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1.390 Aktuelle Fachpublikationen zum Thema Malaria

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Uncomplicating malaria

29.06.2018 | Caroline Ash; Catherine A. Charneski, Science , 2018

Malaria Severe malaria is caused by the parasite Plasmodium falciparum . Infections can result in organ failure and life-threatening hematological or metabolic abnormalities. Lee et al. sequenced patient and parasite transcriptomes from 46 P. falciparum –infected Gambian children to better

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Surface antibody maturation

22.06.2018 | Caroline Ash; Seth Thomas Scanlon, Science , 2018

Immunology Affinity maturation in B cells generates antibodies with increasingly enhanced antigen-binding properties. Imkeller et al. investigated the maturation of human B cells that express protective antibodies against the circumsporozoite protein of the malaria-causing parasite Plasmodium

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Early life malaria exposure and academic performance

22.06.2018 | Ninja Ritter Klejnstrup; Julie Buhl-Wiggers; Sam Jones; John Rand, PLoS ONE, 2018

by Ninja Ritter Klejnstrup, Julie Buhl-Wiggers, Sam Jones, John Rand Malaria is a major cause of morbidity and mortality in sub-Saharan Africa. It is also a dynamic contributor to poverty through its effects on children’s cognitive development. This paper examines the degree to which malaria in ...

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Dark nights, bright stars

15.06.2018 | Jon Cohen, Science , 2018

At a time when HIV epidemics in Western Europe are shrinking, Russia's is growing by about 10% a year. Russia, in fact, between 2010 and 2015 accounted for more than 80% of all the new infections in Eastern Europe and Central Asia. Not only has the country turned away assistance from The Global ...

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Seasonal variations in Plasmodium falciparum parasite prevalence assessed by varying diagnostic tests in asymptomatic children in southern Ghana

15.06.2018 | Ruth Ayanful-Torgby; Neils B. Quashie; Johnson N. Boampong; Kim C. Williamson; Linda E. Amoah, PLoS ONE, 2018

by Ruth Ayanful-Torgby, Neils B. Quashie, Johnson N. Boampong, Kim C. Williamson, Linda E. Amoah Plasmodium falciparum infections presenting either as symptomatic or asymptomatic may contain sexual stage parasites (gametocytes) that are crucial to malaria transmission. In this study, the ...

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Kinetics of antibody responses to PfRH5-complex antigens in Ghanaian children with Plasmodium falciparum malaria

08.06.2018 | Frederica D. Partey; Filip C. Castberg; Edem W. Sarbah; Sarah E. Silk; Gordon A. Awandare; Simon J. Draper; Nicholas ..., PLoS ONE, 2018

by Frederica D. Partey, Filip C. Castberg, Edem W. Sarbah, Sarah E. Silk, Gordon A. Awandare, Simon J. Draper, Nicholas Opoku, Margaret Kweku, Michael F. Ofori, Lars Hviid, Lea Barfod Plasmodium falciparum PfRH5 protein binds Ripr, CyRPA and Pf113 to form a complex that is essential for ...

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Associated patterns of insecticide resistance in field populations of malaria vectors across Africa [Applied Biological Sciences]

05.06.2018 | Penelope A. Hancock; Antoinette Wiebe; Katherine A. Gleave; Samir Bhatt; Ewan Cameron; Anna Trett; David Weetman; Da ..., Proceedings of the National Academy of Sciences current issue, 2018

Malaria control programs rely on chemical insecticides to target mosquito vectors and are potentially threatened by the emergence of insecticide resistance in African vector populations. Insecticide resistance management initiatives require comprehensive quantification of resistance in field ...

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Volatile biomarkers of symptomatic and asymptomatic malaria infection in humans [Medical Sciences]

29.05.2018 | Consuelo M. De Moraes; Caroline Wanjiku; Nina M. Stanczyk; Hannier Pulido; James W. Sims; Heike S. Betz; Andrew F. R ..., Proceedings of the National Academy of Sciences current issue, 2018

Malaria elimination efforts are hindered by the prevalence of asymptomatic infections, which frequently go undetected and untreated. Consequently, there is a pressing need for improved diagnostic screening methods. Based on extensive collections of skin odors from human populations in Kenya, we ...

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Reducing resistance allele formation in CRISPR gene drive [Genetics]

22.05.2018 | Jackson Champer; Jingxian Liu; Suh Yeon Oh; Riona Reeves; Anisha Luthra; Nathan Oakes; Andrew G. Clark; Philipp W. M ..., Proceedings of the National Academy of Sciences current issue, 2018

A functioning gene drive mechanism could fundamentally change our strategies for the control of vector-borne diseases, such as malaria, dengue, and Zika. CRISPR homing gene drive promises such a mechanism, which could be used to rapidly spread genetic modifications among the mosquitoes that ...

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Plasmodium parasite exploits host aquaporin-3 during liver stage malaria infection

18.05.2018 | Dora Posfai; Kayla Sylvester; Anupama Reddy; Jack G. Ganley; Johannes Wirth; Quinlan E. Cullen; Tushar Dave; Nobutak ..., PLoS Pathogens, 2018

by Dora Posfai, Kayla Sylvester, Anupama Reddy, Jack G. Ganley, Johannes Wirth, Quinlan E. Cullen, Tushar Dave, Nobutaka Kato, Sandeep S. Dave, Emily R. Derbyshire Within the liver a single Plasmodium parasite transforms into thousands of blood-infective forms to cause malaria. Here, we use ...

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