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Viruses, Vol. 8, Pages 44: A KDEL Retrieval System for ER-Golgi Transport of Japanese Encephalitis Viral Particles

05.02.2016 | Wang, Robert YL; Wu, Yu-Jen ; Chen, Han-Shan ; Chen, Chih-Jung, Viruses, 2016

Evidence has emerged that RNA viruses utilize the host secretory pathway for processing and trafficking mature viral particles and for exiting the infected cells. Upon completing the complex assembly process, the viral particles take advantage of the cellular secretory trafficking machinery for ...

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GAD2 Alternative Transcripts in the Human Prefrontal Cortex, and in Schizophrenia and Affective Disorders

05.02.2016 | Kasey N. Davis et al., PLoS ONE, 2016

by Kasey N. Davis, Ran Tao, Chao Li, Yuan Gao, Marjorie C. Gondré-Lewis, Barbara K. Lipska, Joo Heon Shin, Bin Xie, Tianzhang Ye, Daniel R. Weinberger, Joel E. Kleinman, Thomas M. Hyde Genetic variation and early adverse environmental events work together to increase risk for schizophrenia. ...

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Expression of Streptococcus pneumoniae Bacteriocins Is Induced by Antibiotics via Regulatory Interplay with the Competence System

03.02.2016 | Morten Kjos et al., PLoS Pathogens, 2016

by Morten Kjos, Eric Miller, Jelle Slager, Frank B. Lake, Oliver Gericke, Ian S. Roberts, Daniel E. Rozen, Jan-Willem Veening Pneumococcal bacteriocins (pneumocins) are antibacterial toxins that mediate intra-species competition within the human host. However, the triggers of pneumocin ...

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An updated evolutionary study of Flaviviridae NS3 helicase and NS5 RNA-dependent RNA polymerase, reveals novel invariable motifs as potential pharmacological targets.

03.02.2016 | Louis Papageorgiou; Styliani Loukatou; Sofia Kossida; Dimitris Maroulis; Dimitrios Vlachakis, Molecular BioSystems, 2016

The rate of Flaviviridae family viruses infections worldwide has increased dramatically in the last few years. In addition, infections caused by arthropod vectors viruses including Hepatitis C, West Nile, Dengue fever, Yellow fever and Japanese encephalitis are emerging throughout the world. ...

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Multiple protein-protein interactions converging on the Prp38 protein during activation of the human spliceosome [ARTICLE]

01.02.2016 | Tonio Schütze; Alexander K.C. Ulrich; Luise Apelt; Cindy L. Will; Natascha Bartlick; Martin Seeger; Gert Weber; Rein ..., RNA, 2016

Spliceosomal Prp38 proteins contain a conserved amino-terminal domain, but only higher eukaryotic orthologs also harbor a carboxy-terminal RS domain, a hallmark of splicing regulatory SR proteins. We show by crystal structure analysis that the amino-terminal domain of human Prp38 is organized ...

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Sequencing of lariat termini in S. cerevisiae reveals 5' splice sites, branch points, and novel splicing events [ARTICLE]

01.02.2016 | Daoming Qin; Lei Huang; Alissa Wlodaver; Jorge Andrade; Jonathan P. Staley, RNA, 2016

Pre-mRNA splicing is a central step in the shaping of the eukaryotic transcriptome and in the regulation of gene expression. Yet, due to a focus on fully processed mRNA, common approaches for defining pre-mRNA splicing genome-wide are suboptimal—especially with respect to defining the branch ...

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Genetic Determinism and Evolutionary Reconstruction of a Host Jump in a Plant Virus

01.02.2016 | Nikon Vassilakos; Vincent Simon; Aliki Tzima; Elisabeth Johansen; Benoît Moury, Molecular Biology and Evolution, 2016

In spite of their widespread occurrence, only few host jumps by plant viruses have been evidenced and the molecular bases of even fewer have been determined. A combination of three independent approaches, 1) experimental evolution followed by reverse genetics analysis, 2) positive selection ...

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Pyruvate Kinase Isoform Switching and Hepatic Metabolic Reprogramming by the Environmental Contaminant 2,3,7,8-Tetrachlorodibenzo-p-Dioxin

01.02.2016 | Rance Nault; Kelly A. Fader; Mathew P. Kirby; Shaimaa Ahmed; Jason Matthews; A. Daniel Jones; Sophia Y. Lunt; Timoth ..., Toxicological Sciences, 2016

The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) elicits dose-dependent hepatotoxicity that includes fat accumulation, inflammation, and fibrosis that may progress to hepatocellular carcinoma. To further investigate these effects, RNA-Seq data were integrated with ...

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The Zinc-Finger Protein SOP1 Is Required for a Subset of the Nuclear Exosome Functions in Arabidopsis

01.02.2016 | Kian Hématy et al., PLoS Genetics, 2016

by Kian Hématy, Yannick Bellec, Ram Podicheti, Nathalie Bouteiller, Pauline Anne, Céline Morineau, Richard P. Haslam, Frederic Beaudoin, Johnathan A. Napier, Keithanne Mockaitis, Dominique Gagliardi, Hervé Vaucheret, Heike Lange, Jean-Denis Faure Correct gene expression requires tight RNA ...

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Cold-inducible RNA-binding protein CIRP/hnRNP A18 regulates telomerase activity in a temperature-dependent manner

29.01.2016 | Youwei Zhang; Yangxiu Wu; Pingsu Mao; Feng Li; Xin Han; Yi Zhang; Shuai Jiang; Yuxi Chen; Junjiu Huang; Dan Liu; Yon ..., Nucleic Acids Research, 2016

The telomerase is responsible for adding telomeric repeats to chromosomal ends and consists of the reverse transcriptase TERT and the RNA subunit TERC. The expression and activity of the telomerase are tightly regulated, and aberrant activation of the telomerase has been observed in >85% of human ...

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