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Deficiency of {alpha}-glucosidase I alters glycoprotein glycosylation and lifespan in Caenorhabditis elegans

01.10.2013 | Toshihiko Katoh; Juri Takase; Yasushi Tani; Ryuta Amamoto; Naofumi Aoshima; Michael Tiemeyer; Kenji Yamamoto; Hisash ..., Glycobiology , 2013

Endoplasmic reticulum (ER) α-glucosidase I is an enzyme that trims the distal α1,2-linked glucose (Glc) residue from the Glc3Man9GlcNAc2 oligosaccharide following its addition to nascent glycoproteins in the initial step of processing. This reaction is critical to the subsequent processing of ...


Broad MICA/B Expression in the Small Bowel Mucosa: A Link between Cellular Stress and Celiac Disease

13.09.2013 | Yessica L. Allegretti et al., PLoS ONE, 2013

by Yessica L. Allegretti, Constanza Bondar, Luciana Guzman, Eduardo Cueto Rua, Nestor Chopita, Mercedes Fuertes, Norberto W. Zwirner, Fernando G. Chirdo The MICA/B genes (MHC class I chain related genes A and B) encode for non conventional class I HLA molecules which have no role in antigen ...


Sulfiredoxin plays peroxiredoxin‐dependent and –independent roles via the HOG signaling pathway in Cryptococcus neoformans and contributes to fungal virulence

03.09.2013 | Rajendra Upadhya, Hyelim Kim, Kwang‐Woo Jung, Goun Park, Woei Lam, Jennifer K. Lodge, Yong‐Sun Bahn, Molecular Microbiology, 2013

Summary Mechanisms of oxidative stress resistance are crucial virulence factors for survival and proliferation of fungal pathogens within the human host. In this study we have identified and functionally characterized the role of sulfiredoxin, Srx1, in oxidative stress resistance of ...


Early Phosphoproteomic Changes in the Mouse Spleen During Deoxynivalenol-Induced Ribotoxic Stress

01.09.2013 | Xiao Pan; Douglas A. Whitten; Ming Wu; Christina Chan; Curtis G. Wilkerson; James J. Pestka, Toxicological Sciences, 2013

The trichothecene mycotoxin deoxynivalenol (DON) targets the innate immune system and is of public health significance because of its frequent presence in human and animal food. DON-induced proinflammatory gene expression and apoptosis in the lymphoid tissue have been associated with a ribotoxic ...


CD36 Recruits α5β1 Integrin to Promote Cytoadherence of P. falciparum-Infected Erythrocytes

29.08.2013 | Shevaun P. Davis et al., PLoS Pathogens, 2013

by Shevaun P. Davis, Kristine Lee, Mark R. Gillrie, Lina Roa, Matthias Amrein, May Ho The adhesion of Plasmodium falciparum-infected erythrocytes (IRBC) to receptors on different host cells plays a divergent yet critical role in determining the progression and outcome of the infection. Based on ...


Heat‐shock protein 70 binds microtubules and interacts with kinesin in tobacco pollen tubes

28.08.2013 | Luigi Parrotta, Mauro Cresti, Giampiero Cai, Cell Motility and the Cytoskeleton, 2013

Abstract The heat‐shock proteins of 70 kD are a family of ubiquitously expressed proteins important for protein folding. Heat‐shock protein 70 assists other nascent proteins to achieve the spatial structure and ultimately helps the cell to protect against stress factors, such as heat. These ...


Fluctuating Asymmetry as Risk Marker for Stress and Structural Defects in a Toxicologic Experiment

26.08.2013 | Matteo Breno, Jessica Bots, Luc Schaepdrijver, Stefan Dongen, Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2013

Fluctuating asymmetry (the directionally random asymmetry of bilateral structures, FA) is commonly used as a measure of developmental instability, and may increase with stress. As several studies reported a relation between FA and developmental abnormalities, we investigate whether FA could be ...


Association of N‐terminal domain polymorphisms of the porcine glucocorticoid receptor with carcass composition and meat quality traits

26.08.2013 | Henry Reyer, Siriluck Ponsuksili, Klaus Wimmers, Eduard Murani, Animal Genetics, 2013

Summary The glucocorticoid receptor (GR) is a ubiquitously acting transcription factor that is responsible for mediating the physiological response to stress and adaptation to environmental conditions. Genetic variation of a GR gene (NR3C1) may therefore contribute to multiple phenotypic ...


Non-labelled monitoring of targeted liposome interactions with a model receptor surfa effect of flow rate and water content

25.08.2013 | Author(s): Huamin Liang , Jussi-Pekka Tuppurainen , Julia Lehtinen , Tapani Viitala , Marjo Yliperttula, European Journal of Pharmaceutical Science, 2013

Publication date: Available online 24 August 2013 Source:European Journal of Pharmaceutical Sciences Author(s): Huamin Liang , Jussi-Pekka Tuppurainen , Julia Lehtinen , Tapani Viitala , Marjo Yliperttula In this study, we present a novel in vitro approach that utilizes two ...


X-Box Binding Protein 1 (XBP1s) Is a Critical Determinant of Pseudomonas aeruginosa Homoserine Lactone-Mediated Apoptosis

22.08.2013 | Cathleen D. Valentine et al., PLoS Pathogens, 2013

by Cathleen D. Valentine, Marc O. Anderson, Feroz R. Papa, Peter M. Haggie Pseudomonas aeruginosa infections are associated with high mortality rates and occur in diverse conditions including pneumonias, cystic fibrosis and neutropenia. Quorum sensing, mediated by small molecules including ...


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