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1.959 Aktuelle Fachpublikationen zum Thema Addition

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The effect of an alginate carrier on bone formation in a hydroxyapatite scaffold

27.06.2015 | Melanie J. Coathup, Thomas C. Edwards, Sorousheh Samizadeh, Wei‐Jen Lo, Gordon W. Blunn, Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2015

Abstract This study investigated the osteoconductive properties of a porous hydroxyapatite (HA) scaffold manufactured using a novel technique similar to the bread‐making process, alone and in combination with an alginate polysaccharide fiber gel (HA/APFG putty) and autologous bone marrow ...


Homozygous 16p13.11 duplication associated with mild intellectual disability and urinary tract malformations in two siblings born from consanguineous parents

26.06.2015 | N. Houcinat, B. Llanas, S. Moutton, J. Toutain, D. Cailley, B. Arveiler, C. Combe, D. Lacombe, C. Rooryck, American Journal of Medical Genetics Part A, 2015

The use of array‐comparative genomic hybridization (array‐CGH) in routine clinical work has allowed the identification of many new copy number variations (CNV). The 16p13.11 duplication has been implicated in various congenital anomalies and neurodevelopmental disorders, but it has also been ...


Expanding the SPECC1L mutation phenotypic spectrum to include Teebi hypertelorism syndrome

25.06.2015 | Elizabeth J. Bhoj, Dong Li, Margaret H. Harr, Lifeng Tian, Tiancheng Wang, Yan Zhao, Haijun Qiu, Cecilia Kim, Jodi D ..., American Journal of Medical Genetics Part A, 2015

Teebi hypertelorism syndrome is a rare autosomal dominant disorder that has eluded a molecular etiology since first described in 1987. Here we report on two unrelated families with a Teebi hypertelorism‐like syndrome and Teebi hypertelorism phenotype who have missense mutations in Sperm Antigen ...


Effect of Serenoa Repens on Oxidative Stress, Inflammatory and Growth Factors in Obese Wistar Rats with Benign Prostatic Hyperplasia

24.06.2015 | Juventino III Colado‐Velázquez, Patrick Mailloux‐Salinas, JML Medina‐Contreras, David Cruz‐Robles, Guadalupe Bravo, Phytotherapy Research, 2015

Serenoa repens has been widely used to treat benign prostatic hyperplasia and lower urinary tract symptoms; however, most of the studies have been conducted in individuals with normal weight and not obese. In this study, the effects of a lipidic extract of S. repens, in markers of oxidative ...


Role of peptide self‐assembly in antimicrobial peptides

23.06.2015 | Xibo Tian, Fude Sun, Xi‐Rui Zhou, Shi‐Zhong Luo, Long Chen, Journal of Peptide Science, 2015

Antimicrobial peptides (AMPs) are considered as potential antibiotic substitutes because of their potent activities. Previous studies mainly focused on the effects of peptide charges and secondary structures, but the self‐assembly of AMPs was neglected. As more and more researchers notice the ...


Selective killing of gastric cancer cells by a small molecule targeting ROS‐mediated ER stress activation

18.06.2015 | Peng Zou, Yiqun Xia, Tongke Chen, Junru Zhang, Zhe Wang, Wenbo Chen, Minxiao Chen, Karvannan Kanchana, Shulin Yang, ..., Molecular Carcinogenesis, 2015

Gastric cancer is one of the leading causes of cancer mortality in the world. Curcumin is a natural product with multiple pharmacological activities, while its clinical application has been limited by the poor chemical stability. We have previously designed a series of curcumin derivatives with ...


A sacrificial process for fabrication of biodegradable polymer membranes with submicron thickness

16.06.2015 | Luke A. Beardslee, Judith Stolwijk, Dimitrius A. Khaladj, Mohamed Trebak, Justin Halman, Karen Y. Torrejon, Nuttawee ..., Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2015

Abstract A new sacrificial molding process using a single mask has been developed to fabricate ultrathin 2‐dimensional membranes from several biocompatible polymeric materials. The fabrication process is similar to a sacrificial microelectromechanical systems (MEMS) process flow, where a mold ...


The Role of miR‐21 in Cancer

16.06.2015 | Susan R. Pfeffer, Chuan He Yang, Lawrence M. Pfeffer, Drug Development Research, 2015

ABSTRACT MicroRNAs (miRNAs) are small endogenous noncoding RNAs that suppress gene expression at the post‐transcriptional level. In the past decade, miRNAs have been extensively studied in a number of different human cancers. MiRNAs have been identified to act both as oncogenes ...


Enhanced analgesic effects of tramadol and common trace element coadministration in mice

16.06.2015 | Teodora Alexa, Aurelia Marza, Tudor Voloseniuc, Bogdan Tamba, Journal of Neuroscience Research, 2015

Chronic pain is managed mostly by the daily administration of analgesics. Tramadol is one of the most commonly used drugs, marketed in combination with coanalgesics for enhanced effect. Trace elements are frequent ingredients in dietary supplements and may enhance tramadol's analgesic effect ...


Schisandrin C Ameliorates Learning and Memory Deficits by Aβ1–42‐induced Oxidative Stress and Neurotoxicity in Mice

15.06.2015 | Xin Mao, Zhengzheng Liao, Lin Guo, Xuan Xu, Bo Wu, Mengjie Xu, Xu Zhao, Kaishun Bi, Ying Jia, Phytotherapy Research, 2015

Schisandrin C (SCH‐C) is a main and typical antioxidative lignan isolated from the fruits of Schisandra chinensis (Trucz.) Baill (a widely used traditional Chinese medicine). The present study aimed to characterize the effect of SCH‐C on memory impairment and further research on pathological ...


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