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Loss of MITF expression during human embryonic stem cell differentiation disrupts retinal pigment epithelium development and optic vesicle cell proliferation

01.12.2014 | Elizabeth E. Capowski; Joseph M. Simonett; Eric M. Clark; Lynda S. Wright; Sara E. Howden; Kyle A. Wallace; Anna M. ..., Human Molecular Genetics, 2014

Microphthalmia-associated transcription factor (MITF) is a master regulator of pigmented cell survival and differentiation with direct transcriptional links to cell cycle, apoptosis and pigmentation. In mouse, Mitf is expressed early and uniformly in optic vesicle (OV) cells as they evaginate ...


Indoleamine 2,3-dioxygenase increases p53 levels in alloreactive human T cells, and both indoleamine 2,3-dioxygenase and p53 suppress glucose uptake, glycolysis and proliferation

01.12.2014 | Theodoros Eleftheriadis; Georgios Pissas; Georgia Antoniadi; Aginor Spanoulis; Vassilios Liakopoulos; Ioannis Stefanidis, International Immunology, 2014

Indoleamine 2,3-dioxygenase (IDO) suppresses adaptive immunity by inhibiting T-cell proliferation and altering glucose metabolism. The tumor suppressor p53 also alters these cellular processes with similar results. The effect of IDO on p53 and on glucose metabolism was evaluated in alloreactive T ...


Follicle‐stimulating hormone promotes age‐related endometrial atrophy through cross‐talk with transforming growth factor beta signal transduction pathway

13.11.2014 | Dan Zhang, Jingyi Li, Gufeng Xu, Runjv Zhang, Chengliang Zhou, Yeqing Qian, Yifeng Liu, Luting Chen, Bo Zhu, Xiaoqun ..., Aging Cell, 2014

Summary It is widely believed that endometrial atrophy in postmenopausal women is due to an age‐related reduction in estrogen level. But the role of high circulating follicle‐stimulating hormone (FSH) in postmenopausal syndrome is not clear. Here, we explored the role of high circulating FSH ...


Role of p38 MAPK in enhanced human cancer cells killing by the combination of aspirin and ABT‐737

11.11.2014 | Chong Zhang, Jing Shi, Shi‐ying Mao, Ya‐si Xu, Dan Zhang, Lin‐yi Feng, Bo Zhang, You‐you Yan, Si‐cong Wang, Jian‐pin ..., Journal of Cellular and Molecular Medicine, 2014

Abstract Regular use of aspirin after diagnosis is associated with longer survival among patients with mutated‐PIK3CA colorectal cancer, but not among patients with wild‐type PIK3CA cancer. In this study, we showed that clinically achievable concentrations of aspirin and ABT‐737 in combination ...


5‐fluorouracil combined with apigenin enhances anticancer activity through ΔΨm‐mediated apoptosis in hepatocellular carcinoma

01.11.2014 | Xiao‐Yun Hu, Ji‐Yun Liang, Xue‐Jun Guo, Li Liu, Ya‐Bing Guo, Clinical and Experimental Pharmacology and Physiology, 2014

Abstract The development of chemo‐resistance may reduce the efficacy of chemotherapeutic drugs for treating hepatocellular carcinoma (HCC). Here, the effects of apigenin on intensifying the chemosensitivity of HCC cells and an HCC xenograft model in response to 5‐fluorouracil (5‐fu) were ...


Arginine methylation of hnRNPK negatively modulates apoptosis upon DNA damage through local regulation of phosphorylation

01.11.2014 | Jen-Hao Yang; Yi-Ying Chiou; Shu-Ling Fu; I-Yun Shih; Tsai-Hsuan Weng; Wey-Jinq Lin; Chao-Hsiung Lin, Nucleic Acids Research, 2014

Heterogeneous nuclear ribonucleoprotein K (hnRNPK) is an RNA/DNA-binding protein involved in chromatin remodeling, RNA processing and the DNA damage response. In addition, increased hnRNPK expression has been associated with tumor development and progression. A variety of post-translational ...


Conformational study reveals amino acid residues essential for hemagglutinating and anti-proliferative activities of Clematis montana lectin

01.11.2014 | Bangmin Lu; Bin Zhang; Wei Qi; Yanan Zhu; Yan Zhao; Nan Zhou; Rong Sun; Jinku Bao; Chuanfang Wu, Acta Biochimica et Biophysica Sinica, 2014

Clematis montana lectin (CML), a novel mannose-binding lectin purified from C. montana Buch.-Ham stem (Ranunculaceae), has been proved to have hemagglutinating activity in rabbit erythrocytes and apoptosis-inducing activity in tumor cells. However, the biochemical properties of CML have not ...


Gastrokine 1 inhibits the carcinogenic potentials of Helicobacter pylori CagA

01.11.2014 | Jung Hwan Yoon; Ho Suk Seo; Sung Sook Choi; Hyun Suk Chae; Won Seok Choi; Olga Kim; Hassan Ashktorab; Duane T. Smoot ..., Carcinogenesis , 2014

Helicobacter pylori CagA directly injected by the bacterium into epithelial cells via a type IV secretion system, leads to cellular changes such as morphology, apoptosis, proliferation and cell motility, and stimulates gastric carcinogenesis. We investigated the effects of cytotoxin-associated ...


Impact of the mitogen‐activated protein kinase pathway on the subproteome of detergent‐resistant microdomains of colon carcinoma cells

31.10.2014 | Christian V. Recktenwald, Rudolf Lichtenfels, Jens Wulfaenger, Anja Müller, Sven P. Dressler, Barbara Seliger, PROTEOMICS, 2014

Lipid rafts play a key role in the regulation of fundamentally important cellular processes, including cell proliferation, differentiation and survival. The composition of such detergent‐resistant microdomains (DRM) is altered under pathologic conditions, including cancer. Although DRM have been ...


Antitumor effects of ponatinib in glioblastoma

29.10.2014 | OncoTargets and Therapy, 2014

Glioblastoma is one of the most common malignant tumors in the nervous system in both adult and pediatric patients. Studies suggest that abnormal activation of receptor tyrosine kinases contributes to pathological development of glioblastoma. However, current therapies targeting tyrosine kinase ...


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