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834 Aktuelle Fachpublikationen zum Thema Addition

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SRD: a Staphylococcus regulatory RNA database [ARTICLES]

01.05.2015 | Mohamed Sassi; Yoann Augagneur; Tony Mauro; Lorraine Ivain; Svetlana Chabelskaya; Marc Hallier; Olivier Sallou; Bric ..., RNA, 2015

An overflow of regulatory RNAs (sRNAs) was identified in a wide range of bacteria. We designed and implemented a new resource for the hundreds of sRNAs identified in Staphylococci, with primary focus on the human pathogen Staphylococcus aureus. The "Staphylococcal Regulatory RNA Database" (SRD, ...

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ALS-linked mutations in ubiquilin-2 or hnRNPA1 reduce interaction between ubiquilin-2 and hnRNPA1

01.05.2015 | Kathleen M. Gilpin; Lydia Chang; Mervyn J. Monteiro, Human Molecular Genetics, 2015

Amyotrophic lateral sclerosis (ALS)-linked mutations in UBQLN2 and some members of the heterogeneous nuclear ribonucleoproteins (hnRNPs) family cause ALS. Most mutations in UBQLN2 are missense mutations that occur in and around a PXX repeat motif located in the central domain of the encoded ...

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Asymmetric Transcript Discovery by RNA-seq in C . elegans Blastomeres Identifies neg-1 , a Gene Important for Anterior Morphogenesis

13.04.2015 | Erin Osborne Nishimura et al., PLoS Genetics, 2015

by Erin Osborne Nishimura, Jay C. Zhang, Adam D. Werts, Bob Goldstein, Jason D. Lieb After fertilization but prior to the onset of zygotic transcription, the C. elegans zygote cleaves asymmetrically to create the anterior AB and posterior P1 blastomeres, each of which goes on to generate ...

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Inhibition of viral protein translation by indomethacin in vesicular stomatitis virus infection: role of eIF2α kinase PKR

09.04.2015 | Carla Amici, Simone La Frazia, Claudia Brunelli, Mirna Balsamo, Mara Angelini, M. Gabriella Santoro, Cellular Microbiology, 2015

Summary Indomethacin, a cyclooxygenase‐1 and ‐2 inhibitor widely used in the clinic for its potent anti‐inflammatory/analgesic properties, also possesses antiviral activity against several viral pathogens; however, the mechanism of antiviral action remains elusive. We have recently shown that ...

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A large-scale, in vivo transcription factor screen defines bivalent chromatin as a key property of regulatory factors mediating Drosophila wing development [RESEARCH]

01.04.2015 | Schertel, C., Albarca, M., Rockel-Bauer, C., Kelley, N. W., Bischof, J., Hens, K., van Nimwegen, E., Basler, K., Dep ..., Genome Research, 2015

Transcription factors (TFs) are key regulators of cell fate. The estimated 755 genes that encode DNA binding domain-containing proteins comprise ~5% of all Drosophila genes. However, the majority has remained uncharacterized so far due to the lack of proper genetic tools. We generated 594 ...

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Brr2 plays a role in spliceosomal activation in addition to U4/U6 unwinding

31.03.2015 | Lingdi Zhang; Xueni Li; Ryan C. Hill; Yan Qiu; Wenzheng Zhang; Kirk C. Hansen; Rui Zhao, Nucleic Acids Research, 2015

Brr2 is a DExD/H-box RNA helicase that is responsible for U4/U6 unwinding, a critical step in spliceosomal activation. Brr2 is a large protein (~250 kD) that consists of an N-terminal domain (~500 residues) with unknown function and two Hel308-like modules that are responsible for RNA unwinding. ...

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A positioned +1 nucleosome enhances promoter-proximal pausing

31.03.2015 | Silvia Jimeno-González; María Ceballos-Chávez; José C. Reyes, Nucleic Acids Research, 2015

Chromatin distribution is not uniform along the human genome. In most genes there is a promoter-associated nucleosome free region (NFR) followed by an array of nucleosomes towards the gene body in which the first (+1) nucleosome is strongly positioned. The function of this characteristic ...

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GAGA Factor Maintains Nucleosome-Free Regions and Has a Role in RNA Polymerase II Recruitment to Promoters

27.03.2015 | Nicholas J. Fuda et al., PLoS Genetics, 2015

by Nicholas J. Fuda, Michael J. Guertin, Sumeet Sharma, Charles G. Danko, André L. Martins, Adam Siepel, John T. Lis Previous studies have shown that GAGA Factor (GAF) is enriched on promoters with paused RNA Polymerase II (Pol II), but its genome-wide function and mechanism of action remain ...

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Positive Role of Promyelocytic Leukemia Protein in Type I Interferon Response and Its Regulation by Human Cytomegalovirus

26.03.2015 | Young-Eui Kim et al., PLoS Pathogens, 2015

by Young-Eui Kim, Jin-Hyun Ahn Promyelocytic leukemia protein (PML), a major component of PML nuclear bodies (also known as nuclear domain 10), is involved in diverse cellular processes such as cell proliferation, apoptosis, gene regulation, and DNA damage response. PML also acts as a ...

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Down‐regulation of microRNA‐9 leads to activation of IL‐6/Jak/STAT3 pathway through directly targeting IL‐6 in HeLa cell

25.03.2015 | Jiangbo Zhang, Junqiao Jia, Lijun Zhao, Xiaojun Li, Qing Xie, Xiangmei Chen, Jianliu Wang, Fengmin Lu, Molecular Carcinogenesis, 2015

MicroRNA‐9 (miR‐9) presents to exert distinct and even opposite functions in different kinds of tumors through targeting different cellular genes. However, its role in cervical adenocarcinoma remains uncertain. Here, we report that miR‐9 is down‐regulated in cervical adenocarcinoma due to its ...

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