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720 Aktuelle Fachpublikationen zum Thema Addition

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Eight Pairs of Epimeric Triterpenoids Involving a Characteristic Spiro-E/F Ring from Abies faxoniana

02.01.2015 | Guo-Wei Wang; Chao Lv; Xin Fang; Xin-Hui Tian; Ji Ye; Hui-Liang Li; Lei Shan; Yun-Heng Shen; Wei-Dong Zhang, Journal of Natural Products, 2015

Five pairs of new epimeric lanostane-type triterpenoids, abiespirones A–D (1–4) and G (7), two pairs of new epimeric cycloartane-type triterpenoids, abiespirones E and F (5, 6), and a pair of new epimeric 7(8→9)abeo-spirolanostane abiespirones H (8) with spiro-B/C and -E/F ring systems were ...


The regulation and function of YAP transcription co-activator

01.01.2015 | Chu Zhu; Li Li; Bin Zhao, Acta Biochimica et Biophysica Sinica, 2015

The Hippo pathway was initially identified in Drosophila by genetic mosaic screens for tumor suppressor genes. Researches indicated that the Hippo pathway is a key regulator of organ size and is conserved during evolution. Furthermore, studies of mouse models and clinical samples demonstrated the ...


Roles Histone H3K27 tri‐methylase Ezh2 in retinal proliferation and differentiation

30.12.2014 | Atsumi Iida, Toshiro Iwagawa, Yukihiro Baba, Shinya Satoh, Yujin Mochizuki, Hiromitsu Nakauchi, Takahisa Furukawa, H ..., Developmental Neurobiology, 2014

Abstract The histone modification H3K27me3 regulates transcription negatively, and Jmjd3 and Ezh2 demethylate and methylate H3K27me3 and H3K27, respectively. We demonstrated previously that Jmjd3 plays pivotal roles in the differentiation of subsets of bipolar cells by regulating H3K27me3 ...


The multiple functional roles of mesenchymal stem cells in participating in treating liver diseases

23.12.2014 | Wei‐hui Liu, Fu‐qiang Song, Li‐na Ren, Wen‐qiong Guo, Tao Wang, Ya‐xing Feng, Li‐jun Tang, Kun Li, Journal of Cellular and Molecular Medicine, 2014

Abstract Mesenchymal stem cells (MSCs) are a group of stem cells derived from the mesodermal mesenchyme. MSCs can be obtained from a variety of tissues, including bone marrow, umbilical cord tissue, umbilical cord blood, peripheral blood and adipose tissue. Under certain conditions, MSCs can ...


High cell density cultivation of human leukemia T Cells (Jurkat Cells) in semipermeable polyelectrolyte microcapsules

19.12.2014 | Melanie Werner, Daria Schmoldt, Frank Hilbrig, Valérie Jérôme, Alexander Raup, Kenny Zambrano, Holger Hübner, Rainer ..., Engineering in Life Sciences, 2014

The ex vivo expansion of human T cells is of considerable scientific and medical interest. Currently, this requires the addition of massive amounts of stimuli. Here, human leukemia T cells (Jurkat cells) were used as model cells to demonstrate the in vitro expansion of T cells in the absence of ...


Cellular Oxidative Stress Response Controls the Antiviral and Apoptotic Programs in Dengue Virus-Infected Dendritic Cells

18.12.2014 | David Olagnier et al., PLoS Pathogens, 2014

by David Olagnier, Suraj Peri, Courtney Steel, Nadine van Montfoort, Cindy Chiang, Vladimir Beljanski, Michael Slifker, Zhong He, Carmen N. Nichols, Rongtuan Lin, Siddharth Balachandran, John Hiscott Dengue virus (DENV) is a re-emerging arthropod borne flavivirus that infects more than 300 ...


Effects of Vitexin on the Pharmacokinetics and mRNA Expression of CYP Isozymes in Rats

01.12.2014 | Xin‐shuai Wang, Xiao‐chen Hu, Gui‐ling Chen, Xiang Yuan, Rui‐na Yang, Shuo Liang, Jing Ren, Jia‐chun Sun, Guo‐qiang ..., Phytotherapy Research, 2014

In traditional therapy with Chinese medicine, vitexin has several pharmacological properties, including antinociceptive, antispasmodic, antioxidant, antimyeloperoxidase, and α‐glucosidase inhibitory activities. Recently, vitexin was shown to protect the heart against ischemia/reperfusion injury ...


Action of thyroxine on the survival and neurite maintenance of cerebellar granule neurons in culture

01.12.2014 | Koshi Oyanagi, Takayuki Negishi, Tomoko Tashiro, Journal of Neuroscience Research, 2014

Developmental hypothyroidism causes severe impairments in the cerebellum. To understand the role of thyroid hormones (THs) in cerebellar development, we examined the effect of three different THs, thyroxine (T4), 3,5,3′‐triidothyronine (T3), and 3,3′,5′‐triiodothyronine (reverse T3; rT3), on the ...


Loss of MITF expression during human embryonic stem cell differentiation disrupts retinal pigment epithelium development and optic vesicle cell proliferation

01.12.2014 | Elizabeth E. Capowski; Joseph M. Simonett; Eric M. Clark; Lynda S. Wright; Sara E. Howden; Kyle A. Wallace; Anna M. ..., Human Molecular Genetics, 2014

Microphthalmia-associated transcription factor (MITF) is a master regulator of pigmented cell survival and differentiation with direct transcriptional links to cell cycle, apoptosis and pigmentation. In mouse, Mitf is expressed early and uniformly in optic vesicle (OV) cells as they evaginate ...


Indoleamine 2,3-dioxygenase increases p53 levels in alloreactive human T cells, and both indoleamine 2,3-dioxygenase and p53 suppress glucose uptake, glycolysis and proliferation

01.12.2014 | Theodoros Eleftheriadis; Georgios Pissas; Georgia Antoniadi; Aginor Spanoulis; Vassilios Liakopoulos; Ioannis Stefanidis, International Immunology, 2014

Indoleamine 2,3-dioxygenase (IDO) suppresses adaptive immunity by inhibiting T-cell proliferation and altering glucose metabolism. The tumor suppressor p53 also alters these cellular processes with similar results. The effect of IDO on p53 and on glucose metabolism was evaluated in alloreactive T ...


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