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Genome‐wide Association Study of Autism Spectrum Disorder in the East Asian Populations

28.08.2015 | Xiaoxi Liu, Takafumi Shimada, Takeshi Otowa, Yu‐Yu Wu, Yoshiya Kawamura, Mamoru Tochigi, Yasuhide Iwata, Tadashi Ume ..., Autism Research, 2015

Autism spectrum disorder is a heterogeneous neurodevelopmental disorder with strong genetic basis. To identify common genetic variations conferring the risk of ASD, we performed a two‐stage genome‐wide association study using ASD family and healthy control samples obtained from East Asian ...

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Enhancement of the anti‐inflammatory activity of temporin‐1Tl‐derived antimicrobial peptides by tryptophan, arginine and lysine substitutions

27.08.2015 | Ganesan Rajasekaran, Radhakrishnan Kamalakannan, Song Yub Shin, Journal of Peptide Science, 2015

Temporin‐1Tl (TL) is a 13‐residue frog antimicrobial peptide (AMP) exhibiting potent antimicrobial and anti‐inflammatory activity. To develop novel AMP with improved anti‐inflammatory activity and antimicrobial selectivity, we designed and synthesized a series of TL analogs by substituting Trp, ...

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The TFG‐TEC oncoprotein induces transcriptional activation of the human β‐enolase gene via chromatin modification of the promoter region

27.08.2015 | Ah‐young Kim, Bobae Lim, JeeHyun Choi, Jungho Kim, Molecular Carcinogenesis, 2015

Recurrent chromosome translocations are the hallmark of many human cancers. A proportion of human extraskeletal myxoid chondrosarcomas (EMCs) are associated with the characteristic chromosomal translocation t(3;9)(q11–12;q22), which results in the formation of a chimeric protein in which the ...

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Seasonal‐like variation in song control system volume of wild zebra finches

24.08.2015 | Nicole Perfito, Richard A. Zann, Michaela Hau, George E. Bentley, Journal of Experimental Zoology Part A: Ecological Genetics and Physiology, 2015

ABSTRACT Zebra finches have been extensively used as a model system for studying the underlying neuroplasticity that allows for song learning during development. Zebra finches are considered age‐limited or close‐ended learners, in which fixed songs are learned within a certain window of time ...

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The association between economic development, lifestyle differentiation, and C‐reactive protein concentration within rural communities in Hainan Island, China

22.08.2015 | Yosuke Inoue, Andrew Stickley, Aki Yazawa, Dandan Li, Jianwei Du, Yuming Jin, Yan Chen, Chiho Watanabe, American Journal of Human Biology, 2015

Objective Earlier fieldwork in rural areas of Hainan Island, China, demonstrated that during the course of economic development increasing differences had emerged in lifestyles within communities. It is possible that these variations might have stratified residents into subpopulations with ...

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Clinical and genetic characteristics of craniosynostosis in Hungary

20.08.2015 | Beáta Bessenyei, Andrea Nagy, Katalin Szakszon, Attila Mokánszki, Erzsébet Balogh, Anikó Ujfalusi, Mariann Tihanyi, ..., American Journal of Medical Genetics Part A, 2015

Craniosynostosis, the premature closure of cranial sutures, is a common craniofacial disorder with heterogeneous etiology and appearance. The purpose of this study was to investigate the clinical and molecular characteristics of craniosynostoses in Hungary, including the classification of ...

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Body shape in terrestrial isopods: A morphological mechanism to resist desiccation?

20.08.2015 | Pierre Broly, Cédric Devigne, Jean‐Louis Deneubourg, Journal of Morphology, 2015

ABSTRACT Woodlice are fully terrestrial crustaceans and are known to be sensitive to water loss. Their half‐ellipsoidal shapes represent simple models in which to investigate theoretical assumptions about organism morphology and rates of exchange with the environment. We examine the influence ...

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Genetic architecture for human aggression: A study of gene–phenotype relationship in OMIM

19.08.2015 | Yanli Zhang‐James, Stephen V. Faraone, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2015

Genetic studies of human aggression have mainly focused on known candidate genes and pathways regulating serotonin and dopamine signaling and hormonal functions. These studies have taught us much about the genetics of human aggression, but no genetic locus has yet achieved genome‐significance. ...

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An injectable hydrogel derived from small intestine submucosa as a stem cell carrier

13.08.2015 | Kyungsook Kim, Moon Suk Kim, Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2015

Abstract Small intestine submucosa (SIS) is used as an attractive biomaterial in the field of regenerative medicine because it possesses numerous bioactive factors such as cell adhesion proteins, growth factors, and glycosaminoglycans. In most cases, SIS has been used as sheet and sponge‐like ...

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Combination of three angiogenic growth factors has synergistic effects on sprouting of endothelial cell/mesenchymal stem cell‐based spheroids in a 3D matrix

13.08.2015 | Sook Kyoung Kim, Jaeyeon Lee, Myeongjin Song, Mirim Kim, Soon Jung Hwang, Hwanseok Jang, Yongdoo Park, Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2015

Abstract Combinations of angiogenic growth factors have been shown to have synergistic effects on angiogenesis and natural wound healing in various animal models. Each growth factor has unique roles during angiogenesis; vascular endothelial growth factor (VEGF) plays a key role during the ...

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