01.06.2013 | Paolo Innocenti; Stephen F. Chenoweth, Molecular Biology and Evolution, 2013

Change in gene expression is a major facilitator of phenotypic evolution. Understanding the evolutionary potential of gene expression requires taking into account complex systems of regulatory networks, the structure of which could potentially bias evolutionary trajectories. We analyzed the ...

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01.06.2013 | Tal Naggan Perl; Bernhard G.M. Schmid; Jonas Schwirz; Ariel D. Chipman, Molecular Biology and Evolution, 2013

The orphan nuclear receptor gene knirps and its relatives encode a small family of highly conserved proteins. We take advantage of the conservation of the family, using the recent prevalence of genomic data, to reconstruct its evolutionary history, identifying duplication events and tracing ...

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01.06.2013 | Patrick C. Brunner; Stefano F.F. Torriani; Daniel Croll; Eva H. Stukenbrock; Bruce A. McDonald, Molecular Biology and Evolution, 2013

Zymoseptoria tritici is an important fungal pathogen on wheat that originated in the Fertile Crescent. Its closely related sister species Z. pseudotritici and Z. ardabiliae infect wild grasses in the same region. This recently emerged host–pathogen system provides a rare opportunity to ...

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15.05.2013 | Aaron W. Reinke, Jiyeon Baek, Orr Ashenberg, Amy E. Keating, Science , 2013

A comparative study of a dimeric transcription factor family looks at the evolution of protein interactions.

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15.05.2013 | Wensi Song; Fan Wang; Marzia Savini; Ashley Ake; Alberto di Ronza; Marco Sardiello; Laura Segatori, Human Molecular Genetics, 2013

Loss-of-function diseases are often caused by destabilizing mutations that lead to protein misfolding and degradation. Modulating the innate protein homeostasis (proteostasis) capacity may lead to rescue of native folding of the mutated variants, thereby ameliorating the disease phenotype. ...

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15.05.2013 | Isabel Valsecchi; Emilie Guittard-Crilat; Regis Maldiney; Yvette Habricot; Sabrina Lignon; Régine Lebrun; Emile Migi ..., Molecular BioSystems, 2013

TCPs are plant specific transcription factors with non-canonical basic helix-loop-helix domains. While Arabidopsis thaliana has 24 TCPs involved in cell proliferation and differentiation, their mode of action has not been fully elucidated. Using bioinformatic tools, we demonstrate that TCP ...

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11.05.2013 | Yuefang Gao, Han Liu, Chuanjing An, Yuhong Shi, Xia Liu, Wanqiong Yuan, Bing Zhang, Jin Yang, Caixia Yu, Hongbo Gao, The Plant Journal, 2013

Summary ARC5 is a dynamin‐related GTPase essential for the division of chloroplasts in plants. The arc5 mutant frequently exhibits enlarged, dumbbell‐shaped chloroplasts, indicating a role for ARC5 in the constriction of the chloroplast division site. In a screen for chloroplast division ...

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11.05.2013 | Dachan Kim, Young‐hyun Cho, Hojin Ryu, Yoonhee Kim, Tae‐Houn Kim, Ildoo Hwang, The Plant Journal, 2013

Summary The signal transduction pathway governed by the phytohormone abscisic acid (ABA) regulates not only abiotic stress responses but also the early developmental programs, such as seed dormancy, germination, and seedling growth, in response to environmental signals. Optimal plant ...

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10.05.2013 | Amanda L. M. Bloom, J. T. Graham Solomons, Virginia E. Havel, John C. Panepinto, Molecular Microbiology, 2013

Summary The pathogenic fungus Cryptococcus neoformans must overcome multiple stressors to cause disease in its human host. In this study, we report that C. neoformans rapidly and transiently repressed ribosomal protein (RP) transcripts during a transition from 30oC to host‐temperature. ...

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10.05.2013 | Kyung Moon, David A. Six, Hyun‐Jung Lee, Christian R.H. Raetz, Susan Gottesman, Molecular Microbiology, 2013

Summary The PhoQ/PhoP two‐component system activates many genes for lipopolysaccharide (LPS) modification when cells are grown at low Mg2+ concentrations. An additional target of PhoQ and PhoP is MgrR, an Hfq‐dependent small RNA that negatively regulates expression of eptB, also encoding ...

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