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The MYB96‐HHP Module Integrates Cold and ABA Signaling to Activate the CBF‐COR Pathway in Arabidopsis

25.04.2015 | Hong Gil Lee, Pil Joon Seo, The Plant Journal, 2015

Summary Various environmental stresses limit plant growth, development and reproductive success. Thus, plants have evolved sophisticated adaptive responses to deal with environmental challenges. Plant responses to environmental stresses are mainly mediated by abscisic acid (ABA)‐dependent and ...


Arabidopsis C3HC4‐RING finger E3 ubiquitin ligase AtAIRP4 positively regulates stress‐responsive abscisic acid signaling

24.04.2015 | Liang Yang, Qiaohong Liu, Zhibin Liu, Hao Yang, Jianmei Wang, Xufeng Li, Yi Yang, Journal of Integrative Plant Biology, 2015

Abstract Degradation of proteins via the ubiquitin system is an important step in many stress signaling pathways in plants. E3 ligases recognize ligand proteins and dictate the high specificity of protein degradation, and thus, play a pivotal role in ubiquitination. Here, we identified a ...


Distinct functions of serial metal binding domains in the Escherichia coli P1B‐ATPase CopA

21.04.2015 | Steffen L. Drees, Dominik F. Beyer, Christina Lomscher, Mathias Lübben, Molecular Microbiology, 2015

Summary P1B‐ATPases are among the most common resistance factors to metal induced stress. Belonging to the superfamily of P‐type ATPases, they are capable of exporting transition metal ions at the expense of ATP hydrolysis. P1B‐ATPases share a conserved structure of three cytoplasmic domains ...


The lactate receptor, G‐protein‐coupled receptor 81/hydroxycarboxylic acid receptor 1: Expression and action in brain

16.04.2015 | Cecilie Morland, Knut Husø Lauritzen, Maja Puchades, Signe Holm‐Hansen, Krister Andersson, Albert Gjedde, Håvard Att ..., Journal of Neuroscience Research, 2015

We have proposed that lactate is a “volume transmitter” in the brain and underpinned this by showing that the lactate receptor, G‐protein‐coupled receptor 81 (GPR81, also known as HCA1 or HCAR1), which promotes lipid storage in adipocytes, is also active in the mammalian brain. This includes the ...


Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake

10.04.2015 | Adam P. Sharples, David C. Hughes, Colleen S. Deane, Amarjit Saini, Colin Selman, Claire E. Stewart, Aging Cell, 2015

Summary Advancing age is associated with a progressive loss of skeletal muscle (SkM) mass and function. Given the worldwide aging demographics, this is a major contributor to morbidity, escalating socio‐economic costs and ultimately mortality. Previously, it has been established that a ...


Long Term Effect of Curcumin in Restoration of Tumour Suppressor p53 and Phase-II Antioxidant Enzymes via Activation of Nrf2 Signalling and Modulation of Inflammation in Prevention of Cancer

10.04.2015 | Laxmidhar Das et al., PLoS ONE, 2015

by Laxmidhar Das, Manjula Vinayak Inhibition of carcinogenesis may be a consequence of attenuation of oxidative stress via activation of antioxidant defence system, restoration and stabilization of tumour suppressor proteins along with modulation of inflammatory mediators. Previously we have ...


Acceleration of Vascular Sprouting from Fabricated Perfusable Vascular-Like Structures

10.04.2015 | Tatsuya Osaki et al., PLoS ONE, 2015

by Tatsuya Osaki, Takahiro Kakegawa, Tatsuto Kageyama, Junko Enomoto, Tadashi Nittami, Junji Fukuda Fabrication of vascular networks is essential for engineering three-dimensional thick tissues and organs in the emerging fields of tissue engineering and regenerative medicine. In this study, we ...


The Varieties of Immunological Experience: Of Pathogens, Stress, and Dendritic Cells

10.04.2015 | Bali Pulendran, Annual Review of Immunology, 2015

In the 40 years since their discovery, dendritic cells (DCs) have been recognized as central players in immune regulation. DCs sense microbial stimuli through pathogen-recognition receptors (PRRs) and decode, integrate, and present information derived from such stimuli to T cells, thus ...


Poly(3,4‐ethylenedioxythiophene) Nanoparticle and Poly(ε‐caprolactone) Electrospun Scaffold Characterization for Skeletal Muscle Regeneration

09.04.2015 | K.D. McKeon‐Fischer, D.P. Browe, R.M. Olabisi, J.W. Freeman, Journal of Biomedical Materials Research Part A, 2015

Abstract Injuries to peripheral nerves and/or skeletal muscle can cause scar tissue formation and loss of function. The focus of this paper is the creation of a conductive, biocompatible scaffold with appropriate mechanical properties to regenerate skeletal muscle. ...


Decimal growth stages for precision wheat production in changing environments?

08.04.2015 | H.M. Barber, J. Carney, F. Alghabari, M.J. Gooding, Annals of Applied Biology, 2015

Abstract The utility of the decimal growth stage (DGS) scoring system for cereals is reviewed. The DGS is the most widely used scale in academic and commercial applications because of its comprehensive coverage of cereal developmental stages, the ease of use and definition provided and ...


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