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1.783 Aktuelle Fachpublikationen zum Thema Addition

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Trifluoroethanol‐containing RP‐HPLC mobile phases for the separation of transmembrane peptides human glycophorin‐A, integrin alpha‐1, and p24: analysis and prevention of potential side reactions due to formic acid

12.12.2014 | Toshiaki Hara, Yue Huang, Akihiro Ito, Toru Kawakami, Hironobu Hojo, Michio Murata, Journal of Peptide Science, 2014

Reversed‐phase high‐pressure liquid chromatography analysis and purification of three hydrophobic, aggregation‐prone peptides, composed mainly of the transmembrane (TM) sequence, were performed using elution systems containing 2,2,2‐trifluoroethanol (TFE). The addition of 10–16% TFE to a common ...


Honokiol inhibits melanoma stem cells by targeting notch signaling

09.12.2014 | Gaurav Kaushik, Anand Venugopal, Prabhu Ramamoorthy, David Standing, Dharmalingam Subramaniam, Shahid Umar, Roy A. J ..., Molecular Carcinogenesis, 2014

Melanoma is an aggressive disease with limited therapeutic options. Here, we determined the effects of honokiol (HNK), a biphenolic natural compound on melanoma cells and stemness. HNK significantly inhibited melanoma cell proliferation, viability, clonogenicity and induced autophagy. In ...


Prevalence of human papillomavirus and its genotype among 1336 invasive cervical cancer patients in Hunan province, central south China

08.12.2014 | Linqian Wang, Baiping Wu, Junjun Li, Liyu Chen, Journal of Medical Virology, 2014

Existing data on the genotype distribution of human papillomavirus (HPV) are limited in Hunan province, central south China. To evaluate the prevalence of HPV infection and its genotype among women with invasive cervical cancer in Hunan, a total of 1,336 patients were included in this study ...


In vitro electromagnetic stimulation to enhance cell proliferation in extracellular matrix constructs with and without metallic nanoparticles

03.12.2014 | Daniel N. Grant, Matthew J. Cozad, David A. Grant, Richard A. White, Sheila A. Grant, Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2014

Abstract Extremely low frequency electromagnetic fields (ELF‐EMFs) can induce beneficial effects including enhanced protein synthesis and cell proliferation on healing bone and skin wounds. This study investigated the effects of ELF‐EMFs on acellular tissue constructs with and without gold ...


Real‐Time Assessment of Granule Densification in High Shear Wet Granulation and Application to Scale‐up of a Placebo and a Brivanib Alaninate Formulation

02.12.2014 | Ajit S. Narang, Valery A. Sheverev, Vadim Stepaniuk, Sherif Badawy, Tim Stevens, Kevin Macias, Avi Wolf, Preetanshu ..., Journal of Pharmaceutical Sciences, 2014

Real‐time monitoring and control of high shear wet granulation (HSWG) using process analytical technologies is crucial to process design, scale‐up, and reproducible manufacture. Although significant progress has been made in real‐time measurement of granule size distribution using focused beam ...


Achieving Continuous Manufacturing: Technologies and Approaches for Synthesis, Workup, and Isolation of Drug Substance

02.12.2014 | Ian R. Baxendale, Richard D. Braatz, Benjamin K Hodnett, Klavs F. Jensen, Martin D Johnson, Paul Sharratt, Jon‐Paul ..., Journal of Pharmaceutical Sciences, 2014

This whitepaper highlights current challenges and opportunities associated with continuous synthesis, workup, and crystallization of active pharmaceutical ingredients (drug substances). We describe the technologies and requirements at each stage and emphasize the different considerations for ...


Increasing proteome coverage for gel‐based human tear proteome maps: towards a more comprehensive profiling

02.12.2014 | Neda Saraygord‐Afshari, Hossein Naderi‐Manesh, Mostafa Naderi, Biomedical Chromatography, 2014

ABSTRACT In situations where the molecular mechanism of many ocular disorders is unknown, owing to the difficulties associated with sampling from ocular tissues, human tear film can be a promising medium in ophthalmic research. The present study demonstrates an in‐depth gel‐based proteome ...


Tumor‐Targeted Paclitaxel Delivery and Enhanced Penetration Using TAT‐Decorated Liposomes Comprising Redox‐Responsive Poly(Ethylene Glycol)

01.12.2014 | Han Fu, Kairong Shi, Guanlian Hu, Yuting Yang, Qifang Kuang, Libao Lu, Li Zhang, Wenfei Chen, Mingling Dong, Yantao ..., Journal of Pharmaceutical Sciences, 2014

To combine the advantage of poly(ethylene gylcol) (PEG) for longer circulation and cell‐penetrating peptides (CPPs) for efficient cellular uptake, paclitaxel (PTX)‐loaded liposomes functionalized with TAT, the most frequently used CPP, and cleavable PEG via a redox‐responsive disulfide linker ...


Equipment and Analytical Companies Meeting Continuous Challenges

01.12.2014 | Trevor Page, Henry Dubina, Gabriele Fillipi, Roland Guidat, Saroj Patnaik, Peter Poechlauer, Phil Shering, Martin Gu ..., Journal of Pharmaceutical Sciences, 2014

This white paper focuses on equipment, and analytical manufacturers’ perspectives, regarding the challenges of continuous pharmaceutical manufacturing across five prompt questions. In addition to valued input from several vendors, commentary was provided from experienced pharmaceutical ...


Multivalent Nanomaterials: Learning from Vaccines and Progressing to Antigen‐Specific Immunotherapies

01.12.2014 | Brittany L. Hartwell, Lorena Antunez, Bradley P. Sullivan, Sharadvi Thati, Joshua O. Sestak, Cory Berkland, Journal of Pharmaceutical Sciences, 2014

Continued development of multivalent nanomaterials has provided opportunities for the advancement of antigen‐specific immunotherapies. New insights emerge when considering the backdrop of vaccine design, which has long employed multivalent presentation of antigen to more strongly engage and ...


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