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882 Aktuelle Fachpublikationen zum Thema Addition

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The Ll.LtrB intron from Lactococcus lactis excises as circles in vivo: insights into the group II intron circularization pathway [ARTICLES]

01.07.2015 | Caroline Monat; Cecilia Quiroga; Felix Laroche-Johnston; Benoit Cousineau, RNA, 2015

Group II introns are large ribozymes that require the assistance of intron-encoded or free-standing maturases to splice from their pre-mRNAs in vivo. They mainly splice through the classical branching pathway, being released as RNA lariats. However, group II introns can also splice through ...


Contribution of two conserved histidines to the dual activity of archaeal RNA guide-dependent and -independent pseudouridine synthase Cbf5 [REPORTS]

01.07.2015 | Anne-Sophie Tillault; Jean-Baptiste Fourmann; Christine Loegler; Hans-Joachim Wieden; Ute Kothe; Bruno Charpentier, RNA, 2015

In all organisms, several distinct stand-alone pseudouridine synthase (PUS) family enzymes are expressed to isomerize uridine into pseudouridine () by specific recognition of RNAs. In addition, s are generated in Archaea and Eukaryotes by PUS enzymes which are organized as ribonucleoprotein ...


EnD-Seq and AppEnD: sequencing 3' ends to identify nontemplated tails and degradation intermediates [METHODS]

01.07.2015 | Joshua D. Welch; Michael K. Slevin; Deirdre C. Tatomer; Robert J. Duronio; Jan F. Prins; William F. Marzluff, RNA, 2015

Existing methods for detecting RNA intermediates resulting from exonuclease degradation are low-throughput and laborious. In addition, mapping the 3' ends of RNA molecules to the genome after high-throughput sequencing is challenging, particularly if the 3' ends contain post-transcriptional ...


Clinical evaluation of dengue RNA, NS1 and IgM for diagnosis of dengue in Southern China

28.06.2015 | Xinliang Chen, Rui Chen, Wenshen Gu, Jian He, Weipeng Cai, Jiajia Li, Chaohui Duan, Haiyan Yan, Journal of Medical Virology, 2015

Abstract Objectives In 2014 a large outbreak of dengue occurred in Guangzhou, China. This outbreak prompted us to evaluate NS1 and RNA for the early diagnosis of acute dengue infection, in addition to the combination with IgM antibody. We aimed to find the differences of three assays about ...


Viruses, Vol. 7, Pages 3443-3461: The Subcellular Localisation of the Human Papillomavirus (HPV) 16 E7 Protein in Cervical Cancer Cells and Its Perturbation by RNA Aptamers

26.06.2015 | Cesur, Özlem ; Nicol, Clare ; Groves, Helen ; Mankouri, Jamel ; Blair, George Eric; Stonehouse, Nicola J., Viruses, 2015

Human papillomavirus (HPV) is the most common viral infection of the reproductive tract, affecting both men and women. High-risk oncogenic types are responsible for almost 90% of anogenital and oropharyngeal cancers including cervical cancer. Some of the HPV “early” genes, particularly E6 and E7, ...


A time of change: Dynamics of chromatin and transcriptional regulation during nuclear programming in early Drosophila development

23.06.2015 | Ann Boija, Mattias Mannervik, Molecular Reproduction and Development, 2015

In order for a new organism to form, the genomes of the highly specialized egg and sperm need to be reprogrammed into a totipotent state that is capable of generating all of the cell types that comprise an organism. This reprogramming occurs by erasing chromatin modifications, leaving the cells ...


Human nucleolar protein Nop52 (RRP1/NNP-1) is involved in site 2 cleavage in internal transcribed spacer 1 of pre-rRNAs at early stages of ribosome biogenesis

23.06.2015 | Harunori Yoshikawa; Hideaki Ishikawa; Keiichi Izumikawa; Yutaka Miura; Toshiya Hayano; Toshiaki Isobe; Richard J. Si ..., Nucleic Acids Research, 2015

During the early steps of ribosome biogenesis in mammals, the two ribosomal subunits 40S and 60S are produced via splitting of the large 90S pre-ribosomal particle (90S) into pre-40S and pre-60S pre-ribosomal particles (pre-40S and pre-60S). We previously proposed that replacement of fibrillarin ...


[Report] Recruitment of RNA polymerase II by the pioneer transcription factor PHA-4

19.06.2015 | H.‐T. Hsu; H.‐M. Chen; Z. Yang; J. Wang; N. K. Lee; A. Burger; K. Zaret; T. Liu; E. Levine; S. E. Mango, Science , 2015

Pioneer transcription factors initiate cell-fate changes by binding to silent target genes. They are among the first factors to bind key regulatory sites and facilitate chromatin opening. Here, we identify an additional role for pioneer factors. In early Caenorhabditis elegans foregut ...


Viruses, Vol. 7, Pages 3130-3154: Evaluation of Signature Erosion in Ebola Virus Due to Genomic Drift and Its Impact on the Performance of Diagnostic Assays

17.06.2015 | Sozhamannan, Shanmuga ; Holland, Mitchell Y.; Hall, Adrienne T.; Negrón, Daniel A.; Ivancich, Mychal ; Koehler, Jeff ..., Viruses, 2015

Genome sequence analyses of the 2014 Ebola Virus (EBOV) isolates revealed a potential problem with the diagnostic assays currently in use; i.e., drifting genomic profiles of the virus may affect the sensitivity or even produce false-negative results. We evaluated signature erosion in ebolavirus ...


Association of UBP1 to ribonucleoprotein complexes is regulated by interaction with the trypanosome ortholog of the human multifunctional P32 protein

15.06.2015 | Alejandro Cassola, María Albertina Romaniuk, Debora Primrose, Gabriela Cervini, Iván D′Orso, Alberto Carlos Frasch, Molecular Microbiology, 2015

Summary Regulation of gene expression in trypanosomatid parasitic protozoa is mainly achieved posttranscriptionally. RNA‐binding proteins (RBPs) associate to 3′ untranslated regions in mRNAs through dedicated domains such as the RNA recognition motif (RRM). Trypanosoma cruzi UBP1 (TcUBP1) is ...


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