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A Comprehensive Transcriptomic and Proteomic Analysis of Hydra Head Regeneration

01.08.2015 | Hendrik O. Petersen; Stefanie K. Höger; Mario Looso; Tobias Lengfeld; Anne Kuhn; Uwe Warnken; Chiemi Nishimiya-Fujis ..., Molecular Biology and Evolution, 2015

The cnidarian freshwater polyp Hydra sp. exhibits an unparalleled regeneration capacity in the animal kingdom. Using an integrative transcriptomic and stable isotope labeling by amino acids in cell culture proteomic/phosphoproteomic approach, we studied stem cell-based regeneration in Hydra ...

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RNautophagy/DNautophagy possesses selectivity for RNA/DNA substrates

27.07.2015 | Katsunori Hase; Yuuki Fujiwara; Hisae Kikuchi; Shu Aizawa; Fumihiko Hakuno; Shin-Ichiro Takahashi; Keiji Wada; Tomoh ..., Nucleic Acids Research, 2015

Lysosomes can degrade various biological macromolecules, including nucleic acids, proteins and lipids. Recently, we identified novel nucleic acid-degradation systems termed RNautophagy/DNautophagy (abbreviated as RDA), in which RNA and DNA are directly taken up by lysosomes in an ATP-dependent ...

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Computer‐aided design of T‐cell epitope‐based vaccines: addressing population coverage

24.07.2015 | P. Oyarzun, B. Kobe, International Journal of Immunogenetics, 2015

Summary Epitope‐based vaccines (EVs) make use of short antigen‐derived peptides corresponding to immune epitopes, which are administered to trigger a protective humoral and/or cellular immune response. EVs potentially allow for precise control over the immune response activation by focusing on ...

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Cholesterol conjugation potentiates the antiviral activity of an HIV immunoadhesin

24.07.2015 | Richard A. Urbanowicz, Krzysztof Lacek, Armin Lahm, Krystyna Bienkowska‐Szewczyk, Jonathan K. Ball, Alfredo Nicosia, ..., Journal of Peptide Science, 2015

Immunoadhesins are engineered proteins combining the constant domain (Fc) of an antibody with a ligand‐binding (adhesion) domain. They have significant potential as therapeutic agents, because they maintain the favourable pharmacokinetics of antibodies with an expanded repertoire of ...

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Proteomic analysis of extracellular vesicles derived from Mycobacterium tuberculosis

23.07.2015 | Jaewook Lee, Si‐Hyun Kim, Dong‐Sic Choi, Jong Seok Lee, Dae‐Kyum Kim, Gyeongyun Go, Seon‐Min Park, Si Hyun Kim, Jeon ..., PROTEOMICS, 2015

The release of extracellular vesicles, also known as outer membrane vesicles, membrane vesicles, exosomes, and microvesicles, is an evolutionarily conserved phenomenon from bacteria to eukaryotes. It has been reported that Mycobacterium tuberculosis releases extracellular vesicles harboring ...

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Hairless Streaks in Cattle Implicate TSR2 in Early Hair Follicle Formation

23.07.2015 | Leonardo Murgiano et al., PLoS Genetics, 2015

by Leonardo Murgiano, Vera Shirokova, Monika Maria Welle, Vidhya Jagannathan, Philippe Plattet, Anna Oevermann, Aldona Pienkowska-Schelling, Daniele Gallo, Arcangelo Gentile, Marja Mikkola, Cord Drögemüller Four related cows showed hairless streaks on various parts of the body with no ...

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Absolute quantification of Dengue virus serotype 4 chimera vaccine candidate in Vero cell culture by targeted mass spectrometry

22.07.2015 | Rougemont Blandine, Simon Romain, Carrière Romain, Biarc Jordane, Fonbonne Catherine, Salvador Arnaud, Huillet Célin ..., PROTEOMICS, 2015

Infection by dengue flavivirus is transmitted by mosquitoes and affects tens to hundreds of millions people around the world each year. Four serotypes have been described, all of which cause similar disease. Currently, there no approved vaccines or specific therapeutics for dengue, although ...

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Advanced Proteogenomic Analysis Reveals Multiple Peptide Mutations and Complex Immunoglobulin Peptides in Colon Cancer

21.07.2015 | Sunghee Woo; Seong Won Cha; Stefano Bonissone; Seungjin Na; David L. Tabb; Pavel A. Pevzner; Vineet Bafna, Journal of Proteome Research, 2015

Aiming toward an improved understanding of the regulation of proteins in cancer, recent studies from the Clinical Proteomic Tumor Analysis Consortium (CPTAC) have focused on analyzing cancer tissue using proteomic technologies and workflows. Although many proteogenomics approaches for the study ...

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Losartan ameliorates dystrophic epidermolysis bullosa and uncovers new disease mechanisms

21.07.2015 | Alexander Nyström, Kerstin Thriene, Venugopal Mittapalli, Johannes S Kern, Dimitra Kiritsi, Jörn Dengjel, Leena Bruc ..., EMBO Molecular Medicine, 2015

Abstract Genetic loss of collagen VII causes recessive dystrophic epidermolysis bullosa (RDEB)—a severe skin fragility disorder associated with lifelong blistering and disabling progressive soft tissue fibrosis. Causative therapies for this complex disorder face major hurdles, and clinical ...

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Regulation of biofilm formation and cellular buoyancy through modulating intracellular cyclic di‐GMP levels in engineered cyanobacteria

20.07.2015 | Marco Agostoni, Christopher M. Waters, Beronda L. Montgomery, Biotechnology and Bioengineering, 2015

ABSTRACT The second messenger cyclic dimeric (3′→5′) GMP (cyclic di‐GMP or c‐di‐GMP) has been implicated in the transition between motile and sessile lifestyles in bacteria. In this study, we demonstrate that biofilm formation, cellular aggregation or flocculation, and cellular buoyancy are ...

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