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Defects in optineurin- and myosin VI-mediated cellular trafficking in amyotrophic lateral sclerosis

01.07.2015 | Vinod Sundaramoorthy; Adam K. Walker; Vanessa Tan; Jennifer A. Fifita; Emily P. Mccann; Kelly L. Williams; Ian P. Bl ..., Human Molecular Genetics, 2015

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder primarily affecting motor neurons. Mutations in optineurin cause a small proportion of familial ALS cases, and wild-type (WT) optineurin is misfolded and forms inclusions in sporadic ALS patient motor neurons. However, it ...


Spatio-temporal Dynamics and Mechanisms of Stress Granule Assembly

26.06.2015 | Daisuke Ohshima et al., PLoS Computational Biology, 2015

by Daisuke Ohshima, Kyoko Arimoto-Matsuzaki, Taichiro Tomida, Mutsuhiro Takekawa, Kazuhisa Ichikawa Stress granules (SGs) are non-membranous cytoplasmic aggregates of mRNAs and related proteins, assembled in response to environmental stresses such as heat shock, hypoxia, endoplasmic reticulum ...


Effect of mitochondrial stress on systemic metabolism

22.06.2015 | Myung‐Shik Lee, Annals of the New York Academy of Sciences, 2015

In our studies investigating the role of autophagy in systemic metabolism, we found that mitochondrial dysfunction due to autophagy deficiency in insulin target tissues, such as skeletal muscle or liver, leads to the induction of fibroblast growth factor (FGF)21 as a mitokine and protection ...


Selective killing of gastric cancer cells by a small molecule targeting ROS‐mediated ER stress activation

18.06.2015 | Peng Zou, Yiqun Xia, Tongke Chen, Junru Zhang, Zhe Wang, Wenbo Chen, Minxiao Chen, Karvannan Kanchana, Shulin Yang, ..., Molecular Carcinogenesis, 2015

Gastric cancer is one of the leading causes of cancer mortality in the world. Curcumin is a natural product with multiple pharmacological activities, while its clinical application has been limited by the poor chemical stability. We have previously designed a series of curcumin derivatives with ...


Vancomycin and maltodextrin affect structure and activity of Staphylococcus aureus biofilms

18.06.2015 | Mia Mae Kimco, Erhan Atci, Qaiser Farid Khan, Abdelrhman Mohamed, Ryan S. Renslow, Nehal Abu‐Lail, Boel A. Fransson, ..., Biotechnology and Bioengineering, 2015

Abstract Hyperosmotic agents such as maltodextrin negatively impact bacterial growth through osmotic stress without contributing to drug resistance. We hypothesized that a combination of maltodextrin (osmotic agent) and vancomycin (antibiotic) would be more effective against S. aureus ...


Association of UBP1 to ribonucleoprotein complexes is regulated by interaction with the trypanosome ortholog of the human multifunctional P32 protein

15.06.2015 | Alejandro Cassola, María Albertina Romaniuk, Debora Primrose, Gabriela Cervini, Iván D′Orso, Alberto Carlos Frasch, Molecular Microbiology, 2015

Summary Regulation of gene expression in trypanosomatid parasitic protozoa is mainly achieved posttranscriptionally. RNA‐binding proteins (RBPs) associate to 3′ untranslated regions in mRNAs through dedicated domains such as the RNA recognition motif (RRM). Trypanosoma cruzi UBP1 (TcUBP1) is ...


Transcriptional regulation of the Chlamydia heat shock stress response in an intracellular infection

15.06.2015 | Brett R. Hanson, Ming Tan, Molecular Microbiology, 2015

Summary Bacteria encode heat shock proteins that aid in survival during stressful growth conditions. In addition, the major heat shock proteins of the intracellular bacterium Chlamydia trachomatis have been associated with immune pathology and disease. We developed a ChIP‐qPCR method to study ...


Judging the Intensity of Emotional Expression in Faces: the Effects of Colored Tints on Individuals With Autism Spectrum Disorder

09.06.2015 | Lydia Whitaker, Catherine R.G. Jones, Arnold J. Wilkins, Debi Roberson, Autism Research, 2015

Individuals with autism spectrum disorder (ASD) often show atypical processing of facial expressions, which may result from visual stress. In the current study, children with ASD and matched controls judged which member of a pair of faces displayed the more intense emotion. Both faces showed ...


Viruses, Vol. 7, Pages 2858-2883: Protein-Protein Interactions of Viroporins in Coronaviruses and Paramyxoviruses: New Targets for Antivirals?

04.06.2015 | Torres, Jaume ; Surya, Wahyu ; Li, Yan ; Liu, Ding Xiang, Viruses, 2015

Viroporins are members of a rapidly growing family of channel-forming small polypeptides found in viruses. The present review will be focused on recent structural and protein-protein interaction information involving two viroporins found in enveloped viruses that target the respiratory tract; (i) ...


Putative bacterial volatile‐mediated growth in soybean (Glycine max L. Merrill) and expression of induced proteins under salt stress

03.06.2015 | Anukool Vaishnav, Sarita Kumari, Shekhar Jain, Ajit Varma, Devendra Kumar Choudhary, Journal of Applied Microbiology, 2015

Abstract Aims Plant root‐associated rhizobacteria elicit plant immunity referred to as induced systemic tolerance (IST) against multiple abiotic stresses. Among multibacterial determinants involved in IST, the induction of IST and promotion of growth by putative bacterial volatile compounds ...


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