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News about antibodies
  • Gene therapy improves immunity in babies with 'bubble boy' disease

    Early evidence suggests that gene therapy developed at St. Jude Children's Research Hospital will lead to broad protection for infants with the devastating immune disorder X-linked severe combined immunodeficiency disorder. Preliminary results from the ongoing, multicenter study were included in the more

  • Zika vaccine induces strong immune response in three phase 1 studies

    Three Phase 1 human clinical trials evaluating an Army-developed Zika purified inactivated virus (ZPIV) vaccine have shown it was safe and well-tolerated in healthy adults and induced a robust immune response. Each of the three studies included in the paper was designed to address a unique question more

  • New vaccine technique effectively fights breast cancer in mice

    A new vaccine technique can fight a certain type of breast cancer in mice. So-called HER2-positive breast cancer accounts for between 20 and 30 per cent of all cases of breast cancer in humans. Researchers from the University of Copenhagen and the University of Bologna now show that the same type of more

  • Computer analysis fills gaps in antibody blueprint

    Antibodies defend our bodies against intruders. These molecules consist of proteins with attached sugars. However, the blueprint directing the processing of these sugars on the protein was not well understood until now. Scientists from the Helmholtz Zentrum München used computer analysis to complete more

  • Pneumonia: Treatment with Vaccines instead of Antibiotics

    A properly functioning immune system is key to resolve bacterial pneumonia. Researchers from the University Children’s Hospital Zurich and UZH working with an international team have now found that specific immune cells are crucial for recovery. The researchers’ work paves the way for developing new more

White paper on antibodies
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Publications on antibodies
  • Programmed recognition of microbiota

    Innate Immunity Increasingly, we recognize that the gut is a specialized organ for maintaining microbial symbioses alongside nutritional functions. The gut produces large quantities of immunoglobulin A (IgA), which adheres to the surface of gut microbes. Bunker et al. discovered that antibodies more

  • Principles for computational design of binding antibodies [Biophysics and Computational Biology]

    Natural proteins must both fold into a stable conformation and exert their molecular function. To date, computational design has successfully produced stable and atomically accurate proteins by using so-called “ideal” folds rich in regular secondary structures and almost devoid of loops and destabil more

  • Inhibition of EBV-mediated membrane fusion by anti-gHgL antibodies [Microbiology]

    Herpesvirus entry into cells requires the coordinated action of multiple virus envelope glycoproteins, including gH, gL, and gB. For EBV, the gp42 protein assembles into complexes with gHgL heterodimers and binds HLA class II to activate gB-mediated membrane fusion with B cells. EBV tropism is dicta more

  • Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques

    The development of an effective AIDS vaccine has been challenging because of viral genetic diversity and the difficulty of generating broadly neutralizing antibodies (bnAbs). We engineered trispecific antibodies (Abs) that allow a single molecule to interact with three independent HIV-1 envelope de more

  • A triple threat for HIV

    HIV Therapy The HIV virus continually evolves tricks to evade elimination by the host. Prevention and a cure will likely rely on broadly neutralizing antibodies that can recognize and conquer multiple viral strains or subtypes. Xu et al. engineered a single antibody molecule to recognize three more

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