01.06.2013 | Mélisande Blein-Nicolas; Warren Albertin; Benoît Valot; Philippe Marullo; Delphine Sicard; Christophe Giraud; Sylvie ..., Molecular Biology and Evolution, 2013

Saccharomyces cerevisiae and S. uvarum are two domesticated species of the Saccharomyces sensu stricto clade that diverged around 100 Ma after whole-genome duplication. Both have retained many duplicated genes associated with glucose fermentation and are characterized by the ability to ...

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16.05.2013 | Robert G. Brannan, Andrew S. Myers, Christopher S. Herrick, European Journal of Lipid Science and Technology, 2013

Summary Producers of deep‐fried foods seek new methods to lower the fat content of these foods. The effectiveness of edible films of proteins and carbohydrates and the addition of prefrying dips of egg white lower fat absorption. Common additions of chemicals to films called plasticizers ...

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16.05.2013 | Vincent Vagenende et al., PLoS Computational Biology, 2013

by Vincent Vagenende, Alvin X. Han, Han B. Pek, Bernard L. W. Loo Although the nature of solvent-protein interactions is generally weak and non-specific, addition of cosolvents such as denaturants and osmolytes strengthens protein-protein interactions for some proteins, whereas it weakens ...

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15.05.2013 | Hai Dang Nguyen, Sandra Studenik, Gabriele Diekert, FEMS Microbiology Letters, 2013

Abstract The O‐demethylases of anaerobes are corrinoid‐dependent, ether‐cleaving methyltransferase enzyme systems consisting of four components. The interaction of the O‐demethylase components of the acetogenic bacterium Acetobacterium dehalogenans was studied by protein mobility on ...

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15.05.2013 | Tuan Phan-Xuan; Dominique Durand; Taco Nicolai; Laurence Donato; Christophe Schmitt; Lionel Bovetto, Biomacromolecules, 2013

The effect of the addition of NaCl or CaCl2 on the structure of protein particles and gels was investigated in detail for aqueous solutions of the globular milk protein β-lactoglobulin at 40g/L and pH 7.0. When heated in the presence of NaCl or at very low CaCl2 concentrations, the proteins ...

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15.05.2013 | Yong-Cui Wang; Shi-Long Chen; Nai-Yang Deng; Yong Wang, Bioinformatics, 2013

Motivation: Discovering drug’s Anatomical Therapeutic Chemical (ATC) classification rules at molecular level is of vital importance to understand a vast majority of drugs action. However, few studies attempt to annotate drug’s potential ATC-codes by computational approaches. Results: Here, ...

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15.05.2013 | Jun Fu; Dimpy Koul; Jun Yao; Shuzhen Wang; Ying Yuan; Howard Colman; Erik. P. Sulman; Frederick. F. Lang; W.K. Alfre ..., Cancer Research, 2013

Genetic heterogeneity and signaling alterations diminish the effectiveness of single-agent therapies in glioblastoma multiforme (GBM). HSP90 is a molecular chaperone for several signaling proteins that are deregulated in glioma cells. Thus, HSP90 inhibition may offer an approach to ...

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14.05.2013 | Lyudmila G. Burdelya; Craig M. Brackett; Bojidar Kojouharov; Ilya I. Gitlin; Katerina I. Leonova; Anatoli S. Gleiber ..., Proceedings of the National Academy of Sciences current issue, 2013

Vertebrate Toll-like receptor 5 (TLR5) recognizes bacterial flagellin proteins and activates innate immune responses to motile bacteria. In addition, activation of TLR5 signaling can inhibit growth of TLR5-expressing tumors and protect normal tissues from radiation and ischemia-reperfusion ...

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13.05.2013 | Sunita Sinha, Joshua Mell, Rosemary Redfield, Molecular Microbiology, 2013

Summary Many bacteria are naturally competent, able to bind and take up DNA from their extracellular environment. This DNA can serve as a significant source of nutrients, in addition to providing genetic material for recombination. The regulation of competence in several model organisms ...

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10.05.2013 | Megan S. Kane, Mark E. Lindsay, Daniel P. Judge, Jemima Barrowman, Colette Ap Rhys, Lisa Simonson, Harry C. Dietz, S ..., American Journal of Medical Genetics Part A, 2013

Abstract Hutchinson–Gilford Progeria Syndrome (HGPS) is a premature aging disorder caused by mutations in LMNA, which encodes the nuclear scaffold proteins lamin A and C. In HGPS and related progerias, processing of prelamin A is blocked at a critical step mediated by the zinc ...

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