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1.370 Aktuelle Fachpublikationen zum Thema Malaria

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Extracellular vesicles from early‐stage P. falciparum‐infected red blood cells contain PfEMP1 and induce transcriptional changes in human monocytes

19.01.2018 | Natália G. Sampaio, Samantha Emery, Alexandra Garnham, Qiao Y. Tan, Xavier Sisquella, Matthew A. Pimentel, Neta Rege ..., Cellular Microbiology, 2018

Abstract Pathogens can release extracellular vesicles (EVs) for cell‐cell communication and host modulation. EVs from Plasmodium falciparum, the deadliest malaria parasite species, can transfer drug resistance genes between parasites. EVs from late‐stage parasite‐infected RBC (iRBC‐EVs) are ...

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Remarkable Similarity in Plasmodium falciparum and Plasmodium vivax Geranylgeranyl Diphosphate Synthase (GGPPS) Dynamics and its Implication for Anti‐Malarial Drug Design

18.01.2018 | Aishwarya Venkatramani, Clarisse G.Ricci, Eric Oldfield, J. Andrew McCammon, Chemical Biology & Drug Design, 2018

Abstract Malaria, mainly caused by Plasmodium falciparum and Plasmodium vivax, has been a growing cause of morbidity and mortality. P. falciparum is more lethal than is P. vivax, but there is a vital need for effective drugs against both species. Geranylgeranyl diphosphate synthase (GGPPS) is ...

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Remarkable Similarity in Plasmodium falciparum and Plasmodium vivax Geranylgeranyl Diphosphate Synthase (GGPPS) Dynamics and its Implication for Anti‐Malarial Drug Design

18.01.2018 | Aishwarya Venkatramani, Clarisse G.Ricci, Eric Oldfield, J. Andrew McCammon, Chemical Biology & Drug Design, 2018

Abstract Malaria, mainly caused by Plasmodium falciparum and Plasmodium vivax, has been a growing cause of morbidity and mortality. P. falciparum is more lethal than is P. vivax, but there is a vital need for effective drugs against both species. Geranylgeranyl diphosphate synthase (GGPPS) is ...

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Tissue-specific immunopathology during malaria infection

15.01.2018 | Cevayir Coban; Michelle Sue Jann Lee; Ken J. Ishii, Nature Reviews Immunology, 2018

Tissue-specific immunopathology during malaria infection Tissue-specific immunopathology during malaria infection, Published online: 15 January 2018; doi:10.1038/nri.2017.138 Although systemic infection is a hallmark of malaria disease, less is known regarding how parasitized erythrocytes ...

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Modeling the genetic relatedness of Plasmodium falciparum parasites following meiotic recombination and cotransmission

09.01.2018 | Wesley Wong; Edward A. Wenger; Daniel L. Hartl; Dyann F. Wirth, PLoS Computational Biology, 2018

by Wesley Wong, Edward A. Wenger, Daniel L. Hartl, Dyann F. Wirth Unlike in most pathogens, multiple-strain (polygenomic) infections of P. falciparum are frequently composed of genetic siblings. These genetic siblings are the result of sexual reproduction and can coinfect the same host when ...

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A Perspective on Proteomics of Infectious Diseases

28.12.2017 | Apoorva Venkatesh, Concha Gil, Manuel Fuentes, Joshua LaBaer, Sanjeeva Srivastava, PROTEOMICS, 2017

Abstract Pneumonia, HIV/AIDS, tuberculosis, malaria and several other diseases caused by pathogens largely contribute to the enormous burden of infectious diseases. Over the last few decades, the impact of infectious diseases on a population has been drastic and remains a major health concern ...

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Interferon Regulatory Factor 1 is essential for pathogenic CD8+ T cell migration and retention in the brain during experimental cerebral malaria

27.12.2017 | Sin Yee Gun, Carla Claser, Teck Hui Teo, Shanshan W. Howland, Chek Meng Poh, Rebecca Ren Ying Chye, Lisa F.P. Ng, La ..., Cellular Microbiology, 2017

Abstract Host immune response has a key role in controlling the progression of malaria infection. In the well‐established murine model of experimental cerebral malaria (ECM) with P. berghei ANKA infection, pro‐inflammatory Th1 and CD8+ T cells response are essential for disease development. ...

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Antibody Profiling by Proteome Microarray with Multiplex Isotype Detection Reveals Overlap between Human and Aotus nancymaae Controlled Malaria Infections

19.12.2017 | Omid Taghavian, Aarti Jain, Chester J. Joyner, Sunny Ketchum, Rie Nakajima, Algis Jasinskas, Li Liang, Rich Fong, Ch ..., PROTEOMICS, 2017

Abstract The development of vaccines against malaria and serodiagnostic tests for detecting recent exposure requires tools for antigen discovery and suitable animal models. The protein microarray is a high‐throughput, sample sparing technique, with applications in infectious disease research, ...

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Plasmodium yoelii S4/CelTOS is important for sporozoite gliding motility and cell traversal

18.12.2017 | Ryan W.J. Steel, Ying Pei, Nelly Camargo, Alexis Kaushansky, Dorender A. Dankwa, Thomas Martinson, Thao Nguyen, Will ..., Cellular Microbiology, 2017

Abstract Gliding motility and cell traversal by the Plasmodium ookinete and sporozoite invasive stages allow penetration of cellular barriers to establish infection of the mosquito vector and mammalian host, respectively. Motility and traversal are not observed in red cell infectious ...

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Cost-effectiveness analysis of introducing malaria diagnostic testing in drug shops: A cluster-randomised trial in Uganda

15.12.2017 | Kristian Schultz Hansen; Siân E. Clarke; Sham Lal; Pascal Magnussen; Anthony K. Mbonye, PLoS ONE, 2017

by Kristian Schultz Hansen, Siân E. Clarke, Sham Lal, Pascal Magnussen, Anthony K. Mbonye Background Private sector drug shops are an important source of malaria treatment in Africa, yet diagnosis without parasitological testing is common among these providers. Accurate rapid diagnostic tests ...

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