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PINK1 phosphorylates transglutaminase 2 and blocks its proteasomal degradation

30.12.2014 | Boram Min, Young‐Chang Kwon, Kwang‐Min Choe, Kwang Chul Chung, Journal of Neuroscience Research, 2014

Parkinson's disease (PD) is characterized by progressive dopaminergic neuronal loss and the formation of abnormal protein aggregates, referred to as Lewy bodies (LBs). PINK1 is a serine/threonine protein kinase that protects cells from stress‐induced mitochondrial dysfunction. PINK1 gene ...


Efficient and High‐Speed Transduction of an Antibody into Living Cells Using a Multifunctional Nanocarrier System to Control Intracellular Trafficking

26.12.2014 | Yuma Yamada, Sandra Milena Vergara Perez, Mai Tabata, Jiro Abe, Yukari Yasuzaki, Hideyoshi Harashima, Journal of Pharmaceutical Sciences, 2014

The transduction of antibodies into living cells would represent a major contribution to both basic and applied biomedical fields, as currently available methods suffer from limitations such as low‐uptake efficiency and endosomal entrapment. In this study, a liposome‐based carrier was designed ...


Quantitative multigene FISH on breast carcinomas identifies der(1;16)(q10;p10) as an early event in luminal A tumors

26.12.2014 | Inga H. Rye, Pär Lundin, Susanne Månér, Renathe Fjelldal, Bjørn Naume, Michael Wigler, James Hicks, Anne‐Lise Børres ..., Genes, Chromosomes and Cancer, 2014

In situ detection of genomic alterations in cancer provides information at the single cell level, making it possible to investigate genomic changes in cells in a tissue context. Such topological information is important when studying intratumor heterogeneity as well as alterations related to ...


Effect of the preparation methods on architecture, crystallinity, hydrolytic degradation, bioactivity, and biocompatibility of PCL/bioglass composite scaffolds

23.12.2014 | Michal Dziadek, Justyna Pawlik, Elzbieta Menaszek, Ewa Stodolak‐Zych, Katarzyna Cholewa‐Kowalska, Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2014

Abstract In this study, two different composition gel derived silica‐rich (S2) or calcium‐rich (A2) bioactive glasses (SBG) from a basic CaOP2O5SiO2 system were incorporated into poly(ε‐caprolactone) (PCL) matrix to obtain novel bioactive composite scaffolds for bone tissue engineering ...


Tl(I) and Tl(III) alter the expression of EGF‐dependent signals and cyclins required for pheochromocytoma (PC12) cell‐cycle resumption and progression

22.12.2014 | María T. L. Pino, Sandra V. Verstraeten, Journal of Applied Toxicology, 2014

ABSTRACT The effects of thallium [Tl(I) and Tl(III)] on the PC12 cell cycle were evaluated without (EGF−) or with (EGF+) media supplementation with epidermal growth factor (EGF). The following markers of cell‐cycle phases were analyzed: cyclin D1 (G1); E2F‐1, cyclin E and cytosolic p21 (G1→S ...


Ginsenoside Re protects methamphetamine‐induced mitochondrial burdens and proapoptosis via genetic inhibition of protein kinase C δ in human neuroblastoma dopaminergic SH‐SY5Y cell lines

19.12.2014 | Yunsung Nam, Myung Bok Wie, Eun‐Joo Shin, Thuy‐Ty Lan Nguyen, Seung‐Yeol Nah, Sung Kwon Ko, Ji Hoon Jeong, Choon‐Gon ..., Journal of Applied Toxicology, 2014

ABSTRACT Recently, we have demonstrated that ginsenoside Re protects methamphetamine (MA)‐induced dopaminergic toxicity in mice via genetic inhibition of PKCδ and attenuation of mitochondrial stress. In addition, we have reported that induction of mitochondrial glutathione peroxidase (GPx) is ...


Synthesis and evaluation of novel lipidated neuromedin U analogs with increased stability and effects on food intake

18.12.2014 | Louise S. Dalbøge, Søren L. Pedersen, Søren B. Witteloostuijn, Jakob E. Rasmussen, Kristoffer T. G. Rigbolt, Knud J. ..., Journal of Peptide Science, 2014

Neuromedin U (NMU) is a 25 amino acid peptide expressed and secreted in the brain and gastrointestinal tract. Data have shown that peripheral administration of human NMU decreases food intake and body weight and improves glucose tolerance in mice, suggesting that NMU receptors constitute a ...


Lipid‐dependent pore formation by antimicrobial peptides arenicin‐2 and melittin demonstrated by their proton transfer activity

18.12.2014 | Sergei V. Sychev, Sergey V. Balandin, Pavel V. Panteleev, Leonid I. Barsukov, Tatiana V. Ovchinnikova, Journal of Peptide Science, 2014

This work presents a comparative study of proton transfer activity (PTA) of two cationic (+6) antimicrobial peptides, β‐structural arenicin‐2 and α‐helical melittin. A new approach was proposed for the detection of passive proton transfer by using proteoliposomes containing bacteriorhodopsin, ...


Homozygous deletions at 3p22, 5p14, 6q15, and 9p21 result in aberrant expression of tumor suppressor genes in gastric cancer

17.12.2014 | Bona Lee, Kwiyeom Yoon, Sunghoon Lee, Jin Muk Kang, Junil Kim, Sung Han Shim, Hak‐Min Kim, Sanghoon Song, Kazuhito N ..., Genes, Chromosomes and Cancer, 2014

Homozygous deletion is a frequent mutational mechanism of silencing tumor suppressor genes in cancer. Therefore, homozygous deletions have been analyzed for identification of tumor suppressor genes that can be utilized as biomarkers or therapeutic targets for cancer treatment. In this study, to ...


Determination of three antidepressants in urine using simultaneous derivatization and temperature‐assisted dispersive liquid–liquid microextraction followed by gas chromatography–flame ionization detection

16.12.2014 | Ali Akbar Alizadeh Nabil, Nina Nouri, Mir Ali Farajzadeh, Biomedical Chromatography, 2014

ABSTRACT This paper presents a fast and simple method for the extraction, preconcentration and determination of fluvoxamine, nortriptyline and maprotiline in urine using simultaneous derivatization and temperature‐assisted dispersive liquid–liquid microextraction (TA‐DLLME) followed by gas ...


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