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Positive Role of Promyelocytic Leukemia Protein in Type I Interferon Response and Its Regulation by Human Cytomegalovirus

26.03.2015 | Young-Eui Kim et al., PLoS Pathogens, 2015

by Young-Eui Kim, Jin-Hyun Ahn Promyelocytic leukemia protein (PML), a major component of PML nuclear bodies (also known as nuclear domain 10), is involved in diverse cellular processes such as cell proliferation, apoptosis, gene regulation, and DNA damage response. PML also acts as a ...

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Synthesis and Anticancer Activity Evaluation of Some Benzothiazole-Piperazine Derivatives

25.03.2015 | Ece Gurdal, Enise; Buclulgan, Ebru; Durmaz, Irem; Cetin-Atalay, Rengul; Yarim, Mine, Anti-Cancer Agents in Medicinal Chemistry , 2015

Abstract: Synthesis, characterization and cytotoxic activities of ten benzothiazole-piperazine derivatives were reported. In vitro cytotoxic activities of compounds were screened against hepatocellular (HUH-7), breast (MCF-7) and colorectal (HCT-116) cancer cell lines by sulphorhodamine B ...

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Viruses, Vol. 7, Pages 1429-1453: Modulation of SIV and HIV DNA Vaccine Immunity by Fas-FasL Signaling

23.03.2015 | Yan, Jiabin ; Zapata, Juan Carlos; Pauza, Charles David; Salvato, Maria S., Viruses, 2015

Signaling through the Fas/Apo-1/CD95 death receptor is known to affect virus-specific cell-mediated immune (CMI) responses. We tested whether modulating the Fas-apoptotic pathway can enhance immune responses to DNA vaccination or lymphocytic choriomeningitis virus (LCMV) infection. Mice were ...

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Als kills breast cancer cells

16.03.2015 | Drug Design, Development and Therapy, 2015

Alisertib (ALS) is an investigational potent Aurora A kinase inhibitor currently undergoing clinical trials for the treatment of hematological and non-hematological malignancies. However, its antitumor activity has not been tested in human breast cancer. This study aimed to investigate the effect ...

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Spata7 is a retinal ciliopathy gene critical for correct RPGRIP1 localization and protein trafficking in the retina

15.03.2015 | Aiden Eblimit; Thanh-Minh T. Nguyen; Yiyun Chen; Julian Esteve-Rudd; Hua Zhong; Stef Letteboer; Jeroen Van Reeuwijk; ..., Human Molecular Genetics, 2015

Leber congenital amaurosis (LCA) and juvenile retinitis pigmentosa (RP) are severe hereditary diseases that causes visual impairment in infants and children. SPATA7 has recently been identified as the LCA3 and juvenile RP gene in humans, whose function in the retina remains elusive. Here, we show ...

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Genetic Events That Limit the Efficacy of MEK and RTK Inhibitor Therapies in a Mouse Model of KRAS-Driven Pancreatic Cancer

15.03.2015 | Piergiorgio Pettazzoni; Andrea Viale; Parantu Shah; Alessandro Carugo; Haoqiang Ying; Huamin Wang; Giannicola Genove ..., Cancer Research, 2015

Mutated KRAS (KRAS*) is a fundamental driver in the majority of pancreatic ductal adenocarcinomas (PDAC). Using an inducible mouse model of KRAS*-driven PDAC, we compared KRAS* genetic extinction with pharmacologic inhibition of MEK1 in tumor spheres and in vivo. KRAS* ablation blocked ...

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Meloxicam inhibits fipronil‐induced apoptosis via modulation of the oxidative stress and inflammatory response in SH‐SY5Y cells

13.03.2015 | Jae Hyeon Park, Youn Sun Park, Je‐Bong Lee, Kyung‐Hun Park, Min‐kyoung Paik, Mihye Jeong, Hyun Chul Koh, Journal of Applied Toxicology, 2015

ABSTRACT Oxidative stress and inflammatory responses have been identified as key elements of neuronal cell apoptosis. In this study, we investigated the mechanisms by which inflammatory responses contribute to apoptosis in human neuroblastoma SH‐SY5Y cells treated with fipronil (FPN). Based on ...

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Exploring the link between scavenger receptor B1 expression and chronic obstructive pulmonary disease pathogenesis

12.03.2015 | Giuseppe Valacchi, Emanuela Maioli, Claudia Sticozzi, Franco Cervellati, Alessandra Pecorelli, Carlo Cervellati, Jou ..., Annals of the New York Academy of Sciences, 2015

Chronic obstructive pulmonary disease (COPD) has been recognized as one of the major causes of morbidity and mortality in the United States; it is the third leading cause of deaths in the United States, with approximately 15 million Americans affected with COPD. Although exposure to cigarette ...

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Marine Drugs, Vol. 13, Pages 1267-1289: Acetylated Chitosan Oligosaccharides Act as Antagonists against Glutamate-Induced PC12 Cell Death via Bcl-2/Bax Signal Pathway

12.03.2015 | Hao, Cui ; Gao, Lixia ; Zhang, Yiran ; Wang, Wei ; Yu, Guangli ; Guan, Huashi ; Zhang, Lijuan ; Li, Chunxia, Marine Drugs, 2015

Chitosan oligosaccharides (COSs), depolymerized products of chitosan composed of β-(1→4) d-glucosamine units, have broad range of biological activities such as antitumour, antifungal, and antioxidant activities. In this study, peracetylated chitosan oligosaccharides (PACOs) and N-acetylated ...

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Up‐regulation of galectin‐9 induces cell migration in human dendritic cells infected with dengue virus

06.03.2015 | Yu‐Lin Hsu, Mei‐Yi Wang, Ling‐Jun Ho, Chuan‐Yueh Huang, Jenn‐Haung Lai, Journal of Cellular and Molecular Medicine, 2015

Abstract Galectin‐9 (Gal‐9) exerts immunosuppressive effects by inducing apoptosis in T cells that produce interferon‐γ and interleukin (IL)‐17. However, Gal‐9 can be pro‐inflammatory in lipopolysaccharide‐stimulated monocytes. Using microarray analysis, we observed that Gal‐9 was up‐regulated ...

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