01.06.2013 | Nuno S. Osório; Fernando Rodrigues; Sebastien Gagneux; Jorge Pedrosa; Marta Pinto-Carbó; António G. Castro; Douglas ..., Molecular Biology and Evolution, 2013

Tuberculosis (TB) is a global health problem estimated to kill 1.4 million people per year. Recent advances in the genomics of the causative agents of TB, bacteria known as the Mycobacterium tuberculosis complex (MTBC), have allowed a better comprehension of its population structure and ...

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01.06.2013 | Mélisande Blein-Nicolas; Warren Albertin; Benoît Valot; Philippe Marullo; Delphine Sicard; Christophe Giraud; Sylvie ..., Molecular Biology and Evolution, 2013

Saccharomyces cerevisiae and S. uvarum are two domesticated species of the Saccharomyces sensu stricto clade that diverged around 100 Ma after whole-genome duplication. Both have retained many duplicated genes associated with glucose fermentation and are characterized by the ability to ...

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01.06.2013 | Etienne Simon-Loriere; Edward C. Holmes, Molecular Biology and Evolution, 2013

Gene duplication generates genetic novelty and redundancy and is a major mechanism of evolutionary change in bacteria and eukaryotes. To date, however, gene duplication has been reported only rarely in RNA viruses. Using a conservative BLAST approach we systematically screened for the ...

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01.06.2013 | Tal Naggan Perl; Bernhard G.M. Schmid; Jonas Schwirz; Ariel D. Chipman, Molecular Biology and Evolution, 2013

The orphan nuclear receptor gene knirps and its relatives encode a small family of highly conserved proteins. We take advantage of the conservation of the family, using the recent prevalence of genomic data, to reconstruct its evolutionary history, identifying duplication events and tracing ...

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01.06.2013 | David W Scott; Rakesh P Patel, Glycobiology , 2013

Inflammation is a major contributing element to a host of diseases with the interaction between leukocytes and the endothelium being key in this process. Much is understood about the nature of the adhesion molecule proteins expressed on any given leukocyte and endothelial cell that modulates ...

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01.06.2013 | Armen Petrosyan; Pi-Wan Cheng, Glycobiology , 2013

The Golgi apparatus undergoes morphological changes under stress or malignant transformation, but the precise mechanisms are not known. We recently showed that non-muscle myosin IIA (NMIIA) binds to the cytoplasmic tail of Core 2 N-acetylglucosaminyltransferase mucus-type (C2GnT-M) and ...

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01.06.2013 | Linda Lindberg; Jining Liu; Stefan Gaunitz; Anki Nilsson; Tomas Johansson; Niclas G Karlsson; Jan Holgersson, Glycobiology , 2013

Assays for quantification, and methods for removal, of anti-A and anti-B antibodies are the key for the success of ABO incompatible organ transplantation programs. In order to produce tools that can be used as substrates in tests for anti-A/anti-B quantification and specificity determination ...

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15.05.2013 | Michael Bremang; Alessandro Cuomo; Anna Maria Agresta; Magdalena Stugiewicz; Valeria Spadotto; Tiziana Bonaldi, Molecular BioSystems, 2013

Protein methylation is a post-translational modification (PTM) by which a variable number of methyl groups is transferred to lysine and arginine residues within proteins. Despite increased interest in this modification due to its reversible nature and its emerging role in a diverse set of ...

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15.05.2013 | Anath C. Lionel; Andrea K. Vaags; Daisuke Sato; Matthew J. Gazzellone; Elyse B. Mitchell; Hong Yang Chen; Gregory Co ..., Human Molecular Genetics, 2013

The GPHN gene codes for gephyrin, a key scaffolding protein in the neuronal postsynaptic membrane, responsible for the clustering and localization of glycine and GABA receptors at inhibitory synapses. Gephyrin has well-established functional links with several synaptic proteins that have ...

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15.05.2013 | Andrew J. Streets; Oliver Wessely; Dorien J.M. Peters; Albert C.M. Ong, Human Molecular Genetics, 2013

Mutations in PKD1 (85%) or PKD2 (15%) account for almost all cases of autosomal dominant polycystic kidney disease (ADPKD). The ADPKD proteins, termed as polycystin-1 (PC1) and polycystin-2 (PC2), interact via their C-termini to form a receptor–ion channel complex whose function and ...

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