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Genetic variation in cell cycle regulatory gene AURKA and association with intrinsic breast cancer subtype

18.10.2014 | Nicholas J. Taylor, Jeannette T. Bensen, Charles Poole, Melissa A. Troester, Marilie D. Gammon, Jingchun Luo, Robert ..., Molecular Carcinogenesis, 2014

AURKA is a putative low‐penetrance tumor susceptibility gene due to its prominent role in cell cycle regulation and centrosomal function. Germline variation in AURKA was evaluated for association with breast cancer and intrinsic breast cancer subtypes in the Carolina Breast Cancer Study (CBCS), ...


Elevated expression of long intergenic non‐coding RNA HOTAIR in a basal‐like variant of MCF‐7 breast cancer cells

18.10.2014 | Yan Zhuang, Hong T. Nguyen, Matthew E. Burow, Ying Zhuo, Samir S. El‐Dahr, Xiao Yao, Subing Cao, Erik K. Flemington, ..., Molecular Carcinogenesis, 2014

Epigenetic regulation of gene expression is critical to phenotypic maintenance and transition of human breast cancer cells. HOX antisense intergenic RNA (HOTAIR) is a long intergenic non‐coding RNA that epigenetically represses gene expression via recruitment of enhancer of zeste homolog 2 ...


GABA and its B‐receptor are present at the node of Ranvier in a small population of sensory fibers, implicating a role in myelination

18.10.2014 | Mikael Corell, Grzegorz Wicher, Katarzyna J. Radomska, E. Duygu Dağlıkoca, Randi Elberg Godskesen, Robert Fredriksso ..., Journal of Neuroscience Research, 2014

The γ‐aminobutyric acid (GABA) type B receptor has been implicated in glial cell development in the peripheral nervous system (PNS), although the exact function of GABA signaling is not known. To investigate GABA and its B receptor in PNS development and degeneration, we studied the expression ...


Microornamentation of leaf chameleons (Chamaeleonidae: Brookesia, Rhampholeon, and Rieppeleon)—with comments on the evolution of microstructures in the chamaeleonidae

18.10.2014 | Jendrian Riedel, Wolfgang Böhme, Horst Bleckmann, Marlene Spinner, Journal of Morphology, 2014

ABSTRACT Chameleons (Chamaeleonidae) feature many adaptations to their arboreal lifestyle, including zygodactylous feet, a prehensile tail, and epidermal microstructures. In arboreal tree chameleons, the substrate‐contacting site of the feet and tail is covered by microscopic hair‐like ...


Paternal age predicts offspring chances of marriage and reproduction

18.10.2014 | Martin Fieder, Susanne Huber, American Journal of Human Biology, 2014

Objectives Mutation‐selection balance theory proposes that a balance of forces between constantly arising mildly harmful mutations and selection causes variation in genetic configuration and phenotypic condition. As mutations are predominantly deleterious, the entry of variation due to ...


Diurnal variation in salivary cortisol across age classes in Ache Amerindian males of Paraguay

18.10.2014 | Dorsa Amir, Peter T. Ellison, Kim R. Hill, Richard G. Bribiescas, American Journal of Human Biology, 2014

Objectives Cortisol levels exhibit a diurnal rhythm in healthy men, with peaks in the morning and troughs in the evening. Throughout age, however, this rhythm tends to flatten. This diurnal flattening has been demonstrated in a majority of industrialized populations, although the results have ...


Increased circulating cell‐free DNA levels and mtDNA fragments in interventional cardiologists occupationally exposed to low levels of ionizing radiation

18.10.2014 | Andrea Borghini, Antonella Mercuri, Stefano Turchi, Maria Rosa Chiesa, Emanuela Piccaluga, Maria Grazia Andreassi, Environmental and Molecular Mutagenesis, 2014

Circulating cell‐free DNA (ccf‐DNA) and mtDNA (ccf‐mtDNA) have often been used as indicators of cell death and tissue damage in acute and chronic disorders, but little is known about changes in ccf‐DNA and ccf‐mtDNA concentrations following radiation exposure. The aim of the study was to ...


Prenatal phthalate exposure, infant growth, and global DNA methylation of human placenta

18.10.2014 | Yan Zhao, Hui‐jing Shi, Chang‐ming Xie, Jiao Chen, Hannah Laue, Yun‐hui Zhang, Environmental and Molecular Mutagenesis, 2014

Prenatal phthalate exposure has been shown to be associated with reduced fetal growth. Epigenetic changes such as DNA methylation might be a molecular mechanism through which phthalate exposure affects fetal growth. In this study, we examined associations between prenatal phthalate exposure, ...


Metabolic profiling study on potential toxicity and immunotoxicity‐biomarker discovery in rats treated with cyclophosphamide using HPLC‐ESI‐IT‐TOF‐MS

17.10.2014 | Jing Li, Wensi Lin, Weiwei Lin, Peng Xu, Jianmei Zhang, Haisong Yang, Xiaomei Ling, Biomedical Chromatography, 2014

ABSTRACT Despite the recent advances in understanding toxicity mechanism of cyclophosphamide (CTX), the development of biomarkers is still essential. CTX‐induced immunotoxicity in rats by a metabonomics approach was investigated using high‐performance liquid chromatography coupled with ion ...


Determination of a novel nonfluorinated quinolone, nemonoxacin, in human feces and its glucuronide conjugate in human urine and feces by high‐performance liquid chromatography–triple quadrupole mass spectrometry

17.10.2014 | Gaoli He, Beining Guo, Jicheng Yu, Jing Zhang, Xiaojie Wu, Guoying Cao, Yaoguo Shi, Cheng‐yuan Tsai, Biomedical Chromatography, 2014

ABSTRACT Three methods were developed and validated for determination of nemonoxacin in human feces and its major metabolite, nemonoxacin acyl‐β‐d‐glucuronide, in human urine and feces. Nemonoxacin was extracted by liquid–liquid extraction in feces homogenate samples and nemonoxacin ...


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