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714 Aktuelle Fachpublikationen zum Thema Addition

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Effects of Vitexin on the Pharmacokinetics and mRNA Expression of CYP Isozymes in Rats

01.12.2014 | Xin‐shuai Wang, Xiao‐chen Hu, Gui‐ling Chen, Xiang Yuan, Rui‐na Yang, Shuo Liang, Jing Ren, Jia‐chun Sun, Guo‐qiang ..., Phytotherapy Research, 2014

In traditional therapy with Chinese medicine, vitexin has several pharmacological properties, including antinociceptive, antispasmodic, antioxidant, antimyeloperoxidase, and α‐glucosidase inhibitory activities. Recently, vitexin was shown to protect the heart against ischemia/reperfusion injury ...


Action of thyroxine on the survival and neurite maintenance of cerebellar granule neurons in culture

01.12.2014 | Koshi Oyanagi, Takayuki Negishi, Tomoko Tashiro, Journal of Neuroscience Research, 2014

Developmental hypothyroidism causes severe impairments in the cerebellum. To understand the role of thyroid hormones (THs) in cerebellar development, we examined the effect of three different THs, thyroxine (T4), 3,5,3′‐triidothyronine (T3), and 3,3′,5′‐triiodothyronine (reverse T3; rT3), on the ...


Loss of MITF expression during human embryonic stem cell differentiation disrupts retinal pigment epithelium development and optic vesicle cell proliferation

01.12.2014 | Elizabeth E. Capowski; Joseph M. Simonett; Eric M. Clark; Lynda S. Wright; Sara E. Howden; Kyle A. Wallace; Anna M. ..., Human Molecular Genetics, 2014

Microphthalmia-associated transcription factor (MITF) is a master regulator of pigmented cell survival and differentiation with direct transcriptional links to cell cycle, apoptosis and pigmentation. In mouse, Mitf is expressed early and uniformly in optic vesicle (OV) cells as they evaginate ...


Indoleamine 2,3-dioxygenase increases p53 levels in alloreactive human T cells, and both indoleamine 2,3-dioxygenase and p53 suppress glucose uptake, glycolysis and proliferation

01.12.2014 | Theodoros Eleftheriadis; Georgios Pissas; Georgia Antoniadi; Aginor Spanoulis; Vassilios Liakopoulos; Ioannis Stefanidis, International Immunology, 2014

Indoleamine 2,3-dioxygenase (IDO) suppresses adaptive immunity by inhibiting T-cell proliferation and altering glucose metabolism. The tumor suppressor p53 also alters these cellular processes with similar results. The effect of IDO on p53 and on glucose metabolism was evaluated in alloreactive T ...


RFX-1-dependent activation of SHP-1 inhibits STAT3 signaling in hepatocellular carcinoma cells

01.12.2014 | Jung-Chen Su; Heng-Chieh Chiang; Ping-Hui Tseng; Wei-Tien Tai; Cheng-Yi Hsu; Yong-Shi Li; Jui-Wen Huang; Ching-Huai ..., Carcinogenesis , 2014

Regulatory factor X-1 (RFX-1) is a transcription factor that has been linked to negative regulation of tumor progression; however, its biological function and signaling cascades are unknown. Here, we performed several studies to elucidate the roles of RFX-1 in the regulation of SHP-1 in ...


Genetic Deletion of LXR{alpha} Prevents Arsenic-Enhanced Atherosclerosis, But Not Arsenic-Altered Plaque Composition

01.12.2014 | Maryse Lemaire; Catherine A. Lemarié; Manuel Flores Molina; Cynthia Guilbert; Stéphanie Lehoux; Koren K. Mann, Toxicological Sciences, 2014

Arsenic exposure has been linked to an increased incidence of atherosclerosis. Previously, we have shown in vitro and in vivo that arsenic inhibits transcriptional activation of the liver X receptors (LXRs), key regulators of lipid homeostasis. Therefore, we evaluated the role of LXRα in ...


BET Protein Inhibitor JQ1 Attenuates Myc-Amplified MCC Tumor Growth In Vivo

01.12.2014 | Qiang Shao; Aarthi Kannan; Zhenyu Lin; Brendan C. Stack, Jr; James Y. Suen; Ling Gao, Cancer Research, 2014

Merkel cell carcinoma (MCC) is an aggressive neuroendocrine tumor of the skin currently with no cure. In this study, we have first demonstrated that c-Myc overexpression is common in MCC. By targeting c-Myc, bromodomain inhibitors have demonstrated antitumor efficacy in several preclinical human ...


Carvedilol Promotes Neurological Function, Reduces Bone Loss and Attenuates Cell Damage after Acute Spinal Cord Injury in Rats

25.11.2014 | Da Liu, Ying Huang, Bin Li, Changqing Jia, Feng Liang, Qin Fu, Clinical and Experimental Pharmacology and Physiology, 2014

Abstract Acute spinal cord injury (SCI) leads to permanent functional deficits via mechanical injury and secondary mechanisms, but the therapeutic strategy for SCI is limited. Carvedilol has been shown to possess multiple biological and pharmacological properties. This study aims to ...


Follicle‐stimulating hormone promotes age‐related endometrial atrophy through cross‐talk with transforming growth factor beta signal transduction pathway

13.11.2014 | Dan Zhang, Jingyi Li, Gufeng Xu, Runjv Zhang, Chengliang Zhou, Yeqing Qian, Yifeng Liu, Luting Chen, Bo Zhu, Xiaoqun ..., Aging Cell, 2014

Summary It is widely believed that endometrial atrophy in postmenopausal women is due to an age‐related reduction in estrogen level. But the role of high circulating follicle‐stimulating hormone (FSH) in postmenopausal syndrome is not clear. Here, we explored the role of high circulating FSH ...


Role of p38 MAPK in enhanced human cancer cells killing by the combination of aspirin and ABT‐737

11.11.2014 | Chong Zhang, Jing Shi, Shi‐ying Mao, Ya‐si Xu, Dan Zhang, Lin‐yi Feng, Bo Zhang, You‐you Yan, Si‐cong Wang, Jian‐pin ..., Journal of Cellular and Molecular Medicine, 2014

Abstract Regular use of aspirin after diagnosis is associated with longer survival among patients with mutated‐PIK3CA colorectal cancer, but not among patients with wild‐type PIK3CA cancer. In this study, we showed that clinically achievable concentrations of aspirin and ABT‐737 in combination ...


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