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2.391 Aktuelle Fachpublikationen zum Thema Addition

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Single-molecule analysis uncovers the difference between the kinetics of DNA decatenation by bacterial topoisomerases I and III

01.02.2015 | Ksenia Terekhova; John F. Marko; Alfonso Mondragón, Nucleic Acids Research, 2015

Escherichia coli topoisomerases I and III can decatenate double-stranded DNA (dsDNA) molecules containing single-stranded DNA regions or nicks as well as relax negatively supercoiled DNA. Although the proteins share a mechanism of action and have similar structures, they participate in different ...


Tls1 regulates splicing of shelterin components to control telomeric heterochromatin assembly and telomere length

01.02.2015 | Jiyong Wang; Xavier Tadeo; Haitong Hou; Stuart Andrews; James J. Moresco; John R. Yates III; Peter L. Nagy; Songtao Jia, Nucleic Acids Research, 2015

Heterochromatin preferentially forms at repetitive DNA elements through RNAi-mediated targeting of histone-modifying enzymes. It was proposed that splicing factors interact with the RNAi machinery or regulate the splicing of repeat transcripts to directly participate in heterochromatin assembly. ...


Silkworm HP1a transcriptionally enhances highly expressed euchromatic genes via association with their transcription start sites

01.02.2015 | Keisuke Shoji; Kahori Hara; Munetaka Kawamoto; Takashi Kiuchi; Shinpei Kawaoka; Sumio Sugano; Toru Shimada; Yutaka S ..., Nucleic Acids Research, 2015

Heterochromatin protein 1 (HP1) is an evolutionarily conserved protein across different eukaryotic species and is crucial for heterochromatin establishment and maintenance. The silkworm, Bombyx mori, encodes two HP1 proteins, BmHP1a and BmHP1b. In order to investigate the role of BmHP1a in ...


Agarose‐Assisted Micro‐Contact Printing for High‐Quality Biomolecular Micro‐Patterns

03.01.2015 | Min Jee Jang, Yoonkey Nam, Macromolecular Bioscience, 2015

Micro‐contact printing has been developed to print biomolecules, such as cell adhesive molecules, proteins, or DNAs, on a substrate, which can serve as experimental platforms for investigating biological issues and engineering biosensors. Despite the popularity of this method, it has been ...


Characterization of new Myoviridae bacteriophage WZ1 against multi‐drug resistant (MDR) Shigella dysenteriae

02.01.2015 | Muhsin Jamal, Waqas Nasir Chaudhry, Tahir Hussain, Chythanya Rajanna Das, Saadia Andleeb, Journal of Basic Microbiology, 2015

Shigella dysenteriae is a normal inhabitant of the human gastrointestinal tract, but sometimes it causes severe infection known as shigellosis (bacillary dysentery). Bacteriophages are considered very safe and effective agents for controlling bacterial infections and contaminations. In this ...


Prediction of Indel flanking regions in protein sequences using a variable-order Markov model

01.01.2015 | Mufleh Al-Shatnawi; M. Omair Ahmad; M.N.S. Swamy, Bioinformatics, 2015

Motivation: Insertion/deletion (indel) and amino acid substitution are two common events that lead to the evolution of and variations in protein sequences. Further, many of the human diseases and functional divergence between homologous proteins are more related to indel mutations, even though ...


Formation of a Protein Corona on Silver Nanoparticles Mediates Cellular Toxicity via Scavenger Receptors

01.01.2015 | Jonathan H. Shannahan; Ramakrishna Podila; Abdullah A. Aldossari; Hilary Emerson; Brian A. Powell; Pu Chun Ke; Appar ..., Toxicological Sciences, 2015

Addition of a protein corona (PC) or protein adsorption layer on the surface of nanomaterials following their introduction into physiological environments may modify their activity, bio-distribution, cellular uptake, clearance, and toxicity. We hypothesize that silver nanoparticles (AgNPs) will ...


Schisandrol B Protects Against Acetaminophen-Induced Hepatotoxicity by Inhibition of CYP-Mediated Bioactivation and Regulation of Liver Regeneration

01.01.2015 | Yiming Jiang; Xiaomei Fan; Ying Wang; Pan Chen; Hang Zeng; Huasen Tan; Frank J. Gonzalez; Min Huang; Huichang Bi, Toxicological Sciences, 2015

Acetaminophen (APAP) overdose is the most frequent cause of drug-induced acute liver failure. Schisandra sphenanthera is a traditional hepato-protective Chinese medicine and Schisandrol B (SolB) is one of its major active constituents. In this study, the protective effect of SolB against ...


G protein-coupled receptors: bridging the gap from the extracellular signals to the Hippo pathway

01.01.2015 | Xin Zhou; Zhen Wang; Wei Huang; Qun-Ying Lei, Acta Biochimica et Biophysica Sinica, 2015

The Hippo pathway is crucial in organ size control, whereas its dysregulation contributes to organ degeneration or tumorigenesis. The kinase cascade of MST1/2 and LATS1/2 and the coupling transcription co-activators YAP/TAZ represent the core components of the Hippo pathway. Extensive studies ...


Structural basis of HIV-1 capsid recognition by PF74 and CPSF6 [Biophysics and Computational Biology]

30.12.2014 | Akash Bhattacharya; Steven L. Alam; Thomas Fricke; Kaneil Zadrozny; Jaroslaw Sedzicki; Alexander B. Taylor; Borries ..., Proceedings of the National Academy of Sciences current issue, 2014

Upon infection of susceptible cells by HIV-1, the conical capsid formed by ∼250 hexamers and 12 pentamers of the CA protein is delivered to the cytoplasm. The capsid shields the RNA genome and proteins required for reverse transcription. In addition, the surface of the capsid mediates numerous ...


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