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2.342 Aktuelle Fachpublikationen zum Thema Addition

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Single-molecule analysis uncovers the difference between the kinetics of DNA decatenation by bacterial topoisomerases I and III

01.02.2015 | Ksenia Terekhova; John F. Marko; Alfonso Mondragón, Nucleic Acids Research, 2015

Escherichia coli topoisomerases I and III can decatenate double-stranded DNA (dsDNA) molecules containing single-stranded DNA regions or nicks as well as relax negatively supercoiled DNA. Although the proteins share a mechanism of action and have similar structures, they participate in different ...


Tls1 regulates splicing of shelterin components to control telomeric heterochromatin assembly and telomere length

01.02.2015 | Jiyong Wang; Xavier Tadeo; Haitong Hou; Stuart Andrews; James J. Moresco; John R. Yates III; Peter L. Nagy; Songtao Jia, Nucleic Acids Research, 2015

Heterochromatin preferentially forms at repetitive DNA elements through RNAi-mediated targeting of histone-modifying enzymes. It was proposed that splicing factors interact with the RNAi machinery or regulate the splicing of repeat transcripts to directly participate in heterochromatin assembly. ...


Silkworm HP1a transcriptionally enhances highly expressed euchromatic genes via association with their transcription start sites

01.02.2015 | Keisuke Shoji; Kahori Hara; Munetaka Kawamoto; Takashi Kiuchi; Shinpei Kawaoka; Sumio Sugano; Toru Shimada; Yutaka S ..., Nucleic Acids Research, 2015

Heterochromatin protein 1 (HP1) is an evolutionarily conserved protein across different eukaryotic species and is crucial for heterochromatin establishment and maintenance. The silkworm, Bombyx mori, encodes two HP1 proteins, BmHP1a and BmHP1b. In order to investigate the role of BmHP1a in ...


Translational stalling at polyproline stretches is modulated by the sequence context upstream of the stall site

01.12.2014 | Agata L. Starosta; Jürgen Lassak; Lauri Peil; Gemma C. Atkinson; Kai Virumäe; Tanel Tenson; Jaanus Remme; Kirsten Ju ..., Nucleic Acids Research, 2014

The polymerization of amino acids into proteins occurs on ribosomes, with the rate influenced by the amino acids being polymerized. The imino acid proline is a poor donor and acceptor for peptide-bond formation, such that translational stalling occurs when three or more consecutive prolines (PPP) ...


Dual roles of c-Myc in the regulation of hTERT gene

01.12.2014 | Yuanjun Zhao; De Cheng; Shuwen Wang; Jiyue Zhu, Nucleic Acids Research, 2014

Human telomerase gene hTERT is important for cancer and aging. hTERT promoter is regulated by multiple transcription factors (TFs) and its activity is dependent on the chromatin environment. However, it remains unsolved how the interplay between TFs and chromatin environment controls hTERT ...


Mucin-type O-glycosylation is critical for vascular integrity

01.12.2014 | Brett H Herzog; Jianxin Fu; Lijun Xia, Glycobiology , 2014

Vascular endothelial cells, in addition to many other mammalian cell types, express proteins that are highly modified with mucin-type O-glycosylation, a specific type of glycosylation that begins with the addition of an N-acetylgalactosamine moiety to serine or threonine residues within the ...


Regulatory role of glycans in the control of hypoxia-driven angiogenesis and sensitivity to anti-angiogenic treatment

01.12.2014 | Diego O Croci; Juan P Cerliani; Nicolas A Pinto; Luciano G Morosi; Gabriel A Rabinovich, Glycobiology , 2014

Abnormal glycosylation is a typical hallmark of the transition from healthy to neoplastic tissues. Although the importance of glycans and glycan-binding proteins in cancer-related processes such as tumor cell adhesion, migration, metastasis and immune escape has been largely appreciated, our ...


Early miR-155 upregulation contributes to neuroinflammation in Alzheimer's disease triple transgenic mouse model

01.12.2014 | Joana R. Guedes; Carlos M. Custódia; Ricardo J. Silva; Luís P. de Almeida; Maria C. Pedroso de Lima; Ana L. Cardoso, Human Molecular Genetics, 2014

MicroRNAs (miRNAs) have emerged as a class of small, endogenous, regulatory RNAs that exhibit the ability to epigenetically modulate the translation of mRNAs into proteins. This feature enables them to control cell phenotypes and, consequently, modify cell function in a disease context. The role ...


Exercise training protects against atherosclerotic risk factors through vascular NADPH oxidase, ERK1/2 and SAPK/JNK down‐regulation in obese rats

15.11.2014 | Sabeur Touati, Augusto C.I. Montezano, Fayçal Meziri, Catherine Riva, Rhian M. Touyz, Pascal Laurant, Clinical and Experimental Pharmacology and Physiology, 2014

Abstract Exercise training reverses atherosclerotic risk factors associated with metabolic syndrome and obesity. The objective is to determine the molecular anti‐inflammatory, anti‐oxidative and anti‐atherogenic aspects in aorta from rats with high‐fat diet‐induced obesity. Male Sprague‐Dawley ...


A systems biology strategy to identify molecular mechanisms of action and protein indicators of traumatic brain injury

15.11.2014 | Chenggang Yu, Angela Boutté, Xueping Yu, Bhaskar Dutta, Jacob D. Feala, Kara Schmid, Jitendra Dave, Gregory J. Tawa, ..., Journal of Neuroscience Research, 2014

The multifactorial nature of traumatic brain injury (TBI), especially the complex secondary tissue injury involving intertwined networks of molecular pathways that mediate cellular behavior, has confounded attempts to elucidate the pathology underlying the progression of TBI. Here, systems ...


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