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2.400 Aktuelle Fachpublikationen zum Thema Addition

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Arginine methylation and citrullination of splicing factor proline- and glutamine-rich (SFPQ/PSF) regulates its association with mRNA [ARTICLES]

01.03.2015 | Ambrosius P. Snijders; Guillaume M. Hautbergue; Alex Bloom; James C. Williamson; Thomas C. Minshull; Helen L. Philli ..., RNA, 2015

Splicing factor proline- and glutamine-rich (SFPQ) also commonly known as polypyrimidine tract-binding protein-associated-splicing factor (PSF) and its binding partner non-POU domain-containing octamer-binding protein (NONO/p54nrb), are highly abundant, multifunctional nuclear proteins. However, ...

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atBRX1-1 and atBRX1-2 are involved in an alternative rRNA processing pathway in Arabidopsis thaliana [ARTICLES]

01.03.2015 | Benjamin L. Weis; Denise Palm; Sandra Missbach; Markus T. Bohnsack; Enrico Schleiff, RNA, 2015

Ribosome biogenesis is an essential process in all organisms. In eukaryotes, multiple ribosome biogenesis factors (RBFs) act in the processing of ribosomal (r)RNAs, assembly of ribosomal subunits and their export to the cytoplasm. We characterized two genes in Arabidopsis thaliana coding for ...

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A founder CEP120 mutation in Jeune asphyxiating thoracic dystrophy expands the role of centriolar proteins in skeletal ciliopathies

01.03.2015 | Ranad Shaheen; Miriam Schmidts; Eissa Faqeih; Amal Hashem; Ekkehart Lausch; Isabel Holder; Andrea Superti-Furga; UK1 ..., Human Molecular Genetics, 2015

Jeune asphyxiating thoracic dystrophy (JATD) is a skeletal dysplasia characterized by a small thoracic cage and a range of skeletal and extra-skeletal anomalies. JATD is genetically heterogeneous with at least nine genes identified, all encoding ciliary proteins, hence the classification of JATD ...

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Regulators of Autophagosome Formation in Drosophila Muscles

18.02.2015 | Jonathan Zirin et al., PLoS Genetics, 2015

by Jonathan Zirin, Joppe Nieuwenhuis, Anastasia Samsonova, Rong Tao, Norbert Perrimon Given the diversity of autophagy targets and regulation, it is important to characterize autophagy in various cell types and conditions. We used a primary myocyte cell culture system to assay the role of ...

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Hibiscus sabdariffa Leaf Polyphenolic Extract Induces Human Melanoma Cell Death, Apoptosis, and Autophagy

17.02.2015 | Chun‐Tang Chiu, Shu‐Wen Hsuan, Hui‐Hsuan Lin, Cheng‐Chin Hsu, Fen‐Pi Chou, Jing‐Hsien Chen, Journal of Food Science, 2015

Abstract Melanoma is the least common but most fatal form of skin cancer. Previous studies have indicated that an aqueous extract of Hibiscus sabdariffa leaves possess hypoglycemic, hypolipidemic, and antioxidant effects. In this study, we want to investigate the anticancer activity of ...

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FuncPatch: a web server for the fast Bayesian inference of conserved functional patches in protein 3D structures

15.02.2015 | Yi-Fei Huang; G. Brian Golding, Bioinformatics, 2015

Motivation: A number of statistical phylogenetic methods have been developed to infer conserved functional sites or regions in proteins. Many methods, e.g. Rate4Site, apply the standard phylogenetic models to infer site-specific substitution rates and totally ignore the spatial correlation of ...

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Inhibition of Autophagy Suppresses Sertraline-Mediated Primary Ciliogenesis in Retinal Pigment Epithelium Cells

11.02.2015 | Eun Sung Kim et al., PLoS ONE, 2015

by Eun Sung Kim, Ji Hyun Shin, So Jung Park, Yoon Kyung Jo, Jae-Sung Kim, Il-Hwan Kang, Jung-Bum Nam, Doo-Young Chung, Yoonchul Cho, EunJoo H. Lee, Jong Wook Chang, Dong-Hyung Cho Primary cilia are conserved cellular organelles that regulate diverse signaling pathways. Autophagy is a complex ...

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ABCE1 Is a Highly Conserved RNA Silencing Suppressor

06.02.2015 | Kairi Kärblane et al., PLoS ONE, 2015

by Kairi Kärblane, Jelena Gerassimenko, Lenne Nigul, Alla Piirsoo, Agata Smialowska, Kadri Vinkel, Per Kylsten, Karl Ekwall, Peter Swoboda, Erkki Truve, Cecilia Sarmiento ATP-binding cassette sub-family E member 1 (ABCE1) is a highly conserved protein among eukaryotes and archaea. Recent ...

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Single-molecule analysis uncovers the difference between the kinetics of DNA decatenation by bacterial topoisomerases I and III

01.02.2015 | Ksenia Terekhova; John F. Marko; Alfonso Mondragón, Nucleic Acids Research, 2015

Escherichia coli topoisomerases I and III can decatenate double-stranded DNA (dsDNA) molecules containing single-stranded DNA regions or nicks as well as relax negatively supercoiled DNA. Although the proteins share a mechanism of action and have similar structures, they participate in different ...

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Tls1 regulates splicing of shelterin components to control telomeric heterochromatin assembly and telomere length

01.02.2015 | Jiyong Wang; Xavier Tadeo; Haitong Hou; Stuart Andrews; James J. Moresco; John R. Yates III; Peter L. Nagy; Songtao Jia, Nucleic Acids Research, 2015

Heterochromatin preferentially forms at repetitive DNA elements through RNAi-mediated targeting of histone-modifying enzymes. It was proposed that splicing factors interact with the RNAi machinery or regulate the splicing of repeat transcripts to directly participate in heterochromatin assembly. ...

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