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781 Aktuelle Fachpublikationen zum Thema Addition

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Two new loci and gene sets related to sex determination and cancer progression are associated with susceptibility to testicular germ cell tumor

15.07.2015 | Wenche Kristiansen; Robert Karlsson; Trine B. Rounge; Thomas Whitington; Bettina K. Andreassen; Patrik K. Magnusson; ..., Human Molecular Genetics, 2015

Genome-wide association (GWA) studies have reported 19 distinct susceptibility loci for testicular germ cell tumor (TGCT). A GWA study for TGCT was performed by genotyping 610 240 single-nucleotide polymorphisms (SNPs) in 1326 cases and 6687 controls from Sweden and Norway. No novel genome-wide ...


Viruses, Vol. 7, Pages 3443-3461: The Subcellular Localisation of the Human Papillomavirus (HPV) 16 E7 Protein in Cervical Cancer Cells and Its Perturbation by RNA Aptamers

26.06.2015 | Cesur, Özlem ; Nicol, Clare ; Groves, Helen ; Mankouri, Jamel ; Blair, George Eric; Stonehouse, Nicola J., Viruses, 2015

Human papillomavirus (HPV) is the most common viral infection of the reproductive tract, affecting both men and women. High-risk oncogenic types are responsible for almost 90% of anogenital and oropharyngeal cancers including cervical cancer. Some of the HPV “early” genes, particularly E6 and E7, ...


AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance

25.06.2015 | Romina Burla et al., PLoS Genetics, 2015

by Romina Burla, Mariateresa Carcuro, Grazia D. Raffa, Alessandra Galati, Domenico Raimondo, Angela Rizzo, Mattia La Torre, Emanuela Micheli, Laura Ciapponi, Giovanni Cenci, Enrico Cundari, Antonio Musio, Annamaria Biroccio, Stefano Cacchione, Maurizio Gatti, Isabella Saggio Telomeres are ...


Synthesis, characterization and anticancer activity of novel lipophilic emodin cationic derivatives

24.06.2015 | Xiang Yang, Wenna Zhao, Xiufang Hu, Xianxiao Hao, Fang Hong, Jianlong Wang, Liping Xiang, Yunhui Zhu, Yaofeng Yuan, ..., Chemical Biology & Drug Design, 2015

Abstract Seventeen novel emodin derivatives were synthesized,and the structures were confirmed by IR, H NMR, MS and elemental analysis. The cytotoxic activity of the derivatives was evaluated against A375, BGC‐823, HepG2 and HELF cells by MTT assay. Compound 9a with highest potency and low ...


Marine Drugs, Vol. 13, Pages 3936-3949: Induction of Apoptosis and Antitumor Activity of Eel Skin Mucus, Containing Lactose-Binding Molecules, on Human Leukemic K562 Cells

19.06.2015 | Kwak, Choong-Hwan ; Lee, Sook-Hyun ; Lee, Sung-Kyun ; Ha, Sun-Hyung ; Suh, Seok-Jong ; Kwon, Kyung-Min ; Chung, Tae- ..., Marine Drugs, 2015

For innate immune defense, lower animals such as fish and amphibian are covered with skin mucus, which acts as both a mechanical and biochemical barrier. Although several mucus sources have been isolated and studied for their biochemical and immunological functions, the precise mechanism(s) of ...


Selective killing of gastric cancer cells by a small molecule targeting ROS‐mediated ER stress activation

18.06.2015 | Peng Zou, Yiqun Xia, Tongke Chen, Junru Zhang, Zhe Wang, Wenbo Chen, Minxiao Chen, Karvannan Kanchana, Shulin Yang, ..., Molecular Carcinogenesis, 2015

Gastric cancer is one of the leading causes of cancer mortality in the world. Curcumin is a natural product with multiple pharmacological activities, while its clinical application has been limited by the poor chemical stability. We have previously designed a series of curcumin derivatives with ...


Compound MQA, a Caffeoylquinic Acid Derivative, Protects Against NMDA‐Induced Neurotoxicity and Potential Mechanisms In Vitro

16.06.2015 | Xing Tian, Li An, Ling‐Yue Gao, Jun‐Peng Bai, Jian Wang, Wei‐Hong Meng, Tian‐Shu Ren, Qing‐Chun Zhao, CNS Neuroscience & Therapeutics, 2015

Summary Aims Compound MQA (1,5‐O‐dicaffeoyl‐3‐O‐[4‐malic acid methyl ester]‐quinic acid) is a natural derivative of caffeoylquinic acid isolated from Arctium lappa L. roots. However, we know little about the effects of MQA on the central nervous system. This study aims to investigate the ...


The Role of miR‐21 in Cancer

16.06.2015 | Susan R. Pfeffer, Chuan He Yang, Lawrence M. Pfeffer, Drug Development Research, 2015

ABSTRACT MicroRNAs (miRNAs) are small endogenous noncoding RNAs that suppress gene expression at the post‐transcriptional level. In the past decade, miRNAs have been extensively studied in a number of different human cancers. MiRNAs have been identified to act both as oncogenes ...


Necrotic Cells Actively Attract Phagocytes through the Collaborative Action of Two Distinct PS-Exposure Mechanisms

10.06.2015 | Zao Li et al., PLoS Genetics, 2015

by Zao Li, Victor Venegas, Yuji Nagaoka, Eri Morino, Prashant Raghavan, Anjon Audhya, Yoshinobu Nakanishi, Zheng Zhou Necrosis, a kind of cell death closely associated with pathogenesis and genetic programs, is distinct from apoptosis in both morphology and mechanism. Like apoptotic cells, ...


Crystal Structure of USP7 Ubiquitin-like Domains with an ICP0 Peptide Reveals a Novel Mechanism Used by Viral and Cellular Proteins to Target USP7

05.06.2015 | Roland Pfoh et al., PLoS Pathogens, 2015

by Roland Pfoh, Ira Kay Lacdao, Anna A. Georges, Adam Capar, Hong Zheng, Lori Frappier, Vivian Saridakis Herpes simplex virus-1 immediate-early protein ICP0 activates viral genes during early stages of infection, affects cellular levels of multiple host proteins and is crucial for effective ...


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