15.05.2013 | Abdul‐Lateef Molan, Zhuojian Liu, Gabriel Plimmer, Phytotherapy Research, 2013

The purpose of this study was to determine in healthy humans whether First Leaf (FL; composed of blackcurrant extract powder, lactoferrin and lutein) and Cassis Anthomix 30 (CAM30; blackcurrant extract powder) can positively modify the colonic microbiota by enhancing the growth of the ...

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14.05.2013 | B. Greig, M. Stetler‐Stevenson, J. Lea, Cytometry Part B: Clinical Cytometry, 2013

Abstract Background: Flow cytometric immunophenotpying (FCI) of cerebrospinal fluid (CSF) and other paucicellular fluids has been demonstrated to have increased sensitivity in detection of lymphoma and leukemia when compared to cytomorphology [(1) de Graaf et al., Cytometry Part B 2011, ...

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10.05.2013 | Megan S. Kane, Mark E. Lindsay, Daniel P. Judge, Jemima Barrowman, Colette Ap Rhys, Lisa Simonson, Harry C. Dietz, S ..., American Journal of Medical Genetics Part A, 2013

Abstract Hutchinson–Gilford Progeria Syndrome (HGPS) is a premature aging disorder caused by mutations in LMNA, which encodes the nuclear scaffold proteins lamin A and C. In HGPS and related progerias, processing of prelamin A is blocked at a critical step mediated by the zinc ...

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10.05.2013 | Tomomi Mito, Koji Yoshioka, Michiko Noguchi, Shoko Yamashita, Hiroyoshi Hoshi, Molecular Reproduction and Development, 2013

Abstract The biological functions of recombinant human follicle‐stimulating hormone (FSH) and transforming growth factor‐α (TGF‐α) on in vitro maturation of porcine oocytes were investigated. Cumulus‐oocyte complexes were matured in defined porcine oocyte medium containing 0–0.1 IU/ml ...

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09.05.2013 | Laurie J. Reitsema, American Journal of Human Biology, 2013

ABSTRACT Analysis of stable carbon and nitrogen isotopes from soft or mineralized tissues is a direct and widely‐used technique for modeling diets. In addition to its continued role in paleodiet analysis, stable isotope analysis is now contributing to studies of physiology, disease, and ...

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09.05.2013 | Shunsuke Ozaki, Ikuo Kushida, Taro Yamashita, Takashi Hasebe, Osamu Shirai, Kenji Kano, Journal of Pharmaceutical Sciences, 2013

Abstract The impact of water‐soluble polymers on drug supersaturation behavior was investigated to elucidate the role of water‐soluble polymers in enhancing the supersaturation levels of amorphous pharmaceuticals. Hydroxypropyl methylcellulose (HPMC), polyvinylpyrrolidone (PVP), and ...

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09.05.2013 | Huiying Jia, Lei L. Kerr, Journal of Pharmaceutical Sciences, 2013

Abstract Developing coatings on implant surface as drug carriers can reduce organ toxicity and effectively deliver drug locally to the target compared with the oral approach. Titanium dioxide (TiO2) nanotube has great potential for this application for widely used Ti implants because of ...

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07.05.2013 | Danhua Pu, Yiping Shen, Jie Wu, Autism Research, 2013

Methylenetetrahydrofolate reductase (MTHFR) is essential for DNA biosynthesis and the epigenetic process of DNA methylation, and its gene polymorphisms have been implicated as risk factors for birth defects, neurological disorders, and cancers. However, reports on the association of MTHFR ...

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07.05.2013 | Lesley Caldwell, Peter Harries, Sebastian Sydlik, Christof J. Schwiening, Synapse, 2013

Abstract Both intracellular pH (pHi) and synaptic cleft pH change during neuronal activity yet little is known about how these pH shifts might affect synaptic transmission by influencing vesicle fusion. To address this we imaged pH‐ and Ca2+sensitive fluorescent indicators (HPTS, Oregon ...

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07.05.2013 | Ekneet Kaur Sahni, Robin H. Bogner, Bodhisattwa Chaudhuri, Journal of Pharmaceutical Sciences, 2013

Abstract A systematic experimental investigation of contact drying operation was carried out in an agitated Charles Thompson filter‐dryer. In this study, the effect of process parameters (wall temperature, impeller speed, fill level) on the drying performance in the filter‐dryer is ...

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