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1.720 Aktuelle Fachpublikationen zum Thema Addition

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Q and B values are critical measurements required for inter‐instrument standardization and development of multicolor flow cytometry staining panels

23.10.2014 | Stephen P. Perfetto, Pratip K. Chattopadhyay, James Wood, Richard Nguyen, David Ambrozak, Juliane P. Hill, Mario Roe ..., Cytometry Part A, 2014

Abstract Much of the complexity of multicolor flow cytometry experiments lies within the development of antibody staining panels and the standardization of instruments. In this article, we propose a theoretical metric and describe how measurements of sensitivity and resolution can be used to ...


Twenty‐one years to the right diagnosis – clinical overlap of Simpson–Golabi–Behmel and Beckwith–Wiedemann Syndrome

22.10.2014 | C. Knopp, S. Rudnik‐Schöneborn, K. Zerres, M. Gencik, S. Spengler, T. Eggermann, American Journal of Medical Genetics Part A, 2014

Clinical overlap makes the diagnosis of overgrowth syndromes challenging. Clinical overlap exists between Simpson–Golabi–Behmel syndrome (SGBS) and Beckwith–Wiedemann syndrome (BWS) which share pre‐ and postnatal overgrowth, macroglossia, umbilical hernia, organomegaly, ear lobe creases, and ...


Pulsed magnetic field accelerate proliferation and migration of cardiac microvascular endothelial cells

22.10.2014 | Fei Li, Yuan Yuan, Ying Guo, Nan Liu, Da Jing, Haichang Wang, Wenyi Guo, Bioelectromagnetics, 2014

Heart failure is a disease with multifactorial causes. Recently it was established that reduction in vascular density promoted the progression from adaptive cardiac hypertrophy to heart failure, therefore, therapeutic angiogenesis may be a promising method for treating heart failure. Cardiac ...


Inhibitory Effects of French Pine Bark Extract, Pycnogenol®, on Alveolar Bone Resorption and on the Osteoclast Differentiation

22.10.2014 | Hideki Sugimoto, Kiyoko Watanabe, Toshizo Toyama, Shun‐suke Takahashi, Shuta Sugiyama, Masaichi‐Chang‐il Lee, Nobush ..., Phytotherapy Research, 2014

Pycnogenol® (PYC) is a standardized bark extract from French maritime pine (Pinus pinaster Aiton). We examined the inhibitory effects of PYC on alveolar bone resorption, which is a characteristic feature of periodontitis, induced by Porphyromonas gingivalis (P. gingivalis) and osteoclast ...


Improved Oral Bioavailability of Human Growth Hormone by a Combination of Liposomes Containing Bio‐Enhancers and Tetraether Lipids and Omeprazole

21.10.2014 | Johannes Parmentier, Götz Hofhaus, Silke Thomas, Laura Clusa Cuesta, Felix Gropp, Rasmus Schröder, Klaus Hartmann, G ..., Journal of Pharmaceutical Sciences, 2014

Liposomes for the oral delivery of human growth hormone (hGH) containing bio‐enhancers and tetraether lipids were prepared by dual asymmetric centrifugation. Cetylpyridinium chloride (CpCl), d‐α‐tocopheryl polyethylene glycol 400 succinate, phenylpiperazine, sodium caprate or octadecanethiol ...


Addition of an NK1 receptor antagonist to an SSRI did not enhance the antidepressant effects of SSRI monotherapy: results from a randomized clinical trial in patients with major depressive disorder

20.10.2014 | William A. Ball, Duane B. Snavely, Richard J. Hargreaves, Armin Szegedi, Christopher Lines, Scott A. Reines, Human Psychopharmacology: Clinical and Experimental, 2014

Objective Aprepitant is a neurokinin 1 receptor antagonist approved for prevention of chemotherapy‐induced and post‐operative nausea and vomiting. Early studies demonstrated promising antidepressant activity as monotherapy, although this was unsupported by subsequent phase 3 trials. This phase ...


Potent Effects of the Total Saponins from Dioscorea nipponica Makino Against Streptozotocin‐Induced Type 2 Diabetes Mellitus in Rats

17.10.2014 | Hao Yu, Lingli Zheng, Lina Xu, Lianhong Yin, Yuan Lin, Hua Li, Kexin Liu, Jinyong Peng, Phytotherapy Research, 2014

Abstract The aim of the present paper was to investigate the effects and possible mechanisms of the total saponins from Dioscorea nipponica Makino (TSDN) against type 2 diabetes mellitus. Streptozotocin (STZ) with high‐fat diet induced type 2 diabetes mellitus (T2DM) rats were treated with ...


Hydrolysis‐Determining Substrate Characteristics in Liquid Hot Water Pretreated Hardwood

16.10.2014 | Youngmi Kim, Thomas Kreke, Ja Kyong Ko, Michael R. Ladisch, Biotechnology and Bioengineering, 2014

Abstract Fundamental characterization of pretreated hardwood and its interactions with cellulase enzymes has confirmed that a pathway exists for dramatically reducing the loading of cellulase required for hydrolysis of pretreated biomass. We demonstrate that addition of protein effecting a ...


Up‐regulated dynamin 1 in an acute seizure model and in epileptic patients

16.10.2014 | Ying‐ying Li, Xiao‐ni Chen, Xin‐xin Fan, Yu‐jiao Zhang, Juan Gu, Wei‐xin Fu, Zhi‐hua Wang, Xue‐Feng Wang, Zheng Xiao, Synapse, 2014

Abstract Dynamin 1 is a neuron‐specific guanosine triphosphatase (GTPase) that is an essential component of membrane fission during synaptic vesicle recycling and endocytosis. This study evaluated the dynamin 1 expression pattern in the acute lithium–pilocarpine rat model and in patients with ...


The Shrinking Anthropoid Nose, the Human Vomeronasal Organ, and the Language of Anatomical Reduction

14.10.2014 | Timothy D. Smith, Jeffrey T. Laitman, Kunwar P. Bhatnagar, The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology, 2014

ABSTRACT Humans and most of our closest extant relatives, the anthropoids, are notable for their reduced “snout.” The striking reduction in facial projection is only a superficial similarity. All anthropoids, including those with long faces (e.g., baboons), have lost numerous internal ...


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