global Drug Forecasts and Treatment Analysis to 2020”. The report is an essential source of information and analysis on the global type 2 diabetes therapeutics market. The report provides comp more

• Ovarian Cancer Therapeutics - Global Drug Forecasts and Treatment Analysis 2020

  Introduction GlobalData, the industry analysis specialist, has released its new report, “Ovarian Cancer Therapeutics - Global Drug Forecasts and Treatment Analysis 2020”. The report is an essential source of information and analysis on the global ovarian cancer therapeutics market. The report provi more

• Saudi Arabia Pharmaceuticals and Healthcare Report Q3 2012

  BMI View: The Saudi Arabian government said it will increase its healthcare budget for 2012 by 26%. Though BMI remains slightly more conservative in our growth forecasts, we think the government’s investment in the sector is very positive for the healthcare industry. Furthermore, the announcement more

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