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Oxaliplatin regulates expression of stress ligands in ovarian cancer cells and modulates their susceptibility to natural killer cell-mediated cytotoxicity

01.12.2015 | Yin-Yin Siew; Soek-Ying Neo; Hui-Chuing Yew; Shun-Wei Lim; Yi-Cheng Ng; Si-Min Lew; Wei-Guang Seetoh; See-Voon Seow; ..., International Immunology, 2015

Selected cytotoxic chemicals can provoke the immune system to recognize and destroy malignant tumors. Most of the studies on immunogenic cell death are focused on the signals that operate on a series of receptors expressed by dendritic cells to induce tumor antigen-specific T-cell responses. ...


Multiple myeloma cells modify VEGF/IL‐6 levels and osteogenic potential of bone marrow stromal cells via Notch/miR‐223

24.11.2015 | Rimma Berenstein, Axel Nogai, Marlies Waechter, Olga Blau, Aline Kuehnel, Martin Schmidt‐Hieber, Annegret Kunitz, An ..., Molecular Carcinogenesis, 2015

Bone marrow mesenchymal stromal cells (BMMSCs) represent a crucial component of multiple myeloma (MM) microenvironment supporting its progression and proliferation. Recently, microRNAs have become an important point of interest for research on micro‐environmental interactions in MM with some ...


Marine Drugs, Vol. 13, Pages 6962-6976: Salternamide A Suppresses Hypoxia-Induced Accumulation of HIF-1α and Induces Apoptosis in Human Colorectal Cancer Cells

19.11.2015 | Bach, Duc-Hiep ; Kim, Seong-Hwan ; Hong, Ji-Young ; Park, Hyen Joo; Oh, Dong-Chan ; Lee, Sang Kook, Marine Drugs, 2015

Hypoxia inducible factor-1α (HIF-1α) is an essential regulator of the cellular response to low oxygen concentrations, activating a broad range of genes that provide adaptive responses to oxygen deprivation. HIF-1α is overexpressed in various cancers and therefore represents a considerable ...


Rotavirus induced miR‐142‐5p elicits proviral milieu by targeting Non‐canonical TGFβ signalling and apoptosis in cells

17.11.2015 | Shampa Chanda, Satabdi Nandi, Mamta Chawla‐Sarkar, Cellular Microbiology, 2015

Summary miRNA expression is significantly influenced by viral infection, due to either host antiviral defenses or proviral factors resulting in the modulation of viral propagation. This study was undertaken to identify and analyze the significance of cellular miRNAs during rotavirus (SA11 or ...


Celecoxib antagonizes the cytotoxicity of oxaliplatin in human esophageal cancer cells by impairing the drug influx

15.11.2015 | Author(s): Yi Kong, Chunping Gu, Desheng Zhong, Xuyan Zhao, Qinghuan Lin, Keng Wang, Tianrong Xun, Le ..., European Journal of Pharmaceutical Science, 2015

Publication date: 1 January 2016 Source:European Journal of Pharmaceutical Sciences, Volume 81 Author(s): Yi Kong, Chunping Gu, Desheng Zhong, Xuyan Zhao, Qinghuan Lin, Keng Wang, Tianrong Xun, Le Yu, Shuwen Liu It has been demonstrated that COX-2-selective inhibitor ...


Antitumor activity of fucoidan against diffuse large B cell lymphoma in vitro and in vivo

01.11.2015 | Guang Yang; Qianqiao Zhang; Yuanyuan Kong; Bingqian Xie; Minjie Gao; Yi Tao; Hongwei Xu; Fenghuang Zhan; Bojie Dai; ..., Acta Biochimica et Biophysica Sinica, 2015

Fucoidan is one of the major sulfated polysaccharides isolated from brown seaweeds. In this study, we determined the anti-cancer activity of fucoidan on diffuse large B cell lymphoma (DLBCL) cells both in vitro and in vivo. Fucoidan inhibited the growth of DLBCL cells in a dose- and ...


Mechanism of Mcl‐1 conformational regulation upon small molecule binding revealed by molecular dynamic simulation

31.10.2015 | Anhui Wang, Ting Song, Ziqian Wang, Yubo Liu, Yudan Fan, Yahui Zhang, Zhichao Zhang, Chemical Biology & Drug Design, 2015

Abstract Inhibition of interactions between Mcl‐1 and proapoptotic proteins is considered to be a therapeutic strategy to induce apoptosis in cancer cells. Here we adopted molecular dynamics simulation with molecular mechanics–Poisson Boltzmann/surface area method (MM‐PB/SA) to study the ...


Effects of captopril, telmisartan, and bardoxolone methyl (CDDO‐Me) in ischemia reperfusion‐induced acute kidney injury in rats: an experimental comparative study

30.10.2015 | Cengiz Kocak, Emel Fatma Kocak, Raziye Akcilar, Zeynep Bayat, Bekir Aras, Mehmet Huseyin Metineren, Mehmet Yucel, Ha ..., Clinical and Experimental Pharmacology and Physiology, 2015

Summary Renal ischemia‐reperfusion (IR) injury is one of the most common causes of acute kidney injury. We investigated the effects of captopril (CAP), telmisartan (TEL), and bardoxolone methyl (BM) in animals with renal IR injury. Adult male Wistar‐Albino rats were divided into six groups: ...


Crosslinking of a Peritrophic Matrix Protein Protects Gut Epithelia from Bacterial Exotoxins

27.10.2015 | Toshio Shibata et al., PLoS Pathogens, 2015

by Toshio Shibata, Kouki Maki, Jinki Hadano, Takumi Fujikawa, Kazuki Kitazaki, Takumi Koshiba, Shun-ichiro Kawabata Transglutaminase (TG) catalyzes protein-protein crosslinking, which has important and diverse roles in vertebrates and invertebrates. Here we demonstrate that Drosophila TG ...


SL4, a chalcone‐based compound, induces apoptosis in human cancer cells by activation of the ROS/MAPK signalling pathway

26.10.2015 | L.‐H. Wang, H.‐H. Li, M. Li, S. Wang, X.‐R. Jiang, Y. Li, G.‐F. Ping, Q. Cao, X. Liu, W.‐H. Fang, G.‐L. Chen, J.‐Y. ..., Cell Proliferation, 2015

Abstract Objectives SL4, a chalcone‐based compound, exhibits clearly inhibitory effects on HIF‐1 and has been shown to effectively suppress tumour invasion and angiogenesis in vitro and in vivo. Here, studies were conducted to determine SL4's anti‐apoptotic effects and its underlying ...


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