01.06.2013 | Chunqiao Liu; Chen Lin; D. Thad Whitaker; Hirva Bakeri; Oleg V. Bulgakov; Pinghu Liu; Jingqi Lei; Lijin Dong; Tianse ..., Human Molecular Genetics, 2013

Development of axons and dendrites constitutes a critical event in neuronal maturation and seems to require signaling through the planar cell polarity (PCP) pathway. Mutations in components of the PCP pathway lead to a spectrum of neurological phenotypes and disorders. For example, a ...

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01.06.2013 | Yann Lesecque; Dominique Mouchiroud; Laurent Duret, Molecular Biology and Evolution, 2013

GC-biased gene conversion (gBGC) is a process associated with recombination that favors the transmission of GC alleles over AT alleles during meiosis. gBGC plays a major role in genome evolution in many eukaryotes. However, the molecular mechanisms of gBGC are still unknown. Different steps ...

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01.06.2013 | Alison C MacKinnon; Xiaojun Liu; Patrick WF Hadoke; Mark R Miller; David E Newby; Tariq Sethi, Glycobiology , 2013

Atherosclerosis is a major risk factor for cardiovascular disease (CVD) and stroke. Galectin-3 is a carbohydrate-binding lectin implicated in the pathophysiology of CVD and is highly expressed within atherosclerotic lesions in mice and humans. The object of this present study was to use ...

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22.05.2013 | Elias Vlieg, Science , 2013

Manipulation of crystal growth conditions results in the controlled formation of complex micrometer-scale shapes. [Also see Research Article by Noorduin et al.]

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20.05.2013 | Author(s): Tamás Vigh , Tímea Horváthová , Attila Balogh , Péter Lajos Sóti , Gábor Drávavölgyi , Zsombor Krist ..., European Journal of Pharmaceutical Science, 2013

Publication date: Available online 14 May 2013 Source:European Journal of Pharmaceutical Sciences Author(s): Tamás Vigh , Tímea Horváthová , Attila Balogh , Péter Lajos Sóti , Gábor Drávavölgyi , Zsombor Kristóf Nagy , György Marosi Fast-release nano- and microfibres of ...

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20.05.2013 | Author(s): Felipe A. Oyarzun-Ampuero , Gustavo R. Rivera-Rodríguez , Maria J. Alonso , Dolores Torres, European Journal of Pharmaceutical Science, 2013

Publication date: Available online 15 May 2013 Source:European Journal of Pharmaceutical Sciences Author(s): Felipe A. Oyarzun-Ampuero , Gustavo R. Rivera-Rodríguez , Maria J. Alonso , Dolores Torres Here we report the development of new drug nanocarriers -named hyaluronan ...

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19.05.2013 | Author(s): Raphael J. Gübeli , Dougal Laird , Martin Ehrbar , Benjamin S. Ritter , Thorsten Steinberg , Pascal ..., Acta Biomaterialia, 2013

Publication date: Available online 16 May 2013 Source:Acta Biomaterialia Author(s): Raphael J. Gübeli , Dougal Laird , Martin Ehrbar , Benjamin S. Ritter , Thorsten Steinberg , Pascal Tomakidi , Wilfried Weber Biohybrid materials combining synthetic polymers with biological ...

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19.05.2013 | B. Klosterhalfen, U. Klinge, Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2013

Abstract Textile meshes frequently are implanted in the abdominal wall to reinforce a hernia repair. However, revisions for mesh associated complications confirm that these devices are not completely free of risk. Explanted devices offer an opportunity to define the impact of mesh ...

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18.05.2013 | Toshiki Takenouchi, Hideyuki Saito, Ryo Maruoka, Naoki Oishi, Chiharu Torii, Jun Maeda, Takao Takahashi, Kenjiro Kosaki, American Journal of Medical Genetics Part A, 2013

Abstract Loeys–Dietz syndrome is a recently recognized connective tissue disorder characterized by severe craniofacial and skeletal abnormalities as well as arterial tortuosity with aggressive aneurysm formation. Marfan syndrome, a classic connective tissue disorder, is known to be ...

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17.05.2013 | Margherita Silengo, Claudio Defilippi, Elga Belligni, Elisa Biamino, Elisabetta Flex, Alfredo Brusco, Giovanni Batti ..., American Journal of Medical Genetics Part A, 2013

Abstract The formation of ectopic calcifications in soft tissues can occur either sporadically or as a genetically determined condition, and is seen only infrequently. We report on a girl in whom widespread, rapidly progressive ectopic calcifications were detected shortly after birth. ...

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