01.05.2013 | Yoichiro Fukao; Masami Yoshida; Rie Kurata; Mami Kobayashi; Miyako Nakanishi; Masayuki Fujiwara; Keiji Nakajima; Ali ..., Plant and Cell Physiology, 2013

In the post-genome era, several tools that have increased our global understanding of the molecular basis of several cell-based phenomena have been developed. However, proteomics has not been efficiently integrated with the other ‘omics’ (e.g. transcriptomics and metabolomics), because of ...

mehr

01.05.2013 | Clara Novo; Nausica Arnoult; Win-Yan Bordes; Luis Castro-Vega; Anne Gibaud; Bernard Dutrillaux; Silvia Bacchetti; Ar ..., Nucleic Acids Research, 2013

In contrast with the limited sequence divergence accumulated after separation of higher primate lineages, marked cytogenetic variation has been associated with the genome evolution in these species. Studying the impact of such structural variations on defined molecular processes can provide ...

mehr

01.05.2013 | Seth-Smith, H. M. B., Harris, S. R., Skilton, R. J., Radebe, F. M., Golparian, D., Shipitsyna, E., Duy, P. T., Scott ..., Genome Research, 2013

The use of whole-genome sequencing as a tool for the study of infectious bacteria is of growing clinical interest. Chlamydia trachomatis is responsible for sexually transmitted infections and the blinding disease trachoma, which affect hundreds of millions of people worldwide. Recombination ...

mehr

30.04.2013 | Roland Renzel, Ahmed‐Ramadan Sadek, Cin‐He Chang, William P. Gray, Gerald Seifert, Christian Steinhäuser, Glia, 2013

Glial fibrillary acidic protein (GFAP)‐positive astrocytes with radial processes [radial glia (RG)‐like cells] in the postnatal dentate gyrus share many of the characteristics of embryonic radial glia and appear to act as precursor cells for adult dentate neurogenesis, a process important ...

mehr

30.04.2013 | Peiyan Lin, Weidong Qian, Xiaoying Wang, Li Cao, Shaofen Li, Tianxiu Qian, Biomedical Chromatography, 2013

ABSTRACT A highly sensitive and specific LC‐MS/MS method was developed to investigate the in vivo bio‐transformation of oleuropein in rat. Rat feces and urine samples collected after oral administration were determined by liquid chromatography coupled to tandem mass spectrometry with ...

mehr

30.04.2013 | Qian Zhang, Chang‐hong Wang, Yue‐ming Ma, En‐yuan Zhu, Zheng‐tao Wang, Biomedical Chromatography, 2013

ABSTRACT A rapid and sensitive UPLC‐ESI/MS method was established and validated to determine 17 active constituents (aconitine, hypaconitine, mesaconitine, benzoylaconine, benzoylhypaconine, benzoylmesaconine, berberine, palmatine, jatrorrhizine, coptisine, baicalein, wogonin, baicalin, ...

mehr

26.04.2013 | Alessio Fracasso et al., PLoS ONE, 2013

by Alessio Fracasso, Stefano Targher, Massimiliano Zampini, David Melcher The question of whether perceptual illusions influence eye movements is critical for the long-standing debate regarding the separation between action and perception. To test the role of auditory context on a visual ...

mehr

25.04.2013 | Dai Li‐Bo, Yan Miao, Li Huan‐De, Fang Ping‐Fei, Wang Feng, Deng Yang, Biomedical Chromatography, 2013

ABSTRACT A simple and sensitive analytical method based on ultraperformance liquid chromatography–tandem mass spectrometry (UPLC‐MS/MS) has been developed for determination of moclobemide in human brain cell monolayer as an in vitro model of blood–brain barrier. Brucine was employed as ...

mehr

25.04.2013 | Javad Golji et al., PLoS Computational Biology, 2013

by Javad Golji, Mohammad R. K. Mofrad Vinculin can interact with F-actin both in recruitment of actin filaments to the growing focal adhesions and also in capping of actin filaments to regulate actin dynamics. Using molecular dynamics, both interactions are simulated using different ...

mehr

25.04.2013 | Roumiana Gulemetova, Guy Drolet, Richard Kinkead, Experimental Physiology, 2013

Abstract  Neonatal stress disrupts the developmental trajectory of homeostatic systems. Adult (8 – 10 weeks old) male rats exposed to maternal separation (a form of neonatal stress) display several traits reported in patients suffering from sleep‐disordered breathing, including an augmented ...

mehr