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5.107 Aktuelle Fachpublikationen zum Thema Addition

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Nova1 is a master regulator of alternative splicing in pancreatic beta cells

01.02.2015 | Olatz Villate; Jean-Valery Turatsinze; Loriana G. Mascali; Fabio A. Grieco; Tatiane C. Nogueira; Daniel A. Cunha; Ta ..., Nucleic Acids Research, 2015

Alternative splicing (AS) is a fundamental mechanism for the regulation of gene expression. It affects more than 90% of human genes but its role in the regulation of pancreatic beta cells, the producers of insulin, remains unknown. Our recently published data indicated that the ‘neuron-specific’ ...


MYC and EGR1 synergize to trigger tumor cell death by controlling NOXA and BIM transcription upon treatment with the proteasome inhibitor bortezomib

01.12.2014 | Matthias Wirth; Natasa Stojanovic; Jan Christian; Mariel C. Paul; Roland H. Stauber; Roland M. Schmid; Georg Häcker; ..., Nucleic Acids Research, 2014

The c-MYC (MYC afterward) oncogene is well known for driving numerous oncogenic programs. However, MYC can also induce apoptosis and this function of MYC warrants further clarification. We report here that a clinically relevant proteasome inhibitor significantly increases MYC protein levels and ...


Reduction of AUF1-mediated follistatin mRNA decay during glucose starvation protects cells from apoptosis

01.12.2014 | Xiangwei Gao; Haojie Dong; Chen Lin; Jinghao Sheng; Fan Zhang; Jinfeng Su; Zhengping Xu, Nucleic Acids Research, 2014

Follistatin (FST) performs several vital functions in the cells, including protection from apoptosis during stress. The expression of FST is up-regulated in response to glucose deprivation by an unknown mechanism. We herein showed that the induction of FST by glucose deprivation was due to an ...


Structure and function of TatD exonuclease in DNA repair

01.12.2014 | Yi-Chen Chen; Chia-Lung Li; Yu-Yuan Hsiao; Yulander Duh; Hanna S. Yuan, Nucleic Acids Research, 2014

TatD is an evolutionarily conserved protein with thousands of homologues in all kingdoms of life. It has been suggested that TatD participates in DNA fragmentation during apoptosis in eukaryotic cells. However, the cellular functions and biochemical properties of TatD in bacterial and ...


Arginine methylation of hnRNPK negatively modulates apoptosis upon DNA damage through local regulation of phosphorylation

01.11.2014 | Jen-Hao Yang; Yi-Ying Chiou; Shu-Ling Fu; I-Yun Shih; Tsai-Hsuan Weng; Wey-Jinq Lin; Chao-Hsiung Lin, Nucleic Acids Research, 2014

Heterogeneous nuclear ribonucleoprotein K (hnRNPK) is an RNA/DNA-binding protein involved in chromatin remodeling, RNA processing and the DNA damage response. In addition, increased hnRNPK expression has been associated with tumor development and progression. A variety of post-translational ...


Fanconi anemia signaling and Mus81 cooperate to safeguard development and crosslink repair

01.11.2014 | Meghan Larin; David Gallo; Laura Tamblyn; Jay Yang; Hudson Liao; Nestor Sabat; Grant W. Brown; J. Peter McPherson, Nucleic Acids Research, 2014

Individuals with Fanconi anemia (FA) are susceptible to bone marrow failure, congenital abnormalities, cancer predisposition and exhibit defective DNA crosslink repair. The relationship of this repair defect to disease traits remains unclear, given that crosslink sensitivity is recapitulated in ...


Genetic dissection reveals that Akt is the critical kinase downstream of LRRK2 to phosphorylate and inhibit FOXO1, and promotes neuron survival

01.11.2014 | Chia-Lung Chuang; Yu-Ning Lu; Hung-Cheng Wang; Hui-Yun Chang, Human Molecular Genetics, 2014

Leucine-rich repeat kinase 2 (LRRK2) is a complex kinase and mutations in LRRK2 are perhaps the most common genetic cause of Parkinson's disease (PD). However, the identification of the normal physiological function of LRRK2 remains elusive. Here, we show that LRRK2 protects neurons against ...


Loss of TFB1M results in mitochondrial dysfunction that leads to impaired insulin secretion and diabetes

01.11.2014 | Vladimir V. Sharoyko; Mia Abels; Jiangming Sun; Lisa M. Nicholas; Ines Guerra Mollet; Jelena A. Stamenkovic; Isabel ..., Human Molecular Genetics, 2014

We have previously identified transcription factor B1 mitochondrial (TFB1M) as a type 2 diabetes (T2D) risk gene, using human and mouse genetics. To further understand the function of TFB1M and how it is associated with T2D, we created a β-cell-specific knockout of Tfb1m, which gradually ...


Chalcones Incorporated Pyrazole Ring Inhibit Proliferation, Cell Cycle Progression, Angiogenesis and Induce Apoptosis of MCF7 Cell Line

21.10.2014 | F. Mohamed, Magda; S. Mohamed, Mervat; M. Fathi, Mohamed; A. Shouman, Samia; Abdelshafy Abdelhamid, Ismail, Anti-Cancer Agents in Medicinal Chemistry , 2014

Abstract: A Series of chalcone derivatives containing pyrazole ring was prepared and their cytotoxicity against different human cell lines, including breast (MCF-7), colon (HCT-116) liver (HEPG2) cell lines, as well as normal melanocyte HFB4 was evaluated. Two of these chalcone derivatives ...


A Discussion of MicroRNAs in Cancers

21.10.2014 | Hua, Shi; Yun, Wu; Zhiqiang, Zeng; Zou, Quan, Current Bioinformatics, 2014

Abstract: MicroRNAs (miRNAs) comprise an important class of small single-stranded non-coding RNAs that regulate several important biological processes, including cell differentiation, growth, and apoptosis. The dysregulations of miRNAs are usually correlated with several diseases because of ...


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