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731 Aktuelle Fachpublikationen zum Thema Addition

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Oridonin inhibits BxPC-3 cell growth through cell apoptosis

01.03.2015 | Bin Xu; Wen Shen; Xing Liu; Ting Zhang; Jun Ren; Yongjun Fan; Jian Xu, Acta Biochimica et Biophysica Sinica, 2015

Oridonin, an ent-kaurene diterpenoid extracted from the traditional Chinese herb Rabdosia rubescens, has multiple biological and pharmaceutical functions and has been used clinically for many years. While the antitumor function of oridonin has been corroborated by numerous lines of evidence, its ...


Effects of Resveratrol on Benign Prostatic Hyperplasia by the Regulation of Inflammatory and Apoptotic Proteins

25.02.2015 | Kyung-Sook Chung; Se-Yun Cheon; Hyo-Jin An, Journal of Natural Products, 2015

Resveratrol (1) is a natural polyphenolic compound that has cardioprotective, anticancer, and anti-inflammatory properties. Although diverse biological studies of compound 1 have been conducted, no antiproliferative effects of 1 have been reported in benign prostatic hyperplasia (BPH). BPH is a ...


Proteomic tools for the characterization of cell death mechanisms in drug discovery

24.02.2015 | Veronica G. Anania, Jennie R. Lill, PROTEOMICS, 2015

This review focuses on the use of proteomic tools for the characterization of cell death mechanisms that have contributed to drug discovery efforts. Resistance to cell death plays a major role in the development of many diseases including numerous types of malignancies. Using a multitude of ...


The reverse transcriptase–RNase H: from viruses to antiviral defense

19.02.2015 | Karin Moelling, Felix Broecker, Annals of the New York Academy of Sciences, 2015

Ubiquitous, reverse transcriptase may have contributed to the transition from the RNA to the DNA world, a transition that also involved RNase H–like activities. Both enzymes shaped various genomes and antiviral defense systems as endogenous retroviruses (ERVs) and transposable elements (TEs). A ...


Marine Drugs, Vol. 13, Pages 1084-1104: Fucoidan from Macrocystis pyrifera Has Powerful Immune-Modulatory Effects Compared to Three Other Fucoidans

19.02.2015 | Zhang, Wei ; Oda, Tatsuya ; Yu, Qing ; Jin, Jun-O, Marine Drugs, 2015

Fucoidan, a sulfated polysaccharide purified from brown algae, has a variety of immune-modulation effects, such as promoting activation of dendritic cells (DCs), natural killer (NK) cells and T cells, and enhancing anti-viral and anti-tumor responses. However, the immune-modulatory effect of ...


Necrotic cell death caused by exposure to graphitic carbon‐coated magnetic nanoparticles

17.02.2015 | Jung‐Hee Kim, Jakkid Sanetuntikul, Sangaraju Shanmugam, Eunjoo Kim, Journal of Biomedical Materials Research Part A, 2015

Abstract We synthesized graphitic carbon‐coated magnetic nanoparticles (Fe@C NPs) and evaluated their physicochemical properties and mechanism of cytotoxicity in vitro. The structure of these nanocomposites consisted of an iron core encapsulated by a graphitic‐carbon shell. The diameter of ...


Hibiscus sabdariffa Leaf Polyphenolic Extract Induces Human Melanoma Cell Death, Apoptosis, and Autophagy

17.02.2015 | Chun‐Tang Chiu, Shu‐Wen Hsuan, Hui‐Hsuan Lin, Cheng‐Chin Hsu, Fen‐Pi Chou, Jing‐Hsien Chen, Journal of Food Science, 2015

Abstract Melanoma is the least common but most fatal form of skin cancer. Previous studies have indicated that an aqueous extract of Hibiscus sabdariffa leaves possess hypoglycemic, hypolipidemic, and antioxidant effects. In this study, we want to investigate the anticancer activity of ...


Influence of Intracellular Zinc on Cultures of Rat Cardiac Neural Crest Cells

16.02.2015 | Hsunhui Yang, Carl L. Keen, Louise Lanoue, Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2015

BACKGROUND Developmental zinc (Zn) deficiency increases the incidence of heart anomalies in rat fetuses, in regions and structures derived from the outflow tract. Given that the development of the outflow tract requires the presence of cardiac neural crest cells (cNCC), we speculated that Zn ...


IFI27, a novel epidermal growth factor‐stabilized protein, is functionally involved in proliferation and cell cycling of human epidermal keratinocytes

09.02.2015 | W.‐L. Hsieh, Y.‐H. Huang, T.‐M. Wang, Y.‐C. Ming, C.‐N. Tsai, J.‐H. S. Pang, Cell Proliferation, 2015

Abstract Objectives IFI27 is highly expressed in psoriatic lesions but its function has not been known. The present study aimed to explore its role in proliferation of epidermal keratinocytes. Materials and methods IFI27 knockdown and over‐expression in keratinocytes were used to ...


Cyclooxygenase-1 Serves a Vital Hepato-Protective Function in Chemically Induced Acute Liver Injury

01.02.2015 | Jia Xiao; Emily C. Liong; Hai Huang; Wing On Tse; Kam Shing Lau; Jingfei Pan; Amin A. Nanji; Man Lung Fung; Feiyue X ..., Toxicological Sciences, 2015

Cyclooxygenase-1 (COX-1) is the constitutive form of the COX enzyme family, which produces bioactive lipids called prostanoids. Although the role of COX-2 in liver diseases has been studied, little is known about the function of COX-1 in liver injury. We aimed to investigate the role and ...


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