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2.372 Aktuelle Fachpublikationen zum Thema Addition

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Single-molecule analysis uncovers the difference between the kinetics of DNA decatenation by bacterial topoisomerases I and III

01.02.2015 | Ksenia Terekhova; John F. Marko; Alfonso Mondragón, Nucleic Acids Research, 2015

Escherichia coli topoisomerases I and III can decatenate double-stranded DNA (dsDNA) molecules containing single-stranded DNA regions or nicks as well as relax negatively supercoiled DNA. Although the proteins share a mechanism of action and have similar structures, they participate in different ...


Tls1 regulates splicing of shelterin components to control telomeric heterochromatin assembly and telomere length

01.02.2015 | Jiyong Wang; Xavier Tadeo; Haitong Hou; Stuart Andrews; James J. Moresco; John R. Yates III; Peter L. Nagy; Songtao Jia, Nucleic Acids Research, 2015

Heterochromatin preferentially forms at repetitive DNA elements through RNAi-mediated targeting of histone-modifying enzymes. It was proposed that splicing factors interact with the RNAi machinery or regulate the splicing of repeat transcripts to directly participate in heterochromatin assembly. ...


Silkworm HP1a transcriptionally enhances highly expressed euchromatic genes via association with their transcription start sites

01.02.2015 | Keisuke Shoji; Kahori Hara; Munetaka Kawamoto; Takashi Kiuchi; Shinpei Kawaoka; Sumio Sugano; Toru Shimada; Yutaka S ..., Nucleic Acids Research, 2015

Heterochromatin protein 1 (HP1) is an evolutionarily conserved protein across different eukaryotic species and is crucial for heterochromatin establishment and maintenance. The silkworm, Bombyx mori, encodes two HP1 proteins, BmHP1a and BmHP1b. In order to investigate the role of BmHP1a in ...


Effect of protease inhibitors on pulmonary bioavailability of therapeutic proteins and peptides in the rat

14.12.2014 | Author(s): Kiran Prakash Amancha , Alamdar Hussain, European Journal of Pharmaceutical Science, 2014

Publication date: 20 February 2015 Source:European Journal of Pharmaceutical Sciences, Volume 68 Author(s): Kiran Prakash Amancha , Alamdar Hussain The objective of the present study was to evaluate the effect of protease inhibitors on the pulmonary absorption of therapeutic peptides and ...


Exploring analytical proteomics platforms towards the definition of human cardiac stem cells receptome

12.12.2014 | Patrícia Gomes‐Alves, Margarida Serra, Catarina Brito, Luis R‐Borlado, Juan A. López, Jesús Vázquez, Manuel J.T. Car ..., PROTEOMICS, 2014

Human cardiac stem cells (hCSC) express a portfolio of plasma membrane receptors that are involved in the regulatory auto/paracrine feedback loop mechanism of activation of these cells, and consequently contribute to myocardial regeneration. In order to attain a comprehensive description of hCSC ...


A high cell density transient transfection system for therapeutic protein expression based on a CHO GS‐knockout cell line: process development and product quality assessment

12.12.2014 | Yashas Rajendra, Maria Hougland, Riazul Alam, Teresa Morehead, Gavin Barnard, Biotechnology and Bioengineering, 2014

Abstract Transient gene expression (TGE) is a rapid method for the production of recombinant proteins in mammalian cells. While the volumetric productivity of TGE has improved significantly over the past decade, most methods involve extensive cell line engineering and plasmid vector ...


The biotechnological potential of subtilisin‐like fibrinolytic enzyme from a newly isolated Lactobacillus plantarum KSK‐II in blood destaining and antimicrobials

12.12.2014 | Essam Kotb, Biotechnology Progress, 2014

Abstract An antimicrobial oxidative‐ and SDS‐stable fibrinolytic alkaline protease designated as KSK‐II was produced by L. plantarum KSK‐II isolated from kishk, a traditional Egyptian food. Maximum enzyme productivity was obtained in medium containing 1% lactose and 0.5% soybean flour as ...


Trifluoroethanol‐containing RP‐HPLC mobile phases for the separation of transmembrane peptides human glycophorin‐A, integrin alpha‐1, and p24: analysis and prevention of potential side reactions due to formic acid

12.12.2014 | Toshiaki Hara, Yue Huang, Akihiro Ito, Toru Kawakami, Hironobu Hojo, Michio Murata, Journal of Peptide Science, 2014

Reversed‐phase high‐pressure liquid chromatography analysis and purification of three hydrophobic, aggregation‐prone peptides, composed mainly of the transmembrane (TM) sequence, were performed using elution systems containing 2,2,2‐trifluoroethanol (TFE). The addition of 10–16% TFE to a common ...


Binding of Human Proteins to Amyloid-β Protofibrils

12.12.2014 | M. Mahafuzur Rahman; Henrik Zetterberg; Christofer Lendel; Torleif Härd, ACS Chemical Biology, 2014

The progressive neurodegeneration in Alzheimer’s disease is believed to be linked to the presence of prefibrillar aggregates of the amyloid-β (Aβ) peptide in the brain. The exact role of these aggregates in the disease pathology is, however, still an open question. Any mechanism by which ...


Upward organelle motility

11.12.2014 | Tobias I. Baskin, Journal of Integrative Plant Biology, 2014

Abstract Eukaryotic cells contain a collection of membrane‐bounded organelles, in addition to the nucleus, supporting the large size and diverse activities of this type of cell. Evolving with these compartments are filaments and enzymes that convert chemical energy into work (so‐called motor ...


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