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Find antibodies by searching for a name or antigen and narrow down your results by defining parameters like reactivity, application, conjugate etc.
- Flow Cytometry (FC)
- Fluorescence Microscopy
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- Immunohistochemistry (IHC)
- Immunohistochemistry, frozen sections (IH ...
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- Immunoprecipitation (IP)
- Paraffin-embededded Tissue Sections
A new target for immuno-oncology therapies
By studying a type of immune cells, a team of researchers at the IRCM led by André Veillette, MD, identified the mechanism of action for a new target for novel immune-oncology treatments. The researchers study natural killer (NK) cells, which are crucial to the immune system and protect the body by more
Scientists find way to make leukemia cells kill each other
Scientists at The Scripps Research Institute (TSRI) have found a way to change leukemia cells into leukemia-killing immune cells. The surprise finding could lead to a powerful new therapy for leukemia and possibly other cancers. "It's a totally new approach to cancer, and we're working to test it in more
Detecting HIV diagnostic antibodies with DNA nanomachines
New research may revolutionize the slow, cumbersome and expensive process of detecting the antibodies that can help with the diagnosis of infectious and auto-immune diseases such as rheumatoid arthritis and HIV. An international team of researchers have designed and synthetized a nanometer-scale DNA more
Sugar governs how antibodies work in the immune system
Antibodies protect the body against diseases – but can also harm their own organism if the reactions are misdirected. Researchers from the University of Zurich have now discovered that a particular sugar in the antibodies determines whether one of the body’s own cells is destroyed or not. This resul more
An antibody that can attack HIV in new ways
Proteins called broadly neutralizing antibodies (bNAbs) are a promising key to the prevention of infection by HIV, the virus that causes AIDS. bNAbs have been found in blood samples from some HIV patients whose immune systems can naturally control the infection. These antibodies may protect a patien more
Promotion of Aggregation as a Means of Assessing the Stability of Antibody Molecules
The efficiency of antibody molecules is dependent on their stability. We introduce an assay setup where stability of antibodies is measured. Shaking stress is initiated by the FLUOstar Omega microplate reader and aggregation propensity of antibody ca more
Clinical Biomarkers: Novel Tools for Pharmacodynamic Applications
Biomarkers are currently changing the way we diagnose and treat diseases. Today pharmacodynamic biomarkers are widely used in the industry elaborating optimal dosing of new drugs and predictive biomarkers have an enormous potential for companion diag more
Characterizing Biotherapeutics with HPLC
As demonstrated here, there are a broad range of HPLC applications used in development, production, validation and release of protein therapeutics for human use. Some of the applications mentioned above are mandatory when submitting a new biopharmace more
Agrisera Western Blot recommendations, troubleshooting and protocol
Each antibody-antigen interaction has unique characteristics. A protocol giving good results for one antibody-antigen pair might found to be unsatisfactory for a second antibody even on the same sample. The interaction of antisera with protein epitop more
Functional Analysis of Side Effects of Transfection Reagents in the Context of Bax-induced Apoptosis
FuGENE® HD Transfection Reagent is well-suited for studying the impact of apoptosis-inducing proteins such as bax. Transfection with FuGENE® HD Transfection Reagent produced only minimal cytotoxic side effects while maintaining a high transfection ef more
ReadyTector® is the all-in-one detection solution for Western blotting. ReadyTector® enables a fast one step immunodetection without background more
Long-term stability at 4°C. Industrial stabilizer solutions are now affordable for any laboratory. Even moist storage is possible, but with shorter shelf life. more
Surface expression patterns of defined glycan antigens change during Schistosoma mansoni cercari ...
During the complex lifecycle of Schistosoma mansoni, a large variety of glycans is expressed. To many of these glycans, antibodies are induced by the infected host and some might be targets for vaccines or diagnostic tests. Spatial changes in glycan expression during schistosome development are lar more
An asymmetric antibody repertoire is shaped between plasmablasts and plasma cells after secondar ...
Studies on the structural basis of antibody affinity maturation have been carried out by measuring the affinity of secreted antibodies, and information on structures has often been obtained from nucleotide sequences of BCRs of memory B cells. We considered it important to establish whether the repe more
Role of JNK in late nerve regeneration monitored by in vivo imaging of thy1‐YFP transgenic mice
Abstract Restoring function to injured peripheral nerves separated by a gap requires regeneration across it and reinnervation to target organs. To elucidate these processes, we have established an in vivo monitoring system of nerve regeneration in thy1‐YFP transgenic mice expressing a fluorescen more
[Report] Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota
Antibodies targeting CTLA-4 have been successfully used as cancer immunotherapy. We find that the antitumor effects of CTLA-4 blockade depend on distinct Bacteroides species. In mice and patients, T cell responses specific for B. thetaiotaomicron or B. fragilis were associated with the efficacy of C more
Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging [Immu ...
Signaling through the immune checkpoint programmed cell death protein-1 (PD-1) enables tumor progression by dampening antitumor immune responses. Therapeutic blockade of the signaling axis between PD-1 and its ligand programmed cell death ligand-1 (PD-L1) with monoclonal antibodies has shown remarka more