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848 Aktuelle Fachpublikationen zum Thema Addition

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Genome wide association mapping of time‐dependent growth responses to moderate drought stress in Arabidopsis

03.07.2015 | Johanna A. Bac‐Molenaar, Christine Granier, Joost J. B. Keurentjes, Dick Vreugdenhil, Plant, Cell & Environment, 2015

ABSTRACT Large areas of arable land are often confronted with irregular rainfall resulting in limited water availability for part(s) of the growing seasons, which demands research for drought tolerance of plants. Natural variation was observed for biomass accumulation upon controlled moderate ...

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Dissecting the Mechanisms of Doxorubicin and Oxidative Stress-Induced Cytotoxicity: The Involvement of Actin Cytoskeleton and ROCK1

02.07.2015 | Lei Wei et al., PLoS ONE, 2015

by Lei Wei, Michelle Surma, Gina Gough, Stephanie Shi, Nathan Lambert-Cheatham, Jiang Chang, Jianjian Shi We have recently reported that ROCK1 deficiency in mouse embryonic fibroblasts (MEF) has superior anti-apoptotic and pro-survival effects than antioxidants against doxorubicin, a ...

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Role of habitual physical activity in modulating vascular actions of insulin

01.07.2015 | Jaume Padilla, T. Dylan Olver, John P. Thyfault, Paul J. Fadel, Experimental Physiology, 2015

New Findings What is the topic of this review? This review highlights the importance of increased vascular insulin sensitivity for maintaining glycaemic control and cardiovascular health. What advances does it highlight? We discuss the role of habitual physical activity in ...

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Defects in optineurin- and myosin VI-mediated cellular trafficking in amyotrophic lateral sclerosis

01.07.2015 | Vinod Sundaramoorthy; Adam K. Walker; Vanessa Tan; Jennifer A. Fifita; Emily P. Mccann; Kelly L. Williams; Ian P. Bl ..., Human Molecular Genetics, 2015

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder primarily affecting motor neurons. Mutations in optineurin cause a small proportion of familial ALS cases, and wild-type (WT) optineurin is misfolded and forms inclusions in sporadic ALS patient motor neurons. However, it ...

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A New VMAT‐2 Inhibitor NBI‐641449 in the Treatment of Huntington Disease

30.06.2015 | Sheng Chen, Xiao‐jie Zhang, Wen‐Jie Xie, Hong‐Yan Qiu, Hui Liu, Wei‐Dong Le, CNS Neuroscience & Therapeutics, 2015

Summary Aims To evaluate the effectiveness of a new VMAT‐2 inhibitor NBI‐641449 in controlling hyperkinetic movements of Huntington disease (HD) and to investigate its possible therapeutic effects. Methods We applied three different doses of NBI‐641449 (1, 10, 100mg/kg/day) for ...

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Spatio-temporal Dynamics and Mechanisms of Stress Granule Assembly

26.06.2015 | Daisuke Ohshima et al., PLoS Computational Biology, 2015

by Daisuke Ohshima, Kyoko Arimoto-Matsuzaki, Taichiro Tomida, Mutsuhiro Takekawa, Kazuhisa Ichikawa Stress granules (SGs) are non-membranous cytoplasmic aggregates of mRNAs and related proteins, assembled in response to environmental stresses such as heat shock, hypoxia, endoplasmic reticulum ...

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Effect of mitochondrial stress on systemic metabolism

22.06.2015 | Myung‐Shik Lee, Annals of the New York Academy of Sciences, 2015

In our studies investigating the role of autophagy in systemic metabolism, we found that mitochondrial dysfunction due to autophagy deficiency in insulin target tissues, such as skeletal muscle or liver, leads to the induction of fibroblast growth factor (FGF)21 as a mitokine and protection ...

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Selective killing of gastric cancer cells by a small molecule targeting ROS‐mediated ER stress activation

18.06.2015 | Peng Zou, Yiqun Xia, Tongke Chen, Junru Zhang, Zhe Wang, Wenbo Chen, Minxiao Chen, Karvannan Kanchana, Shulin Yang, ..., Molecular Carcinogenesis, 2015

Gastric cancer is one of the leading causes of cancer mortality in the world. Curcumin is a natural product with multiple pharmacological activities, while its clinical application has been limited by the poor chemical stability. We have previously designed a series of curcumin derivatives with ...

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Vancomycin and maltodextrin affect structure and activity of Staphylococcus aureus biofilms

18.06.2015 | Mia Mae Kimco, Erhan Atci, Qaiser Farid Khan, Abdelrhman Mohamed, Ryan S. Renslow, Nehal Abu‐Lail, Boel A. Fransson, ..., Biotechnology and Bioengineering, 2015

Abstract Hyperosmotic agents such as maltodextrin negatively impact bacterial growth through osmotic stress without contributing to drug resistance. We hypothesized that a combination of maltodextrin (osmotic agent) and vancomycin (antibiotic) would be more effective against S. aureus ...

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Association of UBP1 to ribonucleoprotein complexes is regulated by interaction with the trypanosome ortholog of the human multifunctional P32 protein

15.06.2015 | Alejandro Cassola, María Albertina Romaniuk, Debora Primrose, Gabriela Cervini, Iván D′Orso, Alberto Carlos Frasch, Molecular Microbiology, 2015

Summary Regulation of gene expression in trypanosomatid parasitic protozoa is mainly achieved posttranscriptionally. RNA‐binding proteins (RBPs) associate to 3′ untranslated regions in mRNAs through dedicated domains such as the RNA recognition motif (RRM). Trypanosoma cruzi UBP1 (TcUBP1) is ...

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