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1.974 Aktuelle Fachpublikationen zum Thema Addition

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Cholesterol conjugation potentiates the antiviral activity of an HIV immunoadhesin

24.07.2015 | Richard A. Urbanowicz, Krzysztof Lacek, Armin Lahm, Krystyna Bienkowska‐Szewczyk, Jonathan K. Ball, Alfredo Nicosia, ..., Journal of Peptide Science, 2015

Immunoadhesins are engineered proteins combining the constant domain (Fc) of an antibody with a ligand‐binding (adhesion) domain. They have significant potential as therapeutic agents, because they maintain the favourable pharmacokinetics of antibodies with an expanded repertoire of ...


Intersex in fishes and amphibians: population implications, prevalence, mechanisms and molecular biomarkers

24.07.2015 | Ahmed Abdel‐moneim, David P. Coulter, Cecon T. Mahapatra, Maria S. Sepúlveda, Journal of Applied Toxicology, 2015

Abstract Intersex is defined as the abnormal presence of both testicular and ovarian cells in gonads of gonochoristic animals. Its occurrence is widespread and reports on its presence in the gonads of vertebrates continues to increase. In this review, we use standardized terminology to ...


Antimicrobial agent triclosan is a proton ionophore uncoupler of mitochondria in living rat and human mast cells and in primary human keratinocytes

24.07.2015 | Lisa M. Weatherly, Juyoung Shim, Hina N. Hashmi, Rachel H. Kennedy, Samuel T. Hess, Julie A. Gosse, Journal of Applied Toxicology, 2015

Abstract Triclosan (TCS) is an antimicrobial used widely in hospitals and personal care products, at ~10 mm. Human skin efficiently absorbs TCS. Mast cells are ubiquitous key players both in physiological processes and in disease, including asthma, cancer and autism. We previously showed that ...


Hepatic Clearance Prediction of Nine Human Immunodeficiency Virus Protease Inhibitors in Rat

22.07.2015 | Tom De Bruyn, Patrick F. Augustijns, Pieter P. Annaert, Journal of Pharmaceutical Sciences, 2015

This study aimed to determine the rate‐limiting step in the overall hepatic clearance of the marketed human immunodeficiency virus (HIV) protease inhibitors (PI) in rats by predicting the experimentally determined hepatic in vivo clearance of these drugs based on in vitro clearance values for ...


Structural and mechanical characterization of bioresorbable, elastomeric nanocomposites from poly(glycerol sebacate)/nanohydroxyapatite for tissue transport applications

22.07.2015 | Tabitha N. Rosenbalm, Maria Teruel, Cynthia S. Day, George L. Donati, Michael Morykwas, Louis Argenta, Narayanan Kut ..., Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2015

Abstract Poly(glycerol sebacate) (PGS)/nanohydroxyapatite (nHA) composites were assessed to develop new materials for closure via tissue transport for nonhealing defects (e.g., cleft palate and large skin wounds). The elastic shape memory polymer, PGS, was reinforced with nHA at 3 and 5% ...


Alterations of the CD58 gene in classical Hodgkin lymphoma

21.07.2015 | Markus Schneider, Stefanie Schneider, Reina Zühlke‐Jenisch, Wolfram Klapper, Christer Sundström, Sylvia Hartmann, Ma ..., Genes, Chromosomes and Cancer, 2015

Immune evasion plays a central role in the pathophysiology of classical Hodgkin lymphoma (cHL). As mutations of the CD58 gene contribute to immune evasion of diffuse large B cell lymphoma tumor cells, we studied whether alterations of the CD58 gene also occur in Hodgkin and Reed/Sternberg (HRS) ...


Double‐blind, placebo‐controlled pilot study of adjunctive quetiapine SR in the treatment of PMS/PMDD

20.07.2015 | Christine Jackson, Brenda Pearson, Susan Girdler, Jacqueline Johnson, Robert M. Hamer, Susan Killenberg, Samantha Me ..., Human Psychopharmacology: Clinical and Experimental, 2015

Objective Premenstrual dysphoric disorder (PMDD), a more severe form of premenstrual syndrome (PMS), afflicts 5–8% of reproductive age women and results in significant functional impairment. We conducted a double‐blind, placebo‐controlled trial of adjunctive quetiapine in patients with ...


Lupeol Protects Against Cerulein‐Induced Acute Pancreatitis in Mice

16.07.2015 | Min‐Jun Kim, Gi‐Sang Bae, Sun Bok Choi, Il‐Joo Jo, Dong‐Goo Kim, Joon‐Yeon Shin, Sung‐Kon Lee, Myoung‐Jin Kim, Ho‐Jo ..., Phytotherapy Research, 2015

Lupeol is a triterpenoid commonly found in fruits and vegetables and is known to exhibit a wide range of biological activities, including antiinflammatory and anti‐cancer effects. However, the effects of lupeol on acute pancreatitis specifically have not been well characterized. Here, we ...


Gene‐set and multivariate genome‐wide association analysis of oppositional defiant behavior subtypes in attention‐deficit/hyperactivity disorder

16.07.2015 | Marcel Aebi, Marjolein M. J. van Donkelaar, Geert Poelmans, Jan K. Buitelaar, Edmund J. S. Sonuga‐Barke, Argyris Str ..., American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2015

Oppositional defiant disorder (ODD) is a frequent psychiatric disorder seen in children and adolescents with attention‐deficit‐hyperactivity disorder (ADHD). ODD is also a common antecedent to both affective disorders and aggressive behaviors. Although the heritability of ODD has been estimated ...


Reducible Poly(Oligo‐d‐Arginine) as an Efficient Carrier of the Thymidine Kinase Gene in the Intracranial Glioblastoma Animal Model

16.07.2015 | Hyun Ah Kim, Hyun‐Lin Lee, Eunji Choi, Yong‐Hee Kim, Minhyung Lee, Journal of Pharmaceutical Sciences, 2015

Gene therapy has been considered as an alternative treatment for glioblastoma therapy. In this study, a glioblastoma‐specific suicide gene, pEpo–NI2–SV–TK, was delivered into the intracranial glioblastoma model using reducible poly(oligo‐d‐arginines) (rPOA). pEpo–NI2–SV–TK has the erythropoietin ...


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