25.04.2013 | Yongbo Yuan, Dawn T. Eriksen, Huimin Zhao, Biotechnology and Bioengineering, 2013

Abstract Balancing and increasing the flux through an engineered heterologous pathway in a target organism to achieve high yield and productivity remains an overwhelming challenge in metabolic engineering. Here we report a novel strategy combining directed evolution and promoter ...

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23.04.2013 | Hyun‐Ju Ko, Hae Jong Kim, Su Yeon Kim, Hye‐Young Yun, Kwang Jin Baek, Nyoun Soo Kwon, Wan Kyun Whang, Hye‐Ryung Choi ..., Phytotherapy Research, 2013

We isolated crystals from the chloroform fraction of an ethanol extract of Kaempferia galanga and identified it as ethyl p‐methoxycinnamate through nuclear magnetic resonance analysis. In the present study, we found that ethyl p‐methoxycinnamate significantly decreased melanin synthesis in ...

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22.04.2013 | Author(s): Kristof Kovacs , Madhuri Ancha , Mario Jane , Stephen Lee , Siva Angalakurthi , Maelani Negrito , S ..., European Journal of Pharmaceutical Science, 2013

Publication date: Available online 18 April 2013Source:European Journal of Pharmaceutical Sciences Author(s): Kristof Kovacs , Madhuri Ancha , Mario Jane , Stephen Lee , Siva Angalakurthi , Maelani Negrito , Senan Rasheed , Assumpta Nwaneri , Ilona Petrikovics Present studies ...

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19.04.2013 | Amine Bahi, Jean‐Luc Dreyer, European Journal of Neuroscience, 2013

Abstract Alcohol abuse is a major health, economic and social concern in modern societies, but the exact molecular mechanisms underlying ethanol addiction remain elusive. Recent findings show that small non‐coding microRNA (miRNA) signaling contributes to complex behavioral disorders ...

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19.04.2013 | Manish Manohar Aglawe, Brijesh Gulabrao Taksande, Sharvari Shambabu Kuldhariya, Chandrabhan Tukaram Chopde, Milind J ..., Fundamental & Clinical Pharmacology, 2013

Abstract Despite synergistic morbidity and mortality, concomitant consumption of alcohol and tobacco is increasing, and their antinociceptive effect has been linked with co‐abuse. Present study was designed to investigate the role of imidazoline binding sites in the antinociceptive effect ...

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18.04.2013 | Yu‐Sin Jang, Alok Malaviya, Joungmin Lee, Jung Ae Im, Sang Yup Lee, Julia Lee, Moon‐Ho Eom, Jung‐Hee Cho, Do Young Seung, Biotechnology Progress, 2013

Butanol is considered as a superior biofuel, which is conventionally produced by clostridial acetone‐butanol‐ethanol (ABE) fermentation. Among ABE, only butanol and ethanol can be used as fuel alternatives. Coproduction of acetone thus causes lower yield of fuel alcohols. Thus, this study ...

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18.04.2013 | Heng-Yi Yu; Xiao-Qiong Zhang; Xue- Li; Fan-Bo Zeng; Han-Li Ruan, Journal of Natural Products, 2013

In order to discover anticancer agents from natural sources, an ethanol-soluble extract of the root bark of Juglans cathayensis was investigated and showed cytotoxic effects against various human cancer cell lines. A subsequent phytochemical study on the EtOAc-soluble fraction determined ...

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16.04.2013 | Birgit Voigt, Rebecca Schroeter, Britta Jürgen, Dirk Albrecht, Stefan Evers, Johannes Bongaerts, Karl‐Heinz Maurer, ..., PROTEOMICS, 2013

The heat and ethanol stress response of Bacillus licheniformis DSM13 was analyzed at the transcriptional and/ or translational level. During heat shock, regulons known to be heat‐induced in Bacillus subtilis 168 are upregulated in B. licheniformis, such as the HrcA, SigB, CtsR and CssRS ...

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16.04.2013 | Christoph Gruber, Stefan Krahulec, Bernd Nidetzky, Regina Kratzer, Biotechnology Journal, 2013

Abstract Generally, recombinant and native microorganisms can be employed as whole cell catalysts. The application of native hosts, however, shortens the process development time by avoiding multiple steps of strain construction. Here, we studied the NAD(P)H‐dependent reduction of ...

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16.04.2013 | Tanjina Sharmin, Tomomitsu Satho, Keiichi Irie, Mineo Watanabe, Masato Hosokawa, Yukihiro Hiramatsu, Parimal Talukde ..., Microbiology and Immunology, 2013

ABSTRACT Pyriproxyfen is a juvenile hormone mimic of vital importance for insect development with little risk to humans. This study was performed to investigate whether large doses of pyriproxyfen affect the immune response in mammals. Mice were immunized thrice with ovalbumin in 5% ...

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