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• Researchers identify a molecular switch that controls neuronal migration in the developing brain

  St. Jude Children's Research Hospital investigators have identified key components of a signaling pathway that controls the departure of neurons from the brain niche where they form and allows these cells to start migrating to their final destination. Defects in this system affect the architecture o more

• Trifunctional antibody Removab from Fresenius Biotech awarded Galenus von Pergamon Prize for drug innovation

  The trifunctional antibody Removab® (Catumaxomab) from Fresenius Biotech was awarded this year’s Galenus von Pergamon Prize in the “Specialist Care” category. The jury acknowledged Removab®’s new therapeutic mechanism and medical relevance for the treatment of malignant ascites. The Galenus von Perg more

• Protein highways keep tissues organize
  

  Precise regulation of tissue architecture is critical for organ function. Single cells build up a tissue by communicating with their environment and with other cells, thereby receiving instructions on whether to divide, change shape or migrate. An interdisciplinary group of researchers from several more

White papers Adhesion

• Real-Time Analysis of LNCaP Cell Growth in Different Media
  

  Our results suggest that the influence of androgen receptor-stimulating or -blocking substances strongly depends upon the composition of the growth medium. The use of hormone-depleted FBS in combination with phenol red-free medium is strongly recommended for monitoring stimulator effects, whereas inhibitory effects may be more readily analyzed in medium containing normal FBS. Because the mutated androgen receptor in LNCaP can also be stimulated by estrogens, progestogens, and several antiandrogens, we suggest that the stimulatory effect of normal FBS compared with hormone-reduced FBS may be explained by differences in estradiol levels (192 pg/ml in normal FBS compared with <12 pg/ml in hormone-reduced FBS) rather than by differences in progesterone levels (0.29 ng/ml in normal FBS compared with 0.13 ng/ml in hormone-reduced FBS) or testosterone levels (0.08 ng/ml in normal FBS compared with 0.03 ng/ml in hormone-reduced FBS). Our results show that the optimal time point for monitoring inhibitory and stimulat more

• Real-time and Dynamic Monitoring of Virus-mediated Cytopathogenicity
  

  To understand overall infectivity, virus progression and disease onset it is important to perform a detailed examination of cytopathic effects. Depending on the type of viruses and cells, different cytopathic effects might be observed dependent on the timepoint of infection (e.g., during the growth or stationary phase) and the amount of virus used. One of the most common methods for measuring lysogenic/lytic activity of viruses is the plaque test [1]. In this assay culture plates with confluent cells that are sensitive towards the specific virus type/strain are used. Lytic activity of a virus is detected by macroscopic analysis of plaques in a confluent cell layer after staining (e.g., with crystal violet). This technique is an end-point assay and it is well-suited to determine viral titers; however, it provides no information about the onset of cytopathic effects and kinetics of the viral replication. Moreover, infection with a number of viruses (e.g., attenuated mutants) leads to the formation of small and more

• Miniaturised Platelet Aggregation Assays using the NOVOstar Microplate Reader
  

  Platelet aggregation is a “gold standard” assay of platelet function in the research and clinical laboratory settings which is conventionally measured with aggregometers requiring large volumes of platelet suspensions and only in low throughput format. With the NOVOstar microplate reader from BMG LABTECH we present an alternative optical method to measure platelet aggregation using small volumes in 96-well format more

Publications Adhesion

• Endothelial heterogeneity and adhesion molecules N-glycosylation: Implications in leukocyte trafficking in inflammation

  Inflammation is a major contributing element to a host of diseases with the interaction between leukocytes and the endothelium being key in this process. Much is understood about the nature of the adhesion molecule proteins expressed on any given leukocyte and endothelial cell that modulates adhesi more

• Retraction notice to “Epithelial cell adhesion molecule targeted nutlin-3a loaded immunonanoparticles for cancer therapy” [Acta Biomaterialia 7 (2011) 355–369]

  Publication date: June 2013 Source:Acta Biomaterialia, Volume 9, Issue 6 Author(s): Manasi Das , Sanjeeb K. Sahoo more

• Effect of water-aging on the antimicrobial activities of an ORMOSIL-containing orthodontic acrylic resin

  Publication date: June 2013 Source:Acta Biomaterialia, Volume 9, Issue 6 Author(s): Shi-qiang Gong , D. Jeevanie Epasinghe , Bin Zhou , Li-na Niu , Kirk A. Kimmerling , Frederick A. Rueggeberg , Cynthia K.Y. Yiu , Jing Mao , David H. Pashley , Franklin R. Tay Quaternary ammonium meth more

Market studies Adhesion

• Pathfinder Cell Therapy, Inc. (PFND) - Financial and Strategic SWOT Analysis Review

  Pathfinder Cell Therapy, Inc. (Pathfinder Cell Therapy), formerly known as SyntheMed, Inc., is a biomaterial company. The company principally engages in the development and distribution of anti-adhesion surgical products. The company's product, REPEL-CV, is a bioresorbable film designed to be plac more

• Biotie Therapies Corp. (BTH1V) - Financial and Strategic SWOT Analysis Review

  Biotie Therapies Corp. (Biotie) is a biotechnology company, engaged in the discovery and development of therapeutics for the treatment of central nervous system and inflammatory diseases. The company's develops pipeline products which includes, Nalmefene is an opioid receptor antagonist for alcohol more

• LTT Bio-Pharma Co., Ltd. (4566) - Financial and Strategic SWOT Analysis Review

  LTT Bio-Pharma Co., Ltd. (LTT Bio-Pharma) is a biotech company, engaged in research and development of drugs and new technologies. Its research and development activities are focused on developing the DDS (Drug Delivery System) drug products. The company has also developed an EIP punch, a technology more

Websites Adhesion