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Effect of TAT‐obestatin on proliferation, differentiation, apoptosis and lipolysis in 3T3‐L1 preadipocytes

14.09.2013 | Guangcai Ren, Zuyong He, Peiqing Cong, Jingwei Yu, Yufeng Qin, Yaosheng Chen, Xiaohong Liu, Journal of Peptide Science, 2013

It has been reported that obestatin regulates adipocyte metabolism via receptors on the cell surface. We wondered whether obestatin can interact with intracellular components that activated signalling pathways in adipocytes. Because obestatin (human) only presents one lysine (at position 10), ...


Broad MICA/B Expression in the Small Bowel Mucosa: A Link between Cellular Stress and Celiac Disease

13.09.2013 | Yessica L. Allegretti et al., PLoS ONE, 2013

by Yessica L. Allegretti, Constanza Bondar, Luciana Guzman, Eduardo Cueto Rua, Nestor Chopita, Mercedes Fuertes, Norberto W. Zwirner, Fernando G. Chirdo The MICA/B genes (MHC class I chain related genes A and B) encode for non conventional class I HLA molecules which have no role in antigen ...


Reactive oxygen species production induced by ethanol in Saccharomyces cerevisiae increases because of a dysfunctional mitochondrial iron‐sulfur cluster assembly system

12.09.2013 | Rocio Viridiana Pérez‐Gallardo, Luis Sánchez Briones, Alma Laura Díaz‐Pérez, Sergio Gutiérrez, José Salud Rodríguez‐ ..., FEMS Yeast Research, 2013

Abstract Ethanol accumulation during fermentation contributes to the toxic effects in Saccharomyces cerevisiae, impairing its viability and fermentative capabilities. The iron sulfur (Fe‐S) cluster biogenesis is encoded by the ISC genes. ROS generation is associated with iron release from Fe‐S ...


7‐Ketocholesterol‐induced caspase‐mediated apoptosis in Saccharomyces cerevisiae

12.09.2013 | Qiulin Yue, Xiuhong Zhou, Qianli Leng, Lele Zhang, Beijiu Cheng, Xin Zhang, FEMS Yeast Research, 2013

Abstract The cytotoxicity of cholesterol oxidation products has been documented in several mammalian cell lines. It can lead to a wide range of diseases. However, the molecular mechanisms underlying this toxicity in vivo are scarce. The objective of the present study was to assess the ...


Induction of apoptosis in human myeloid leukemia cells by remote exposure of resistive barrier cold plasma

11.09.2013 | Magesh Thiyagarajan, Heather Anderson, Xavier F. Gonzales, Biotechnology and Bioengineering, 2013

Abstract Cold atmospheric plasma (CAP), an ambient temperature ionized gas, is gaining extensive interest as a promising addition to anti‐tumor therapy primarily due to the ability to generate and control delivery of electrons, ions, excited molecules, UV photons, and reactive species such as ...


N‐acetyl‐L‐cysteine enhances fisetin‐induced cytotoxicity via induction of ROS‐independent apoptosis in human colonic cancer cells

09.09.2013 | Ming‐Shun Wu, Gi‐Shih Lien, Shing‐Chuan Shen, Liang‐Yo Yang, Yen‐Chou Chen, Molecular Carcinogenesis, 2013

Abstract Oxidative stress or excessive antioxidant levels‐caused redox imbalance can alter apoptotic responses, and N‐acetyl‐L‐cysteine (NAC) was able to inhibit H2O2‐mediated cell death, but unable to prevent apoptosis induced by other chemicals such as etoposide. We now demonstrate that 10 ...


Abrogated Thioredoxin System Causes Increased Sensitivity to TNF-α-Induced Apoptosis via Enrichment of p-ERK 1/2 in the Nucleus

06.09.2013 | Min-Hyuk Yoo et al., PLoS ONE, 2013

by Min-Hyuk Yoo, Bradley A. Carlson, Vadim N. Gladyshev, Dolph L. Hatfield Thioredoxin (Trx) and thioredoxin reductase 1 (TR1) are among the major redox regulators in mammalian cells and have a wide variety of roles, including removal of intracellular reactive oxygen species (ROS) and ...


Role of forefinger and thumb loops in production of {Psi}54 and {Psi}55 in tRNAs by archaeal Pus10 [ARTICLES]

01.09.2013 | Archi Joardar; Sujata Jana; Elisabeth Fitzek; Priyatansh Gurha; Mrinmoyee Majumder; Kunal Chatterjee; Matt Geisler; ..., RNA, 2013

Pseudouridines () are found in structurally and functionally important regions of RNAs. Six families of synthases, TruA, TruB, TruD, RsuA, RluA, and Pus10 have been identified. Pus10 is present in Archaea and Eukarya. While most archaeal Pus10 produce both tRNA 54 and 55, some produce only 55. ...


Early Phosphoproteomic Changes in the Mouse Spleen During Deoxynivalenol-Induced Ribotoxic Stress

01.09.2013 | Xiao Pan; Douglas A. Whitten; Ming Wu; Christina Chan; Curtis G. Wilkerson; James J. Pestka, Toxicological Sciences, 2013

The trichothecene mycotoxin deoxynivalenol (DON) targets the innate immune system and is of public health significance because of its frequent presence in human and animal food. DON-induced proinflammatory gene expression and apoptosis in the lymphoid tissue have been associated with a ribotoxic ...


FOXL1, a Novel Candidate Tumor Suppressor, Inhibits Tumor Aggressiveness and Predicts Outcome in Human Pancreatic Cancer

01.09.2013 | Geng Zhang; Peijun He; Jochen Gaedcke; B. Michael Ghadimi; Thomas Ried; Harris G. Yfantis; Dong H. Lee; Nader Hanna; ..., Cancer Research, 2013

The forkhead box L1 (FOXL1) transcription factor regulates epithelial proliferation and development of gastrointestinal tract and has been implicated in gastrointestinal tumorigenesis in mouse models. However, the role of FOXL1 in pancreatic cancer development and progression remains to be ...


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