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2.307 Aktuelle Fachpublikationen zum Thema Addition

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Single-molecule analysis uncovers the difference between the kinetics of DNA decatenation by bacterial topoisomerases I and III

01.02.2015 | Ksenia Terekhova; John F. Marko; Alfonso Mondragón, Nucleic Acids Research, 2015

Escherichia coli topoisomerases I and III can decatenate double-stranded DNA (dsDNA) molecules containing single-stranded DNA regions or nicks as well as relax negatively supercoiled DNA. Although the proteins share a mechanism of action and have similar structures, they participate in different ...

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Tls1 regulates splicing of shelterin components to control telomeric heterochromatin assembly and telomere length

01.02.2015 | Jiyong Wang; Xavier Tadeo; Haitong Hou; Stuart Andrews; James J. Moresco; John R. Yates III; Peter L. Nagy; Songtao Jia, Nucleic Acids Research, 2015

Heterochromatin preferentially forms at repetitive DNA elements through RNAi-mediated targeting of histone-modifying enzymes. It was proposed that splicing factors interact with the RNAi machinery or regulate the splicing of repeat transcripts to directly participate in heterochromatin assembly. ...

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Silkworm HP1a transcriptionally enhances highly expressed euchromatic genes via association with their transcription start sites

01.02.2015 | Keisuke Shoji; Kahori Hara; Munetaka Kawamoto; Takashi Kiuchi; Shinpei Kawaoka; Sumio Sugano; Toru Shimada; Yutaka S ..., Nucleic Acids Research, 2015

Heterochromatin protein 1 (HP1) is an evolutionarily conserved protein across different eukaryotic species and is crucial for heterochromatin establishment and maintenance. The silkworm, Bombyx mori, encodes two HP1 proteins, BmHP1a and BmHP1b. In order to investigate the role of BmHP1a in ...

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Translational stalling at polyproline stretches is modulated by the sequence context upstream of the stall site

01.12.2014 | Agata L. Starosta; Jürgen Lassak; Lauri Peil; Gemma C. Atkinson; Kai Virumäe; Tanel Tenson; Jaanus Remme; Kirsten Ju ..., Nucleic Acids Research, 2014

The polymerization of amino acids into proteins occurs on ribosomes, with the rate influenced by the amino acids being polymerized. The imino acid proline is a poor donor and acceptor for peptide-bond formation, such that translational stalling occurs when three or more consecutive prolines (PPP) ...

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Dual roles of c-Myc in the regulation of hTERT gene

01.12.2014 | Yuanjun Zhao; De Cheng; Shuwen Wang; Jiyue Zhu, Nucleic Acids Research, 2014

Human telomerase gene hTERT is important for cancer and aging. hTERT promoter is regulated by multiple transcription factors (TFs) and its activity is dependent on the chromatin environment. However, it remains unsolved how the interplay between TFs and chromatin environment controls hTERT ...

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Architectural proteins CTCF and cohesin have distinct roles in modulating the higher order structure and expression of the CFTR locus

01.11.2014 | Nehal Gosalia; Daniel Neems; Jenny L. Kerschner; Steven T. Kosak; Ann Harris, Nucleic Acids Research, 2014

Higher order chromatin structures across the genome are maintained in part by the architectural proteins CCCTC binding factor (CTCF) and the cohesin complex, which co-localize at many sites across the genome. Here, we examine the role of these proteins in mediating chromatin structure at the ...

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The DEAD-box helicase Ded1 from yeast is an mRNP cap-associated protein that shuttles between the cytoplasm and nucleus

01.11.2014 | Meriem Senissar; Agnès Le Saux; Naïma Belgareh-Touzé; Céline Adam; Josette Banroques; N. Kyle Tanner, Nucleic Acids Research, 2014

The DEAD-box helicase Ded1 is an essential yeast protein that is closely related to mammalian DDX3 and to other DEAD-box proteins involved in developmental and cell cycle regulation. Ded1 is considered to be a translation-initiation factor that helps the 40S ribosome scan the mRNA from the 5' ...

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Inhibition of protein translation by the DISC1-Boymaw fusion gene from a Scottish family with major psychiatric disorders

01.11.2014 | Baohu Ji; Kerin K. Higa; Minjung Kim; Lynn Zhou; Jared W. Young; Mark A. Geyer; Xianjin Zhou, Human Molecular Genetics, 2014

The t(1; 11) translocation appears to be the causal genetic lesion with 70% penetrance for schizophrenia, major depression and other psychiatric disorders in a Scottish family. Molecular studies identified the disruption of the disrupted-in-schizophrenia 1 (DISC1) gene by chromosome translocation ...

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Vitellogenin RNAi Halts Ovarian Growth and Diverts Reproductive Proteins and Lipids in Young Grasshoppers

01.11.2014 | Derek R. Tokar; Katherine A. Veleta; Joseph Canzano; Daniel A. Hahn; John D. Hatle, Integrative and Comparative Biology, 2014

Reduced reproduction extends lifespan of females in many animals. To test the effects of reproduction on storage of macronutrients, we block reproductive output in the lubber grasshopper by injecting RNAi against the precursor to egg-yolk protein, vitellogenin, in early adulthood. Controls were ...

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Tools for Monitoring Systems Suitability in LC MS/MS Centric Proteomic Experiments

18.10.2014 | Michael S. Bereman, PROTEOMICS, 2014

With advances in LC MS/MS technologies combined with the continued goals of biomarker discovery, clinical applications of established biomarkers, and integrating large multi‐omic datasets (i.e., “big data”), there remains an urgent need for robust tools to assess instrument performance (i.e., ...

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