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Structural basis for misfolding in myocilin-associated glaucoma

15.04.2015 | Rebecca K. Donegan; Shannon E. Hill; Dana M. Freeman; Elaine Nguyen; Susan D. Orwig; Katherine C. Turnage; Raquel L. ..., Human Molecular Genetics, 2015

Olfactomedin (OLF) domain-containing proteins play roles in fundamental cellular processes and have been implicated in disorders ranging from glaucoma, cancers and inflammatory bowel disorder, to attention deficit disorder and childhood obesity. We solved crystal structures of the OLF domain of ...


Use of precisely sculptured thin film (STF) substrates with generalized ellipsometry to determine spatial distribution of adsorbed fibronectin to nanostructured columnar topographies and effect on cell adhesion

12.04.2015 | Author(s): Tadas Kasputis , Alex Pieper , Keith Brian Rodenhausen , Daniel Schmidt , Derek Sekora , Charles Ri ..., Acta Biomaterialia, 2015

Publication date: May 2015 Source:Acta Biomaterialia, Volume 18 Author(s): Tadas Kasputis , Alex Pieper , Keith Brian Rodenhausen , Daniel Schmidt , Derek Sekora , Charles Rice , Eva Schubert , Mathias Schubert , Angela K. Pannier Sculptured thin film (STF) substrates consist of ...


Looking back and moving forward: Recent advances in understanding of cardiovascular development by imaging of zebrafish

10.04.2015 | Shigetomo Fukuhara, Hajime Fukui, Yuki Wakayama, Koji Ando, Hiroyuki Nakajima, Naoki Mochizuki, Development, Growth & Differentiation, 2015

Development requires cell proliferation, migration, differentiation, apoptosis, and many kinds of cell responses. Cells prepare intracellular conditions to respond to extracellular cues from neighboring cells. We have studied the development of the cardiovascular system (CVS) by visualizing ...


Improving protein production of indigenous microalga Chlorella vulgaris FSP‐E by photobioreactor design and cultivation strategies

10.04.2015 | Chun‐Yen Chen, Po‐Jen Lee, Chung Hong Tan, Yung‐Chung Lo, Chieh‐Chen Huang, Pau Loke Show, Chih‐Hung QueLinntal, Jo‐ ..., Biotechnology Journal, 2015

Abstract Fishmeal is currently the major protein source for commercial aquaculture feed. Due to its unstable supply and increasing price, fishmeal is becoming more expensive and its availability will face significant challenges in the near future. Therefore, finding feasible alternatives to ...


Long Term Effect of Curcumin in Restoration of Tumour Suppressor p53 and Phase-II Antioxidant Enzymes via Activation of Nrf2 Signalling and Modulation of Inflammation in Prevention of Cancer

10.04.2015 | Laxmidhar Das et al., PLoS ONE, 2015

by Laxmidhar Das, Manjula Vinayak Inhibition of carcinogenesis may be a consequence of attenuation of oxidative stress via activation of antioxidant defence system, restoration and stabilization of tumour suppressor proteins along with modulation of inflammatory mediators. Previously we have ...


Targeting NAMPT for therapeutic intervention in cance and inflammation: Structure‐based drug design and biological screening

07.04.2015 | Venkat Koushik Pulla, Dinavahi Saketh Sriram, Vijay Soni, Srikant Viswanadha, Dharmarajan Sriram, Yogeeswari Perumal, Chemical Biology & Drug Design, 2015

Abstract Nicotinamide phosphoribosyltransferase (NAMPT) is a rate limiting enzyme that plays an important role in the synthesis of nicotinamide adenine dinucleotide (NAD) via a salvage pathway. Along with a role in bioenergetics, NAMPT regulates the activity of proteins such as SIRT‐1 that ...


A Nonapoptotic Role for BAX and BAK in Eicosanoid Metabolism

06.04.2015 | Tejia Zhang; Loren D. Walensky; Alan Saghatelian, ACS Chemical Biology, 2015

BCL-2 proteins are key regulators of programmed cell death. The interplay between pro and antiapoptotic BCL-2 members has important roles in many cancers. In addition to their apoptotic function, recent evidence supports key nonapoptotic roles for several BCL-2 proteins. We used an unbiased ...


Characterization and distribution of repetitive elements in association with genes in the human genome

05.04.2015 | Author(s): Kai-Chiang Liang , Joseph T. Tseng , Shaw-Jenq Tsai , H. Sunny Sun, Computational Biology and Chemistry, 2015

Publication date: Available online 27 February 2015 Source:Computational Biology and Chemistry Author(s): Kai-Chiang Liang , Joseph T. Tseng , Shaw-Jenq Tsai , H. Sunny Sun Repetitive elements constitute more than 50% of the human genome. Recent studies implied that the complexity of ...


Small Molecule Inhibitor of Formin Homology 2 Domains (SMIFH2) Reveals the Roles of the Formin Family of Proteins in Spindle Assembly and Asymmetric Division in Mouse Oocytes

02.04.2015 | Hak-Cheol Kim et al., PLoS ONE, 2015

by Hak-Cheol Kim, Yu-Jin Jo, Nam-Hyung Kim, Suk Namgoong Dynamic actin reorganization is the main driving force for spindle migration and asymmetric cell division in mammalian oocytes. It has been reported that various actin nucleators including Formin-2 are involved in the polarization of the ...


A TatABC-Type Tat Translocase Is Required for Unimpaired Aerobic Growth of Corynebacterium glutamicum ATCC13032

02.04.2015 | Dan Oertel et al., PLoS ONE, 2015

by Dan Oertel, Sabrina Schmitz, Roland Freudl The twin-arginine translocation (Tat) system transports folded proteins across the cytoplasmic membrane of bacteria and the thylakoid membrane of plant chloroplasts. Escherichia coli and other Gram-negative bacteria possess a TatABC-type Tat ...


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