Stakeholder Opinions: Tropical Diseases - Dengue, Japanese encephalitis and West Nile virus – Increasing attention for neglected diseases

Introduction
Dengue, Japanese encephalitis and West Nile virus are major causes of disease worldwide. Dual market pricing strategies for endemic countries and the Western travelers market offer great commercial opportunities for dengue and Japanese encephalitis vaccines. In contrast, low incidence makes West Nile a less commercially attractive target.

Scope of this research
Discussion of market environment for dengue, Japanese encephalitis and West Nile in US, 5EU and Japan, as well as the rest of the world Thorough assessments of key marketed vaccines and therapeutics, as well as pipeline products Epidemiology section discussing key epidemiological features of disease caused by dengue, Japanese encephalitis and West Nile Detailed background information on dengue, Japanese encephalitis and West Nile, including diagnostics, disease burden and potential drug targets Research and analysis highlights
Although a high disease burden and the spread of dengue make vaccination attractive in selected target groups, uptake in the 7MM will remain limited due to a lack of reimbursement structures.

The JE vaccine SA-14-14-2 (Chengdu) remains the first choice vaccine in many endemic regions. In the US and Europe, Intercell's Ixiaro is now the preferred vaccine for military personnel and travelers. However, a low risk for travelers and out-of-pocket payment for travelers vaccines will limit its commercial potential in the 7MM.

Although West Nile virus has become endemic in the US and several European countries in the last decade, low overall incidence is a big obstacle for the development of antivirals and vaccines, as it complicates clinical trial design and limits commercial prospects.

Key reasons to purchase this research
Review vaccine and antiviral development progress, pipelines and success factors in dengue, JE and West Nile Understand challenges, unmet needs and future opportunities by learning about the views of industry and academic key opinion leaders Understand the epidemiology of dengue, Japanese encephalitis and West Nile virus in the seven major markets and its impact on commercial opportunities