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1.051 Aktuelle Fachpublikationen zum Thema Addition

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High-throughput sequencing of partially edited trypanosome mRNAs reveals barriers to editing progression and evidence for alternative editing [BIOINFORMATICS]

01.05.2016 | Rachel M. Simpson; Andrew E. Bruno; Jonathan E. Bard; Michael J. Buck; Laurie K. Read, RNA, 2016

Uridine insertion/deletion RNA editing in kinetoplastids entails the addition and deletion of uridine residues throughout the length of mitochondrial transcripts to generate translatable mRNAs. This complex process requires the coordinated use of several multiprotein complexes as well as the ...


Trans and cis factors affecting A-to-I RNA editing efficiency of a noncoding editing target in C. elegans [REPORT]

01.05.2016 | Michael C. Washburn; Heather A. Hundley, RNA, 2016

Adenosine-to-inosine RNA editing by ADARs affects thousands of adenosines in an organism's transcriptome. However, adenosines are not edited at equal levels nor do these editing levels correlate well with ADAR expression levels. Therefore, additional mechanisms are utilized by the cell to dictate ...


Hoogsteen-position pyrimidines promote the stability and function of the MALAT1 RNA triple helix [REPORT]

01.05.2016 | Jessica A. Brown; Charles G. Kinzig; Suzanne J. DeGregorio; Joan A. Steitz, RNA, 2016

Triple-stranded RNA was first deduced to form in vitro more than 50 years ago and has since been implicated in RNA catalysis, stability, and small molecule binding. Despite the emerging biological significance of RNA triple helices, it remains unclear how their nucleotide composition contributes ...


Guanosine and its modified derivatives are endogenous ligands for TLR7

01.05.2016 | Takuma Shibata; Umeharu Ohto; Shosaku Nomura; Kayoko Kibata; Yuji Motoi; Yan Zhang; Yusuke Murakami; Ryutaro Fukui; ..., International Immunology, 2016

Toll-like receptor (TLR) 7and 8 were considered to recognize single-strand RNA (ssRNA) from viruses. Although these receptors also respond to synthetic small chemical ligands, such as CL075 and R848, it remains to be determined whether these receptors sense natural small molecules or not. In the ...


Homology-driven assembly of NOn-redundant protEin sequence sets (NOmESS) for mass spectrometry

01.05.2016 | Tikira Temu; Matthias Mann; Markus Räschle; Jürgen Cox, Bioinformatics, 2016

Summary: To enable mass spectrometry (MS)-based proteomic studies with poorly characterized organisms, we developed a computational workflow for the homology-driven assembly of a non-redundant reference sequence dataset. In the automated pipeline, translated DNA sequences (e.g. ESTs, RNA ...


Cleavage and polyadenylation specificity factor 30: An RNA-binding zinc-finger protein with an unexpected 2Fe-2S cluster [Chemistry]

26.04.2016 | Geoffrey D. Shimberg; Jamie L. Michalek; Abdulafeez A. Oluyadi; Andria V. Rodrigues; Beth E. Zucconi; Heather M. Neu ..., Proceedings of the National Academy of Sciences current issue, 2016

Cleavage and polyadenylation specificity factor 30 (CPSF30) is a key protein involved in pre-mRNA processing. CPSF30 contains five Cys3His domains (annotated as “zinc-finger” domains). Using inductively coupled plasma mass spectrometry, X-ray absorption spectroscopy, and UV-visible spectroscopy, ...


Mast Cells Play an Important Role in the Pathogenesis of Hyperglycemia‐Induced Atrial Fibrillation

21.04.2016 | Kenshi Uemura, Hidekazu Kondo, Yumi Ishii, Mami Kobukata, Miho Haraguchi, Takaaki Imamura, Toyokazu Otsubo, Yuki Ike ..., Journal of Cardiovascular Electrophysiology, 2016

Background and Objectives : Recently, it has been reported that mast cells (MCs) could underlie the mechanisms of several cardiovascular diseases. However, the role of MCs in diabetes‐induced atrial fibrillation (AF) has not been notably investigated. We tested the hypothesis that MC ...


Peculiarities of studying the effects of pathogen reduction technologies on platelets

20.04.2016 | Abdimajid Osman, Walter E. Hitzler, Patrick Provost, PROTEOMICS, 2016

The transfusion of platelet concentrates (PCs) is mainly used for treatment of thrombocytopenic, trauma or surgery patients. The integrity and safety of these platelet preparations, however, is compromised by the presence of pathogens, such as viruses, bacteria and parasites. The transfer of ...


Transcriptional, post-transcriptional and chromatin-associated regulation of pri-miRNAs, pre-miRNAs and moRNAs

20.04.2016 | Chirag Nepal; Marion Coolen; Yavor Hadzhiev; Delphine Cussigh; Piotr Mydel; Vidar M. Steen; Piero Carninci; Jesper B ..., Nucleic Acids Research, 2016

MicroRNAs (miRNAs) play a major role in the post-transcriptional regulation of target genes, especially in development and differentiation. Our understanding about the transcriptional regulation of miRNA genes is limited by inadequate annotation of primary miRNA (pri-miRNA) transcripts. Here, we ...


Mapping of internal monophosphate 5′ ends of Bacillus subtilis messenger RNAs and ribosomal RNAs in wild-type and ribonuclease-mutant strains

20.04.2016 | Jeanne M. DiChiara; Bo Liu; Sabine Figaro; Ciarán Condon; David H. Bechhofer, Nucleic Acids Research, 2016

The recent findings that the narrow-specificity endoribonuclease RNase III and the 5' exonuclease RNase J1 are not essential in the Gram-positive model organism, Bacillus subtilis, facilitated a global analysis of internal 5' ends that are generated or acted upon by these enzymes. An RNA-Seq ...


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