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Peroxisome proliferator‐activated receptor ligands and their role in chronic myeloid leukemia: Therapeutic strategies

03.02.2016 | Bahman Yousefi, Nasser Samadi, Behzad Baradaran, Vahid Shafiei‐Irannejad, Nosratollah Zarghami, Chemical Biology & Drug Design, 2016

Abstract Imatinib therapy remains the gold standard for treatment of chronic myeloid leukemia or CML, however, the acquired resistance to this therapeutic agent in patients has urged the scientists to devise modalities for overcoming this chemoresistance. For this purpose, initially ...


Neuroprotective Effect of Ginsenoside Rd on Spinal Cord Injury Rats

02.02.2016 | Lin Cong, Wenting Chen, Basic & Clinical Pharmacology & Toxicology, 2016

Abstract In the present study, the neuroprotective effects of ginsenoside Rd (GS Rd) were evaluated in a rat model of spinal cord injury (SCI). Rats in SCI groups received a T8 laminectomy and a spinal contusion injury. GS Rd 12.5, 25 and 50 mg/kg were administered intraperitoneally one hour ...


Lipid peroxidation and apoptotic response in rat brain areas induced by long‐term administration of nandrolone: the mutual crosstalk between ROS and NF‐kB

01.02.2016 | Emanuela Turillazzi, Margherita Neri, Daniela Cerretani, Santina Cantatore, Paola Frati, Laura Moltoni, Francesco Pa ..., Journal of Cellular and Molecular Medicine, 2016

Abstract The aim of this study was to evaluate the played by oxidative stress in the apoptotic response in different brain areas of rats chronically treated with supra‐physiological doses of nandrolone decanoate (ND). Immunohistochemical study and Western blot analysis were performedto ...


Negative feedback regulation of AXL by miR-34a modulates apoptosis in lung cancer cells [ARTICLE]

01.02.2016 | Chun-Yu Cho; Jhy-Shrian Huang; Shine-Gwo Shiah; Shih-Ying Chung; Jong-Ding Lay; Ya-Yu Yang; Gi-Ming Lai; Ann-Lii Che ..., RNA, 2016

The AXL receptor tyrosine kinase is frequently overexpressed in cancers and is important in cancer invasion/metastasis and chemoresistance. Here, we demonstrate a regulatory feedback loop between AXL and microRNA (miRNA) at the post-transcriptional level. Both the GAS6-binding domain and the ...


Morusin Induces TRAIL Sensitization by Regulating EGFR and DR5 in Human Glioblastoma Cells

01.02.2016 | Dain Park; In Jin Ha; Sang-Yoon Park; Minji Choi; Sung-Lyul Lim; Sung-Hoon Kim; Jun-Hee Lee; Kwang Seok Ahn; Miyong ..., Journal of Natural Products, 2016

Glioblastoma is one of the most malignant primary tumors, and the prognosis for glioblastoma patients remains poor. Tumor-necrosis-factor-related apoptosis-inducing ligand (TRAIL) is considered a promising anticancer agent due to its remarkable ability to selectively kill tumor cells. However, ...


Granulocyte colony‐stimulating factor promotes behavioral recovery in a mouse model of traumatic brain injury

29.01.2016 | Shijie Song, Xiaoyuan Kong, Sandra Acosta, Vasyl Sava, Cesar Borlongan, Juan Sanchez‐Ramos, Journal of Neuroscience Research, 2016

Hematopoietic growth factors such as granulocyte colony‐stimulating factor (G‐CSF) represent a novel approach for treatment of traumatic brain injury (TBI). After mild controlled cortical impact (CCI), mice were treated with G‐CSF (100 μg/kg) for 3 consecutive days. The primary behavioral ...


Glycine supplementation in vitro enhances porcine preimplantation embryo cell number and decreases apoptosis but does not lead to live births

27.01.2016 | Bethany K. Redel, Lee D. Spate, Kiho Lee, Jiude Mao, Kristin M. Whitworth, Randall S. Prather, Molecular Reproduction and Development, 2016

Abstract Most in vitro culture conditions are less than optimal for embryo development. Here, we used a transcriptional‐profiling database to identify culture‐induced differences in gene expression in porcine blastocysts compared to in vivo‐produced counterparts. Genes involved in glycine ...


Quercetin derivative induces cell death in glioma cells by modulating NF-κB nuclear translocation and caspase-3 activation

24.01.2016 | Author(s): Cíntia J. Kiekow, Fabrício Figueiró, Fabrícia Dietrich, Luciana Dalla Vechia, Elisa N.S. Pires, ..., European Journal of Pharmaceutical Science, 2016

Publication date: Available online 21 January 2016 Source:European Journal of Pharmaceutical Sciences Author(s): Cíntia J. Kiekow, Fabrício Figueiró, Fabrícia Dietrich, Luciana Dalla Vechia, Elisa N.S. Pires, Elisa H.F. Jandrey, Simone C.B. Gnoatto, Christianne G. Salbego, ...


Ginkgo Biloba Extract Attenuates Oxidative Stress and Apoptosis in Mouse Cochlear Neural Stem Cells

22.01.2016 | Congpin Wang, Bin Wang, Phytotherapy Research, 2016

In the organ or Corti, oxidative stress could result in damage to the hearing, and neural stem cells (NSCs) hold great therapeutic potential in treating hearing loss. Ginkgo biloba extract (GBE) has been widely shown to exhibit anti‐oxidative and anti‐apoptotic effects in treatments of neural ...


Spatane diterpinoid from the brown algae, Stoechospermum marginatum induces apoptosis via ROS induced mitochondrial mediated caspase dependent pathway in murine B16F10 melanoma cells

19.01.2016 | Loka Reddy Velatooru, Chinna Babu Baggu, Venkateswara Rao Janapala, Molecular Carcinogenesis, 2016

Spatane diterpinoids isolated from the brown marine algae Stoechospermum marginatum were known to have cytotoxic effects in human cancerous cell lines and murine melanoma cells; the underling apoptotic mechanism of diterpinoids still remains unclear so far. Thus, in the present study, the ...


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