17.05.2013 | Fazal Shirazi et al., PLoS ONE, 2013

by Fazal Shirazi, Dimitrios P. Kontoyiannis The incidence of mucormycosis has increased drastically in immunocompromised patients. Also the array of targets whose inhibition results in Mucorales death is limited. Recently, researchers identified mitochondria as important regulators of ...

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15.05.2013 | Jun Fu; Dimpy Koul; Jun Yao; Shuzhen Wang; Ying Yuan; Howard Colman; Erik. P. Sulman; Frederick. F. Lang; W.K. Alfre ..., Cancer Research, 2013

Genetic heterogeneity and signaling alterations diminish the effectiveness of single-agent therapies in glioblastoma multiforme (GBM). HSP90 is a molecular chaperone for several signaling proteins that are deregulated in glioma cells. Thus, HSP90 inhibition may offer an approach to ...

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07.05.2013 | Alexandros Alexandratos, Joachim Clos, Martina Samiotaki, Antonia Efstathiou, George Panayotou, Ketty Soteriadou, De ..., Molecular Microbiology, 2013

Summary Overexpression of Leishmania histone H1 (LeishH1) was previously found to cause a promastigote‐to‐amastigote differentiation handicap, deregulation of cell‐cycle progression, and loss of parasite infectivity. The aim of this study was to identify changes in the proteome of LeishH1 ...

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04.05.2013 | Yulia Y. Tyurina, Daniel E. Winnica, Valentina I. Kapralova, Alexandr A. Kapralov, Vladimir A. Tyurin, Valerian E. Kagan, Molecular Nutrition & Food Research, 2013

Scope Rotenone is a toxicant believed to contribute to the development of Parkinson's disease. Methods and results Using human peripheral blood lymphocytes we demonstrated that exposure to rotenone resulted in disruption of electron transport accompanied by the production of ...

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01.05.2013 | Chi Chiu Mok, Expert Review of Clinical Immunology, 2013

VitaminD is a steroid hormone that, in addition to its actions on calcium and bone metabolism, exhibits a plethora of regulatory effects on growth, proliferation, apoptosis and function of the cells of the immune system that are relevant to the pathophysiology of systemic lupus erythematosus ...

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01.05.2013 | Yi-Hua Lai; Sung-Liang Yu; Hsuan-Yu Chen; Chi-Chung Wang; Huei-Wen Chen; Jeremy J.W. Chen, Carcinogenesis , 2013

HLJ1 is a novel tumour suppressor and is a potential druggable target for non-small-cell lung cancer (NSCLC). In this report, using a promoter-containing enhancer region as the HLJ1-targeting drug-screening platform, we identified several herbal compounds from a Chinese herbal bank with the ...

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01.05.2013 | Shengchao Ma; Huiping Zhang; Weiwei Sun; HuiHui Gong; Yanhua Wang; Changjian Ma; Ju Wang; Chengjian Cao; Xiaoling Ya ..., Acta Biochimica et Biophysica Sinica, 2013

Hyperhomocysteinemia (HHcy) is a risk factor for cardiovascular disease and has a strong correlation with heart failure. However, the effects of HHcy on cardiac tissue remain less well understood. To elucidate the role of p53-dependent apoptosis in HHcy-induced cardiac injury, we fed ApoE–/– ...

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01.05.2013 | Sabry M. Attia; Saleh A. Bakheet, Mutagenesis, 2013

The intention of the current study was to investigate the effect of non-toxic doses of dihydrokainate on the capacity of repair of DNA damage and apoptosis induced by doxorubicin in mouse bone-marrow cells. The scoring of micronuclei and olive tail moment was undertaken in the current study ...

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26.04.2013 | JingJing Gong, Saikartik A. Kumar, Gilian Graham, Addanki P. Kumar, Molecular Carcinogenesis, 2013

Abstract Cancerous growth is one of the most difficult diseases to target as there is no one clear cause, and targeting only one pathway does not generally produce quantifiable improvement. For a truly effective cancer therapy, multiple pathways must be targeted at the same time. One way ...

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26.04.2013 | Xia Gong, Li Zhang, Rong Jiang, Chang‐Dong Wang, Xin‐Ru Yin, Jing‐Yuan Wan, Journal of Applied Toxicology, 2013

ABSTRACT The prognosis for fulminant hepatic failure (FHF) still remains extremely poor with a high mortality and, therefore, better treatments are urgently needed. Syringin, a main active substance isolated from Eleutherococcus senticosus, has been reported to exhibit immunomodulatory ...

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