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Looking back and moving forward: Recent advances in understanding of cardiovascular development by imaging of zebrafish

10.04.2015 | Shigetomo Fukuhara, Hajime Fukui, Yuki Wakayama, Koji Ando, Hiroyuki Nakajima, Naoki Mochizuki, Development, Growth & Differentiation, 2015

Development requires cell proliferation, migration, differentiation, apoptosis, and many kinds of cell responses. Cells prepare intracellular conditions to respond to extracellular cues from neighboring cells. We have studied the development of the cardiovascular system (CVS) by visualizing ...

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Lentinan exerts synergistic apoptotic effects with paclitaxel in A549 cells via activating ROS‐TXNIP‐NLRP3 inflammasome

09.04.2015 | Wei Liu, Jun Gu, Jun Qi, Xiao‐Ning Zeng, Juan Ji, Zheng‐Zhen Chen, Xiu‐Lan Sun, Journal of Cellular and Molecular Medicine, 2015

Abstract Paclitaxel is generally used to treat cancers in clinic as an inhibitor of cell division. However, the acquired resistance in tumours limits its clinical efficacy. Therefore, the aim of this study was to detect whether co‐treatment with lentinan enhanced the anti‐cancer effects of ...

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Targeting NAMPT for therapeutic intervention in cance and inflammation: Structure‐based drug design and biological screening

07.04.2015 | Venkat Koushik Pulla, Dinavahi Saketh Sriram, Vijay Soni, Srikant Viswanadha, Dharmarajan Sriram, Yogeeswari Perumal, Chemical Biology & Drug Design, 2015

Abstract Nicotinamide phosphoribosyltransferase (NAMPT) is a rate limiting enzyme that plays an important role in the synthesis of nicotinamide adenine dinucleotide (NAD) via a salvage pathway. Along with a role in bioenergetics, NAMPT regulates the activity of proteins such as SIRT‐1 that ...

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A Nonapoptotic Role for BAX and BAK in Eicosanoid Metabolism

06.04.2015 | Tejia Zhang; Loren D. Walensky; Alan Saghatelian, ACS Chemical Biology, 2015

BCL-2 proteins are key regulators of programmed cell death. The interplay between pro and antiapoptotic BCL-2 members has important roles in many cancers. In addition to their apoptotic function, recent evidence supports key nonapoptotic roles for several BCL-2 proteins. We used an unbiased ...

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Network Analyses Reveal Novel Aspects of ALS Pathogenesis

31.03.2015 | Mario Sanhueza et al., PLoS Genetics, 2015

by Mario Sanhueza, Andrea Chai, Colin Smith, Brett A. McCray, T. Ian Simpson, J. Paul Taylor, Giuseppa Pennetta Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by selective loss of motor neurons, muscle atrophy and paralysis. Mutations in the human ...

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GLTSCR2 is an upstream negative regulator of nucleophosmin in cervical cancer

27.03.2015 | Jee‐Youn Kim, Young‐Eun Cho, Yong‐Min An, Sang‐Hoon Kim, Yong‐Gwan Lee, Jae‐Hoon Park, Sun Lee, Journal of Cellular and Molecular Medicine, 2015

Abstract Nucleophosmin (NPM)/B23, a multifunctional nucleolar phosphoprotein, plays an important role in ribosome biogenesis, cell cycle regulation, apoptosis and cancer pathogenesis. The role of NPM in cells is determined by several factors, including total expression level, oligomerization ...

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Positive Role of Promyelocytic Leukemia Protein in Type I Interferon Response and Its Regulation by Human Cytomegalovirus

26.03.2015 | Young-Eui Kim et al., PLoS Pathogens, 2015

by Young-Eui Kim, Jin-Hyun Ahn Promyelocytic leukemia protein (PML), a major component of PML nuclear bodies (also known as nuclear domain 10), is involved in diverse cellular processes such as cell proliferation, apoptosis, gene regulation, and DNA damage response. PML also acts as a ...

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Synthesis and Anticancer Activity Evaluation of Some Benzothiazole-Piperazine Derivatives

25.03.2015 | Ece Gurdal, Enise; Buclulgan, Ebru; Durmaz, Irem; Cetin-Atalay, Rengul; Yarim, Mine, Anti-Cancer Agents in Medicinal Chemistry , 2015

Abstract: Synthesis, characterization and cytotoxic activities of ten benzothiazole-piperazine derivatives were reported. In vitro cytotoxic activities of compounds were screened against hepatocellular (HUH-7), breast (MCF-7) and colorectal (HCT-116) cancer cell lines by sulphorhodamine B ...

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Viruses, Vol. 7, Pages 1429-1453: Modulation of SIV and HIV DNA Vaccine Immunity by Fas-FasL Signaling

23.03.2015 | Yan, Jiabin ; Zapata, Juan Carlos; Pauza, Charles David; Salvato, Maria S., Viruses, 2015

Signaling through the Fas/Apo-1/CD95 death receptor is known to affect virus-specific cell-mediated immune (CMI) responses. We tested whether modulating the Fas-apoptotic pathway can enhance immune responses to DNA vaccination or lymphocytic choriomeningitis virus (LCMV) infection. Mice were ...

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Ketoconazole treatment decreases the viability of immortalized pituitary cell lines associated with an increased expression of apoptosis‐related genes and cell cycle inhibitors

21.03.2015 | Mariana Furieri Guzzo, Luciani Renata Silveira Carvalho, Marcello Delano Bronstein, Journal of Neuroendocrinology, 2015

Abstract Ketoconazole, which was initially developed as an antifungal agent, is a potent inhibitor of adrenal steroidogenesis and has therefore been used in the management of Cushing's disease. Surprisingly, the reduction of cortisol levels during ketoconazole treatment is not accompanied by ...

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