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Tumor Necrosis Factor-α-Induced Ototoxicity in Mouse Cochlear Organotypic Culture

22.05.2015 | Qian Wu et al., PLoS ONE, 2015

by Qian Wu, Guo-Peng Wang, Jing Xie, Jing-Ying Guo, Shu-Sheng Gong Tumor necrosis factor (TNF)-α is a cytokine involved in acute inflammatory phase reactions, and is the primary upstream mediator in the cochlear inflammatory response. Treatment of the organ of Corti with TNF-α can induce hair ...

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The EGFR/ErbB3 Pathway Acts as a Compensatory Survival Mechanism upon c-Met Inhibition in Human c-Met + Hepatocellular Carcinoma

22.05.2015 | Steven N. Steinway et al., PLoS ONE, 2015

by Steven N. Steinway, Hien Dang, Hanning You, C. Bart Rountree, Wei Ding Background c-Met, a high-affinity receptor for Hepatocyte Growth Factor (HGF), plays a critical role in tumor growth, invasion, and metastasis. Hepatocellular carcinoma (HCC) patients with activated HGF/c-Met signaling ...

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Molecular Mechanism Behind the Synergistic Activity of Diphenylmethyl Selenocyanate and Cisplatin Against Murine Tumor Model

20.05.2015 | Chakraborty, Pramita; Singha Roy, Somnath; Bhattacharya, Sudin, Anti-Cancer Agents in Medicinal Chemistry , 2015

Abstract: Various preclinical, clinical and epidemiological studies have already well established the cancer chemopreventive and chemoprotective potential of selenium compounds. In addition to its protective efficacy, recent studies have also proved the abilities of selenium compounds to ...

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Berberine Exhibits Antitumor Effects in Human Ovarian Cancer Cells

20.05.2015 | Jin, Ping; Zhang, Chunjie; Li, Na, Anti-Cancer Agents in Medicinal Chemistry , 2015

Abstract: Background: Berberine is an extract of a traditional Chinese herbal medicine and has been shown to inhibit the proliferation and induce apoptosis in a wide variety of tumour cells. However, the effects of Berberine in ovarian cancer cells are unknown. Aims: To investigate the ...

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Intracellular calcium levels as screening tool for nanoparticle toxicity

15.05.2015 | Claudia Meindl, Tatjana Kueznik, Martina Bösch, Eva Roblegg, Eleonore Fröhlich, Journal of Applied Toxicology, 2015

Abstract The use of engineered nano‐sized materials led to revolutionary developments in many industrial applications and in the medical field. These materials, however, also may cause cytotoxicity. In addition to size, surface properties and shape were identified as relevant parameters for ...

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The fetal brain transcriptome and neonatal behavioral phenotype in the Ts1Cje mouse model of Down syndrome

14.05.2015 | Faycal Guedj, Jeroen L. A. Pennings, Millie A. Ferres, Leah C. Graham, Heather C. Wick, Klaus A. Miczek, Donna K. Sl ..., American Journal of Medical Genetics Part A, 2015

Human fetuses with Down syndrome demonstrate abnormal brain growth and reduced neurogenesis. Despite the prenatal onset of the phenotype, most therapeutic trials have been conducted in adults. Here, we present evidence for fetal brain molecular and neonatal behavioral alterations in the Ts1Cje ...

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FOXO responses to Porphyromonas gingivalis in epithelial cells

11.05.2015 | Qian Wang, Maryta Sztukowska, Akintunde Ojo, David A. Scott, Huizhi Wang, Richard J. Lamont, Cellular Microbiology, 2015

Summary Porphyromonas gingivalis is a prominent periodontal, and emerging systemic, pathogen that redirects host cell signaling pathways and modulates innate immune responses. In this study we show that P. gingivalis infection induces the dephosphorylation and activation of FOXO1, 3, and 4 in ...

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Systems biology approach reveals possible evolutionarily conserved moonlighting functions for enolase

10.05.2015 | Author(s): Gabriela Prado Paludo , Karina Rodrigues Lorenzatto , Diego Bonatto , Henrique Bunselmeyer Ferreira, Computational Biology and Chemistry, 2015

Publication date: Available online 21 April 2015 Source:Computational Biology and Chemistry Author(s): Gabriela Prado Paludo , Karina Rodrigues Lorenzatto , Diego Bonatto , Henrique Bunselmeyer Ferreira Glycolytic enzymes, such as enolase, have been described as multifunctional complex ...

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Caspase-11 Plays an Essential Role in Methamphetamine-Induced Dopaminergic Neuron Apoptosis

01.05.2015 | Weiye Huang; Wei-Bing Xie; Dongfang Qiao; Pingming Qiu; Enping Huang; Bing Li; Chuanxiang Chen; Chao Liu; Qi Wang; Z ..., Toxicological Sciences, 2015

Methamphetamine (METH) is an extremely addictive stimulant drug that is widely used with high potential of abuse. Previous studies have shown that METH exposure damages the nervous system, especially dopaminergic neurons. However, the exact molecular mechanisms of METH-induced neurotoxicity ...

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EphrinA2 Receptor (EphA2) Is an Invasion and Intracellular Signaling Receptor for Chlamydia trachomatis

23.04.2015 | Prema Subbarayal et al., PLoS Pathogens, 2015

by Prema Subbarayal, Karthika Karunakaran, Ann-Cathrin Winkler, Marion Rother, Erik Gonzalez, Thomas F. Meyer, Thomas Rudel The obligate intracellular bacterium Chlamydia trachomatis invades into host cells to replicate inside a membrane-bound vacuole called inclusion. Multiple different host ...

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