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Mast Cells Play an Important Role in the Pathogenesis of Hyperglycemia‐Induced Atrial Fibrillation

21.04.2016 | Kenshi Uemura, Hidekazu Kondo, Yumi Ishii, Mami Kobukata, Miho Haraguchi, Takaaki Imamura, Toyokazu Otsubo, Yuki Ike ..., Journal of Cardiovascular Electrophysiology, 2016

Background and Objectives : Recently, it has been reported that mast cells (MCs) could underlie the mechanisms of several cardiovascular diseases. However, the role of MCs in diabetes‐induced atrial fibrillation (AF) has not been notably investigated. We tested the hypothesis that MC ...


IL‐9 promotes the survival and function of human melanoma ‐ infiltrating CD4+CD8+ double‐positive T cells

20.04.2016 | Tiphaine Parrot, Mathilde Allard, Romain Oger, Houssem Benlalam, Diane Raingeard de la Blétière, Anne Coutolleau, La ..., European Journal of Immunology, 2016

While accounting for a small fraction of PBL in healthy humans, CD4+CD8+ double‐ positive (DP) T cells are often enriched in multiple pathological contexts. We previously demonstrated an accumulation of tumor reactive DP T cells within melanoma‐infiltrating lymphocytes supporting their role in ...


Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells

15.04.2016 | Chih-Hang Anthony Tang; Joseph A. Zundell; Sujeewa Ranatunga; Cindy Lin; Yulia Nefedova; Juan R. Del Valle; Chih-Chi ..., Cancer Research, 2016

Endoplasmic reticulum (ER) stress responses through the IRE-1/XBP-1 pathway are required for the function of STING (TMEM173), an ER-resident transmembrane protein critical for cytoplasmic DNA sensing, IFN production, and cancer control. Here we show that the IRE-1/XBP-1 pathway functions ...


Evaluation of Polybrominated Diphenyl Ether Toxicity on HepG2 Cells ‐ Hexa‐brominated Congener (BDE‐154) is Less Toxic than Tetra‐Brominated Congener (BDE‐47)

07.04.2016 | Alecsandra O Souza, Maria J Tasso, Alana M C Oliveira, Lilian C Pereira, Filipe V Duarte, Danielle P Oliveira, Carlo ..., Basic & Clinical Pharmacology & Toxicology, 2016

Abstract Apoptotic cell death is one of the main consequences of exposure to brominated flame retardants, including PBDEs. However, few of these compounds have had their potential toxicity investigated. BDE‐154 is one of the most poorly studied PBDE congeners, but its level in the environment ...


Polyphenol‐Rich Fraction from Larrea divaricata and its Main Flavonoid Quercetin‐3‐Methyl Ether Induce Apoptosis in Lymphoma Cells Through Nitrosative Stress

01.04.2016 | Renzo Martino, María Laura Barreiro Arcos, Rosario Alonso, Valeria Sülsen, Graciela Cremaschi, Claudia Anesini, Phytotherapy Research, 2016

Larrea divaricata is a plant with antiproliferative principles. We have previously identified the flavonoid quercetin‐3‐methyl ether (Q‐3‐ME) in an ethyl acetate fraction (EA). Both the extract and Q‐3‐ME were found to be effective against the EL‐4 T lymphoma cell line. However, the mechanism ...


An ornamental plant targets epigenetic signaling to block cancer stem cell-driven colon carcinogenesis

01.04.2016 | Ishfaq Ahmed; Badal C. Roy; Dharmalingam Subramaniam; Showkat Ahmad Ganie; Deep Kwatra; Dan Dixon; Shrikant Anant; M ..., Carcinogenesis , 2016

Phytochemicals modulate key cellular signaling pathways and have proven anticancer effects. Alcea rosea (AR; Hollyhock) is an ornamental plant with known anti-inflammatory properties. This study explored its role as an anticancer agent. The AR seed extract (AR extract) inhibited proliferation and ...


Phosphatase PTP4A3 Promotes Triple-Negative Breast Cancer Growth and Predicts Poor Patient Survival

01.04.2016 | Petra den Hollander; Kathryn Rawls; Anna Tsimelzon; Jonathan Shepherd; Abhijit Mazumdar; Jamal Hill; Suzanne A.W. Fu ..., Cancer Research, 2016

Triple-negative breast cancer (TNBC) has the worst prognosis of all breast cancers, and women diagnosed with TNBC currently lack targeted treatment options. To identify novel targets for TNBC, we evaluated phosphatase expression in breast tumors and characterized their contributions to in vitro ...


Curcumin protects against myocardial infarction-induced cardiac fibrosis via SIRT1 activation in vivo and in vitro

29.03.2016 | Drug Design, Development and Therapy, 2016

Curcumin, a polyphenolic compound derived from turmeric, protects against myocardial injury by alleviating oxidative stress, inflammation, apoptosis, and fibrosis. However, the role of curcumin and its mechanism of action on interstitial fibrosis after myocardial infarction (MI) are poorly ...


Quantitative and qualitative toxicological evaluation of thiol‐ene “Click” chemistry‐based polyanhydrides and their degradation products

25.03.2016 | Halimatu S. Mohammed, Brittany L. Snyder, Damien S. K. Samways, Devon A. Shipp, Journal of Biomedical Materials Research Part A, 2016

Abstract Quantitative and qualitative toxicological analyses of crosslinked, surface‐eroding polyanhydrides (PAHs) made from thiol‐ene “click” polymerizations are reported. The cytotoxicity of these PAHs was investigated against three skin‐based cell types; melanoma (A‐375), human dermal ...


Induction of cell cycle arrest and apoptosis with down‐regulation of Hsp90 client proteins and histone modification by 4β‐hydroxywithanolide E isolated from Physalis peruviana

23.03.2016 | Eun‐Jung Park, Mayuramas Sang‐Ngern, Leng Chee Chang, John M. Pezzuto, Molecular Nutrition & Food Research, 2016

Scope : Physalis peruviana (Solanaceae) is used for culinary and medicinal purposes. We currently report withanolides, isolated from P. peruviana, inhibit the growth of colon cancer monolayer and spheroid cultures. A detailed mechanistic evaluation was performed with 4β‐hydroxywithanolide E ...


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