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2.835 Aktuelle Fachpublikationen zum Thema Addition

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Multiple protein-protein interactions converging on the Prp38 protein during activation of the human spliceosome [ARTICLE]

01.02.2016 | Tonio Schütze; Alexander K.C. Ulrich; Luise Apelt; Cindy L. Will; Natascha Bartlick; Martin Seeger; Gert Weber; Rein ..., RNA, 2016

Spliceosomal Prp38 proteins contain a conserved amino-terminal domain, but only higher eukaryotic orthologs also harbor a carboxy-terminal RS domain, a hallmark of splicing regulatory SR proteins. We show by crystal structure analysis that the amino-terminal domain of human Prp38 is organized ...

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Structure and function of echinoderm telomerase RNA [ARTICLE]

01.02.2016 | Joshua D. Podlevsky; Yang Li; Julian J.-L. Chen, RNA, 2016

Telomerase is a ribonucleoprotein (RNP) enzyme that requires an integral telomerase RNA (TR) subunit, in addition to the catalytic telomerase reverse transcriptase (TERT), for enzymatic function. The secondary structures of TRs from the three major groups of species, ciliates, fungi, and ...

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Disentangling Sources of Selection on Exonic Transcriptional Enhancers

01.02.2016 | Rachel M. Agoglia; Hunter B. Fraser, Molecular Biology and Evolution, 2016

In addition to coding for proteins, exons can also impact transcription by encoding regulatory elements such as enhancers. It has been debated whether such features confer heightened selective constraint, or evolve neutrally. We have addressed this question by developing a new approach to ...

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Controlled transdermal iontophoresis for poly-pharmacotherapy: Simultaneous delivery of granisetron, metoclopramide and dexamethasone sodium phosphate in vitro and in vivo

31.01.2016 | Author(s): Jennyfer Cázares-Delgadillo, Adriana Ganem-Rondero, Virginia Merino, Yogeshvar N. Kalia, European Journal of Pharmaceutical Science, 2016

Publication date: Available online 28 January 2016 Source:European Journal of Pharmaceutical Sciences Author(s): Jennyfer Cázares-Delgadillo, Adriana Ganem-Rondero, Virginia Merino, Yogeshvar N. Kalia Iontophoresis has been used to deliver small molecules, peptides and proteins into ...

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Structural and functional insights into tRNA binding and adenosine N1-methylation by an archaeal Trm10 homologue

29.01.2016 | Bart Van Laer; Martine Roovers; Lina Wauters; Joanna M. Kasprzak; Michal Dyzma; Egon Deyaert; Ranjan Kumar Singh; An ..., Nucleic Acids Research, 2016

Purine nucleosides on position 9 of eukaryal and archaeal tRNAs are frequently modified in vivo by the post-transcriptional addition of a methyl group on their N1 atom. The methyltransferase Trm10 is responsible for this modification in both these domains of life. While certain Trm10 orthologues ...

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Emerging role of long noncoding RNAs as regulators of innate immune cell development and inflammatory gene expression

28.01.2016 | Roland Elling, Jennie Chan, Katherine A. Fitzgerald, European Journal of Immunology, 2016

The innate immune system represents the first line of defense during infection and is initiated by the detection of conserved microbial products by germline‐encoded pattern recognition receptors (PRRs). Sensing through PRRs induces broad transcriptional changes that elicit powerful inflammatory ...

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Borrelia burgdorferi BBK32 Inhibits the Classical Pathway by Blocking Activation of the C1 Complement Complex

25.01.2016 | Brandon L. Garcia et al., PLoS Pathogens, 2016

by Brandon L. Garcia, Hui Zhi, Beau Wager, Magnus Höök, Jon T. Skare Pathogens that traffic in blood, lymphatics, or interstitial fluids must adopt strategies to evade innate immune defenses, notably the complement system. Through recruitment of host regulators of complement to their surface, ...

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ECM-Regulator timp Is Required for Stem Cell Niche Organization and Cyst Production in the Drosophila Ovary

25.01.2016 | John R. Pearson et al., PLoS Genetics, 2016

by John R. Pearson, Federico Zurita, Laura Tomás-Gallardo, Alfonsa Díaz-Torres, María del Carmen Díaz de la Loza, Kristian Franze, María D. Martín-Bermudo, Acaimo González-Reyes The extracellular matrix (ECM) is a pivotal component adult tissues and of many tissue-specific stem cell niches. It ...

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Analysis of dynamic protein carbonylation in rice embryo during germination through AP‐SWATH

23.01.2016 | Hui Zhang, Dongli He, Jianlan Yu, Ming Li, Rebecca Njeri Damaris, Ravi Gupta, Sun Tae Kim, Pingfang Yang, PROTEOMICS, 2016

Seed germination is an important aspect of the plant life cycle, during which, reactive oxygen species (ROS) accumulate. The accumulation of ROS results in an increase in protein oxidation of which carbonylation is the most canonical one. However, there is insufficient information concerning ...

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Overexpression of MdbHLH104 gene enhances the tolerance to iron deficiency in apple

23.01.2016 | Qiang Zhao, Yi‐Ran Ren, Qing‐Jie Wang, Yu‐Xin Yao, Chun‐Xiang You, Yu‐Jin Hao, Plant Biotechnology Journal, 2016

Summary Fe deficiency is a widespread nutritional disorder in plants. The basic helix‐loop‐helix (bHLH) transcription factors (TFs), especially Ib subgroup bHLH TFs which are involved in iron uptake, have been identified. In this study, an IVc subgroup bHLH TF MdbHLH104 was identified and ...

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