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Adimab announces technology transfer agreement with Merck & Co.
Adimab, LLC announced that it has entered into a definitive agreement with Merck, known as MSD outside the United States and Canada, to transfer Adimab’s antibody technology to Merck Research Laboratories for the discovery and optimization of monoclonal and bispecific therapeutic antibody candidates more
Researchers reveal mechanisms of how body remembers, fights infections
Scientists at the Virginia Tech Carilion Research Institute have found a potential way to influence long-term memory formation in the immune system. "We've found that the inherent flexibility of the immune system is even more complex than previously understood," said Kenneth Oestreich, senior author more
Collaboration agreement signed
Sanofi and MAB Discovery GmbH announced that they have entered into a research and license agreement in the field of monoclonal antibodies. Within the scope of this collaboration, MAB Discovery will develop therapeutic antibodies for selected targets of Sanofi and thus support Sanofi in the developm more
A new target for immuno-oncology therapies
By studying a type of immune cells, a team of researchers at the IRCM led by André Veillette, MD, identified the mechanism of action for a new target for novel immune-oncology treatments. The researchers study natural killer (NK) cells, which are crucial to the immune system and protect the body by more
Scientists find way to make leukemia cells kill each other
Scientists at The Scripps Research Institute (TSRI) have found a way to change leukemia cells into leukemia-killing immune cells. The surprise finding could lead to a powerful new therapy for leukemia and possibly other cancers. "It's a totally new approach to cancer, and we're working to test it in more
Promotion of Aggregation as a Means of Assessing the Stability of Antibody Molecules
The efficiency of antibody molecules is dependent on their stability. We introduce an assay setup where stability of antibodies is measured. Shaking stress is initiated by the FLUOstar Omega microplate reader and aggregation propensity of antibody ca more
Clinical Biomarkers: Novel Tools for Pharmacodynamic Applications
Biomarkers are currently changing the way we diagnose and treat diseases. Today pharmacodynamic biomarkers are widely used in the industry elaborating optimal dosing of new drugs and predictive biomarkers have an enormous potential for companion diag more
Characterizing Biotherapeutics with HPLC
As demonstrated here, there are a broad range of HPLC applications used in development, production, validation and release of protein therapeutics for human use. Some of the applications mentioned above are mandatory when submitting a new biopharmace more
Agrisera Western Blot recommendations, troubleshooting and protocol
Each antibody-antigen interaction has unique characteristics. A protocol giving good results for one antibody-antigen pair might found to be unsatisfactory for a second antibody even on the same sample. The interaction of antisera with protein epitop more
Functional Analysis of Side Effects of Transfection Reagents in the Context of Bax-induced Apoptosis
FuGENE® HD Transfection Reagent is well-suited for studying the impact of apoptosis-inducing proteins such as bax. Transfection with FuGENE® HD Transfection Reagent produced only minimal cytotoxic side effects while maintaining a high transfection ef more
HRP-Protector™ - Diluent for long-term storage of HRP conjugates, for better stability and enhanced shelf life more
Long-term stability at 4°C. Industrial stabilizer solutions are now affordable for any laboratory. Even moist storage is possible, but with shorter shelf life. more
Structural changes in histone H2A by methylglyoxal generate highly immunogenic amorphous aggrega ...
The role of aberrant protein modifications in cancer and its diagnosis have emerged as a promising research field. Nonenzymatic glyco-oxidation of proteins under oxidative stress has been associated with carcinogenesis through advanced glycation end products (AGE)–receptors for advanced glycation e more
Ah Receptor Activation by Dioxin Disrupts Activin, BMP, and WNT Signals During the Early Differe ...
The AHR is a ligand-activated transcription factor that mediates gene-environment interactions. Genome-wide expression profiling during differentiation of mouse ES cells into cardiomyocytes showed that AHR activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin; Dioxin (TCDD), its prototypical ligand, di more
Antibody Detection, and Molecular Characterization of Toxoplasma gondii from Bobcats (Lynx rufus ...
Abstract Little is known of the epidemiology of toxoplasmosis in Minnesota. Here, we evaluated Toxoplasma gondii infection in 50 wild bobcats (Lynx rufus) and 75 other animals on/near 10 cattle farms. Antibodies to T. gondii were assayed in serum samples or tissue fluids by the modified agglutin more
Hepatitis B prevalence and treatment needs among Tibetan refugees residing in India
Abstract Background Untreated chronic hepatitis B can lead to liver failure and/or liver cancer. These complications can be avoided through prevention with vaccination or treatment of disease. To inform health policy for the Tibetan community in India, we conducted study of hepatitis B prevale more
Differential Toxicity of Antibodies to the Prion Protein
by Regina R. Reimann, Tiziana Sonati, Simone Hornemann, Uli S. Herrmann, Michael Arand, Simon Hawke, Adriano Aguzzi Antibodies against the prion protein PrPC can antagonize prion replication and neuroinvasion, and therefore hold promise as possible therapeutics against prion diseases. However, th more