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Designing a fibrotic microenvironment to investigate changes in human liver sinusoidal endothelial cell function

23.08.2015 | Author(s): Andrew J. Ford, Gaurav Jain, Padmavathy Rajagopalan, Acta Biomaterialia, 2015

Publication date: 15 September 2015 Source:Acta Biomaterialia, Volume 24 Author(s): Andrew J. Ford, Gaurav Jain, Padmavathy Rajagopalan The deposition of extracellular matrix (ECM) proteins by hepatic cells during fibrosis leads to the stiffening of the organ and perturbed cellular ...


Ablation of the 14‐3‐3gamma Protein Results in Neuronal Migration Delay and Morphological Defects in the Developing Cerebral Cortex

23.08.2015 | Tomoka Wachi, Brett Cornell, Courtney Marshall, Vladimir Zhukarev, Peter W. Baas, Kazuhito Toyo‐oka, Developmental Neurobiology, 2015

ABSTRACT 14‐3‐3 proteins are ubiquitously‐expressed and multifunctional proteins. There are seven isoforms in mammals with a high level of homology, suggesting potential functional redundancy. We previously found that two of seven isoforms, 14‐3‐3epsilon and 14‐3‐3zeta, are important for brain ...


Biomimetic repeat protein derived from Xenopus tropicalis for fibrous scaffold fabrication

22.08.2015 | Yunkyeoung Kwon, Yun Jung Yang, Dooyup Jung, Byeong Hee Hwang, Hyung Joon Cha, Biopolymers, 2015

ABSTRACT Collagen, silk, and elastin are the fibrous proteins consist of representative amino acid repeats. Because these proteins exhibited distinguishing mechanical properties, they have been utilized in diverse applications, such as fiber‐based sensors, filtration membranes, supporting ...


Role of 100S ribosomes in bacterial decay period

20.08.2015 | Ksenia Shcherbakova, Hideki Nakayama, Nobuo Shimamoto, Genes to Cells, 2015

Ribosomal proteins S10 and S2 were each fused with GFP to track the fates of these proteins in the stationary growth phase and the following decay period in Escherichia coli. The fused proteins localized mainly in the cytoplasm, and their amounts were proportional to the colony‐forming unit. ...


MicroRNA‐Based Therapeutic Strategies for Targeting Mutant and Wild Type RAS in Cancer

18.08.2015 | Sriganesh B. Sharma, John Michael Ruppert, Drug Development Research, 2015

ABSTRACT MicroRNAs (miRs) have been causally implicated in the progression and development of a wide variety of cancers. miRs modulate the activity of key cell signaling networks by regulating the translation of pathway component proteins. Thus, the pharmacological targeting of ...


Structures of the T. brucei kRNA editing factor MRB1590 reveal unique RNA-binding pore motif contained within an ABC-ATPase fold

18.08.2015 | Porsha L. R. Shaw; Natalie M. McAdams; Michael A. Hast; Michelle L. Ammerman; Laurie K. Read; Maria A. Schumacher, Nucleic Acids Research, 2015

Kinetoplastid RNA (kRNA) editing is a process that creates translatable mitochondrial mRNA transcripts from cryptogene encoded RNAs and is unique for kinetoplastids, such as Trypanosoma brucei. In addition to the catalytic 20S editosome, multiple accessory proteins are required for this ...


Curation of the Mammalian Palmitoylome Indicates a Pivotal Role for Palmitoylation in Diseases and Disorders of the Nervous System and Cancers

14.08.2015 | Shaun S. Sanders et al., PLoS Computational Biology, 2015

by Shaun S. Sanders, Dale D. O. Martin, Stefanie L. Butland, Mathieu Lavallée-Adam, Diego Calzolari, Chris Kay, John R. Yates, Michael R. Hayden Palmitoylation involves the reversible posttranslational addition of palmitate to cysteines and promotes membrane binding and subcellular ...


Glycoforms of Immunoglobulin G Based Biopharmaceuticals Are Differentially Cleaved by Trypsin Due to the Glycoform Influence on Higher-Order Structure

14.08.2015 | David Falck; Bas C. Jansen; Rosina Plomp; Dietmar Reusch; Markus Haberger; Manfred Wuhrer, Journal of Proteome Research, 2015

It has been reported that glycosylation can influence the proteolytic cleavage of proteins. A thorough investigation of this phenomenon was conducted for the serine protease trypsin, which is essential in many proteomics workflows. Monoclonal and polyclonal immunoglobulin G biopharmaceuticals ...


Neural crest specification by prohibitin1 depends on transcriptional regulation of prl3 and vangl1

11.08.2015 | Christina Deichmann, Martina Link, Melanie Seyfang, Viktoria Knotz, Dietmar Gradl, Doris Wedlich, genesis, 2015

Abstract A complex network of transcription factors regulates specification of neural crest cells at early neurula stage by stabilizing neural crest identity and activating neural crest effector genes so that distinct subpopulations evolve. In this network c‐myc acts on top of the gene ...


Enhanced plasmid DNA utilization in transiently transfected CHO‐DG44 cells in the presence of polar solvents

11.08.2015 | Yashas Rajendra, Sowmya Balasubramanian, Divor Kiseljak, Lucia Baldi, David L. Hacker, Florian M. Wurm, Biotechnology Progress, 2015

Abstract Although the protein yields from transient gene expression (TGE) with Chinese hamster ovary (CHO) cells have recently improved, the amount of plasmid DNA (pDNA) needed for transfection remains relatively high. We describe a strategy to reduce the pDNA amount by transfecting CHO‐DG44 ...


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