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Enrichment of processed pseudogene transcripts in L1-ribonucleoprotein particles

15.09.2013 | Prabhat K. Mandal; Adam D. Ewing; Dustin C. Hancks; Haig H. Kazazian, Jr, Human Molecular Genetics, 2013

Long INterspersed Elements (LINE-1s, L1s) are responsible for over one million retrotransposon insertions and 8000 processed pseudogenes (PPs) in the human genome. An active L1 encodes two proteins (ORF1p and ORF2p) that bind with L1 RNA and form L1-ribonucleoprotein particles (RNPs). Although it ...


Proteomic characterization of the acid tolerance response in Lactobacillus delbrueckii subsp. bulgaricus CAUH1 and functional identification of a novel acid stress‐related transcriptional regulator Ldb0677

13.09.2013 | Zhengyuan Zhai, François P. Douillard, Haoran An, Guohong Wang, Xinghua Guo, Yunbo Luo, Yanling Hao, Environmental Microbiology, 2013

Summary To overcome the deleterious effects of acid stress, L. bulgaricus elicits an adaptive response to acid stress. In this study, proteomics approach complemented by transcriptional analysis revealed some cellular changes in L. bulgaricus CAUH1 during acid adaptation. We observed an ...


In Silico Approach for Predicting Toxicity of Peptides and Proteins

13.09.2013 | Sudheer Gupta et al., PLoS ONE, 2013

by Sudheer Gupta, Pallavi Kapoor, Kumardeep Chaudhary, Ankur Gautam, Rahul Kumar, Open Source Drug Discovery Consortium , Gajendra P. S. Raghava Background Over the past few decades, scientific research has been focused on developing peptide/protein-based therapies to treat various diseases. ...


Molecular farming in tobacco hairy roots by triggering the secretion of a pharmaceutical antibody

12.09.2013 | Suvi T. Häkkinen, Nicole Raven, Maurice Henquet, Marja‐Leena Laukkanen, Tibor Anderlei, Juha‐Pekka Pitkänen, Richard ..., Biotechnology and Bioengineering, 2013

Abstract Recombinant pharmaceutical proteins expressed in hairy root cultures can be secreted into the medium to improve product homogeneity and to facilitate purification, although this may result in significant degradation if the protein is inherently unstable or particularly susceptible to ...


Modulation of Global Low-Frequency Motions Underlies Allosteric Regulation: Demonstration in CRP/FNR Family Transcription Factors

10.09.2013 | Thomas L. Rodgers et al., PLoS Biology, 2013

by Thomas L. Rodgers, Philip D. Townsend, David Burnell, Matthew L. Jones, Shane A. Richards, Tom C. B. McLeish, Ehmke Pohl, Mark R. Wilson, Martin J. Cann Allostery is a fundamental process by which ligand binding to a protein alters its activity at a distinct site. There is growing evidence ...


Altered White Adipose Tissue Protein Profile in C57BL/6J Mice Displaying Delipidative, Inflammatory, and Browning Characteristics after Bitter Melon Seed Oil Treatment

06.09.2013 | Cheng-Hsien Hsieh et al., PLoS ONE, 2013

by Cheng-Hsien Hsieh, Gou-Chun Chen, Pei-Hsuan Chen, Ting-Feng Wu, Pei-Min Chao Objective We have previously shown that bitter melon seed oil (BMSO), which is rich in cis-9, trans-11, trans-13 conjugated linolenic acid, is more potent than soybean oil in attenuating body fat deposition in ...


Effects of butyltins on mitogen‐activated‐protein kinase kinase kinase and Ras activity in human natural killer cells

05.09.2013 | Lindsay J. Celada, Margaret M. Whalen, Journal of Applied Toxicology, 2013

ABSTRACT Butyltins (BTs) contaminate the environment and are found in human blood. BTs, tributyltin (TBT) and dibutyltin (DBT) diminish the cytotoxic function and levels of key proteins of human natural killer (NK) cells. NK cells are an initial immune defense against tumors, virally infected ...


Type I-E CRISPR-Cas Systems Discriminate Target from Non-Target DNA through Base Pairing-Independent PAM Recognition

05.09.2013 | Edze R. Westra et al., PLoS Genetics, 2013

by Edze R. Westra, Ekaterina Semenova, Kirill A. Datsenko, Ryan N. Jackson, Blake Wiedenheft, Konstantin Severinov, Stan J. J. Brouns Discriminating self and non-self is a universal requirement of immune systems. Adaptive immune systems in prokaryotes are centered around repetitive loci called ...


Ribose‐Induced Maillard Reaction as a Quality Index in Frozen Minced Chicken and Pork Meats

03.09.2013 | Thuan‐Chew Tan, Abbas F.M. Alkarkhi, Azhar Mat Easa, Journal of Food Quality, 2013

Abstract Minced meats underwent denaturation, oxidation and aggregation during frozen storage, causing decrease in denaturation enthalpy, sulfhydryl contents and protein solubility, as well as increase in protein carbonyl and disulfide contents. These changes were more evident in samples ...


Mass Spectrometric Identification of Glycosylphosphatidylinositol-Anchored Peptides

03.09.2013 | Yusuke Masuishi; Ayako Nomura; Akiko Okayama; Yayoi Kimura; Noriaki Arakawa; Hisashi Hirano, Journal of Proteome Research, 2013

Glycosylphosphatidylinositol (GPI) anchoring is a post-translational modification widely observed among eukaryotic membrane proteins. GPI anchors are attached to proteins via the carboxy-terminus in the outer leaflet of the cell membrane, where GPI-anchored proteins (GPI-APs) perform important ...


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