01.07.2013 | Caroline Vance; Emma L. Scotter; Agnes L. Nishimura; Claire Troakes; Jacqueline C. Mitchell; Claudia Kathe; Hazel Ur ..., Human Molecular Genetics, 2013

Mutations in the gene encoding Fused in Sarcoma (FUS) cause amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder. FUS is a predominantly nuclear DNA- and RNA-binding protein that is involved in RNA processing. Large FUS-immunoreactive inclusions fill the perikaryon of ...

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06.06.2013 | Johann Böhm et al., PLoS Genetics, 2013

by Johann Böhm, Nasim Vasli, Marie Maurer, Belinda Cowling, G. Diane Shelton, Wolfram Kress, Anne Toussaint, Ivana Prokic, Ulrike Schara, Thomas James Anderson, Joachim Weis, Laurent Tiret, Jocelyn Laporte Amphiphysin 2, encoded by BIN1, is a key factor for membrane sensing and remodelling ...

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06.06.2013 | Yuan-Lin Chou et al., PLoS Pathogens, 2013

by Yuan-Lin Chou, Yi-Jing Hung, Yang-Hao Tseng, Hsiu-Ting Hsu, Jun-Yi Yang, Chiung-Hua Wung, Na-Sheng Lin, Menghsiao Meng, Yau-Heiu Hsu, Ban-Yang Chang The triple-gene-block protein 3 (TGBp3) of Bamboo mosaic virus (BaMV) is an integral endoplasmic reticulum (ER) membrane protein which is ...

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01.06.2013 | Michal Chorev; Liran Carmel, Nucleic Acids Research, 2013

An appreciable fraction of introns is thought to have some function, but there is no obvious way to predict which specific intron is likely to be functional. We hypothesize that functional introns experience a different selection regime than non-functional ones and will therefore show ...

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01.06.2013 | Zhongwei Qiu; Meizhen Liu; Zhaohua Chen; Yanjiao Shao; Hongjie Pan; Gaigai Wei; Chao Yu; Long Zhang; Xia Li; Ping Wa ..., Nucleic Acids Research, 2013

Transcription activator-like effector nucleases (TALENs) are a powerful new approach for targeted gene disruption in various animal models, but little is known about their activities in Mus musculus, the widely used mammalian model organism. Here, we report that direct injection of in vitro ...

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31.05.2013 | Paolo Gaibani et al., PLoS ONE, 2013

by Paolo Gaibani, Francesca Cavrini, Ernest A. Gould, Giada Rossini, Anna Pierro, Maria Paola Landini, Vittorio Sambri Usutu virus (USUV) is a mosquito-borne flavivirus, belonging to the Japanese encephalitis antigenic complex, that circulates among mosquitoes and birds. We describe and ...

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21.05.2013 | Marjoke F. Debets, William P. J. Leenders, Kiek Verrijp, Marleen Zonjee, Silvie A. Meeuwissen, Irene Otte‐Höller, Ja ..., Macromolecular Bioscience, 2013

Abstract Targeted carrier systems (e.g., liposomes or nanoparticles) are used to specifically deliver drugs to a site of interest. Site‐direction can be achieved by attachment of targeting molecules, such as peptides, DNA/RNA, or antibodies, to the surface of the carrier. Here, the ...

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17.05.2013 | Sen Lian et al., PLoS ONE, 2013

by Sen Lian, Jong-Seung Lee, Won Kyong Cho, Jisuk Yu, Mi-Kyeong Kim, Hong-Soo Choi, Kook-Hyung Kim Tomato spotted wilt virus (TSWV) severely damages and reduces the yield of many economically important plants worldwide. In this study, we determined the whole-genome sequences of 10 TSWV ...

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16.05.2013 | Kuan‐Yu Lin, Yau‐Heiu Hsu, Hsin‐Chuan Chen, Na‐Sheng Lin, Molecular Plant Pathology, 2013

Summary Plant genetic engineering has broadened the options for plant virus resistance and is mostly based on pathogen‐derived resistance. Previously, we have shown that interfering satellite RNA (satRNA) of Bamboo mosaic virus (satBaMV) greatly reduces Bamboo mosaic virus (BaMV) ...

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14.05.2013 | Christof B. Mast; Severin Schink; Ulrich Gerland; Dieter Braun, Proceedings of the National Academy of Sciences current issue, 2013

For the emergence of early life, the formation of biopolymers such as RNA is essential. However, the addition of nucleotide monomers to existing oligonucleotides requires millimolar concentrations. Even in such optimistic settings, no polymerization of RNA longer than about 20 bases could be ...

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