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The water network in galectin-3 ligand binding site guides inhibitor design

01.03.2015 | Jiyong Su; Tao Zhang; Peiqi Wang; Fengjian Liu; Guihua Tai; Yifa Zhou, Acta Biochimica et Biophysica Sinica, 2015

Galectin-3 (Gal-3) which shows affinity of β-galactosides is a cancer-related protein. Thus, it is important to understand its ligand binding mechanism and then design its specific inhibitor. It was suggested that the positions of water molecules in Gal-3 ligand-binding site could be replaced by ...


Two distinct roles of the yorkie/yap gene during homeostasis in the planarian Dugesia japonica

24.02.2015 | Byulnim Hwang, Yang An, Kiyokazu Agata, Yoshihiko Umesono, Development, Growth & Differentiation, 2015

Adult planarians possess somatic pluripotent stem cells called neoblasts that give rise to all missing cell types during regeneration and homeostasis. Recent studies revealed that the Yorkie (Yki)/Yes‐associated protein (YAP) transcriptional coactivator family plays an important role in the ...


Development of lamellar gel phase emulsion containing marigold oil (Calendula officinalis) as a potential modern wound dressing

15.02.2015 | Author(s): C.H. Okuma , T.A.M. Andrade , G.F. Caetano , L.I. Finci , N.R. Maciel , J.F. Topan , L.C. Cefali , ..., European Journal of Pharmaceutical Science, 2015

Publication date: Available online 12 February 2015 Source:European Journal of Pharmaceutical Sciences Author(s): C.H. Okuma , T.A.M. Andrade , G.F. Caetano , L.I. Finci , N.R. Maciel , J.F. Topan , L.C. Cefali , A.C.M. Polizello , T. Carlo , A.P. Rogerio , A.C.C. Spadaro , ...


[In Depth] Seafloor grooves record the beat of the ice ages

06.02.2015 | Eric Hand, Science , 2015

In addition to carving up the continents, the ice ages also tattoo the sea floor with rhythmic patterns, according to two studies published this week. At seafloor spreading centers, plates of ocean crust diverge and magma erupts in the gap, building new crust onto the plates' trailing edges. ...


In vitro Exposure to the Herbicide Atrazine Inhibits T Cell Activation, Proliferation, and Cytokine Production and Significantly Increases the Frequency of Foxp3+ Regulatory T Cells

01.02.2015 | Lindsay E. Thueson; Tiffany R. Emmons; Dianna L. Browning; Joanna M. Kreitinger; David M. Shepherd; Scott A. Wetzel, Toxicological Sciences, 2015

The herbicide atrazine (2-chloro-4-[ethylamino]-6-[isopropylamino]-s-triazine) is the most common water contaminant in the United States. Atrazine is a phosphodiesterase inhibitor and is classified as an estrogen disrupting compound because it elevates estrogen levels via induction of the enzyme ...


Molecular Mechanisms of Acrolein Toxicity: Relevance to Human Disease

01.02.2015 | Akshata Moghe; Smita Ghare; Bryan Lamoreau; Mohammad Mohammad; Shirish Barve; Craig McClain; Swati Joshi-Barve, Toxicological Sciences, 2015

Acrolein, a highly reactive unsaturated aldehyde, is a ubiquitous environmental pollutant and its potential as a serious environmental health threat is beginning to be recognized. Humans are exposed to acrolein per oral (food and water), respiratory (cigarette smoke, automobile exhaust, and ...


Water balance and expression of heat-shock protein 70 in Codringtonia species: a study within a phylogenetic framework

01.02.2015 | Panayiota Kotsakiozi; Aristeidis Parmakelis; Ioanna-Katerina Aggeli; Catherine Gaitanaki; Sinos Giokas; Efstratios D ..., Journal of Molluscan Studies, 2015

Seasonal differences in the water content of four Codringtonia species were investigated using specimens collected from the field. In addition, rate of water loss and expression of heat-shock protein 70 (Hsp70) were measured in a laboratory setting with six Codringtonia species subjected to a ...


In Situ Nitrogen Mineralization, Nitrification, and Ammonia Volatilization in Maize Field Fertilized with Urea in Huanghuaihai Region of Northern China

30.01.2015 | Xuelin Zhang et al., PLoS ONE, 2015

by Xuelin Zhang, Qun Wang, Jun Xu, Frank S. Gilliam, Nicolas Tremblay, Chaohai Li Nitrogen (N) fertilization potentially affects soil N mineralization and leaching, and can enhance NH3 volatilization, thus impacting crop production. A fertilizer experiment with five levels of N addition (0, 79, ...


Utilization of Recycled Asphalt Concrete with Warm Mix Asphalt and Cost-Benefit Analysis

09.01.2015 | Julide Oner et al., PLoS ONE, 2015

by Julide Oner, Burak Sengoz The asphalt paving industries are faced with two major problems. These two important challenges are generated with an increase in demand for environmentally friendly paving mixtures and the problem of rapidly rising raw materials. Recycling of reclaimed asphalt ...


Characterization of new Myoviridae bacteriophage WZ1 against multi‐drug resistant (MDR) Shigella dysenteriae

02.01.2015 | Muhsin Jamal, Waqas Nasir Chaudhry, Tahir Hussain, Chythanya Rajanna Das, Saadia Andleeb, Journal of Basic Microbiology, 2015

Shigella dysenteriae is a normal inhabitant of the human gastrointestinal tract, but sometimes it causes severe infection known as shigellosis (bacillary dysentery). Bacteriophages are considered very safe and effective agents for controlling bacterial infections and contaminations. In this ...


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