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1.850 Aktuelle Fachpublikationen zum Thema Addition

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Craniofacial abnormalities and developmental delay in two families with overlapping 22q12.1 microdeletions involving the MN1 gene

22.03.2015 | Megan Beck, Jess F. Peterson, Juliann McConnell, Marianne McGuire, Miya Asato, Joseph E. Losee, Urvashi Surti, Sunee ..., American Journal of Medical Genetics Part A, 2015

Deletions spanning the MN1 gene (22q12.1) have recently been proposed as playing a role in craniofacial abnormalities that include cleft palate, as mouse studies have demonstrated that Mn1 haploinsufficiency results in skull abnormalities and secondary cleft palate. We report on four patients ...

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The “New Polyethylene Glycol Dilemma”: Polyethylene Glycol Impurities and Their Paradox Role in mAb Crystallization

21.03.2015 | Christian Hildebrandt, Lea Joos, Rainer Saedler, Gerhard Winter, Journal of Pharmaceutical Sciences, 2015

Polyethylene glycols (PEG) represent the most successful and frequently applied class of excipients used for protein crystallization. PEG auto‐oxidation and formation of impurities such as peroxides and formaldehydes that foster protein drug degradation is known. However, their effect on mAb ...

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Microcystin‐LR promotes migration and invasion of colorectal cancer through matrix metalloproteinase‐13 up‐regulation

19.03.2015 | Chen Miao, Yan Ren, Meng Chen, Zhen Wang, Ting Wang, Molecular Carcinogenesis, 2015

Microcystin‐LR (MC–LR) is an environmental toxin from blooms of cyanobacteria and it has been shown to be one of the environmental carcinogens for the progression of colorectal carcinoma. However, there is no direct evidence that MC–LR can induce colorectal cancer migration and invasion. In the ...

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Diverse impact of neuronal activity at θ frequency on hippocampal long‐term plasticity

18.03.2015 | Tomasz Wójtowicz, Jerzy W. Mozrzymas, Journal of Neuroscience Research, 2015

Brain oscillatory activity is considered an essential aspect of brain function, and its frequency can vary from 200 Hz, depending on the brain states and projection. Episodes of rhythmic activity accompany hippocampus‐dependent learning and memory in vivo. Therefore, long‐term synaptic ...

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Influence of depression and anxiety on circulating endothelial progenitor cells in patients with acute coronary syndromes

18.03.2015 | Francesca Felice, Rossella Di Stefano, Stefano Pini, Gianfranco Mazzotta, Francesco M. Bovenzi, Daniele Bertoli, Mar ..., Human Psychopharmacology: Clinical and Experimental, 2015

Objectives Circulating endothelial progenitor cells (EPCs) are related to endothelial function and progression of coronary artery disease. There is evidence of decreased numbers of circulating EPCs in patients with a current episode of major depression. We investigated the relationships ...

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A morphological novelty for feeding and sound production in the yellowtail clownfish

16.03.2015 | Damien Olivier, Bruno Frédérich, Anthony Herrel, Eric Parmentier, Journal of Experimental Zoology Part A: Ecological Genetics and Physiology, 2015

ABSTRACT The yellowtail clownfish Amphiprion clarkii is able to close its mouth very quickly by means of the cerato‐mandibular (c‐md) ligament, a synapomorphic trait of Pomacentridae joining the hyoid bar to the medial part of the lower jaw. This fast closure induces tooth collision, thus ...

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Dynamic 3D culture: Models of chondrogenesis and endochondral ossification

16.03.2015 | Nicola C. Foster, James R. Henstock, Yvonne Reinwald, Alicia J. El Haj, Birth Defects Research Part C: Embryo Today: Reviews, 2015

The formation of cartilage from stem cells during development is a complex process which is regulated by both local growth factors and biomechanical cues, and results in the differentiation of chondrocytes into a range of subtypes in specific regions of the tissue. In fetal development cartilage ...

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Novel mutation in the BMPR1B gene (R486L) in a polish family and further delineation of the phenotypic features of BMPR1B‐Related brachydactyly

16.03.2015 | Magdalena Badura‐Stronka, Dariusz Mróz, Peter Beighton, Sebastian Łukawiecki, Katarzyna Wicher, Anna Latos‐Bieleńska ..., Birth Defects Research Part A: Clinical and Molecular Teratology, 2015

Background Lehmann et al., [2003, 2006] have documented two different substitutions at position 486 of the BMPR1B gene which resulted in a phenotype of brachydactyly A2 [MIM 112600] or brachydactyly C with symphalangism [MIM 113100]. Methods In this article we report a family of Polish ...

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Meloxicam inhibits fipronil‐induced apoptosis via modulation of the oxidative stress and inflammatory response in SH‐SY5Y cells

13.03.2015 | Jae Hyeon Park, Youn Sun Park, Je‐Bong Lee, Kyung‐Hun Park, Min‐kyoung Paik, Mihye Jeong, Hyun Chul Koh, Journal of Applied Toxicology, 2015

ABSTRACT Oxidative stress and inflammatory responses have been identified as key elements of neuronal cell apoptosis. In this study, we investigated the mechanisms by which inflammatory responses contribute to apoptosis in human neuroblastoma SH‐SY5Y cells treated with fipronil (FPN). Based on ...

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Biocompatibility of calcium phosphate bone cement with optimized mechanical properties

12.03.2015 | Iwan Palmer, John Nelson, Wolfgang Schatton, Nicholas J. Dunne, Fraser J. Buchanan, Susan A. Clarke, Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2015

Abstract The broad aim of this work was to investigate and optimize the properties of calcium phosphate bone cements (CPCs) for use in vertebroplasty to achieve effective primary fixation of spinal fractures. The incorporation of collagen, both bovine and from a marine sponge (Chondrosia ...

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