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1.908 Aktuelle Fachpublikationen zum Thema Addition

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Hydrodynamic Effects on Drug Dissolution and Deaggregation in the Small Intestine—A Study with Felodipine as a Model Drug

16.05.2015 | Lennart Lindfors, Malin Jonsson, Emelie Weibull, James G. Brasseur, Bertil Abrahamsson, Journal of Pharmaceutical Sciences, 2015

The aim of this study was to understand and predict the influence of hydrodynamic effects in the small intestine on dissolution of primary and aggregated drug particles. Dissolution tests of suspensions with a low‐solubility drug, felodipine, were performed in a Couette cell under hydrodynamic ...


Intracellular calcium levels as screening tool for nanoparticle toxicity

15.05.2015 | Claudia Meindl, Tatjana Kueznik, Martina Bösch, Eva Roblegg, Eleonore Fröhlich, Journal of Applied Toxicology, 2015

Abstract The use of engineered nano‐sized materials led to revolutionary developments in many industrial applications and in the medical field. These materials, however, also may cause cytotoxicity. In addition to size, surface properties and shape were identified as relevant parameters for ...


The fetal brain transcriptome and neonatal behavioral phenotype in the Ts1Cje mouse model of Down syndrome

14.05.2015 | Faycal Guedj, Jeroen L. A. Pennings, Millie A. Ferres, Leah C. Graham, Heather C. Wick, Klaus A. Miczek, Donna K. Sl ..., American Journal of Medical Genetics Part A, 2015

Human fetuses with Down syndrome demonstrate abnormal brain growth and reduced neurogenesis. Despite the prenatal onset of the phenotype, most therapeutic trials have been conducted in adults. Here, we present evidence for fetal brain molecular and neonatal behavioral alterations in the Ts1Cje ...


Human infection with an avian influenza A (H9N2) virus in the middle region of China

12.05.2015 | Yiwei Huang, Xiaodan Li, Hong Zhang, Bozhong Chen, Yonglin Jiang, Lei Yang, Wenfei Zhu, Shixiong Hu, Siyu Zhou, Yunl ..., Journal of Medical Virology, 2015

During the epidemic period of the novel H7N9 viruses, an influenza A (H9N2) virus was isolated from a 7‐year‐old boy with influenza‐like illness in Yongzhou city of Hunan province in November 2013. To identify the possible source of infection, environmental specimens collected from local live ...


Dimensionally stable and bioactive membrane for guided bone regeneration: An in vitro study

08.05.2015 | Matthew J. Rowe, Krzysztof Kamocki, Divya Pankajakshan, Ding Li, Angela Bruzzaniti, Vinoy Thomas, Steve B. Blanchard ..., Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2015

Abstract Composite fibrous electrospun membranes based on poly(dl‐lactide) (PLA) and poly(ε‐caprolactone) (PCL) were engineered to include borate bioactive glass (BBG) for the potential purposes of guided bone regeneration (GBR). The fibers were characterized using scanning and transmission ...


Reinforcement of injectable calcium phosphate cement by gelatinized starches

08.05.2015 | Huiling Liu, Ying Guan, Donglei Wei, Chunxia Gao, Huilin Yang, Lei Yang, Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2015

Abstract Current injectable calcium phosphate bone cements (CPC) encounter the problems of low strength, high brittleness, and low cohesion in aqueous environment, which greatly hinder their clinical applications for loading–bearing bone substitution and minimally invasive orthopedic ...


Breastfeeding over two years is associated with longer birth intervals, but not measures of growth or health, among children in Kilimanjaro, TZ

06.05.2015 | Siobhán M. Mattison, Katherine Wander, Katie Hinde, American Journal of Human Biology, 2015

Objectives Breastfeeding has been associated with numerous health and well‐being benefits for both children and their mothers, including prolonging the birth interval to the subsequent sibling. The clearest associations between breastfeeding and health outcomes, per se, reflect exclusive ...


A simple LC‐MS/MS method for quantitative analysis of underivatized neurotransmitters in rats urine: assay development, validation and application in the CUMS rat model

06.05.2015 | Xue‐jia Zhai, Fen Chen, Chao‐ran Zhu, Yong‐ning Lu, Biomedical Chromatography, 2015

Abstract Many amino acid neurotransmitters in urine are associated with chronic stress as well as major depressive disorders. To better understand depression, an analytical LC‐MS/MS method for the simultaneous determination of 11 underivatized neurotransmitters (4‐aminohippurate, 5‐HIAA, ...


Ion‐exchange vs reversed‐phase chromatography for separation and determination of basic psychotropic drugs

06.05.2015 | Anna Petruczynik, Karol Wróblewski, Michał Deja, Monika Waksmundzka‐Hajnos, Biomedical Chromatography, 2015

Abstract Ion exchange chromatography, an alternative to reversed‐phase (RP) chromatography, is described in this paper. We aimed to obtain optimal conditions for the separation of basic drugs because silica‐based RP stationary phases show silanol effect and make the analysis of basic analytes ...


Boymaw, overexpressed in brains with major psychiatric disorders, may encode a small protein to inhibit mitochondrial function and protein translation

06.05.2015 | Baohu Ji, Minjung Kim, Kerin K Higa, Xianjin Zhou, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2015

The t(1,11) chromosome translocation co‐segregates with major psychiatric disorders in a large Scottish family. The translocation disrupts the DISC1and Boymaw (DISC1FP1) genes on chromosomes 1 and 11, respectively. After translocation, two fusion genes are generated. Our recent studies found ...


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