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1.712 Aktuelle Fachpublikationen zum Thema Addition

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Potent Effects of the Total Saponins from Dioscorea nipponica Makino Against Streptozotocin‐Induced Type 2 Diabetes Mellitus in Rats

17.10.2014 | Hao Yu, Lingli Zheng, Lina Xu, Lianhong Yin, Yuan Lin, Hua Li, Kexin Liu, Jinyong Peng, Phytotherapy Research, 2014

Abstract The aim of the present paper was to investigate the effects and possible mechanisms of the total saponins from Dioscorea nipponica Makino (TSDN) against type 2 diabetes mellitus. Streptozotocin (STZ) with high‐fat diet induced type 2 diabetes mellitus (T2DM) rats were treated with ...


Hydrolysis‐Determining Substrate Characteristics in Liquid Hot Water Pretreated Hardwood

16.10.2014 | Youngmi Kim, Thomas Kreke, Ja Kyong Ko, Michael R. Ladisch, Biotechnology and Bioengineering, 2014

Abstract Fundamental characterization of pretreated hardwood and its interactions with cellulase enzymes has confirmed that a pathway exists for dramatically reducing the loading of cellulase required for hydrolysis of pretreated biomass. We demonstrate that addition of protein effecting a ...


Up‐regulated dynamin 1 in an acute seizure model and in epileptic patients

16.10.2014 | Ying‐ying Li, Xiao‐ni Chen, Xin‐xin Fan, Yu‐jiao Zhang, Juan Gu, Wei‐xin Fu, Zhi‐hua Wang, Xue‐Feng Wang, Zheng Xiao, Synapse, 2014

Abstract Dynamin 1 is a neuron‐specific guanosine triphosphatase (GTPase) that is an essential component of membrane fission during synaptic vesicle recycling and endocytosis. This study evaluated the dynamin 1 expression pattern in the acute lithium–pilocarpine rat model and in patients with ...


The Shrinking Anthropoid Nose, the Human Vomeronasal Organ, and the Language of Anatomical Reduction

14.10.2014 | Timothy D. Smith, Jeffrey T. Laitman, Kunwar P. Bhatnagar, The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology, 2014

ABSTRACT Humans and most of our closest extant relatives, the anthropoids, are notable for their reduced “snout.” The striking reduction in facial projection is only a superficial similarity. All anthropoids, including those with long faces (e.g., baboons), have lost numerous internal ...


Nasal Morphometry in Marmosets: Loss and Redistribution of Olfactory Surface Area

14.10.2014 | Timothy D. Smith, Thomas P. Eiting, Christopher J. Bonar, Brent A. Craven, The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology, 2014

ABSTRACT The two major groups of primates differ in internal nasal anatomy. Strepsirrhines (e.g., lemurs) have more numerous turbinals and recesses compared with haplorhines (e.g., monkeys). Since detailed quantitative comparisons of nasal surface area (SA) have not been made, we measured ...


Tour of a Labyrinth: Exploring the Vertebrate Nose

14.10.2014 | Blaire Valkenburgh, Timothy D. Smith, Brent A. Craven, The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology, 2014

ABSTRACT This special issue of The Anatomical Record is the outcome of a symposium entitled “Inside the Vertebrate Nose: Evolution, Structure and Function.” The skeletal framework of the nasal cavity is a complicated structure that often houses sinuses and comprises an internal skeleton of ...


Bone substitute materials supplemented with prolyl hydroxylase inhibitors decrease osteoclastogenesis in vitro

14.10.2014 | Philipp Vinzenz, Stefan Schröckmair, Reinhard Gruber, Hermann Agis, Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2014

Abstract Background and objective: Inhibition of prolyl hydroxylases stimulates bone regeneration. Consequently, bone substitute materials were developed that release prolyl hydroxylase inhibitors. However, the impact of prolyl hydroxylase inhibitors released from these carriers on ...


Pioglitazone, a PPARγ agonist, inhibits growth and invasion of human hepatocellular carcinoma via blockade of the rage signaling

12.10.2014 | Yuan Yang, Ling‐Hao Zhao, Bo Huang, Ruo‐Yu Wang, Sheng‐Xian Yuan, Qi‐Fei Tao, Yong Xu, Han‐Yong Sun, Chuan Lin, Wei‐ ..., Molecular Carcinogenesis, 2014

Pioglitazone (PGZ), a synthetic PPARγ ligand, is known to have anti‐tumor activity. However, it is unclear how it acts against hepatocellular carcinoma (HCC). We hypothesized that the pathological receptor for advanced glycation end products (RAGE) is involved in the PGZ anti‐tumor process. To ...


The effect of sulforaphane on histone deacetylase activity in keratinocytes: Differences between in vitro and in vivo analyses

12.10.2014 | Sally E. Dickinson, Jadrian J. Rusche, Sergiu L. Bec, David J. Horn, Jaroslav Janda, So Hyun Rim, Catharine L. Smith ..., Molecular Carcinogenesis, 2014

Sulforaphane is a natural product found in broccoli, which is known to exert many different molecular effects in the cell, including inhibition of histone deacetylase (HDAC) enzymes. Here, we examine for the first time the potential for sulforaphane to inhibit HDACs in HaCaT keratinocytes and ...


Enzyme‐ and Transporter‐Mediated Drug Interactions with Small Molecule Tyrosine Kinase Inhibitors

10.10.2014 | Jie Shao, John S. Markowitz, Di Bei, Guohua An, Journal of Pharmaceutical Sciences, 2014

Among the novel and target‐specific classes of anticancer drugs, small molecule tyrosine kinase inhibitors (TKIs) represent an extremely promising and rapidly expanding group. TKIs attack cancer‐specific targets and therefore have a favorable safety profile. However, as TKIs are taken orally ...


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