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Arginine methylation of hnRNPK negatively modulates apoptosis upon DNA damage through local regulation of phosphorylation

01.11.2014 | Jen-Hao Yang; Yi-Ying Chiou; Shu-Ling Fu; I-Yun Shih; Tsai-Hsuan Weng; Wey-Jinq Lin; Chao-Hsiung Lin, Nucleic Acids Research, 2014

Heterogeneous nuclear ribonucleoprotein K (hnRNPK) is an RNA/DNA-binding protein involved in chromatin remodeling, RNA processing and the DNA damage response. In addition, increased hnRNPK expression has been associated with tumor development and progression. A variety of post-translational ...


SAR405838: An Optimized Inhibitor of MDM2–p53 Interaction That Induces Complete and Durable Tumor Regression

15.10.2014 | Shaomeng Wang; Wei Sun; Yujun Zhao; Donna McEachern; Isabelle Meaux; Cédric Barrière; Jeanne A. Stuckey; Jennifer L. ..., Cancer Research, 2014

Blocking the oncoprotein murine double minute 2 (MDM2)–p53 protein–protein interaction has long been considered to offer a broad cancer therapeutic strategy, despite the potential risks of selecting tumors harboring p53 mutations that escape MDM2 control. In this study, we report a novel ...


Pioglitazone, a PPARγ agonist, inhibits growth and invasion of human hepatocellular carcinoma via blockade of the rage signaling

12.10.2014 | Yuan Yang, Ling‐Hao Zhao, Bo Huang, Ruo‐Yu Wang, Sheng‐Xian Yuan, Qi‐Fei Tao, Yong Xu, Han‐Yong Sun, Chuan Lin, Wei‐ ..., Molecular Carcinogenesis, 2014

Pioglitazone (PGZ), a synthetic PPARγ ligand, is known to have anti‐tumor activity. However, it is unclear how it acts against hepatocellular carcinoma (HCC). We hypothesized that the pathological receptor for advanced glycation end products (RAGE) is involved in the PGZ anti‐tumor process. To ...


Plant‐derived flavones as inhibitors of aurora B kinase and their quantitative structure–activity relationships

08.10.2014 | Yearam Jung, Soon Young Shin, Yeonjoong Yong, Hyeryoung Jung, Seunghyun Ahn, Young Han Lee, Yoongho Lim, Chemical Biology & Drug Design, 2014

Abstract Although several plant‐derived flavones inhibit aurora B kinase (aurB), quantitative relationships between the structural properties of plant‐derived flavones and their inhibitory effects on aurB remain unclear. In this report, these quantitative structure–activity relationships were ...


A Steroidal Na+/K+ ATPase Inhibitor Triggers Pro-apoptotic Signaling and Induces Apoptosis in Prostate and Lung Tumor Cells

07.10.2014 | Honisch, Sabina; Alkahtani, Saad; Kounenidakis, Michalis; Liu, Guilai; Alarifi, Saud; Al-Yahya, Hamad; Dimas, Konsta ..., Anti-Cancer Agents in Medicinal Chemistry , 2014

Abstract: Recently we have reported potent anti-cancer actions of various steroidal Na+/K+ ATPase inhibitors in multiple cell lines. Furthermore, the most powerful compound identified in this study, the 3-[(R)-3-pyrrolidinyl]oxime derivative (3-R-POD), was highly effective in various tumor ...


Cucurbitacin B Induces DNA Damage, G2/M Phase Arrest, and Apoptosis Mediated by Reactive Oxygen Species (ROS) in Leukemia K562 Cells

07.10.2014 | Guo, Jiajie; Zhao, Wenwen; Hao, Wenhui; Ren, Guowen; Lu, Jinjian; Chen, Xiuping, Anti-Cancer Agents in Medicinal Chemistry , 2014

Abstract: Cucurbitacin B (Cuc B) is a natural product with potent anti-cancer activities in solid tumors. We investigated the anti-cancer effect of Cuc B on K562 leukemia cells. Cuc B drastically decreased cell viability in a concentration-dependent manner. Cuc B treatment caused DNA damage, as ...


Baicalin Induces Apoptosis of Gallbladder Carcinoma Cells in vitro via a Mitochondrial-Mediated Pathway and Suppresses Tumor Growth in vivo

07.10.2014 | Shu, Yi-Jun; Bao, Run-Fa; Wu, Xiang-Song; Weng, Hao; Ding, Qian; Cao, Yang; Li, Mao-Lan; Mu, Jia-Sheng; Wu, Wen-Guan ..., Anti-Cancer Agents in Medicinal Chemistry , 2014

Abstract: Baicalin, the main active ingredient in the Scutellaria baicalensis (SB), is prescribed for the treatment of various inflammatory diseases and tumors in clinics in China. In the present study, we evaluated the antitumor activity of baicalin for gallbladder carcinoma and the ...


Adenosine Receptors and Renal Ischemia Reperfusion Injury

07.10.2014 | May M. Rabadi, H. Thomas Lee, Acta Physiologica, 2014

Abstract One of the frequent clinical complications that results in billions of dollars in health care costs annually in the United States is acute kidney injury (AKI). Ischemia reperfusion (IR) injury is a major cause AKI. Unfortunately, no effective treatment or preventive measure for AKI ...


TIGAR Has a Dual Role in Cancer Cell Survival through Regulating Apoptosis and Autophagy

15.09.2014 | Jia-Ming Xie; Bin Li; Hong-Pei Yu; Quan-Geng Gao; Wei Li; Hao-Rong Wu; Zheng-Hong Qin, Cancer Research, 2014

The p53-induced glycolysis and apoptosis regulator (TIGAR) inhibits glycolysis, resulting in higher intracellular NADPH, lower reactive oxygen species (ROS) and autophagy activity. In this study, we investigated whether TIGAR might exert dual impacts on cancer cell survival based on its ability ...


Rice ORMDL Controls Sphingolipid Homeostasis Affecting Fertility Resulting from Abnormal Pollen Development

05.09.2014 | Chutharat Chueasiri et al., PLoS ONE, 2014

by Chutharat Chueasiri, Ketsuwan Chunthong, Keasinee Pitnjam, Sriprapai Chakhonkaen, Numphet Sangarwut, Kanidta Sangsawang, Malinee Suksangpanomrung, Louise V. Michaelson, Johnathan A. Napier, Amorntip Muangprom The orosomucoids (ORM) are ER-resisdent polypeptides encoded by ORM and ORMDL ...


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