Meine Merkliste  

823 Aktuelle Fachpublikationen zum Thema Addition

mit folgenden Suchkriterien:

Diazirine Photocrosslinking Recruits Activated FTO Demethylase Complexes for Specific N6-methyladenosine Recognition

16.03.2015 | Hyun Seok Jeong; Gosuke Hayashi; Akimitsu Okamoto, ACS Chemical Biology, 2015

N6-methyladenosine (m6A) is a prevalent modification of RNAs. m6A exists in mRNA and plays an important role in RNA biological pathways and in RNA epigenetic regulation. We applied diazirine photocrosslinking to the event of m6A recognition mediated by the fat mass and obesity associated (FTO) ...


Nuclear TDP-43 causes neuronal toxicity by escaping from the inhibitory regulation by hnRNPs

15.03.2015 | Hiroaki Suzuki; Yoshio Shibagaki; Seisuke Hattori; Masaaki Matsuoka, Human Molecular Genetics, 2015

Dysregulation of transactive response DNA-binding protein-43 (TDP-43) is thought to be linked to the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). TDP-43 normally localizes in the nucleus but its main localization shifts to the cytoplasm in most ...


Evolutionary non-linear modelling for selecting vaccines against antigenically variable viruses

15.03.2015 | Tameera Rahman; Mana Mahapatra; Emma Laing; Yaochu Jin, Bioinformatics, 2015

Motivation: Invitro and invivo selection of vaccines is time consuming, expensive and the selected vaccines may not be able to provide protection against broad-spectrum viruses because of emerging antigenically novel disease strains. A powerful computational model that incorporates these ...


Structural plasticity of Cid1 provides a basis for its distributive RNA terminal uridylyl transferase activity

11.03.2015 | Luke A. Yates; Benjamin P. Durrant; Sophie Fleurdépine; Karl Harlos; Chris J. Norbury; Robert J.C. Gilbert, Nucleic Acids Research, 2015

Terminal uridylyl transferases (TUTs) are responsible for the post-transcriptional addition of uridyl residues to RNA 3' ends, leading in some cases to altered stability. The Schizosaccharomyces pombe TUT Cid1 is a model enzyme that has been characterized structurally at moderate resolution and ...


The beta hairpin structure within ribosomal protein S5 mediates interplay between domains II and IV and regulates HCV IRES function

11.03.2015 | Prasanna Bhat; Shivaprasad Shwetha; Divya Khandige Sharma; Agnel Praveen Joseph; Narayanaswamy Srinivasan; Saumitra Das, Nucleic Acids Research, 2015

Translation initiation in Hepatitis C Virus (HCV) is mediated by Internal Ribosome Entry Site (IRES), which is independent of cap-structure and uses a limited number of canonical initiation factors. During translation initiation IRES–40S complex formation depends on high affinity interaction of ...


The beta-3 adrenergic agonist (CL-316,243) restores the expression of down-regulated fatty acid oxidation genes in type 2 diabetic mice

08.03.2015 | Kumar, Amit; Shiloach, Joseph; Betenbaugh, Michael J; Gallagher, Emily J, Nutrition & Metabolism, 2015

Background: The hallmark of Type 2 diabetes (T2D) is hyperglycemia, although there are multiple other metabolic abnormalities that occur with T2D, including insulin resistance and dyslipidemia. To advance T2D prevention and develop targeted therapies for its treatment, a greater understanding of ...


Arginine methylation and citrullination of splicing factor proline- and glutamine-rich (SFPQ/PSF) regulates its association with mRNA [ARTICLES]

01.03.2015 | Ambrosius P. Snijders; Guillaume M. Hautbergue; Alex Bloom; James C. Williamson; Thomas C. Minshull; Helen L. Philli ..., RNA, 2015

Splicing factor proline- and glutamine-rich (SFPQ) also commonly known as polypyrimidine tract-binding protein-associated-splicing factor (PSF) and its binding partner non-POU domain-containing octamer-binding protein (NONO/p54nrb), are highly abundant, multifunctional nuclear proteins. However, ...


Functional Conservation of Both CDS- and 3′-UTR-Located MicroRNA Binding Sites between Species

01.03.2015 | Guojing Liu; Rui Zhang; Jin Xu; Chung-I Wu; Xuemei Lu, Molecular Biology and Evolution, 2015

MicroRNAs (miRNAs) mediate gene regulation posttranscriptionally through pairing of their seed (2–7 nt) to 3'-untranslated regions (3'-UTRs) or coding regions (coding sequences [CDSs]) of their target genes. CDS target sites generally show weaker repression effects than 3'-UTR sites. However, ...


Epigenetic heredity: RNA‐mediated modes of phenotypic variation

27.02.2015 | Minoo Rassoulzadegan, François Cuzin, Annals of the New York Academy of Sciences, 2015

In addition to the Mendelian mutations, several instances of heritable phenotypic variation have been reported. We have observed, in mice, a role for sperm RNAs in the induction of such stable phenotypic variation. When experimentally transferred by RNA microinjection into fertilized mouse eggs, ...


Deciphering the impact of parameters influencing transgene expression kinetics after repeated cell transduction with integration‐deficient retroviral vectors

27.02.2015 | Juliane W. Schott, Nico M. Jaeschke, Dirk Hoffmann, Tobias Maetzig, Matthias Ballmaier, Tamaryin Godinho, Toni Catho ..., Cytometry Part A, 2015

Abstract Lentiviral and gammaretroviral vectors are state‐of‐the‐art tools for transgene expression within target cells. The integration of these vectors can be deliberately suppressed to derive a transient gene expression system based on extrachromosomal circular episomes with intact coding ...


Seite 1 von 83
Suche per e-Mail abonnieren

Sie erhalten passend zu Ihrer Suche die neusten Suchergebnisse per E-Mail. Dieser Service ist für Sie kostenlos und kann jederzeit abbestellt werden.

Ihr Bowser ist nicht aktuell. Microsoft Internet Explorer 6.0 unterstützt einige Funktionen auf Chemie.DE nicht.