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788 Aktuelle Fachpublikationen zum Thema Addition

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Potent immunotherapy against well‐established thymoma using adoptively transferred transgene IL‐6‐engineered dendritic cell‐stimulated CD8+ T‐cells with prolonged survival and enhanced cytotoxicity

24.07.2015 | Kalpana Kalyanasundaram Bhanumathy, Bei Zhang, Yufeng Xie, Aizhang Xu, Xin Tan, Jim Xiang, The Journal of Gene Medicine, 2015

Abstract Background Adoptive transfer of CD8+ T‐cells specific for tumor‐antigens is an attractive strategy for anti‐tumor therapy. In this study, the subsets TA and TB were used to represent the population of CD8+ T cells generated by culturing the respective cells with irradiated dendritic ...


Resveratrol as a novel treatment for diseases with mTOR pathway hyperactivation

22.07.2015 | Anya Alayev, Sara Malka Berger, Marina K. Holz, Annals of the New York Academy of Sciences, 2015

The mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway is hyperactivated in a variety of cancers and tumor syndromes. Therefore, mTORC1 inhibitors are being actively investigated for treatment of neoplasms. The concern with the monotherapy use of mTORC1 inhibitors, such as ...


The Zinc Ion Chelating Agent TPEN Attenuates Neuronal Death/apoptosis Caused by Hypoxia/ischemia Via Mediating the Pathophysiological Cascade Including Excitotoxicity, Oxidative Stress, and Inflammation

20.07.2015 | Wei‐Ming Wang, Zhao Liu, Ai‐Jun Liu, Yu‐Xiang Wang, Hong‐Gang Wang, Di An, Bin Heng, Lai‐Hua Xie, Jun‐Li Duan, Yan‐Q ..., CNS Neuroscience & Therapeutics, 2015

Summary Aims We aim to determine the significant effect of TPEN, a Zn2+ chelator, in mediating the pathophysiological cascade in neuron death/apoptosis induced by hypoxia/ischemia. Methods We conducted both invivo and invitro experiments in this study. PC12 cells were used to ...


Two new loci and gene sets related to sex determination and cancer progression are associated with susceptibility to testicular germ cell tumor

15.07.2015 | Wenche Kristiansen; Robert Karlsson; Trine B. Rounge; Thomas Whitington; Bettina K. Andreassen; Patrik K. Magnusson; ..., Human Molecular Genetics, 2015

Genome-wide association (GWA) studies have reported 19 distinct susceptibility loci for testicular germ cell tumor (TGCT). A GWA study for TGCT was performed by genotyping 610 240 single-nucleotide polymorphisms (SNPs) in 1326 cases and 6687 controls from Sweden and Norway. No novel genome-wide ...


Differential proteomic analysis reveals that EGCG inhibits HDGF and activates apoptosis to increase the sensitivity of non‐small cells lung cancer to chemotherapy

14.07.2015 | Ali Flores‐Pérez, Laurence A. Marchat, Lidia López Sánchez, Diana Romero‐Zamora, Elena Arechaga‐Ocampo, Nayeli Ramír ..., PROTEOMICS, 2015

Purpose : To search for regulated proteins in response to green tea (–)‐epigallocatechin‐3‐gallate (EGCG) in A549 lung cancer cells. Experimental design : Two‐dimensional electrophoresis and electrospray ionization/multi‐stage mass spectrometry (ESI‐MS/MS) was performed to identify ...


Nepro is localized in the nucleolus and essential for preimplantation development in mice

14.07.2015 | Masakazu Hashimoto, Tatsuya Sato, Yuko Muroyama, Lisa Fujimura, Masahiko Hatano, Tetsuichiro Saito, Development, Growth & Differentiation, 2015

We generated knockout (KO) mice of Nepro, which has been shown to be necessary to maintain neural progenitor cells downstream of Notch in the mouse developing neocortex by using knockdown experiments, to explore its function in embryogenesis. Nepro KO embryos were morphologically ...


Marine Drugs, Vol. 13, Pages 4310-4330: Multiple Mechanisms of Anti-Cancer Effects Exerted by Astaxanthin

14.07.2015 | Zhang, Li ; Wang, Handong, Marine Drugs, 2015

Astaxanthin (ATX) is a xanthophyll carotenoid which has been approved by the United States Food and Drug Administration (USFDA) as food colorant in animal and fish feed. It is widely found in algae and aquatic animals and has powerful anti-oxidative activity. Previous studies have revealed that ...


Dissecting the Mechanisms of Doxorubicin and Oxidative Stress-Induced Cytotoxicity: The Involvement of Actin Cytoskeleton and ROCK1

02.07.2015 | Lei Wei et al., PLoS ONE, 2015

by Lei Wei, Michelle Surma, Gina Gough, Stephanie Shi, Nathan Lambert-Cheatham, Jiang Chang, Jianjian Shi We have recently reported that ROCK1 deficiency in mouse embryonic fibroblasts (MEF) has superior anti-apoptotic and pro-survival effects than antioxidants against doxorubicin, a ...


Viruses, Vol. 7, Pages 3443-3461: The Subcellular Localisation of the Human Papillomavirus (HPV) 16 E7 Protein in Cervical Cancer Cells and Its Perturbation by RNA Aptamers

26.06.2015 | Cesur, Özlem ; Nicol, Clare ; Groves, Helen ; Mankouri, Jamel ; Blair, George Eric; Stonehouse, Nicola J., Viruses, 2015

Human papillomavirus (HPV) is the most common viral infection of the reproductive tract, affecting both men and women. High-risk oncogenic types are responsible for almost 90% of anogenital and oropharyngeal cancers including cervical cancer. Some of the HPV “early” genes, particularly E6 and E7, ...


AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance

25.06.2015 | Romina Burla et al., PLoS Genetics, 2015

by Romina Burla, Mariateresa Carcuro, Grazia D. Raffa, Alessandra Galati, Domenico Raimondo, Angela Rizzo, Mattia La Torre, Emanuela Micheli, Laura Ciapponi, Giovanni Cenci, Enrico Cundari, Antonio Musio, Annamaria Biroccio, Stefano Cacchione, Maurizio Gatti, Isabella Saggio Telomeres are ...


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