23.10.2013 | Ata Abbas, William Patterson III, Philippe T. Georgel, Biochemistry and Cell Biology, 2013

Le cancer de la prostate est une maladie grandement affectée par le style de vie, particulièrement la diète, et il est plus fréquent aux États-Unis et dans les pays européens comparativement à l'Asie de sud et de l'est. Parmi les nombreuses causes et facteurs de risques connus, la nutrition ...

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01.06.2013 | David Rodríguez; Andrew J. Ramsay; Víctor Quesada; Cecilia Garabaya; Elías Campo; José M. P. Freije; Carlos López-Otín, Human Molecular Genetics, 2013

Next-generation sequencing techniques have emerged as powerful tools for the understanding of cancer genomes. In recent years, whole-exome and whole-genome sequencing strategies have enabled the annotation of a comprehensive mutation landscape of chronic lymphocytic leukemia (CLL), the most ...

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01.06.2013 | Roser Ufartes; Tomasz Schneider; Lena Sünke Mortensen; Camino de Juan Romero; Klaus Hentrich; Hendrik Knoetgen; Vadi ..., Human Molecular Genetics, 2013

Kv10.1 (Eag1), member of the Kv10 family of voltage-gated potassium channels, is preferentially expressed in adult brain. The aim of the present study was to unravel the functional role of Kv10.1 in the brain by generating knockout mice, where the voltage sensor and pore region of Kv10.1 ...

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01.06.2013 | Yu Wang; Xin He; Qi Yu; Charis Eng, Human Molecular Genetics, 2013

Androgen receptor (AR) expression by immunohistochemistry correlates with better prognosis and survival among breast cancer patients. We and others have shown that AR inhibits proliferation and induces apoptosis in breast cancer cells. However, the mechanism of AR's anti-tumor effect in ...

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01.06.2013 | Yi Shu; Farzin Haque; Dan Shu; Wei Li; Zhenqi Zhu; Malak Kotb; Yuri Lyubchenko; Peixuan Guo, RNA, 2013

Due to structural flexibility, RNase sensitivity, and serum instability, RNA nanoparticles with concrete shapes for in vivo application remain challenging to construct. Here we report the construction of 14 RNA nanoparticles with solid shapes for targeting cancers specifically. These RNA ...

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01.06.2013 | Masahiko Yabu; Hiroaki Korekane; Koji Hatano; Yasufumi Kaneda; Norio Nonomura; Chihiro Sato; Ken Kitajima; Yasuhide ..., Glycobiology , 2013

We previously reported on the accumulation of a substantial amount of free N-acetylneuraminic acid (Neu5Ac)-containing complex-type N-glycans in human pancreatic cancer cells (Yabu M, Korekane H, Takahashi H, Ohigashi H, Ishikawa O, Miyamoto Y. 2013. Accumulation of free Neu5Ac-containing ...

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01.06.2013 | Armen Petrosyan; Pi-Wan Cheng, Glycobiology , 2013

The Golgi apparatus undergoes morphological changes under stress or malignant transformation, but the precise mechanisms are not known. We recently showed that non-muscle myosin IIA (NMIIA) binds to the cytoplasmic tail of Core 2 N-acetylglucosaminyltransferase mucus-type (C2GnT-M) and ...

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22.05.2013 | Marc Alard Morgan, Ali Shilatifard, Science , 2013

Misregulation of the pattern and localization of histone modifications may result in cancer development. [Also see Report by Lewis et al.]

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22.05.2013 | Zarogoulidis K, Latsios D, Porpodis K, Zarogoulidis P, Darwiche K, Antoniou N, Hohenforst-Schmidt W, Eleftheriadou E ..., OncoTargets and Therapy, 2013

Zarogoulidis K, Latsios D, Porpodis K, Zarogoulidis P, Darwiche K, Antoniou N, Hohenforst-Schmidt W, Eleftheriadou E, Boutsikou E, Kontakiotis T

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18.05.2013 | Stephen Roper, Marina Zemskova, Benjamin A. Neely, Arch Martin, Peng Gao, E. Ellen Jones, Andrew S. Kraft, Richard R ..., PROTEOMICS, 2013

Purpose Effectively identifying the proteins present in this cellular secretome is complicated due to the presence of cellular protein leakage and serum protein supplements in culture media. A metabolic labeling and click chemistry capture method is described that facilitates the ...

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