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1.824 Aktuelle Fachpublikationen zum Thema Addition

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p16INK4A inhibits the pro‐metastatic potentials of osteosarcoma cells through targeting the ERK pathway and TGF‐β1

01.03.2015 | Gabriela Silva, Abdelilah Aboussekhra, Molecular Carcinogenesis, 2015

Extracellular signal‐regulated kinase (ERK) is a downstream component of the evolutionarily conserved mitogen‐activated protein kinase‐signaling pathway, which controls the expression of a plethora of genes implicated in various physiological processes. This pathway is often hyper‐activated by ...


Asthma and Allergies in Children With Autism Spectrum Disorders: Results From the CHARGE Study

27.02.2015 | Kristen Lyall, Judy Van de Water, Paul Ashwood, Irva Hertz‐Picciotto, Autism Research, 2015

Immune aberrations are often noted in children with autism spectrum disorder (ASD), but whether asthma and allergy are related to ASD is not well defined. This study examined asthma and allergies in association with ASD and phenotypic subsets. Participants were 560 children with confirmed ASD ...


Evaluation of Acid Tolerance of Drugs Using Rats and Dogs Controlled for Gastric Acid Secretion

27.02.2015 | Yohei Kosugi, Syunsuke Yamamoto, Noriyasu Sano, Atsutoshi Furuta, Tomoko Igari, Yasushi Fujioka, Nobuyuki Amano, Journal of Pharmaceutical Sciences, 2015

We attempted to establish animal models to evaluate the effects of drug degradation in the stomach on oral bioavailability. In addition, we assessed the utilization of animal studies in determining the need for enteric‐coated formulations. In order to control the gastric pH in rats and dogs, ...


Response of Corynebacterium glutamicum exposed to oscillating cultivation conditions in a two‐ and a novel three‐compartment scale‐down bioreactor

26.02.2015 | Anja Lemoine, Nina Maya Martίnez‐Iturralde, Robert Spann, Peter Neubauer, Stefan Junne, Biotechnology and Bioengineering, 2015

ABSTRACT The oscillatory conditions in substrate and oxygen supply that typically occur on a large (industrial) scale are usually simulated in two‐compartment scale‐down reactors. In this study, the performance of nutrient‐limited fed‐batch cultivations of Corynebacterium glutamicum in a ...


Redox and anti‐oxidant state within cattle oocytes following in vitro maturation with bone morphogenetic protein 15 and follicle stimulating hormone

26.02.2015 | Melanie L. Sutton‐McDowall, Malcolm Purdey, Hannah M. Brown, Andrew D. Abell, David G. Mottershead, Pablo D. Cetica, ..., Molecular Reproduction and Development, 2015

SUMMARY The developmental competence of cumulus oocyte complexes (COCs) can be increased during in vitro oocyte maturation with the addition of exogenous oocyte‐secreted factors, such as bone morphogenetic protein 15 (BMP15), in combination with hormones. FSH and BMP15, for example, induce ...


Fe–Au and Fe–Ag composites as candidates for biodegradable stent materials

26.02.2015 | Tao Huang, Jian Cheng, Dong Bian, Yufeng Zheng, Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2015

Abstract In this study, Fe–Ag and Fe–Au composites were fabricated by powder metallurgy using spark plasma sintering. Their microstructures, mechanical properties, and biocorrosion behavior were investigated by using optical microscopy, X‐ray diffraction, environment scanning electronic ...


Tenofovir rescue regimen following prior suboptimal response to entecavir and adefovir combination therapy in chronic hepatitis B patients exposed to multiple treatment failures

25.02.2015 | Qian Zhang, Tao Han, Cai‐Yun Nie, Fu‐Shuang Ha, Lei Liu, Hua Liu, Journal of Medical Virology, 2015

In clinical practice, establishing a subsequent optimum treatment for chronic hepatitis B patients with a history of multiple NAs treatment failures, including a suboptimal response to a final therapy with combined ETV and ADV, is a complicated but crucial challenge. This study investigated the ...


Psychiatric disorders in children with Prader–Willi syndrome—Results of a 2‐year longitudinal study

25.02.2015 | S.T. Lo, P.J.L. Collin, A.C.S. Hokken‐Koelega, American Journal of Medical Genetics Part A, 2015

Psychiatric disorders such as psychosis are highly prevalent in adults with Prader–Willi syndrome (PWS). However, knowledge about the presence and progression of psychiatric disorders in children with PWS is very limited. Sixty‐one children with PWS aged 7–17 years were tested using the ...


Ischemia preconditioning protects astrocytes from ischemic injury through 14‐3‐3γ

25.02.2015 | Ying Pang, Chao Rui Chai, Kai Gao, Xi Hua Jia, Jin Ge Kong, Xiao Qian Chen, Greg Vatcher, Jian Guo Chen, Albert Cheu ..., Journal of Neuroscience Research, 2015

Stroke is a leading cause of death and disability, and new strategies are required to reduce neuronal injury and improve prognosis. Ischemia preconditioning (IPC) is an intrinsic phenomenon that protects cells from subsequent ischemic injury and might provide promising mechanisms for clinical ...


Human papillomavirus infections in Mexican women with normal cytology, precancerous lesions, and cervical cancer: Type‐specific prevalence and HPV coinfections

24.02.2015 | Adriana Aguilar‐Lemarroy, Verónica Vallejo‐Ruiz, Elva I Cortés‐Gutiérrez, Manuel Eduardo Salgado‐Bernabé, Norma Patr ..., Journal of Medical Virology, 2015

The prevalence and genotype distribution of human papillomavirus (HPV) provides the basis for designing HPV prevention programs. The prevalence rates of type‐specific HPV and coinfections in samples of Mexican women were investigated in 822 women aged 18–87 years. HPV detection was performed ...


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