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DICER/AGO-dependent epigenetic silencing of D4Z4 repeats enhanced by exogenous siRNA suggests mechanisms and therapies for FSHD

01.09.2015 | Jong-Won Lim; Lauren Snider; Zizhen Yao; Rabi Tawil; Silvère M. Van Der Maarel; Frank Rigo; C. Frank Bennett; Galina ..., Human Molecular Genetics, 2015

Facioscapulohumeral muscular dystrophy (FSHD) is caused by the aberrant expression of the DUX4 transcription factor in skeletal muscle. The DUX4 retrogene is encoded in the D4Z4 macrosatellite repeat array, and smaller array size or a mutation in the SMCHD1 gene results in inefficient epigenetic ...


The NMR structure of the II-III-VI three-way junction from the Neurospora VS ribozyme reveals a critical tertiary interaction and provides new insights into the global ribozyme structure [ARTICLE]

01.09.2015 | Eric Bonneau; Nicolas Girard; Sébastien Lemieux; Pascale Legault, RNA, 2015

As part of an effort to structurally characterize the complete Neurospora VS ribozyme, NMR solution structures of several subdomains have been previously determined, including the internal loops of domains I and VI, the I/V kissing-loop interaction and the III–IV–V junction. Here, we expand this ...


RNA-Seq Analysis of Abdominal Fat Reveals Differences between Modern Commercial Broiler Chickens with High and Low Feed Efficiencies

21.08.2015 | Zhu Zhuo et al., PLoS ONE, 2015

by Zhu Zhuo, Susan J. Lamont, William R. Lee, Behnam Abasht For economic and environmental reasons, chickens with superior feed efficiency (FE) are preferred in the broiler chicken industry. High FE (HFE) chickens typically have reduced abdominal fat, the major adipose tissue in chickens. In ...


An atlas of RNA base pairs involving modified nucleobases with optimal geometries and accurate energies

18.08.2015 | Mohit Chawla; Romina Oliva; Janusz M. Bujnicki; Luigi Cavallo, Nucleic Acids Research, 2015

Posttranscriptional modifications greatly enhance the chemical information of RNA molecules, contributing to explain the diversity of their structures and functions. A significant fraction of RNA experimental structures available to date present modified nucleobases, with half of them being ...


Structures of the T. brucei kRNA editing factor MRB1590 reveal unique RNA-binding pore motif contained within an ABC-ATPase fold

18.08.2015 | Porsha L. R. Shaw; Natalie M. McAdams; Michael A. Hast; Michelle L. Ammerman; Laurie K. Read; Maria A. Schumacher, Nucleic Acids Research, 2015

Kinetoplastid RNA (kRNA) editing is a process that creates translatable mitochondrial mRNA transcripts from cryptogene encoded RNAs and is unique for kinetoplastids, such as Trypanosoma brucei. In addition to the catalytic 20S editosome, multiple accessory proteins are required for this ...


X chromosome-linked intellectual disability protein PQBP1 associates with and regulates the translation of specific mRNAs

15.08.2015 | Didi Wan; Zi Chao Zhang; Xiaoyan Zhang; Qian Li; Junhai Han, Human Molecular Genetics, 2015

X chromosome-linked intellectual disability is a common developmental disorder, and mutations of the polyglutamine-binding protein 1 (PQBP1) gene have been linked to this disease. In addition to existing in the nucleus as a splicing factor, PQBP1 is also found in cytoplasmic RNA granules, where ...


Paeoniflorin ameliorates ANIT‐induced cholestasis by activating Nrf2 through an PI3K/Akt‐dependent pathway in rats

13.08.2015 | Zhe Chen, Xiao Ma, Yun Zhu, Yanling Zhao, Jiabo Wang, Ruisheng Li, Chang Chen, Shizhang Wei, Wenjuan Jiao, Yaming Zh ..., Phytotherapy Research, 2015

Cholestasis causes hepatic accumulation of bile acids leading to liver injury, fibrosis and liver failure. Paeoniflorin, the major active compound isolated from the roots of Paeonia lactiflora pall and Paeonia veitchii Lynch, is extensively used for liver diseases treatment in China. However, ...


Lentivirus‐mediated RNA interference targeting LAPTM4B inhibits human ovarian cancer cell invasion in vitro

06.08.2015 | Fanling Meng, Xiuwei Chen, Hongtao Song, Ge Lou, Songbin Fu, Chemical Biology & Drug Design, 2015

Abstract Background This study examines the effects of RNA interference‐mediated downregulation of human lysosomal‐associated protein transmembrane 4 beta (LAPTM4B) expression on the biological behavior of the human serous adenocarcinoma cell line NIH:OVCAR3. Methods This study ...


Let-7 Represses Carcinogenesis and a Stem Cell Phenotype in the Intestine via Regulation of Hmga2

05.08.2015 | Blair B. Madison et al., PLoS Genetics, 2015

by Blair B. Madison, Arjun N. Jeganathan, Rei Mizuno, Monte M. Winslow, Antoni Castells, Miriam Cuatrecasas, Anil K. Rustgi Let-7 miRNAs comprise one of the largest and most highly expressed family of miRNAs among vertebrates, and is critical for promoting differentiation, regulating ...


CBR antimicrobials inhibit RNA polymerase via at least two bridge-helix cap-mediated effects on nucleotide addition [Biochemistry]

04.08.2015 | Brian Bae; Dhananjaya Nayak; Ananya Ray; Arkady Mustaev; Robert Landick; Seth A. Darst, Proceedings of the National Academy of Sciences current issue, 2015

RNA polymerase inhibitors like the CBR class that target the enzyme’s complex catalytic center are attractive leads for new antimicrobials. Catalysis by RNA polymerase involves multiple rearrangements of bridge helix, trigger loop, and active-center side chains that isomerize the triphosphate of ...


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