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Find antibodies by searching for a name or antigen and narrow down your results by defining parameters like reactivity, application, conjugate etc.
- Flow Cytometry (FC)
- Fluorescence Microscopy
- Frozen Tissue Sections
- Functional Assays (FN)
- Immunochemistry (IC)
- Immunocytochemistry (ICC)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Immunohistochemistry, frozen sections (IH ...
- Immunohistochemistry, paraffin-embedded s ...
- Immunoprecipitation (IP)
- Paraffin-embededded Tissue Sections
Discovery of Cellular Mechanism of Action of tACPA in Rheumatoid Arthritis
ModiQuest B.V announces that it has discovered the cellular mechanism of action of its therapeutic anti-citrullinated protein lead antibodies (tACPA) for the treatment of rheumatoid arthritis (RA) and other diseases. To accelerate tACPA development towards clinical Proof of Concept, facilitate fundi more
Antibody response linked to lower mother-to-child HIV transmission
How most babies are protected from acquiring HIV from their infected mothers has been a matter of scientific controversy. Now researchers at Duke Medicine provide new data identifying an antibody response that had long been discounted as inadequate to confer protection.Mother-to-child transmissions more
HER-Vaxx Re-Formulation Shows Dramatic Ten-Fold Increase in Antibodies and Early Onset of Response
Imugene Limited, a clinical stage immuno-oncology company developing HER-2 positive gastric and breast cancer immunotherapies, announces that Imugene’s lead candidate HER-Vaxx has demonstrated a powerful increase in the production of cancer fighting antibodies in preclinical animal model testing. Th more
AbbVie And C2N Enter Into A Worldwide License Agreement For Alzheimer's Disease Therapy
AbbVie announced that it has entered into an exclusive worldwide license agreement with C2N Diagnostics to develop and commercialize a portfolio of anti-tau antibodies for the treatment of Alzheimer's Disease and other neurological disorders. This partnership builds upon AbbVie's commitment to pur more
Genmab Acquires Antibody Assets from iDD Biotech
Genmab A/S announced that its subsidiary Genmab Holding B.V. entered into an agreement to purchase antibodies and related patents and know-how from iDD Biotech SAS. The pre-clinical stage antibodies are directed to DR5, also known as Trail Receptor 2 (TRAIL-R2), an emerging cancer target. Under t more
Promotion of Aggregation as a Means of Assessing the Stability of Antibody Molecules
The efficiency of antibody molecules is dependent on their stability. We introduce an assay setup where stability of antibodies is measured. Shaking stress is initiated by the FLUOstar Omega microplate reader and aggregation propensity of antibody candidates is measured in 96-well format more
Clinical Biomarkers: Novel Tools for Pharmacodynamic Applications
Biomarkers are currently changing the way we diagnose and treat diseases. Today pharmacodynamic biomarkers are widely used in the industry elaborating optimal dosing of new drugs and predictive biomarkers have an enormous potential for companion diag more
Agrisera Western Blot recommendations, troubleshooting and protocol
Each antibody-antigen interaction has unique characteristics. A protocol giving good results for one antibody-antigen pair might found to be unsatisfactory for a second antibody even on the same sample. The interaction of antisera with protein epitop more
Characterizing Biotherapeutics with HPLC
As demonstrated here, there are a broad range of HPLC applications used in development, production, validation and release of protein therapeutics for human use. Some of the applications mentioned above are mandatory when submitting a new biopharmace more
Functional Analysis of Side Effects of Transfection Reagents in the Context of Bax-induced Apoptosis
FuGENE® HD Transfection Reagent is well-suited for studying the impact of apoptosis-inducing proteins such as bax. Transfection with FuGENE® HD Transfection Reagent produced only minimal cytotoxic side effects while maintaining a high transfection ef more
ReadyTector® is the all-in-one detection solution for Western blotting. ReadyTector® enables a fast one step immunodetection without background more
Long-term stability at 4°C. Industrial stabilizer solutions are now affordable for any laboratory. Even moist storage is possible, but with shorter shelf life. more
Disruption of the lamin A and matrin-3 interaction by myopathic LMNA mutations
The nuclear face of the nuclear membrane is enriched with the intermediate filament protein lamin A. Mutations in LMNA, the gene encoding lamin A, lead to a diverse set of inherited conditions including myopathies that affect both the heart and skeletal muscle. To gain insight about lamin A protein more
A global RNA‐seq‐driven analysis of CHO host and production cell lines reveals distinct differen ...
Abstract Boehringer Ingelheim uses two CHO‐DG44 lines for manufacturing biotherapeutics, BI‐HEX‐1 and BI‐HEX‐2, which produce distinct cell type‐specific antibody glycosylation patterns. A recently established CHO‐K1 descended host, BI‐HEX‐K1, generates antibodies with glycosylation profiles dif more
Suppression of conformational heterogeneity at a protein-protein interface [Biophysics and Compu ...
Staphylococcal protein A (SpA) is an important virulence factor from Staphylococcus aureus responsible for the bacterium’s evasion of the host immune system. SpA includes five small three-helix–bundle domains that can each bind with high affinity to many host proteins such as antibodies. The interac more
Visualization of delayed release of compounds from pH‐sensitive capsules in vitro and in vivo in ...
Delayed controlled release is an innovative strategy to locally administer therapeutic compounds (e.g. chemotherapeutics, antibodies etc.). This would improve efficiency and reduce side effects compared with systemic administration. To enable the evaluation of the efficacy of controlled release st more
Aptamer for imaging and therapeutic targeting of brain tumor glioblastoma
Abstract Aptamers are short single‐stranded nucleic acids (RNA or ssDNA), identified by an in vitro selection process, denominated SELEX, from a partially random oligonucleotide library. They bind to a molecular target, a protein or other complex macromolecular structures of interest with high a more