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I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3{beta} signaling pathway

01.09.2015 | Etsuro Ohta; Tomoko Nihira; Akiko Uchino; Yoichi Imaizumi; Yohei Okada; Wado Akamatsu; Kayoko Takahashi; Hideki Haya ..., Human Molecular Genetics, 2015

Leucine-rich repeat kinase 2 (LRRK2) is the causative molecule of the autosomal dominant hereditary form of Parkinson's disease (PD), PARK8, which was originally defined in a study of a Japanese family (the Sagamihara family) harboring the I2020T mutation in the kinase domain. Although a number ...


Nosema bombycis (Microsporidia) suppresses apoptosis in BmN cells (Bombyx mori)

01.09.2015 | Xinyi He; Zhangwuke Fu; Mingqian Li; Han Liu; Shunfeng Cai; Nana Man; Xingmeng Lu, Acta Biochimica et Biophysica Sinica, 2015

Nosema bombycis (N. bombycis, Nb) is a fungus-related and obligate intracellular parasite that causes chronic pebrine disease in the silkworm. After infecting the host, spores obtain energy from host cells and survive for several days. This symbiosis between the pathogen and the host cell ...


Resveratrol selectively induces apoptosis in malignant cells with the JAK2V617F mutation by inhibiting the JAK2 pathway

27.08.2015 | Ly Quoc Trung, J. Luis Espinoza, Dao T. An, Nguyen Hoang Viet, Kazuya Shimoda, Shinji Nakao, Molecular Nutrition & Food Research, 2015

Scope Resveratrol is a natural occurring polyphenol with several health promoting activities, including anticancer potential. Here, we analyzed the cytotoxic effects of resveratrol against malignant cells characterized by aberrant activation of the Janus kinase 2 (JAK2). Methods and ...


Impact of Histone Deacetylase Inhibitors on microRNA Expression and Cancer Therapy: A Review

25.08.2015 | Saira R. Ali, Karen J. Humphreys, Ross A. McKinnon, Michael Z. Michael, Drug Development Research, 2015

ABSTRACT Chromatin‐modifying drugs, such as histone deacetylase inhibitors (HDACi), have shown potential as cancer therapeutics, either alone or in combination with other therapies. HDACi have the ability to reverse aberrant epigenetic modifications associated with cancer, namely ...


Enzyme-mediated hyaluronic acid–tyramine hydrogels for the propagation of human embryonic stem cells in 3D

23.08.2015 | Author(s): Keming Xu, Karthikeyan Narayanan, Fan Lee, Ki Hyun Bae, Shujun Gao, Motoichi Kurisawa, Acta Biomaterialia, 2015

Publication date: 15 September 2015 Source:Acta Biomaterialia, Volume 24 Author(s): Keming Xu, Karthikeyan Narayanan, Fan Lee, Ki Hyun Bae, Shujun Gao, Motoichi Kurisawa The propagation of human embryonic stem cells (hESCs) in three-dimensional (3D) scaffolds facilitates the ...


The histone deacetylase inhibitor butyrate improves metabolism and reduces muscle atrophy during aging

20.08.2015 | Michael E. Walsh, Arunabh Bhattacharya, Kavithalakshmi Sataranatarajan, Rizwan Qaisar, Lauren Sloane, Md M. Rahman, ..., Aging Cell, 2015

Summary Sarcopenia, the loss of skeletal muscle mass and function during aging, is a major contributor to disability and frailty in the elderly. Previous studies found a protective effect of reduced histone deacetylase activity in models of neurogenic muscle atrophy. Because loss of muscle ...


Viruses, Vol. 7, Pages 4756-4771: The Antiviral Effect of Baicalin on Enterovirus 71 In Vitro

19.08.2015 | Li, Xiang ; Liu, Yuanyuan ; Wu, Tingting ; Jin, Yue ; Cheng, Jianpin ; Wan, Changbiao ; Qian, Weihe ; Xing, Fei ; Sh ..., Viruses, 2015

Baicalin is a flavonoid compound extracted from Scutellaria roots that has been reported to possess antibacterial, anti-inflammatory, and antiviral activities. However, the antiviral effect of baicalin on enterovirus 71 (EV71) is still unknown. In this study, we found that baicalin showed ...


MiR‐133b‐5p regulates the expression of the heat shock protein 70 during rat neuronal cell apoptosis induced by the gp120 V3 loop peptide

18.08.2015 | Chenglai Xia, Yantao Cai, Yuyi Lin, Ronghua Guan, Jie Yang, Guohong Xiao, Journal of Medical Virology, 2015

ABSTRACT Background Neuronal cell dysfunction and apoptosis, the main causes of HIV‐associated dementia, and its underlying mechanism are important unsolved health problems. Many research reports suggest that miRNAs regulate HIV‐1‐induced apoptosis. Methods We used the HIV‐1 gp120 V3 ...


Nexrutine inhibits azoxymethane‐induced colonic aberrant crypt formation in rat colon and induced apoptotic cell death in colon adenocarcinoma cells

10.08.2015 | Shamshad Alam, Anu Pal, Rahul Kumar, Snober S. Mir, Kausar M. Ansari, Molecular Carcinogenesis, 2015

Colon cancer is the third most common cause of death in the United States. Therefore, new preventive strategies are warranted for preventing colon cancer. Nexrutine (NX), an herbal extract from Phellodendron amurense, has been shown to have anti‐inflammatory, anti‐microbial and anti‐cancer ...


Periostin down‐regulation attenuates the pro‐fibrogenic response of hepatic stellate cells induced by TGF‐β1

07.08.2015 | Li Hong, Dai Shejiao, Chen Fenrong, Zhao Gang, Dong Lei, Journal of Cellular and Molecular Medicine, 2015

Abstract Liver fibrosis is characterized by an exacerbated accumulation of deposition of the extracellular matrix (ECM), and the activation of hepatic stellate cells (HSC) plays a pivotal role in the development of liver fibrosis. Periostin has been shown to regulate cell adhesion, ...


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